Anti-estrogen ọgwụ ọjọọ: nkọwa, ngwa

Estrogen-blockers bụ chemical ogige na-egbochi ihe nke estrogen. Antiestrogen ọgwụ ọjọọ na-eji na ọgwụgwọ nke ọrịa dị iche iche. Ha na n'ọtụtụ ebe, na-eji maka ọgwụgwọ nke ọrịa cancer nke ara Filiks ibelata akpụ ibu ma ọ bụ nlọghachi azụ mgbochi. Dị ka ọ dị na ọgwụ ọjọọ ndị ọzọ na-emekọ ihe homonụ ke idem, ndị a ọgwụ ọjọọ eme ihe a ga-eji n'okpuru nlekọta nke ndị ọrụ.

Abamuru na Harms nke estrogen

Estrogen, ma ọ bụ a steroid hormone synthesized bụ isi ihe na ovaries. Ọ na-emetụta a nọmba nke usoro nke ahu. Women toruworo ịmụ nwa nwere kasị elu larịị nke eke hormone. Gabigara ego, Otú ọ dị, nwere ike ime ka a syndrome maara dị ka hyperestrogenia. Nke a na ọrịa nwere ike ime ka cancer usoro na ara na endometrial cancer. Anti-estrogen ọgwụ ọjọọ na estrogen blockers na aromatase inhibitors nwere ike ọ idozi ihe niile. Ọgwụ ndị a, Otú ọ dị, nwere nti na ọjọọ metụtara na ndị inyom na ndị ikom.

Types of estrogen-blockers na ha were

E nwere ọnụ ọgụgụ dị iche iche na iche nke estrogen-blockers. aromatase inhibitors n'ezie egbochi mmepụta nke estrogen. Nhọrọ estrogen ihe nnabata modulators, dị ka "Tamoxifen" "Clomiphene", iji igbochi estrogen anabata, na-akpa àgwà dị iche iche maka iche iche iche iche nke na-akpa ákwà. Antiestrogens nwekwara igbochi estrogen anabata.

Antiestrogens gbochie akakabarede nke testosterone na estradiol na estrogen homonụ kwusi iji rụọ ọrụ ma ọ bụ na-egbochi.

Na cancer ọgwụgwọ, ọgwụ ndị a na-eji nwayọọ mmepe nke etuto ahụ. Na nke a, nhọrọ estrogen ihe nnabata modulators nwere ike iche na kpọmkwem estrogen anabata. Blockers, gụnyere "Clomiphene" a na-mgbe ụfọdụ na-eji na ọgwụgwọ nke infertility, ha nwere ike inyere ụfọdụ ndị inyom ndị nwere ike ịghọ ime. Ọgwụ ndị a na-eji site na ụfọdụ clinicians na ọgwụgwọ nke ụmụ na-egbu oge mmalite oge uto ruo mgbe ha toruru.

N'etiti bodybuilders ya ji estrogen-blockers n'ihi estrogenic mmetụta nke elu-etoju nke testosterone ke idem. Testosterone bụ a precursor nke ihe estrogen, aromatase inhibitors ike ga-eji kwụsị guzobe muscle uka ngafe nke estrogen, ịnọgide na-enwe a ala ozo ke idem. Nke a na-eme ka dọtara ọtụtụ, karịsịa mgbe mgbochi estrogen ọgwụ ọjọọ na-eji isi n'ihi ịchọ mma nzube. Na nke a, ndị mmadụ na-eji mbadamba na ekwukwa n'akwụkwọ Mmeju enweghị nlekọta nke ndị ọrụ.

mmetụta

E nwere mmetụta nke mgbochi estrogen ọgwụ ọjọọ. Ha nwere ike ime ka dizziness, isi ọwụwa, sweating, na-ekpo ọkụ mgbukepụ na mgbagwoju anya. Naanị endocrinologist pụrụ ikpebi ihe kwesịrị ekwesị onunu ogwu maka a ndidi dabere na ọnọdụ, na-anara nke nbata-uzọ nke mmetụta. The endocrinologist nwekwara ike idepụta mgbe ọbara ule hormone etoju mgbe adabere na n'ozuzu ike nke onye ọrịa na-egosi na ojiji nke mgbochi estrogens bụ nchebe na ọtọ n'ihi ọrịa.

ikom ọgwụgwọ

Na afọ, nwoke testosterone etoju dobe. Otú ọ dị, ọ bụrụ na testosterone na-ngwa ngwa ma ọ bụ ukwuu belata, ọ pụrụ iduga ya mmepe nke hypogonadism. Nke a kwuo e ji ahụ apụghị ịmị a dị mkpa hormone, nwere ike ime ka a dịgasị iche iche nke ihe mgbaàmà, gụnyere:

• ọnwụ nke libido;
• Mbelata mmepụta na àgwà nke spam;
• erectile dysfunction;
• ike ọgwụgwụ.

Ọ bụrụ na anyị na-ekwu banyere estrogen, ihe mbụ ndị mmadụ na-eche na ọ bụ nwaanyị hormone, ma ya edidu ana achi achi na nwoke ahụ a na-arụ ọrụ kwesịrị ekwesị. E nwere atọ ụdị nke estrogens: estriol, estrone na estradiol. Estradiol - bụ isi ụdị nke nọ n'ọrụ estrogen na mmadụ. Ọ na-arụ ọrụ dị mkpa ịnọgide na-enwe ọrụ nke nwoke nkwonkwo na ụbụrụ anụ ahụ. Antiestrogen ọgwụ ọjọọ na-enye ohere na-spam ka nke ọma.

Mmiri ọgwụ ahaghị nhata - azụ larịị nke estrogen na-ebelata testosterone - emepụta nsogbu. Ukwuu estrogen na nwoke ahụ pụrụ iduga:

• gynecomastia (oké mmepe nke ara anụ ahụ);
• obi nsogbu;
• n'ihe ize ndụ nke a ọrịa strok;
• ibu ibu;
• Nsogbu na prostate.

Ị nwere ike na-ọtụtụ ihe iji weghachi nguzozi na larịị nke estrogen. Ka ihe atụ, ọ bụrụ na gị na ngafe estrogen jikọtara ala etoju nke testosterone, na ike bara uru dị ka a testosterone nnọchi ọgwụ nke estrogen blocker.

Pharmaceutical estrogen-blockers

Ụfọdụ na-emepụta ọgwụ na ngwaahịa nwere ike na-emepụta estrogen-igbochi mmetụta na mmadụ. Dị ka a na-achị, ọtụtụ mgbe ha na-na-bu n'obi maka site na nwanyi, ma na-inweta ke ewu n'etiti ndị mmadụ, karịsịa ndị na-achọ ka ụmụ. Testosterone Mmeju pụrụ iduga infertility. Ma estrogen blockers dị ka "Clomid" nwere ike iweghachi mmiri ọgwụ itule na o megideghị ọmụmụ.

Ọtụtụ ọgwụ na-mara dị ka nhọrọ estrogen ihe nnabata modulators, a na ahịa dị ka ọgwụ ọjọọ eme ihe maka ọgwụgwọ nke ọrịa ara ure. Ma ha nwekwara ike-eji na-egbochi estrogen na mmadụ. Ọgwụ ndị a na-eji a dịgasị iche iche nke ọnọdụ metụtara ala testosterone, gụnyere:

• infertility;
• ala spam ọnụ;
• gynecomastia;
• osteoporosis.

Ọgwụ ndị a ga-eji bibiri, dabere na onye ọrịa. Iji dị otú ahụ na-emegide estrogen ọgwụ ọjọọ. Na ahịa ọgwụ ị pụrụ ịzụta:

• "Tamoxifen".
• 'Arimidex'.
• "Letrozole."
• "Raloxifene".

Mmetụta na ọkpụkpụ

Dị ka clinicians, ruo ogologo oge n'ebe estrogen ọgwụ ọjọọ nwere ike ime ka endometrial cancer na nwanyi. "Raloxifene" - a nhọrọ estrogen ihe nnabata modulator - pụrụ igbochi mmepe nke cancer, bibiri nkanka na absorption nke estrogen. A ọgwụ Otú ọ dị, nwekwara ike inhibiting mma mmetụta nke estrogen na ọkpụkpụ njupụta. The ọgwụ ọhụrụ - "lasofoxifene" - nwere ike idozi nsogbu a. Ọ na-egbochi ọnwụ nke ọkpụkpụ njupụta postmenopausal inyom na ebelata brittleness nke ọkpụkpụ anụ ahụ. The ojiji nke a ọgwụ bụ n'ozuzu nchebe, ma nwere ike mụbaa ọbara-egbochi mkpụkọ.

ọgwụ interactions

Estrogen blocker "Tamoxifen" nwere ike nyere aka gbochie cancer. Cancer ọrịa na-enwekarị ahụ ịda mbà n'obi, na otu a ọgwụ ọjọọ nwere ike emekọ na-ezighị ezi na ọgwụ, antidepressants. Kwesịrị "Paroxetine", n'ihi na eziokwu na ndị inyom na-ewere "Tamoxifen" na "Paroxetine", obere ihe ize ndụ nke ọnwụ karịa ndị inyom ndị na-ewere "Tamoxifen" ma ọ bụla ọzọ antidepressant. Nke a bụ n'ihi na "Paroxetine" na-eme bibiri.

Antiestrogen mmadụ na ọgwụ ọjọọ

The disclosures nke ndị a niile ego na-egosi na onye ọ bụla ọgwụ na-eji n'otu n'otu na a kpọmkwem.

"Clomid" ma ọ bụ "clomiphene citrate" bụ otu n'ime ndị mbụ ọgwụ ọjọọ na-eji na ọgwụgwọ nke gynecomastia, n'ihi na ọ na-eweta ahụ larịị nke eke testosterone. E nwere ụfọdụ mmetụta si ogologo oge ojiji, dị ka ọhụụ nsogbu. E nwere ihe ọzọ dị irè bekee na ahịa, nke na-eme ihe n'otu ụzọ ahụ ma "Clomid" bụ ka irè na ọnụ mix maka ihe ọ bụla na-eme egwuregwu.

Nke a abụghị ihe anabolic steroid, a ọgwụ ọtụtụ ọgwụ dị ka onye aka na ndị inyom na infertility, n'ihi na o nwere a akpọ ike na-akpali ovulation, nke na-enweta site igbochi / n'ibelata mmetụta nke estrogen ke idem. Iji ọzọ ụfọdụ, "Clomid" - chemical Njirimara nke sịntetik estrogen agonist /-eti ọkpọ. Na ụfọdụ lekwasịrị anụ ahụ ya nwere ike igbochi ikike nke estrogen eke agbụ na kwekọrọ ekwekọ ihe nnabata. Ya na-adakarị ojiji bụ ịrụ ụka na-adịghị mma nzaghachi nke estrogen na hypothalamus-pituitary-ovarian usoro, nke welie ntọhapụ nke LH na FSH. All a na-eduga ná ovulation.

Maka egwuregwu nzube "clomiphene citrate" ndị inyom na-enweghị mmetụta. Na ndị ikom na Otú ọ dị, e nwere mụbara mmepụta nke FSH na (isi) luteinizing hormone na-akpali eke testosterone. Nke a pụrụ isi kwuo bụ karịsịa bara uru na-eme egwuregwu na njedebe nke a steroid okirikiri mgbe endogenous testosterone etoju na-ada mbà n'obi. Enweghị testosterone (ma ọ bụ ndị ọzọ androgens), "Cortisol" enwe Mmeri na-emetụta protein njikọ na muscle. Ma ọ ngwa ngwa "na-eri" ọtụtụ ndị nwetara ọhụrụ na muscle mgbe kagbuo. Clomid nwere ike igwu a dị ịrịba ama ọrụ na-egbochi nke a ọdịda iji nweta egwuregwu na-arụpụta. N'ihi na ndị inyom, na uru nke edinam Clomid - Ikike ịchịkwa endogenous estrogen larịị. Nke a ga-eme ka ọnwụ nke abụba na muscle, karịsịa na ebe dị ka thighs na ike. "Clomiphene citrate" Otú ọ dị, mgbe mgbe, na-arụpụta mmetụta na ndị inyom, ma, o sina dị, ina n'etiti otu a nke na-eme egwuregwu.

"Tamoxifen" igbochi estrogen anabata na ara cancer mkpụrụ ndụ. Nke a na-akwụsị na estrogen si inwe mmekọrịta ha na ha na-egbochi uto na nkewa nke mkpụrụ ndụ. Ezie na "Tamoxifen" na-eme dị ka ihe antiestrogen na mammary gland mkpụrụ ndụ, ọ na-eme dị ka ihe estrogen na ndị ọzọ anụ ahụ: ọkpụkpụ na akpanwa.

Women na dabere ara "Tamoxifen" invasive cancer ga-eji na 5-10 afọ mgbe ọrụ, iji belata likelihood nke metastasis dissemination. Ọ na-ebelata ihe ize ndụ nke na-emepe emepe cancer na ndị ọzọ na ara. N'ihi na n'oge ogbo nke a nkwadebe na-eji isi nke ndị ọrịa na-adịghị menopause. Aromatase inhibitors bụ ọgwụgwọ ha họọrọ maka menopausal inyom.

"Tamoxifen" nwekwara ike ịkwụsị uto ma ọ bụ ọbụna asụla etuto ahụ na ọrịa na metastatic cancer ọrịa. Ọ nwekwara ike-eji na-ebelata ihe ize ndụ nke na-emepe emepe ara onkologicheskihz Filiks.

A ọgwụ e ji ọnụ na, na-na-na ụdị nke mbadamba.

Oghom mmetụta nke mgbochi estrogen ọgwụ ọjọọ na-agụnye ike ọgwụgwụ, na-ekpo ọkụ mgbukepụ, mmamiri nkụ ma ọ bụ oké mmiri na ọnọdụ swings.

Ụfọdụ ụmụ nwaanyị na metastases na ọkpụkpụ anụ ahụ nwere ike ime mgbu na ọzịza na uru ahụ na ọkpụkpụ. Nke a na-emekarị anaghị adịru ogologo, ma na ụfọdụ obere okwu, ndị inyom nwekwara ike imepe elu etoju nke calcium na ọbara, nke na-adịghị prokontroliruesh. Ọ bụrụ na nke a emee, mgbe ahụ, omume nwere ike kwụsịtụrụ ruo oge ụfọdụ.

Obere, ma njọ mmetụta ọjọọ ndị na-ekwe omume. Ndị a ọgwụ ọjọọ nwere ike na-amụba ihe ize ndụ nke na-emepe emepe cancer nke myometrium nwanyi na menopause. Mụbara ọbara clotting bụ ihe ọzọ na-ekwe omume dị oké njọ mmetụta. Deep akwara thrombosis emee, ma mgbe ụfọdụ, a mpempe ọbara clot nwere ike kewapụta na-emecha na-egbochi ndị akwara na ngụgụ (akpa ume embolism).

Adịkarịghị "Tamoxifen" kpatara ọrịa strok na obi ọgụ na postmenopausal inyom.

Dabere na menopausal ọnọdụ nke ndị inyom "Tamoxifen" nwere ike dị iche iche mmetụta na ọkpụkpụ. Na premenopausal inyom, "Tamoxifen" nwere ike ime ka thinning nke ọkpụkpụ, ma na post-menopausal inyom enwekwu larịị nke calcium, dị mkpa maka ọkpụkpụ ike.

The uru nke a ọgwụ karịa ihe ize ndụ nke fọrọ nke nta niile ndị inyom na hormone-ndabere invasive ara cancer.

N'otu aka ahụ, ọgwụ bụ "Toremifene", nke a na-mma n'ihi na ọgwụgwọ nke metastatic ara cancer. Otú ọ dị, nke a na nkà mmụta ọgwụ ga-arụ ọrụ ma ọ bụrụ na-eji "Tamoxifen", ma na-enweghị mmetụta.

"Fulvestrant" bụ ọgwụ na nkanka mbụ estrogen ihe nnabata, na mgbe ahụ nakwa ewepu ihe nnabata-adịgide adịgide ikike. Ọ na-eme dị ka ihe mgbochi-estrogen ofụri idem.

"Fulvestrant" na-eji na-emeso na-agba ọsọ metastatic ara cancer, na ọtụtụ na-eji mgbe ndị ọzọ mmiri ọgwụ ọgwụ ọjọọ ( "Tamoxifen" na aromatase inhibitors) nke kwụsịrị ịrụ ọrụ.

Common mmetụta pụrụ ịgụnye ọkụ mgbukepụ, n'abalị sweats, nwayọọ ọgbụgbọ na ike ọgwụgwụ. Theoretically, ọ pụrụ ime ka ọkpụkpụ (osteoporosis), ma ọ bụrụ na e ruo ogologo oge.

A ọgwụ meriwo ude maka ojiji na postmenopausal inyom na-adịghị azaghachi "Tamoxifen" ma ọ bụ "Toremifene." Ọ bụ mgbe ụfọdụ na-eji maka ya bipụta ya, nzube premenopausal inyom, mgbe mgbe, na Nchikota na a luteinizing hormone-atọhapụ agonist gbanyụọ ovaries.

"Raloxifene" na-eji ndị inyom maka igbochi na ọgwụgwọ nke ọkpụkpụ ọnwụ ma ọ bụ osteoporosis mgbe menopause. Ọ na-enyere ịnọgide na-enwe ike ọkpụkpụ, na-ebelata ihe ize ndụ nke fractures.

"Raloxifene" na-ike gbochie omume nke invasive ara cancer mgbe menopause. Ọ bụghị estrogen hormone, ma eme ka estrogen na akụkụ ụfọdụ nke ahụ, dị ka ọkpụkpụ. Na n'akụkụ ndị ọzọ nke ahu (ara na akpanwa), "Raloxifene" na-eme dị ka ihe estrogen blocker. Ọ dịghị dochie a dịgasị iche iche nke menopausal syndrome. Raloxifene akọ a na klas nke ọgwụ ọjọọ maara dị ka nhọrọ estrogen ihe nnabata modulators-SERMs (estrogenic na antiestrogenic ọgwụ ọjọọ).

Anti-estrogen ọgwụ ọjọọ na Sports

Ụfọdụ ọgwụ ọjọọ eme ihe na-ọtụtụ-eji bodybuilders wuo muscle.

"Cyclofenil" - bụ neanabolichesky / androgenic steroid. Ọ na-arụ ọrụ dị ka ihe mgbochi-estrogen na testosterone ka a stimulant. "Cyclofenil" bụ nnọọ na-adịghị ike, nke dịkwa nwayọọ estrogen, ma ọ na-ejikọ estrogen anabata ma na-egbochi nkịtị nke eke estrogen anabata. N'ezie, ọ na-arụ ọrụ nke ọma nke na ụfọdụ na-eme egwuregwu na-ọgwụ ọjọọ n'oge a steroid ọgwụgwọ na iji nọgide ala etoju nke estrogen. N'ihi - mbenata ego nke ọmụmụ ke idem, nke e kere na Steroid na Mbelata ke gynecomastia. The na-eme egwuregwu nwere a siri ike mputa, iji dị otú ahụ ọgwụ ọjọọ eme ihe, nke nwere ike nwere ike iwere n'oge nkwadebe maka a mpi. Bodybuilders Otú ọ dị, na-eji ya obere mgbe n'ihi na ha na-ahọrọ a ọzọ oké ọnụ 'Nolvadex' na 'Proviron. "

Dị ka "Clomid", "Cyclofenil" bụ adighi ike inyom, dị ka ọ nwere nti mmetụta na na mmepụta nke homonụ na ndị ikom. Ịzụ larịị nke testosterone mere site a ọgwụ bụ ezughị ikwu okwu banyere oké ndozi, ma ọ ga-enye ike uru, ọbụna a obere na-abawanye na ahu arọ, a dị ịrịba ama mmụba na ume ọrụ na-abawanye na imu na o kwere omume. Ndị a na-arụpụta na-anya karịsịa na elu na-eme egwuregwu ndị nwere obere ma ọ bụ ọ na ahụmahụ na Steroid. Jiri ihe na-anya nanị mgbe a izu.

Mgbe ụfọdụ, na-eme egwuregwu na-ekiri eruptions dị ka otutu, ụba mmekọahụ mbanye na-ekpo ọkụ flushes. Ndị a mgbaàmà ndị karịsịa indicative àmà na compound bụ n'ezie irè. Mgbe discontinuation nke ụfọdụ kọrọ dara mbà n'obi na ọnọdụ na a nta ọnụ ke nkịtị ike. Ndị na-ọgwụ dị ka ihe mgbochi-estrogen n'oge steroid ọgwụgwọ, ike na-edebe ihe na-abụghị mmetụta mgbe mmetụta nke gị n'ụlọnga na-kwụsịrị.

"Proviron" bụ otu n'ime ndị kasị ochie anabolic androgenic Steroid na ahịa. Eze maara dị ka "Mesterolone", ọ na-anọgide otu n'ime ndị kasị n'enweghị ndị bịara buru n'etiti anabolic steroid ọrụ.

On a ọtọ ndabere Proviron nwere anọ na isi ọrụ, nke dị n'ụzọ dị ukwuu ikpebi ya omume. Mbụ niile, ọ bụ ya bụ otu n'ime ndị kasị dị ike anabolic Steroid, n'ihi na ọ na-enwekwu ego nke-ekesa free testosterone, nke bụ ihe dị mkpa maka anabolic Filiks bodybuilders. A ụzọ dị mfe anya ya: ọ bụrụ na ị na-na-anabolic Steroid, na muscle uka na-amụba.

"Proviron®" na-nwere ikike na-emekọ na enzyme aromatase, nke bụ maka na ntughari nke testosterone na estrogen. Site nkịtị ka aromatase, "Proviron®" pụrụ n'ezie inhibit ya ọrụ, si otú na-enye nchebe pụọ oghom mmetụta nke estrogen.

On "Mesterolone" nwekwara a siri ike mmekọrita maka androgen ihe nnabata. Nke a anabolic steroid nke na-adịghị ebelata gonadotropins yiri ndị ọzọ anabolic Steroid. Nke a na-eme ka o kwe omume na-amụba mmepụta nke spam nakwa dị ka androgens mkpa maka mmetuta nke spermatogenesis. Nke a bụghị naanị enwekwu ọnụ ọgụgụ nke spam, ma mma ya mma.

Mmetụta "Proviron" anaghị agụnye gynecomastia ma ọ bụ ngafe ọmụmụ. Nke a ga-budata belata ihe ize ndụ nke ọbara mgbali elu metụtara na-ewere anabolic Steroid. N'ezie, "Proviron" nwere mgbochi estrogenic mmetụta site nkwụsị na ntughari nke testosterone na estrogen, ma ọ bụ ọ dịghị ihe ọzọ jiri nwayọọ na usoro a.

The n'elu-e kwuru ọgwụ ọjọọ na-adịghị belata estrogen larịị ma emetụta metabolism n'ozuzu.

The ìgwè nke antiestrogenic ọgwụ ọjọọ na-agụnye agonists atọhapụ ihe gonadotropic homonụ ( "Buserelin" na ya analogs), megestrol acetate ( "Megeys") "Parlodel" na "Dostinex" na-eji dị ka ọgwụ ọjọọ, suspending prolactin secretion. Ha onwe ha were na ọgwụgwọ nke na-abụghị ò.

Ọgwụgwọ nke cancer

Ke adianade "Tamoxifen" Ndị na-esonụ estrogen ihe nnabata blockers.

Atọ ọgwụ ọjọọ na-akwụsị estrogen mmepụta ke postmenopausal inyom, e mma na-emeso ma n'oge na elu ara cancer: "Letrozole" ( "Femara"), "Anastrozole" ( 'Arimidex') na "Exemestane" ( "AROMASIN") .

The usoro nke ihe nke mgbochi estrogen ọgwụ ọjọọ na otu a - na igbochi nke enzyme (aromatase) na adipose anụ ahụ, nke bụ maka obere estrogen na post-menopausal inyom. Ha adịghị emetụta ovaries, otú ahụ nanị irè n'ihi na ndị inyom na onye ovaries anaghị arụ ọrụ, ma ọ bụghị n'ihi menopause ma ọ bụ n'ihi na nke mmetụta nke luteinizing hormone analọg. Ọgwụ ndị a na-e kwa na Erere ụdị. Ha na-arụ ọrụ dokwara ọma na ọgwụgwọ nke oncological Filiks ke ara na prostate.

Mgbe ụfọdụ, ọrịa ara ure ọgwụgwọ na-achọ ọgwụ na ovarian. Nke a nwere ike mere na ọgwụ ọjọọ analogues nke luteinizing hormone-atọhapụ hormone (LHRH), n'ihi na ihe atụ, "Goserelin" ( "Zoladex") ma ọ bụ "leuprolide" ( "Lyupron"). Ọgwụ ndị a na-egbochi ndị mgbaàmà nke na-eziga ka ahụ na ovaries na-emepụta estrogen ha. Ha ga-eji naanị ma ọ bụ na "tamoxifen", aromatase inhibitors, "Fulvestrant" maka mmiri ọgwụ ọgwụ na premenopausal inyom.