"Mesakol": ntụziaka ntụziaka, nyocha, analogues

Ọnyá afọ na Crohn ọrịa na-hụrụ ọrịa bụ nnọọ obere. Ma, n'agbanyeghị nke a, e nwere ọtụtụ ọgwụ ndị e mere iji na-agwọ ọrịa ndị a. Otu n'ime ha bụ Mesakol. Ntuziaka maka ojiji, ụdị, nzaghachi na ụgwọ nke ngwá ọrụ a ga-enye n'okpuru.

Ngwakọta, ụdị ntọhapụ, nkwakọ ngwaahịa na nkọwa

Ngwurugwu "Mesakol", nke nyocha ya na-enweghị mgbagwoju anya, na-ere ere n'ụdị mbadamba aja na-acha uhie uhie. A na-ekpuchi ha mkpuchi ụlọ, na-enwekwa ụdị gburugburu na biconvex.

Isi ihe nke a bụ mesalazine (5-ASA). Ke adianade ya nke ọgwụ na-agụnye ọzọ mmiri dị ka ọka starch, calcium phosphate dihydrate, talc ọcha, microcrystalline cellulose, titanium oxide, hypromellose 2208, silica colloid, povidone K90, sodium carboxymethyl starch, na copolymer acid methacrylic na methyl methacrylate, red ígwè oxide, Macrogol 6000 na phthalate dibutyl.

A na-emepụta "Mesakol" na mbadamba aluminum na ngwugwu kaadiboodu, n'otu n'otu.

Nkà ọgwụ

Ị ma ihe Mesakol bụ? Ntuziaka maka ojiji na-egosi na nke a bụ onye na-eme ihe na-egbu egbu, nke a na-eme n'ime ya n'ime eriri afọ. A jikọtara ihe a nke ọgwụ ahụ na ike ya imechi ọrụ nke njikọ nke leukotrienes na prostaglandins, yana neutrophilic lipoxygenase.

Ekwesiri ighota na ogwu ajuju ajuju na-eme ka mgbochi, phagocytosis na degranulation nke neutrophils, nakwa nke secretion nke immunoglobulin site na lymphocytes.

Kedu ihe ndị ọzọ a na - eji ọgwụ "Mesakol", ọnụahịa nke a na - egosi n'okpuru ebe a? Mesalazine nwere mmetụta antimicrobial megide ụfọdụ cocci na Escherichia coli (n'ime nnukwu eriri afọ).

Pharmacokinetics nke ọgwụ

Kedu ihe mgbochi kinetic nke mbadamba Mesakol? Ntuziaka maka ojiji na-ekwu na mgbe ha natara ha, a tọhapụrụ mesalazine site na sheba mgbe ihe dị ka minit 115-165, mgbe izu 170-230 gasịrị, mbadamba nkume ahụ kwụsịrị.

N'ihi ihe nkiri ahụ, a na-ewepụta ọgwụ dị na 60-80% na akụkụ ahụ dị oke nke eriri afọ, na 15-30% na eriri afọ. N'okwu a, ihe na-arụsi ọrụ ike na-abanye na nhazi usoro ahụ nanị na pasent 10% nke ọgwụ a. Mmetụta nke mesalazine na plasma dị ala.

Njikọ nke ihe na-arụsi ọrụ ike na protein protein plasma bụ 43%. Ọgwụ a na-ajụ ajụjụ, nakwa nke ndị metabolites, na-abanye n'ime mmiri ara ara.

Metabolism nke mesalazine na-eme n'ime eriri afọ na imeju. Nke a na-emepụta N-acetyl-5-aminosalicylic acid.

Ọkara ndụ nke ọgwụ ahụ bụ minit 60-120 (dabere na ojiji a). A na-enye ọgwụ ahụ site akụrụ na site na eriri afọ.

Ntuziaka maka ịṅụ ọgwụ

Olee ọrịa ndị Mesakol na-agwọ? Ihe ndị dọkịta na-ekwu kwuru na ngwọta a dị irè n'ịgwọ ọrịa Crohn na ulcerative colitis.

Ekwesiri ikwuputa na ekwesiri itinye ogwu di na ogugu n'omume ndi ahu ekwuru n'elu, kamakwa iji gbochie nsogbu ha.

Nkwekọrịta ịṅụ ọgwụ

A naghị atụ aro ka ị dee ọgwụ "Mesakol":

• Na ọnyá ekpenta nke usoro nsị;
• Ọrịa ọbara;
• Severe renal ọdịda;
• Hemorrhagic diathesis;
• N'oge nwata;
• Ọgwụ ezughị oke siri ike;
• Ịchọpụta ihe dị iche iche nke ọgwụ;
• Enweghị glucose-6-phosphate dehydrogenase.

Na nlekọta pụrụ iche a na-eji ọgwụ a eme ihe maka ịdị arọ dị oke oke nke akụrụ akụrụ, nakwa dị ka nke na-adịghị ahụkebe ma dị nwayọ.

Mbadamba Mesakol: ntuziaka maka ojiji

A na - eji ọnụ ekwu okwu n'ụlọnga ahụ naanị mgbe o risịrị nri.

Mgbe ọrịa ahụ na-arịwanye elu, a na-edepụta ya na ihe ruru 400-800 mg (ya bụ, 1-2 mbadamba) ugboro atọ n'ụbọchị. Emere ọgwụ maka izu 9-12.

Iji gbochie mgbochi, a na-eji ọgwụ ahụ eme ihe na 400 mg ugboro atọ n'ụbọchị. A na-ewere mbadamba ụrọ n'ozuzu ya, saa ya na mmiri dị larịị.

Kedu ka e kwesịrị isi nye ọgwụ ụmụaka Mesakol? Candles, microclysters na nkwusioru - ọ bụ na nke a na-egosi na ọgwụ a na ụmụ ọhụrụ.

Mmeghachi Omume

N'ụzọ dị mwute, ịṅụ ọgwụ a na-ebutekarị nsogbu. Ha gụnyere ihe ndị a:

• Pericarditis, tachycardia, nsogbu nkwonkwo obi, ọbara mgbali elu, mgbali obi, nkwupụta ụda, palpitations, dyspnea;
• Nausea, agụụ na-arịwanye elu, na-agbọ agbọ, na-amụbawanye ọrụ nke transaminases hepatic, nrịkasi obi, stomatitis, afọ ọsịsa, ịba ọcha n'anya, mgbu abdominal, pancreatitis, ọnụ mmiri;
• oliguria, proteinuria, crystalluria, hematuria, nephrotic syndrome, anuria;
• Nkwụsị, isi ọwụwa, hallucinations, tinnitus, ehighi ura, polyneuropathy, njigide, egwu, ịda mbà n'obi;
• Eosinophilia, thrombocytopenia, anaemia (hemolytic, aplastic ma ọ bụ megaloblastic), agranulocytosis, anaemia, hypoprothrombinemia;
• Oligospermia, enweghị ike;
• Ọdịdị, photosensitivity, parotitis, ọnụ ọgụgụ na mmepụta nke mmiri ozuzo, lupus-like syndrome, alopecia;
• Akpụkpọ anụ, dermatosis, itching, bronchospasm, erythema.

Ihe ịrịba ama nke nnyefere

Mgbaàmà nke njubiga ókè na ọgwụ ndị a na-atụle bụ ụdị ụbụrụ dịka ọgbụgbọ, ikuku, vomiting, ụra na adịghị ike. Maka mkpochapu ha, ụkọ mmiri, ọgwụ ndị na-edozi ahụ na ọgwụ mgbaàmà ka e kenyere.

Mmekọrịta na ngwaọrụ ndị ọzọ

Ọgwụ "Mesakol" na-eme ka ọrụ "Spironolactone" pụta, "Furosemide", "Rifampicin" na sulfonamides. Ọ na-emekwa ka mmetụta dị iche iche nke hypoglycem nke sulfonylurea pụta, toxicity nke methotrexate na ulcerogenicity nke GCS.

Ekwesiri iburu n'uche na ọgwụ a na-eme ka ntanye nke cyanocobalamin mebie ngwa ngwa, ma na - emekwa ka mmetụta nke ndị na - ahụ maka ndị uricosuric (ya bụ, ndị na - emepụta ihe na - emepụta tubular) na - eme ka mmetụta nke anticoagulants dịkwuo elu.

Nkwenye Ndị Pụrụ Iche

• Mgbawa nke na-eme na ọgwụ Mesakol abụghị mgbe ọ bụla ịmalite ọgwụ. Ọnọdụ a nwere ike ịbụ ihe àmà nke ọrịa dị oké njọ.
• Mgbe ị na-aṅụ ọgwụ a, ị kwesịrị ị na-eme mgbe niile ule ọbara na mmamịrị ule.
• Ọ bụrụ na e mejọrọ dose ahụ, mgbe ahụ, a ga - ewere ya na oge ọ bụla ọzọ.
• Mgbe a na-agwọ ya ọgwụ a, a na-ese mpempe akwụkwọ na ụrọ nke onye ọrịa na agba odo-acha odo odo.

Mesakol: analogues na ọnụ

Ị nwere ike dochie ọgwụ a na ngwaọrụ ndị dị ka Salazopyridazine, 5-ASA, Tidokol, Asakol, Samezil, Salofalk, Mesalazin, Salosinal, Pentasa.

Ego ole ka mbadamba Mesakol? Ọnụahịa nke ọgwụ a bụ 600-680 rubles (maka mbadamba 50).

Nyocha ndị ahịa

Ndị ọrịa na-ahapụ nyocha dị oke egwu banyere Mesakol. Ụfọdụ n'ime ha na-akọ na ọgwụ a na-agwọ ọrịa ọrịa obi. Ndị ọzọ na-arụ ụka na ọgwụ ndị a abaghị uru. Ya mere, a ga-ekwusi ike na "Mesakol" nwere mmetụta dị iche n'ahụ ndị ọrịa dị iche iche.

Ntughachi azụ nke ọgwụ a bụ ọnụnọ nke ọnụọgụgụ na mmejọ omume.