"Kosopt": ntuziaka maka ojiji, reviews. Analọg "Kosopta" (anya tụlee)

Maka ọgwụgwọ nke ọrịa metụtara na-adịru nwa oge ma ọ bụ na-adịgide adịgide na-abawanye na mgbali n'ime nwa anya, n'ihi na a ọnụ ke visual acuity na nwoke akwara atrophy, tinye ọgwụ "Kosopt". Analogs enwe dị otú ahụ edinam, nwere ike ịbụ ihe ọzọ a n'ụlọnga.

nkọwa

The ọgwụ dị na ụdị anya tụlee, dị ka a jikọrọ antiglaucoma agwọ ọrịa maka ẹsụhọde intraocular mgbali site na mbenata ntọhapụ nke ọmụmụ secretion ke idem.

N'ịbụ mgbagwoju na Nwa, tụlee "Kosopt" na Ọdịdị abụọ arụ ọrụ bekee. Otu n'ime ha, dorzolamide hydrochloride bụ ugbu ke ichekwa 22,26 mg kwa 1 ml, Ẹkot 20 mg isi dorzolamide. The abụọ n'ọrụ mgwa ihe bụ timolol maleate ke ichekwa 6,83 mg kwa 1 ml, nke bụ Ẹkot 5 mg nke timolol isi. Ka ịmepụta a anụ ihe ngwọta na-eji, ndị ọzọ bekee na-enye nchekwa maka nkwadebe nke na-ekwu adịghị adị ndụ. Ndị a gụnyere: a 50% ngwọta nke benzalkonium chloride, sodium citrate, mannitol, hydroxyethylcellulose, sodium hydroxide solution, distilled mmiri maka ogwu ogbugba.

Nkwadebe "Kosopt" anya tụlee, bụ a uzo, colorless ma ọ bụ ihe fọrọ nke nta colorless, ubé viscous mmiri mmiri. Emepụta plastic vials nke 5 ml.

The usoro nke ihe nke-esi

Antiglaucoma mmetụta dabeere na mmetụta nke abụọ ifịk ifịk mmiri: dorzolamide hydrochloride na timolol maleate. Onye ọ bụla n'ime ha na-ebelata intraocular ọmụmụ secretion, nke na-eduga ná Mbelata elu intraocular mgbali na nkịtị. A n'ihi nke jikọtara ihe nke ha mejupụtara "Kosopt" Nwa (anya tụlee) ntụziaka e ji mara dị ka a ukwuu Mbelata a oke.

Action dorzolamide hydrochloride dabeere na nhọrọ mgbochi nke carbonic anhydrase esịnede II ụdị. Onye na-adịghị arụ ọrụ nke enzyme ebelata secretion nke ciliary ahụ ocular ọmụmụ, nke a na-ejikọta ya na a ọnụ ke guzobe bicarbonate ion, slowing na iga nke sodium ion na mmiri.

N'oge Nde ochichi nke dorzolamide hydrochloride abatakwa general ọbara usoro. Ruo ogologo oge nke a compound na-eduga ka ìgwè nke ya ụmụ irighiri n'ime erythrocytic mkpụrụ ndụ. Nke a bụ n'ihi na nhọrọ na-adịgide adịgide nke abụọ ụdị na carbonic anhydrase dorzolamide hydrochloride, nke na-eduga ná a ọnụ ke ọbara plasma ọgwụ na free ụdị. N bụ a metabolite nke dorzolamide -desetilnoe emepụta, nke bụ obere akpọ igbochi ike carbonic anhydrase abụọ ụdị mgbe tụnyere ihe nke mbụ udi, ma ikekwe ndị mgbochi nke carbonic anhydrase mbụ ụdị. Metabolite ìgwè Oputakwara na erythrocyte mkpụrụ ndụ a ibikwa ụdị na a mbụ ụdị carbonic anhydrase.

Ruo 33% nke ụmụ irighiri jikọọ dorzolamide na ọbara albumin. Nweta nke nọ n'ọrụ mgwa na ya metabolites na mmamịrị na-rụrụ. Ndọrọ ego nke ọgwụ na-eduga ná adịghị n'ahịrị dorzolamide mwepụ nke erythrocyte sel ọbara. Ná mmalite nke ọgwụgwọ, a ngwa ngwa ọnụ nke ya ọdịnaya, na mgbe ahụ na wepụ ifịk umi site erythrocytes na-ebelata. Ọkara-ndụ mgbe instillation nke dorzolamide "Kosopt" nkwadebe ntuziaka maka ojiji ga-dịkarịa ala 4 ọnwa.

Akụkụ nke ihe nke-arụ ọrụ bekee

Timolol maleate egosipụta Njirimara nke a na-abụghị nhọrọ beta-blocker. Ya ọrụ na mbenata intraocular mgbali metụtara na a ọnụ ke mmepụta na ụba intraocular ọmụmụ mwepụ si ohere.

Nde ochichi nke timolol maleate ke "Kosopt" tụlee-eduga na penetration nke umi ke general mgbasa usoro. The hypotensive mmetụta nke timolol amalite 20 nkeji mgbe ochichi, ya kacha mmetụta na-abịa mgbe 120 nkeji na nọgidere na-enwe ụbọchị 1.

egosi

The isi na-egosi maka ọgwụ "Kosopt" (anya tụlee) bụ ihe na-emeghe-na pseudoexfoliation glaucoma na ihe ịrịba ama nke mụbara mgbali n'ime anya mgbe nsogbu outflow nke intraocular ọmụmụ. Ihe nke agwọ ọrịa na-eduzi na ya mkpochapu na Mbelata mmepụta nke mmiri na-akpọkọtara n'ime-ulo nile nke anya, ọ agabiga na optic akwara na-eduga na ya na-aga n'ihu atrophy.

Olee otú iji

Nkwadebe "Kosopt" User Ngwa edepụta itinye 1 dobe na conjunctival nwa nke onye ọrịa ahụ anya ma ọ bụ maka mgbochi nke abụọ anya na 2 ugboro kwa ụbọchị.

Mgbe nzube nke a ọgwụ na-iji na dochie mbụ na-eji tụlee si glaucoma, ha mkpa ha kwụsị iji ụbọchị 1, na mgbe ahụ, eleghị a ọhụrụ n'aka ọgwụgwọ. The ngwọta "Kosopt" ndinọ dịghị ngwa ngwa karịa 10 nkeji mgbe ngwa nke ndị ọzọ Nde ophthalmic preparations.

Eji ngwá ọrụ a na-achọ ndidi na nnabata na pụrụ iche ntụziaka mgbe na-arụ ọrụ na a akpali mmasị ngwọta. Ekpuchighị "Kosopt" Nwa (anya tụlee) na-adụ ọdụ elele ntụziaka tupu mmalite ike n'ezi ihe nke obi iru ala warara.

Unopened vials bụ gaps n'etiti okpu na karama. Iji mepee okpu warara a chọrọ iji wepụ nchedo site oghere.

N'ihi na-emeghe karama okpu bụ unscrewed na ntụziaka gosiri site na directional akụ, emi odude ke okpu.

Tupu kpọmkwem ngwa nke ọgwụ ọrịa na-achụpụ azụ isi-ya, akwusila ihu ala nkuchianaya, iji gosipụta mbara n'etiti n'ime elu nke nkuchianaya na nwa anya.

Next abịazi nọdụ karama, na-eji mkpịsị aka na index mkpịsị aka ga-enyocha enwe n'ime ebe, akpan akara n'elu afụ, na tọhapụrụ naanị otu dobe akpanam n'ime otụk anya. Ọ bụ adịghị anakwere na-emetụ ndị n'olu nke karama na nwa anya ma ọ bụ elu nke narị afọ. Ekwesịghị ịga karama-akpata anya na-efe efe site iche iche na pathogens, nke na-eduga akwa ya pụta na n'ihu ọnwụ nke ọhụụ.

Ọ bụrụ na ma anya-arịa ọrịa, na n'elu-kọwara mkpachapụ na n'otu ụzọ ahụ dị ka rụrụ ọzọ.

Mgbe ojiji kwesịrị tightly ịghasa okpu na karama, ma adịghị mkpa ike pịa cover ka ọ ghara imebi na eri ụdị. The oghere ke n'ọnụ nke spout nwere a dayameta nke na-enye ohere dosed na instillation ngwọta, n'ihi ya, ọ na-ekwesịghị na-agbasa.

oghom Jeremaya mere

Ọma-anabata ọgwụ "Kosopt" (anya tụlee), reviews akọwa mmetụta dị nnọọ obere. Mgbe amụ agwọ ọrịa na-adakarị ọmụmụ nke oghom Jeremaya mere na ndị pụrụ iche na a Nchikota e dere, ma e kwuru ama mara mmetụta nke dorzolamide hydrochloride, timolol maleate na site, ma ndị a mgbaàmà ndị nwayọọ na ọdịdị na achọghị discontinuation nke ọgwụ.

Omumu ọgwụ "Kosopt" na-adakarị ọnwụnwa na mmadụ ọrụ afọ ofufo na 1035. Iji 2.4% nke ọrịa anya tụlee nwere na-kagbuo ruru ka oghom Jeremaya mere mgbe na pụtara na akụkụ nke ọhụụ. Ọ bụ-agaghị ekwe omume ọgwụgwọ 1.2% nke ndị ọrụ afọ ofufo na-ahụ obodo oghom mmetụta jikọtara hypersensitivity na anataghi.

Ndị kasị Ugboro ngosipụta na-emetụtachaghị akụkụ nke anya. Ha gosipụtara a-ere ọkụ sensashion n'anya, corneal ozize, bịara ikiri ọhụụ, mmiri anya.

Mmasị ka ọgwụ ọjọọ, "Kosopt" (anya tụlee) User ngwa na-agụnye a nkọwa nke kwere omume oghom Jeremaya mere ka ifịk ifịk mmiri nke ọgwụ ngwọta, nke nwere ike iru n'ime izugbe mgbasa.

Mmetụta nke dorzolamide hydrochloride na akụkụ nke ọhụụ nwere ike ime mbufụt narị afọ, iyatesịt na ekpepụsị nke anụ na nkuchianaya, iridocyclitis, mgbe keratitis, na-akwụsị akwụsị myopia. Mgbanwe ndị a na-ewere ọnọdụ mgbe oge ụfọdụ gasịrị discontinuation nke ọgwụgwọ na a ọgwụ.

Dorzolamide hydrochloride ihe na ụjọ usoro akara isi ọwụwa, dizziness, nkụnwụ nke aka na ụkwụ na nkụnwụ, tingling ma tingling nke anụ ahụ, ike ọgwụgwụ, na asthenic syndrome.

Anabata nwere ike ime n'ụdị angioedema ihu, na nsọtụ, urticaria, itching, bronchial spasm, pharyngeal mucosa iyatesịt, nkụ na -edeghị ede oghere.

Ekwesighi mmetụta nwere ike gosi na dorzolamide hydrochloride epistaxis.

Mgbe ndinọ ọgwụ ọjọọ, "Kosopt" mmetụta si ikpughe timolol maleate anya nwere ike ime mbufụt na mucosa na cornea, mbufụt ciliary ihu na narị afọ, belata corneal uche, akọrọ mucous visual acuity aghara, oghere Refractive isi anya kewaa anya oyiyi , ptosis nke elu nkuchianaya.

N'ọrụ ọgwụ umi bụ timolol maleate, ịbụ a beta blocker nwere ike ime ka n'akụkụ Jeremaya mere pụta ụwa nke a nke bekee.

The ihe na obi usoro e ji tinnitus, arrhythmia nke obi muscle na ọbara, ọbara mgbali elu, exacerbation nke rịaworo, vasospastic ọdịdị, na-ada mbà, gbasara obi njide, anụ ahụ edema, claudication, sensory ọrịa na nkụnwụ, tingling ma tingling ke ikpa, mgbaàmà nke Raynaud si, oyi aka na ụkwụ.

Nde ochichi nke timolol maleate akpata ụkwara na bronchospasm, karịsịa ụmụ mmadụ na-enwe bronhoobstruktivnogo daa ọrịa.

Skin mgbanwe mere site edinam nke thymol, metụtara na ntutu isi ọnwụ, psoriasiform ọkụ ọkụ ma ọ bụ exacerbation nke psoriatic ọnya.

Ebe ọ bụ na nfụkasị Jeremaya metụtara na ọdịdị nke anaphylactic ujo, angioedema, urticaria, obodo ma ọ bụ generalized ọkụ ọkụ na akpụkpọ.

Timolol maleate emetụta Central ụjọ usoro na mgbaàmà nke dizziness, ịda mbà n'obi, nsogbu ihi ụra, ebe nchekwa na ọnwụ, ike ọgwụgwụ striated muscle.

Digestive umi nke na-eme ka afọ ọsịsa, mkpọchị absorbability, ihicha nke mucous akpụkpọ ahụ nke na-edeghị ede oghere.

eji atụmatụ

Inye tụlee "Kosopt", dọkịta kwesịrị ijide n'aka tupu na ọ dịghị ọdịda nke obi muscle. Ọrịa na oké myocardial daa ọrịa n'oge gara aga na ihe ịrịba ama nke ọdịda n'oge, n'oge ọgwụgwọ ndị dị otú ahụ ọgwụ ga-oge hụ a cardiologist na nyochaa obi gị ọnụego. Arịa ọrịa nke obi na-achọ ozugbo kwụsị iji ọgwụ ọjọọ.

E nwere mgbe ọnwụ si bronchial spasm mere site timolol maleate tụlee "Kosopt" na ọrịa ndị na-arịa ụkwara ume ọkụ na obi ọdịda.

Mmetụta nke ọgwụ na ndị na-hepatic insufficiency, ka e mụọ otú dị mkpa ịkpachapụ anya na ọgwụgwọ nke antiglaucoma mmadụ.

Nsogbu nke acid-isi itule n'ihi na ojiji nke carbonic anhydrase inhibitors nke enzyme, nke na-eduga ná urolithiasis, bụ nke na-amalite na ọrịa na urolithiasis na n'oge gara aga.

Na ọgwụgwọ nke beta-blockers ndị mmadụ na-arịa ọrịa shuga ma ọ bụ hypoglycemia, bụ a distortion nke ụfọdụ mgbaàmà e ji mara nke hypoglycemia.

Beta-blockers, smoothes ịrịba ama nke hyperfunction nke thyroid gland, na-ekpochapụ ndị na ngwá ọrụ nwere ike njọ ọnọdụ.

Tupu ndị na-abịa ịwa ahụ iji general ná Nkụnwụ arụpụta kagbuo anya tụlee maka ụbọchị abụọ tupu ndokwa usoro iji belata mmetụta nke timolol na muscle relaxants na izugbe ọgwụ na-akụnwụ.

Dị ka akụkụ nke "Kosopt" tụlee e benzalkonium chloride, eme ka nri ghara, nke nwere ike ime ka anya iyatesịt. Mgbe na-eji kọntaktị anya ọnụ na ha nkwadebe tupu dị mkpa iji wepu ma na-etinye on 15 nkeji mgbe ochichi nke ngwọta. Akparamagwa nke benzalkonium chloride nwere ike ime ka discolouration nke rọrọ kọntaktị anya m.

Mmetụta nke iji ọgwụ ọjọọ eme siere na-akwọ ụgbọala ma ọ bụ management nke mgbagwoju usoro.

mmekọrịta

Calcium ọwa blockers, beta-blockers, antiarrhythmics, digitalis glycosides, kateholaministoschayuschie mmadụ, parasympathomimetics, opioid analgesics, na monoamine oxidase inhibitors na Nchikota na anya tụlee nke timolol maleate dabeere ngosi hypotensive mmetụta na-eme ka bradycardia a ukwuu.

Systemic Beta-adrenoceptor mgbochi metụtara na a ọnụ ke obi ọnụego, chọpụtara na mmekọrịta nke timolol maleate na quinidine ma ọ bụ nhọrọ inhibitor emetụta reuptake nke serotonin.

Mmekọrịta nke timolol maleate na epinephrine nwere ike ime ka mgbasa nke ọrịa na-ụmụ akwụkwọ.

analogs

The emeputa nke mbụ droplet "Kosopt" bụ Dutch ụlọ ọrụ "Merck Sharpe & Dohme BV", nke laboratories pụrụ iche Ọdịdị maka anya nke abụọ arụ ọrụ bekee nke ngwọta e guzobere (dorzolamide hydrochloride na timolol maleate) na inyeaka mmiri. Ngwá ọrụ a hụrụ mbara ngwa na ọgwụgwọ nke glaucoma.

Romanian ọgwụ ụlọ ọrụ "Ko Rompharm Company SRL "e mepụtara analogue" Kosopta ", na-ekwughachi ihe qualitative na quantitative mejupụtara nke ifịk ifịk mmiri nke mbụ. Ma formulations na-arụpụtara n'ụdị anya tụlee, kpọmkwem ọdịnaya nke dorzolamide hydrochloride na ngwọta ke ichekwa 22,26 mg na 6,84 mg nke timolol maleate, ma e nwere obere ihe dị iche na inyeaka mmiri. Dị analogue "Kosopta" n'okpuru ahia aha "Dorzopt Plus". Ihe nke mbụ ọgwụ ọjọọ na ọnyà ọgwụ na-eduzi na mbenata intraocular mgbali priglaukome, nke pụtara na ha na-kennyeghari na na-anọghị nke na-ere otu onye n'ime ha nwere ike zụta agwọ ọrịa dị na ahịa ọgwụ.

Ọzọ analọg nke anya "Kosopt" ụmụ irighiri mmiri na-emepụta site Croatian "Yadran Galenski dd Laboratory" na-akpọ "Dorzotimol". Dị ka akụkụ nke a ọnyà na-ugbu ke ichekwa dorzolamide hydrochloride 22,26 mg na 6,84 mg nke timolol maleate, Ọzọkwa, ọzọ mmiri ha idako. N'ihi pharmaceuticals preparations ndị yiri, ya mere, nwere ike ọnyà ọzọ dropwise "Kosopt". Ntuziaka maka ojiji analogs na-jikọtara n'ime otu ọgwụ otu - "antiglaucoma ọgwụ ọjọọ." Egosi, usoro ngwa, onunu ogwu, oghom Jeremaya mere na ovadozu (mgbaàmà) niile atọ ọgwụ ga-dakọtara. The emeputa nwere ike ime ka ya nuances na nduzi na ojiji nke anya tụlee.

Na nkwadebe "Kosopt" (anya tụlee) analogs nwere ike ma jikọtara ma ọ bụ monotherapies, ga-emi esịnede ma dorzolamide hydrochloride ma ọ bụ timolol maleate. Na ikpe nke a abụọ n'ọrụ mgwa na-achọkwa analogues abụghị akụkụ nke mbụ ọgwụ ọjọọ na a na-akpata ndịrịta iche nke ịdị irè ha, mmetụta na na na nkwukọrịta ndị ọzọ ọgwụ.

Monotherapy "timolol" n'ụdị nke anya tụlee ka 0,25% na 0,5% - analogue "Kosopta" dabeere na timolol maleate mmepụta Indian ụlọ ọrụ "Gen Biotech Pvt. Co., Ltd. '. Na 1 ml nke gị n'ụlọnga nwere timolol maleate (Ẹkot Timolol) 2,5 mg na 5 mg.

Ọzọ analogue bụ Indian ọgwụ "Okumed" anya dobe na abụọ doses - 0,25% na 0,5%. The emeputa nke a pụtara bụ "Promed Exports Pvt. Co., Ltd. ", India. Na 1 ml ngwọta "Okumed" dị ka na nkwadebe "Timolol", nwere n'ọrụ umi timolol maleate 2.5 na 5 mg (Ẹkot Timolol).

German analogue eyedrops "Kosopt" a agwọ ọrịa "Arutimol" na abụọ doses - 0,25% na 0,5%, nke na-emepụta site "Chauvin ankerfarm GmbH". Na mejupụtara tụlee, dị ka na aga na synonyms nwere timolol maleate 2,5 mg na 5 mg (Ẹkot Timolol).

Na 2008, Russian ahịa nwere a yiri ọgwụ ọjọọ, "Kosopt" analogue nke Russian "timolol-Akos" mmepụta nke na-emepụta ọgwụ factory "njikọ nke." Ọ na-emepụta na ụdị uzo colorless anya tụlee 0,25%. The mejupụtara nke a gị n'ụlọnga na-gụnyere 2,5 mg nke timolol (n'ụdị nke maleate).

Na nkwadebe "Kosopt" bicomponent analogs ịkọrọ a nkịtị nọ n'ọrụ mgwa nke timolol maleate ke ichekwa 5 mg. A na-agụnye a dobe "Azarga" co-mmepụta nke Belgium na United Alaeze enterprise "Alcon Laboratories (UK) Ltd.". The mejupụtara nke a ngwọta na-agụnye ọzọ nọ n'ọrụ mgwa brinzolamide.

Ọzọ yiri ngwaahịa - "Fotil" mmepụta "Santen AO" (Finland) na ihe ndị mejupụtara ihe mejupụtara ụmụ irighiri mmiri nke pilocarpine hydrochloride na 20 na nke 40 mg nke timolol maleate na 5 mg.

Ọzọ analogue "Kosopta" - monotherapy 'Trusopt' mmepụta nke "Merck Sharp & Dohme BV." The mejupụtara nwere ụmụ irighiri mmiri dorzolamide hydrochloride ke ichekwa 2%.

Nyocha nkwadebe "Kosopt"

The ojiji nke antiglaucoma mmadụ agaghị ekwe omume na-enweghị a mbido nnyocha a dọkịta. Tụọ intraocular mgbali naanị ọrịa abụghị ike anyị, anyị kwesịrị a pụrụ iche ngwaọrụ, nke na-eji na-anya dọkịta. Inflated mgbali egosi n'ime-ulo bụ ihe mere ebe "Kosopt" Nwa (anya tụlee). Nyocha banyere uru nke ọgwụ, ndị ọrịa na-ahapụ ndị kasị iche iche. Ndị isi ihe - chọpụta si dọkịta, otú e si eji ọgwụ na o ritere uru ma ọ bụ imerụ ọhụụ. The ọgwụ nwere ike igbochi mmepe nke glaucoma ma ọ bụ aka belata ya mgbaàmà.

On nkwadebe "Kosopt" ndidi reviews na-adịghị mma. Ekwesighi mmetụta dị otú ahụ dị ka itching, ọkụ, nācha ọbara-ọbara nke anya, na-na-ebute discontinuation ọgwụgwọ na anya tụlee. Na nke a, dọkịta n'ahụ maka anya nyere Nchikota preparations, ndị mejupụtara nke n'otu n'otu na-agụnye dorzolamide hydrochloride ma ọ bụ timolol maleate. Ekwe Omume nfụkasị Jeremaya ime naanị na otu n'ime "Kosopt" dobe mmiri, ndidi testimonials na mmetụta nke onye ọ bụla ọgwụ omume ga-enye aka.