Paraneoplastic syndrome dị ka ihe na-egosi malignancy

Dị ka ibuo oncology, akpụ bụ naanị ọrịa, na-ewere ọnọdụ dokwara na ndị nile so na nke ụmụ anụmanụ. The etiology nke cancer, nakwa dị ka ya pathogenesis na-erubeghị ghọtara ọkà mmụta sayensị, ma n'oge e nwere 4 isi chepụtara:

1. Malitere ịrịa. Dị ka ya, carcinogenic Njirimara nwere ụfọdụ nje: Epstein-Barr virus, herpes virus, papilloma virus, na ndị ọzọ.

2. Physico-chemical. Isi ọrụ ke akpụ development ịrụ chemical carcinogens (3,4-benzpyrene, metabolites na amino asịd TIR ATỌ, aflatoxins et al.), Ionizing radieshon.

3. dizontogeneticheskie: neoplastic Filiks ibili si na-ekwesịghị ịdị Ibe edokwubara anụ ahụ n'oge na-okpụkpụ nwa.

4. Mixed - ọdọhọde monoetiologichnost akpụ.

akpụ ngosipụta

Symptomatology oncological Filiks na ahu na-nkewa n'ime obodo na izugbe ịrịba ama. Obodo ndị na-kpọmkwem ihe àmà nke akpụ, ma ọtụtụ mgbe na-egosi mgbe e mesịrị general, na-metụtara etuto ahụ anya mmetụta na iche na akụkụ ma ọ bụ malfunctioning dara mbà n'obi dịghịzi usoro. Ndị dị otú ahụ ihe mgbaàmà na-jikọtara na a na-akpọ paraneoplastic ọrịamkpokọta. Ha na-ji a enweghị nkwurịta okwu na obodo mmetụta nke akpụ iguzogide ọgwụ, mmepe naanị ma ọ bụrụ na e nwere cancer na-akwụsị mgbe buu ọgwụgwọ. Nke a na-enye ohere maka na esi nchoputa nke PNS na onwe ha systemic ọrịa.

The pathogenesis nke PNS

Ebe ọ bụ na paraneoplastic syndrome amalite dabeere ịrụ ọrụ akpụ ma ọ bụ ya metastasis, pathogenesis bụla syndrome metụtara na a metabolic aghara ma ọ bụ ihe dịghịzi usoro reactivity. Yabụ, ọtụtụ etuto ahụ bụ a "na-esi ọnyà" maka nri (vitamin, glucose, amino asịd, lipids), n'ihi na nke ihe na-amalite mbelata nke ọtụtụ anụ ahụ na izugbe cachexia. Ọzọkwa, ọnụnọ nke yiri abụkwara na gbara gharịị mkpụrụ ndụ na-eduga ná cross-nkịtị dịghịzi omume n'ihi mebiri emebi ma ọ bụ maligniziruyutsya nke nkịtị mkpụrụ ndụ. A akpụ na bilie na ndabere nke endocrine mkpụrụ ndụ na-emepụta ọzọ homonụ. Na nke a, paraneoplastic syndrome ga-eme dabere na-echebe belata uche na homonụ anabata na-akawanye njọ metabolic ọrịa.

ụfọdụ PNS

Ndị kasị Ugboro etuto ahụ bụ etuto ahụ nke endocrine anụ ahụ. A na njikọ na e nwere onye endocrine paraneoplastic syndrome. Ya pụta ìhè bụ ihe mụbara ịta nke hormone na ọbara na ya ichebe ọbụna mgbe resection nke ya na-amị glands na-ebelata secretion n'elu mwepụ nke ngwọta.

Articular syndrome-egosipụta dị ka hypertrophic osteoarthropathy, kartsinolidnoy arthropathies, gouty ogbu na nkwonkwo, polyarthritis. Nke a paraneoplastic syndrome emekarị tupu nchoputa nke etuto ahụ ma na-akwalite ọbụna mbụ nchọpụta nke malignancy.

Hematological na akwara ozi ọrịamkpokọta nwere kacha njọ N'ezie na ngwa ngwa ọnwụ. Egosi ịgbanwe quantitative na qualitative mejupụtara ọbara na neuropathy, na-eduga irreversible organic mgbanwe arọ.