"Pipekuroniyu bromide": ntuziaka maka ojiji

Ọgwụ atụrụ ndụ skeletal mọzụlụ, na n'ọtụtụ ebe, na-eji ọ bụghị nanị na n'oge usoro ịwa ahụ nke na-ajụ na ogologo oge, ma na-na omume nke trauma na ebumnuche nke repositioning ma ọ bụ prosthetic nkwonkwo. "Pipekuroniyu bromide" na-ezo aka otu antidepolyarizuyuschih relaxants na nwere a kacha oge nke edinam nke 50-70 nkeji dabere na àgwà nke organism. Ka anyị tụlee ntuziaka maka ojiji nke ọgwụ, na karịsịa na ya iji na anestetiiki omume.

pharmacological akparamagwa

The usoro nke edinam nke ọgwụ jikọtara igbochi synaptic nnyefe na neuromuscular synapse. N'ihi na nke a, e nwere mgbochi nke omume nke ihe ike na muscle eriri akpụkpọ ahụ, na ya mere, muscle cell tụfuru ya ike na kpum.

Na ruo ogologo oge n'ebe ọgwụ dabere "pipekuroniyu bromide" skeletal musculature-eme ka. Nyere na nicotinic cholinergic anabata nke ụdị dị bụghị naanị na kọntaktị ebe efferent esiwọrọ somatic ụjọ usoro na muscle sel nke skeletal uru na ganglia na autonomic ụjọ usoro, iwebata nnukwu doses nke agwọ ọrịa mere ganglioblokiruyuschimi ike mmetụta. Nke a bụ n'ihi na cessation nke nnyefe nke akwara na-akwadoghị akwado na postsynaptic membranes akwara ozi, nke na-eduga ná a ọnụ ke ma ọmịiko na parasympathetic mmetụta.

egosi

Nkwadebe "pipekuroniyu bromide" gosiri maka ntụrụndụ nke skeletal uru n'oge ịwa ahụ. Irè nke ọgwụ maka nzube nke tracheal intubation na n'ibu ventilashion.

contraindications

Dị ka ọgwụ na "pipekuroniyu bromide" ntụziaka, ọgwụ na-nnọọ contraindicated na ọnụnọ nke hypersensitivity na n'iru myasthenia (obere, genetically kpebisiri ọrịa, nke bụ mebiri nke excitation na neuromuscular synapse mmepe na muscle adịghị ike).

The ọgwụ na-contraindicated na ọrịa na mmalite nkebi nke di ime. Na mgbe e mesịrị nkebi nke ọgwụ mee ihe, dị ka ọ na obe na placental mgbochi obere ichekwa.

mmetụta

The ọgwụ nwere ike inhibit ọrụ nke Central ụjọ usoro, ime ka hypersensitivity phenomena.

Si n'akụkụ nke obi mmetụta mere site mgbochi nke cholinergic nnyefe na synapses. Ime otú ahụ pụrụ ibelata obi ọnụego, ala ọbara mgbali, ischemic myocardial ọjọọ, ụbụrụ mmebi metụtara na-ebelata perfusion.

Mgbe ọ gụrụ omume ịda mbà n'obi nke akụkụ okuku ume na usoro nke akụkụ okuku ume ọrụ, omume nke apnea ma ọ bụ apnea (karịsịa n'oge na-akpata nke ọgwụ).

The ọgwụ na-emetụta ndị metabolism na bụ ike ime ka onye na-abawanye na ọbara potassium larịị, na-amụba na ọkwa nke endogenous creatinine ma na ala plasma glucose etoju.

Drug "pipekuroniyu bromide" - ntuziaka maka ojiji

The ọgwụ na-ndinọ naanị n'okpuru nlekọta nke a ọkachamara. Tupu ọgwụ ochichi ga-elele na e anticholinesterases ( "Neostegmina" ma ọ bụ "Pyridostigmine") ma ọ bụ anticholinergics ( "Atropine").

Mgbe mkpachapụ-aga n'ihu ndidi nlekota a rụrụ n'oge mgbake oge mgbe ná Nkụnwụ na ọrịa normalize Akwara ụda.

The onunu ogwu nke agwọ ọrịa na ndabere nke mgbagwoju nyochaa onye ọrịa na nnyocha data analysis laabu usoro. Na ọnụnọ nke odida nke gbasara akụrụ excretory ọrụ, ọtọ imeju ọdịda, oké ibu - dose ga-ala agwọ ọrịa.

The ngwọta na-akwadebe tupu ọgwụ nlekọta "pipekuroniyu bromide." Ụdị ọgwụ ntọhapụ - vials nke lyophilized ntụ nwere 0.004 g nke nọ n'ọrụ umi.

N'ihi na ọrịa na mkpọchị ọbara electrolyte itule na acid-isi itule na-chọrọ dose ukpụhọde. Preferential Mbelata ion ịta na ọbara plasma, hypothermia na ojiji nke gbasara obi glycosides (n'oge digitalization) na-enwe ike ịgbatị oge nke ọgwụ. N'ihe banyere muscle ntụrụndụ na otu a nke ọrịa ibido mkpa normalize ndị electrolyte ọbara, mgbe na-ebu muscle ntụrụndụ. N'ihe banyere ọrịa na-adịghị ala ala obi ọdịda, ọbara nwere ike jiri nwayọọ na na ndọtị nke latent oge nke ọgwụ mmetụta (abawanye na oge n'etiti ochichi na mmalite nke mmetụta).

Ị nwere ike iji ọgwụ ọjọọ na ụmụ 1 afọ. Na nke a na ọ ga-echeta na ahụ nwatakịrị ahụ bụ obere chebaara mmetụta nke muscle relaxant, na ya, na-enweta chọrọ mmetụta, ndị dose nke ọgwụ ga-abakwa ụba.

Ezumike ọgwụ

Idepụta ọgwụ maka "pipekuroniyu bromide" Ntụziaka na Latin pụrụ ọbụna ịga dibịa. Medical alụmdi na-enweta ike bekee site ndepụta A naanị na-arịọ arịrịọ na na ndabere nke ala. Na a iche iche ikpe, "pipekuroniyu bromide" Ntụziaka nwere ike nye iwu ka otu ọkachamara na-eji "red" ụdị, Otú ọ dị, ọ bụghị ihe niile ụlọ ọgwụ na netwọk na-isiokwu mmezu nke ọgwụ ọjọọ na ọgwụ ike, gụnyere muscle relaxants.

ahia aha

Na-emepụta ọgwụ ahịa ọgwụ dị n'okpuru ndị dị otú ahụ na ahia aha dị ka "Arduan" "Vero pipekuroniyu", "Aperamid", "pipekuroniyu bromide." Trade aha nke ọgwụ bụ dabere na emeputa, na-enye a ọgwụ na-emepụta ọgwụ ahịa.

ovadozu

An ovadozu nke ọgwụ na Mbelata mmetụta bụ omume ruru ka iwebata anticholinesterases. Ọgwụ ndị a aka dịkwuo ịta nke ọgụgụ akwara mbufe ozi acetylcholine, si otú mpi na muscle relaxant maka nkịtị na saịtị na ihe nnabata.

Ọzọkwa, ọgwụgwọ ihe na ovadozu iji nwekwuo ọbara mgbali, ịnọgide na-enwe dị mkpa ahu aru, tinyere na-efu nke n'ibu ventilashion.

Drug interactions

The ọgwụ na-apụghị weere na dị iche iche infusion ngwọta, ma e wezụga isotonic ngwọta nke sodium chloride na dextrose. Mmepe nke ọgwụ mmetụta slows ala, nti ọgwụgwọ dose na-ụba n'okpuru ọnọdụ nke preoperative ochichi onye ọrịa na cholinesterase inhibitors.

Na a na nkwonkwo ngwa na muscle relaxant narcotic analgesics omume ịda mbà n'obi nke akụkụ okuku ume center na mmepe nke na-ehi ụra apnea.

Iji nke ọgwụ na depolarizing muscle relaxants ụdị ihe nwere ike ma welie na imebi n'ozuzu muscle relaxant mmetụta. Nke a ọnọdụ bụ n'ihi na onunu ogwu nke ọgwụ ọjọọ, oge nke ochichi, ma na onye uche ọgwụ ahụ.

ọgwụgwụ

Ebu muscle ntụrụndụ n'oge ịwa - akụkụ dị mkpa nke ihe integrated ná Nkụnwụ. Drug "pipekuroniyu bromide" na-ọma-eji na ọgwụ na ahụ ike na-eme maka ndị a na nzube.

Ọ ga-echeta na iwebata nke ọgwụ ọ bụghị nanị na-akpata ntụrụndụ nke skeletal uru maka afọ ofufo ije, ma na-akpata mkpọnwụ nke akụkụ okuku ume uru. Ịtụle nke a, ọgwụ na-eji nanị n'okpuru ọnọdụ na-awa ahụ kpụ ọkụ n'ọnụ na-elekọta nkeji.