Cytomegalovirus ọrịa

Cytomegalovirus, nke a na-akpọ mgbe ụfọdụ malitere ịrịa ọrịa nke emepụta asọ mmiri ma ọ bụ inklyuzionnoy cytomegaly bụ antoropoznoy opportunistic na-emekarị bụ nwayọọ ma ọ bụ latent (zoro).

Cytomegalovirus ọrịa bụ karịsịa ize ndụ n'oge ime, n'ihi na likelihood nke intrauterine ọrịa, nakwa dị ka na ndabere nke dị iche iche immunodeficient ekwu.

The causative gị n'ụlọnga nke ọrịa bụ a DNA virus genome. Ya onye na-adịghị amụba nwere ike ime na cell-enweghị mebiri. Virus inactivation emee n'oge kefriza na kpo oku, na ụlọ okpomọkụ ọ na-anọgide zuru ezu mma. E comparative nkwụsi ike nke virus na onye Onyenwe anyị + 5.0 - 9.0, ma na onye Onyenwe anyị + 3.0 bụ mbibi ya.

Nkesa nwere ike ime ụmụ irighiri mmiri, transplacental na site na kọntaktị. CMV ọrịa bụkwa penetrates site inwe mmekọahụ, n'oge transplantation nke esịtidem akụkụ, ọbara site na nje na-enye onyinye.

Ofufe Ọrịa nwa intrapartum agwa akara ukwuu karịa transplacental penetration. Cytomegalovirus ọrịa bụ kasị dị ize ndụ na nke nwa ebu n'afọ na akpa trimester nke afọ ime. N'ọnọdụ dị otú ahụ, o yikarịrị nnọọ ọrịa nke nwa ebu n'afọ na mmepe.

N'agbanyeghị elu eke susceptibility nke ndị mmadụ, ndị kasị latent ụdị.

Gịnị bụ cytomegalovirus taa?

Ọ ga-kwuru na isi epidemiological atụmatụ nke ọrịa. Edeturu nile ndebanye ọrịa. Banyere njupụta nke ọrịa bụ kwuru detectable na 50-80% nke ndị toworo eto na antiviral-alụso ọrịa ọgụ.

Otú ọ dị, ọtụtụ na-adịghị ọbụna mara na e nwere a cytomegalovirus na ọrịa a nwere a na-elekọta mmadụ na epidemiological mkpa n'ihi na dịgasị iche iche nke ụzọ na polymorphism nke-adakarị n'obiọma.

Ọrịa na-arụ a nnọọ ọrụ dị mkpa Transfusion na nkà mmụta ọgwụ, transplantation, perinatal daa ọrịa. The ọrịa nwere ike ime ka nwa ntụpọ, ịmụ nwa nwụrụ anwụ, prematurity. Okenye, na ọrịa na-esokarị site iche iche na-ekwu, nke immunodeficiency.

Ofufe Ọrịa ọnụego ibu na-eme ka-ebi-amụba gburugburu ebe obibi mmetọ, ojiji nke immunosuppressive na cytotoxic ọgwụ ọjọọ. Karịsịa mkpa na-adịbeghị anya bụ nkpasu-iwe nke ọrịa ndị mmadụ na HIV.

Ọ ga-kwuru na ọrịa nke nwa ebu n'afọ na ime ọrịa na a latent ụdị ọrịa ahụ, ọ dịghị mgbe nile. Ihe ize ndụ nke intra-eriri akpa nwa na-agbasa nke virus ka nke nwa ebu n'afọ n'oge mbụ omume nke n'elu ọrịa.

Dabere na penetration nke virus, nwere ike ije ozi dị ka a ụzọ ámá na mucous membranes nke digestive tract, elu akụkụ okuku ume na ọwa ma ọ bụ kenwe.

Mgbe penetration nke ọrịa n'ime ọbara bụ ngwa ngwa orunótu nke nje na ndabere nke iwebata na mononuclear phagocytes na leukocytes, nke mere ka ya replication. Na nje na mkpụrụ ndụ dịkwuo size, e nwere a typical morphology nke a nuclear ụdị inclusions, nke bụ malitere ịrịa ìgwè. Formation na-esonyere guzobere nodular infiltrates, fibrosis, calcifications dị iche iche akụkụ. Ke adianade do, e ji mara bụ lymphohistiocytic interstitial infiltration, mmepe nke ụbụrụ owuwu zhelezistopodobnyh.

Ọkachamara chọpụta pụta ụwa nnukwu na-adịghị ala ala iche-iche, nakwa dị ka na nnukwu enwetara ọrịa ma ọ bụ generalized mononukleoznoy na latent ụdị.

Active virus na-ewere dị ka ihe na-egosi nke cell ọgụ ntụpọ na bụ otu ìgwè nke ọrịa AIDS na-ọnọdụ.