Site na ihe na-enyere "Nise" (mbadamba)? Ntuziaka maka ojiji, analogs

Ị maara ihe na-eme ka "Nise" (mbadamba)? Ọ bụrụ na ihe ọmụma dị otú ị na-adịghị, mgbe ahụ anyị ga-eweta ya na ihe ndị a n'isiokwu a.

Packaging ngwaahịa na ya mejupụtara

Eziokwu nke ihe na-eme ka "Nise" (mbadamba), anyị na-akọwa n'okpuru. N'ọrụ mgwa a ọgwụ bụ nimesulide. Ọzọkwa na Ọdịdị, ọ na-agụnye mmiri dị ka microcrystalline cellulose, aspartame, calcium phosphate, colloidal sịlịkọn dioxide, ọka starch, magnesium stearate, sodium carboxymethyl starch, talc na painiapulu flavor.

Na ire nke na-atụle agwọ ọrịa na blisters 10 mbadamba, juru n'ọnụ ke katọn.

Ụkpụrụ nke edinam nke ọgwụ

Tupu anyị azaa ajụjụ nke ihe na-eme ka "Nise" (mbadamba), ị kwesịrị ị na-agwa anyị otú anyị na ọgwụ na-arụ ọrụ.

Dị ka ntụziaka, ọ NSAIDs na bibiri egbochi Cox-2, na bụ enzyme abuana ke njikọ nke prostaglandins - ogbugbo nke ihe mgbu, mbufụt na edema. Ọzọkwa mgbochi mkpali Njirimara, na-ewere ọgwụ ngosi analgesic na antipyretic edinam.

Anyị apụghị ikwu na ọgwụ na-egbochi ahụ (reversible) guzobere prostaglandin E2 na-arịgo nociceptive ụzọ usoro na ebe nke mbufụt, nakwa dị ka ụzọ nke conduction nke gboo (mgbu) na ọgidigi azụ.

Nkwadebe "Naiz" analogs nke na-depụtara n'okpuru ebe a, na-ebelata ịta nke prostaglandin H2 (adịteghị), site na nke, n'okpuru nduzi nke prostaglandin isomerase, e prostaglandin E2. Mbenata ịta nke ikpeazụ na-eduga a ọnụ ke ogo ebighị nke ihe nnabata-ụdị Ea (prostanoid), nke na-kwupụtara mkpali na analgesic mmetụta.

Ọ kwesịkwara kwuru na a obere n'ókè ọgwụ na-emetụta ndị na-ewere Cox-1. N'okpuru n'ahụ ọnọdụ, ọ naghị egbochi prostaglandin E2 si arachidonic acid. Nke a na-ebelata ọnụ ọgụgụ nke oghom ọgwụ ihe.

Isi Njirimara nke ọgwụ (NSAID)

Nkwadebe "Naiz" ike inhibit platelet aggregation. Na nke a emee site inhibiting njikọ nke thromboxane A2 na endoperoxides. Ke adianade do, ọ suppresses histamine ntọhapụ usoro, na-ebelata ogo bronchoconstriction, nke e mere site n'ebe acetaldehyde na histamine.

Ọkachamara gaara egosi na a ọma nimesulide egbochi njikọ nke urokinase na IL-6, na-egbochi mbibi nke cartilage. Ọzọkwa, ọ na-egbochi njikọ nke metalloproteases, na-egbochi mbibi nke collagen na proteoglycans.

Dị ka ntụziaka, site na mbenata ọrụ nke myeloperoxidase n'okpuru echiche ọgwụ na-egosipụta antioxidant Njirimara na-egbochi guzobe nke ngwaahịa (nsí) ire ere O _2. Ọ interacts na glucocorticoid anabata na activates ha, nke na-eme ka mgbochi mkpali edinam.

The kinetics nke ọgwụ

Mgbe onu analgesic "Nise" na-etinye obi gị dum na eriri afọ. Nri oriri na-ebelata ọnụego nke absorption nke ọgwụ, ma adịghị emetụta ya ókè.

Ọgụgụ kasị elu ọbara etoju nke nimesulide enweta mgbe 2.6 awa. Ya mkpakọrịta na a protein esịmde 95%.

A ọgwụ penetrates n'ime niile anụ ahụ na nwanyị kenwe. Ọzọkwa, ọ na-hụrụ na ihe acidic ajụ Baịbụl hiwere isi n'ebe mbufụt na synovial ọmụmụ.

Nimesulide metabolism na imeju. Ya ọkara ndụ bụ 5 awa. O gosipụtara na akụrụ, nakwa dị ka ọnụ na bile.

Egosi maka lozenges

Site na ihe na-enyere "Nise" (mbadamba)? Of ego kenyere:

• sciatica, ọrịa ogbu na nkwonkwo, sciatica;
• ọrịa azụ mgbu, osteoarthritis, articular syndrome, rheumatic ọrịa na gout exacerbation;
• psoriatic ogbu na nkwonkwo, arthralgia, ankylosing spondylitis;
• ogbu na nkwonkwo nke dị iche iche si malite, osteochondrosis na radicular syndrome;
• mbufụt nke ụdọ, myalgia, rheumatic na ọrịa ogbu si malite, bursitis, mbufụt nke akwara;

• mgbu ọrịamkpokọta nke dị iche iche si malite (gụnyere trauma, postoperative, eze mgbu, algodismenoree, isi ọwụwa);
• inflammations nke nweekwa usoro adụ anụ ahụ.

Ọ kwesịkwara kwuru na ọma "Nise" okpomọkụ. A ọgwụ na-eji na a fever nke dị iche iche si malite, gụnyere mkpali na-efe efe.

contraindications NSAIDs

Drug "Nise" machibidoro inye ime. Ọzọkwa, ọ na-ekwesịghị-eji:

• "Ịṅụ Ọgwụ Aspirin chi atọ n'ime";
• erosive na ọnyá ọnya nke eriri afọ tract (na exacerbation);
• ara;
• agba ọbara si eriri afọ tract;
• mkpọchị imeju ọrụ;
• na ụmụaka ruo afọ abụọ;
• oké gbasara akụrụ insufficiency;
• giperuvstvitelnosti.

Na pụrụ iche ịkpachara anya na nke a gị n'ụlọnga kenyere maka ọrịa shuga mellitus ụdị, ọbara mgbali na gbasara obi insufficiency.

Olee otú ga-ewere "Nise"?

E lee ya anya ọgwụ n'ụdị mbadamba kenyere naanị n'ime. Okenye ọrịa na-atụ aro na-100 mg ugboro abụọ n'ụbọchị. The kacha onunu ogwu nke ọgwụ kwa ụbọchị bụ 400 mg.

Banyere dispersible mbadamba, mgbe ahụ, n'ihu na-eme dị otú ahụ a na nkà mmụta ọgwụ, ọ ga-na mbụ etisasịwo ke 5 ml nke nkịtị mmiri (1 eji megharịa ọnụ ngaji). Na-eri ngwá ọrụ kwesịrị na njedebe nke a nri ma ọ bụ mgbe a nri.

Children ọgwụ na mbadamba adịghị kenyere. N'ihi na ha, e nwere ụdị ọzọ nke ọgwụ - nkwusioru. Ọ na-atụ aro na-afọ nke afọ abụọ.

phenomena n'akụkụ

Nkwadebe "Naiz", na onunu ogwu nke e gosiri n'elu nwere ike ime ka ekwesighi Jeremaya mere dị ka:

• nrekasi obi, ala ala ịba ọcha n'anya, ọgbụgbọ, anaemia, vomiting;
• agranulocytosis, ihe mgbu na afo, anaemia, afọ ọsịsa, leukopenia;
• erosive na ọnyá ọnya nke eriri afọ tract, isi ọwụwa, na-abawanye na imeju transaminases;
• anaphylactic ujo, dizziness, anụ ọkụ ọkụ;
• prolongation nke na-agba ọbara oge, bronchospasm, hematuria, ọmụmụ njigide.

ikpe nke ovadozu

Gịnị mgbaàmà-eme mgbe na-anata a ọnụ ọgụgụ buru ibu nke "Nise" mbadamba? The onunu ogwu nke a na nkà mmụta ọgwụ ga-ekpebisi ike site ịga dibịa. Bụrụ na nke mberede ingestion nke ọgwụ (na nnukwu quantities), onye ọrịa nwere ike ịzụlite na-esonụ mgbaàmà: ụfụ, mụbara ọbara mgbali, iyatesịt nke eriri afọ tract, mkpọchị ọrụ nke akụrụ, imeju ọdịda, na akụkụ okuku ume na ịda mbà n'obi.

Iji kpochapụ ndị dị otú ahụ na-ekwu, saa ndidi afo, rụọ ọrụ unyi na symptomatic ọgwụ.

ọgwụ interactions

Na n'otu oge preroralnom n'ikuku nkwadebe "Naiz" diuretics "Digoxin" "phenytoin", antihypertensive elekọta mmadụ na lithium mmadụ, nakwa dị ka ndị ọzọ NSAID, cyclosporine, anticoagulants, methotrexate, hypoglycemic ọgwụ (onu), onye ọrịa nwere ike na-egosipụta ọgwụ interactions (site na -this ndị a elekọta mmadụ mpi maka nkịtị na-edozi).

Drug "Nise": analogs na reviews

Dochie ngwá ọrụ ike ga-atụle otú ahụ ọgwụ dị ka "nimulid", "n'elu", "Arcoxia", "Mesulid", "meloxicam", "Nimesil", "Movalis" "nimesulide" "Denebola", "Niemiec".

Ọtụtụ n'ime ndị n'ji reviews na ugbu Nwa na-nti. Dị ka ha, ọ eliminates ngwa ngwa "Nise" ihe mgbu, na ọgwụ a na-eji dị ka a ukwuu irè mgbochi mkpali n'ụlọnga. Ọ bụ ezie na ụfọdụ ndị ọrịa na-ekwu na a ọgwụ nwere otu isi drawback. Ọ bụ nnọọ ihe na-akpatakarị n'akụkụ Jeremaya mere dị ka dizziness, adịghị ike na digestive usoro nsogbu. Na nke a, ndị dọkịta nwere ike ikwu na dochie ọgwụ yiri.