Akpụ welara HE4: transcript. Mgbaàmà nke ovarian cancer na ndị inyom

Kwa afọ, cancer ọrịa na-amụba. Nke a agha dịghị echebe onye ọ bụla. Ọkà mmụta sayensị na ndị dọkịta na-ka na-agbalị obibi na omume nke a cancer na-akpata ma na-achọta ụzọ dị irè nke ọgwụgwọ. N'ụzọ dị mwute, mmalite nkebi nke ọrịa bụ asymptomatic. Ọtụtụ ndị ọrịa bịa na nke dọkịta na mkpesa, na-achọpụta na ha nwere ukwuu nke nsogbu na nke na-alụ ọgụ mbubreyo. Ya mere, ọnwụ ọnụego ruru cancer dị elu. Ma ndị ọkà mmụta sayensị nwere ike ịgakwuru nsogbu. Ọtụtụ ụdị nke cancer nwere ike achọpụtara na n'oge nkebi, dị nnọọ na oge na-eleta dọkịta na inye onyinye ọbara ule. Special laabu usoro kwere kewapụrụ ọbara mmadụ "mgbama" -onkomarkery, a nsogbu mere. Nke a-enye gị ohere ịchọpụta ọrịa na-amalite amalite, nke ga-amụba site na ọtụtụ ugboro Ohere nke mgbake.

Ka ụbọchị, otu n'ime ndị kasị atụ egwu nwanyi cancer - ovarian cancer. Enwe si na ya bụ ndị kasị elu n'etiti ndị ọzọ malignancies nwanyi kenwe. Atụla egwu. Mgbe niile, chọpụta mmalite nke ọrịa nwere ike ná mmalite nkebi nke ya mmepe na-ebelata ihe ize ndụ ize ndụ. Special ọmụmụ nke ọbara n'ihi na ọnụnọ nke akpụ welara HE4 ịzọpụta pụọ n'ihe ize ndụ.

Na-akpata ovarian cancer

Nye kpọmkwem ihe mere ndị ovarian etuto ahụ na ndị inyom, ọ na-agaghị ekwe omume. E nwere ọtụtụ ihe na-akpasu mmepe nke etuto ahụ:

• Mgbanwe mmiri ọgwụ ndabere. Ọtụtụ mgbe, a mmiri ọgwụ ahaghị nhata n'akparamagwa inyom n'oge menopause. N'oge a, na-amụba ka ọnụ ọgụgụ nke nwanyi mmekọahụ homonụ ke idem. N'ihi ya, ọ na-eme ka ntoputa nke cancer etuto ahụ, gụnyere ovarian. Mmiri ọgwụ surges ike-erukwa, na ụmụ agbọghọ na-eto eto ndị inyom. Ya mere, ndị mmadụ n'otu n'otu na oge ufodu ịhụ nsọ cycles mkpa etinye uche pụrụ iche ike.
• Bad àgwà ọma. Ọ bụla isi zuru okè na onye maara na ise siga, na mmanya, adịghị mma nri - enyere aka nke ọrịa dị iche iche. Ọ dịghị ma e wezụga, na ovarian cancer. Ka ihe atụ, ndị inyom na-eme ihe n'ụzọ na ngwaahịa nwere trans abụba, carcinogens, e ji esiji ákwà na ndị ọzọ na-emerụ nwekwara hụrụ na n'ihe ize ndụ onkovracha.
• Na-adịgide adịgide mgbanwe nke enwe mmekọahụ, na-ete ime. Ọ bụrụ na ndị na-agbanwe ka uwe, na-elekọta banyere ahụ ike ha, mgbe ahụ, enwetaghị na-efe efe, ebute site ná mmekọahụ na-efe efe, mfe. N'ọdịnihu a ga-ebelata obodo dịghịzi usoro na, mmọdo, omume nke malignancy. Achọghị ime nwere ike ịbụ a N'ihi ya nke aghara aghara. Ọtụtụ ndị inyom, ebe dịghị ụzọ ọzọ si na-ete ime. Nke a ịwa ahụ aka - a nnukwu nchegbu maka nwaanyị ahụ, nke na-agbanwe mmiri ọgwụ ahụ itule. N'ihi - infertility, ọrịa cancer.
• Operations na ovaries, nke na-akwalite e guzobere gbara gharịị epithelial sel nke ngwa.
• Mkpụrụ ndụ ihe nketa. Ọkà mmụta sayensị na-egosi ọnọdụ ụfọdụ ebe ọnụnọ nke kpọmkwem mkpụrụ ndụ ihe nketa na DNA yinye na-akwalite ọdịdị nke ịza etuto ahụ na ụmụ mmadụ.
• Akpụ nke ovary na ndị inyom mgbe ụfọdụ na-amalite dị ka a N'ihi ya nke ọzọ oncological ọrịa.

Mgbaàmà nke ọrịa

Ná mmalite nkebi nke ovarian cancer iji chọpụta ihe fọrọ agaghị ekwe omume. Mgbaàmà na-egosi mgbe ọrịa gburu a miri ahu. Isi ihe ịrịba ama nke ovarian cancer na ndị inyom:

• ịhụ nsọ ọrịa;
• Ugboro urination;
• na ịpị sensashion ke ala n'afọ;
• igbu mgbu mgbu na ovary;
• nsogbu na defecation;
• erughị ala, ihe mgbu n'oge mmekọahụ.

Ndị a bụ ngosipụta nke ọrịa nwere ike-atụle kpọmkwem maka ovarian cancer. Ya mere, iji zere ọdachi, ọ dị mkpa nleta a ọkachamara n'ọrịa ụmụ nwanyị.

nchọpụta nsogbu

Ndị na-adị nnyocha na a gynecological oche ga-ekpebi mgbanwe ovarian Ọdịdị. Iji gosi na mbụ nchoputa onye ọrịa na-eduzi na-eme ka a ọnụ ọgụgụ nke instrumental ọmụmụ:

• ultrasound nnyocha nke Genital akụkụ;
• anụ ahụ biopsies ikpebi kansa Ọdịdị;
• MRI - a usoro nke na-orunótu na ókè nke etuto ahụ hụrụ na zuru ezu;
• X-ụzarị na a iche ngwọta ga-ekwe ka ịhụ na ọnọdụ nke ngwọta.

Ọzọkwa, maka nchoputa nke ovarian cancer ọrịa zitere maka a ọbara ule, nke ịchọpụta ọnụnọ nke akpụ nrịbama. Na ha ịta ikpe ọnụnọ nke ọrịa. Iji chọpụta ovarian cancer ọbara ngafe-achọpụta ihe abụọ akpụ nrịbama - CA125 na HE4. Nke ikpeazụ ụdị welara na nso nso malitere kọwaa, ma ọ na-kasị n'ụzọ ziri ezi na-egosi na progression nke ọrịa.

Gịnị bụ HE4?

Akpụ - a kpọmkwem umi, nke na-amalite na-emepụta ihe organism na ọnya nke ọ bụla ngwa akpụ. Ọzọkwa, nrịbama nwere ike site na nkịtị onye ahụ gbasiri ike, ma dịkwuo ịta nke cancer ọkachamara na-achọpụta ma na-ekiri ya na-asọ.

HE4 - akpụ welara maka ovarian cancer na ndị inyom, na-emepụta obere obere ke idem ịnọgide na-enwe ahụ ike n'ahụ ọrụ. Ọ bụrụ na ndị emetụtara epithelium nke ovarian cancer, kpọmkwem protein ịta adahade.

Na mbụ, iji gosi na nchoputa, "ovarian cancer" mee Ca-125 welara, nke kpebisiri ike site a kpọmkwem ọbara ule. Ma usoro a bụ nti, n'ihi na ịta nke a welara ike dịkwuo na-abụghị neoplastic ọrịa ma ọ bụ etuto ahụ nke ndị ọzọ na akụkụ. Mụbara ọbara etoju nke Ca-125 nwere ike na 3rd ma ọ bụ 4th ogbo nke ọrịa. Na mbụ nkebi nke ọrịa na-ekpebi site a welara bụ fọrọ nke nta agaghị ekwe omume. Ọtụtụ mgbe, larịị nke "ogidi ọkụ" na-enwekwukwa mgbe egosi adakarị ịrịba ama nke ovarian cancer na nwanyi.

HE4 nwere elu specificity (95%) na uche (76%) tụnyere Ca-125. E nwere ọmụmụ gosiri na ndị inyom na a elu ịta nke HE4 welara Ca-125 ọbara nkịtị. Ya mere, n'ihi na mkpebi siri ike nke ovarian cancer na n'oge ogbo ya bụ mma iji, nke na-ekpebi usoro nke HE4.

N'ihi na ya pụta na-enwe a ukwuu pasent nke ziri ezi, ndị ọkachamara na-akọwa dị nnọọ abụọ akpụ welara (ca-125 na HE4). Mgbe na-eji a pụrụ iche mgbakọ na mwepụ algọridim na yikarịrị ka ekwe na-ekwu okwu banyere mmepe nke oncological Filiks ke ovaries. Specificity na uche nke usoro a enwekwu na ọtụtụ ugboro (ruo 96%).

Akpụ welara HE4: nkịtị inyom

Ịchọpụta, ilekwasị anya naanị na n'ihi nke analysis, nke na-ekpebi HE4 bụ adịghị anakwere. N'ihi na-achọpụta ọrịa ojiji naanị a mbara obibia nnyocha ngwaọrụ na ụzọ kpebie a ule maka akpụ nrịbama. Na analysis, mkpebi siri ike nke a welara maka ovarian cancer ga-egosi, mere na ndị inyom menopause ma ọ bụ, dị ka Nso nke ụkpụrụ ke inyom na menopause n'elu.

Na inyom tupu menopause HE4 index kwesịrị erughị 70 pmoles / ml.

The nwaanyị ẹkenịmde menopause, HE4 larịị nkịtị mgbe gosiri na 140 pmol / ml.

Akpụ welara HE4: transcript

Ka ihu ya. Ọ bụrụ na ngwọta welara HE4 na-elu, ọ na-egosi omume nke epithelial ovarian cancer. Dị nnọọ mara na ndị ọzọ ụdị ọrịa cancer nke ovaries (eg, mucinous) ego nke ọbara HE4 na-adịghị ụba.

The akwa ịta nke HE4 bụghị mgbe niile indicative nke ovarian cancer. Mgbe ụfọdụ larịị nke a welara elu na gbasara akụrụ odida, ọrịa cancer akpa ume, endometrial, akụrụ fibrosis.

Proper nkwadebe maka analysis na-emetụta larịị nke welara ke iyịp.

Nkwadebe maka analysis

Iji chọpụta akpụ welara HE4 ọbara e si a akwara nke buru ọnụ. Ya mere, tupu ị na-aka ndị analysis, 12 awa tupu usoro nwere ike na-agaghị eri abụba oriri, na mmanya, na ato uto, meats, i nwere ike na-aṅụ sịga. N'ụbọchị nke analysis nwere ike na-aṅụ na mmiri obere obere.

ọgwụgwụ

Iji na-arịa nwere ike ịbụ naanị na a dọkịta, ịdabere na data si ọtụtụ ụdị nke nchọpụta nsogbu. Iji zere nsogbu ahụ ike, na-a àgwà otu ugboro n'afọ ego-acha ọkụ. Mgbe niile, mara ihe bụ ike - bụ oké ọnụ ahịa.