"Farmadipin" (tụlee) site na gịnị?

Ugbu a, e nwere ọtụtụ ndị dị iche iche ịgba akwụkwọ maka ọbara mgbali na stenokardicheskie ọgụ. Otu n'ime ha bụ na-dị ka "Farmadipin" (tụlee) na nkà mmụta ọgwụ. Gịnị ka nke a ọgwụ ọjọọ, atụlekwu banyere zuru ezu.

Ọdịdị

The n'ọrụ mgwa na nke a bụ nifedipine (nifedipine). 1 ml nke a ngwọta, ọ bụ na a ụfọdụ ego. Ya bụ, na 100%, nke dabeere na akọrọ-ụdị umi - 20 mg. Ọ na-eme iri atọ tụlee.

"Farmadipin" (ụmụ irighiri mmiri), na ntụziaka nke ngwa ga-atụle n'isiokwu n'okpuru, na Ọdịdị bụ ọnụnọ nke inyeaka bekee ndị dị otú ahụ dị ka polyethylene glycol 400 na 96% ethanol.

pharmacological Njirimara

A ọgwụ nwere a peculiar pharmacodynamics. Ka ugbua kwuru n'elu, na "Farmadipin" (tụlee) nwere nifedipine umi na-enye antihypertensive na mgbochi anginal edinam. Ọ na-akwalite igbochi ntinye nke calcium ion n'ime cardiomyocytes-eji ire ụtọ muscle mkpụrụ ndụ na ụfọdụ elu na akwara akwara site a voltaji-ụdị onye na-adịghị iche ọwa cell membranes. Nke a dị mkpa ihe onwunwe. Nifedipine enyekwa ntụrụndụ nke vaskụla ezigbo muscle, mụbara elu na akwara akwara, mkpochapu apịajighị apịaji. Nke a na-ebelata ọbara mgbali, systemic vaskụla eguzogide, gbasara obi afterload na myocardial oxygen ina. Ọzọkwa, mgbe na-ewere a ọgwụ na-egosipụta ụfọdụ mgbaàmà. Ya bụ, e nwere a nta ọnụ ke myocardial contractility na n'obi ọrụ, nakwa dị ka dịtụ belata platelet aggregation.

Pharmacokinetics

Na nke a, "Farmadipin" (tụlee), ntuziaka maka ojiji nke a na-ewere na nke a akụkọ, nwere ya e ji mara. Mgbe esịtidem n'ikuku o nwere digestive tract ọma etinye obi gị dum. Ya bioavailability bụ banyere 40-60 percent. A karịsịa ngwa mmepe mmetụta (mgbe 5-10 min) kwuru na mmejuputa sublingual ochichi. Ọ dị mkpa ịmara. A, onye kasị ukwuu mmetụta hụrụ na 30-40 nkeji. Mmejuputa ingestion na-karịsịa emetụta ọnụego nke absorption nke n'ụlọnga. The ngosipụta nke hemodynamic mmetụta ga-adịgide ruo 4-6 awa. N'ihi ya pasent 90 nke nifedipine ewee ọbara plasma-edozi. Ọ metabolized dị nkwadebe dị ka "Farmadipin" (dobe) na imeju. Ọnụnọ nke ngụkọta nwechapụ nke nifedipine bụ site 0.4 na 0,6 l / kg / Ọrụ Nchịkwa. Ọ na-ghọtara site n'ahụ tumadi dị metabolites-adịghị ejekwa ozi ụdị. Oge nke ọkara ndụ nwere ike ịdị iche iche site 2 4 awa. Ndị agadi na ọrịa na imeju nke imeju, nifedipine metabolism slows ala budata. N'ihi ya, ha nwere ọkara ndụ nke na-egosi ụzọ nwere ike mụbara dị 2-anọghị n'ogige atụrụ. Na nke a ọ dị mkpa iji belata dose ma dịkwuo nkeji n'etiti oriri nke kwuru Nwa. Nifedipinv ahụ na-adịghị cumulated. Ọzọkwa ọ na a obere ego nwere ike iru ọbara-ụbụrụ na placental mgbochi. Na nke a, ọ na-anyụpụ na mmiri ara.

egosi

Kara Aka "Farmadipin" (dobe) na ndị na-esonụ mgbe:

• Na omume nke oké mkpa ọbara mgbali na symptomatic.
• Maka ọgwụgwọ na mgbochi stenokardicheskie ọgụ.
• Mgbe hypertrophic cardiomyopathy.
• Mgbe Raynaud oria.

ngwa

Were "Farmadipin" (tụlee) sublingually. Mgbe nkọ ọbara mgbali elu (e.g., 180 / 100-190 / 110 mm HG. V.), A otu mbụ dose of ọgwụ maka okenye n'ozuzu bụ mkpokọta 3-5 tụlee (2-3,35 mg). Ọrịa na nká na-kenyere a kpọmkwem usoro onunu ogwu. Ya bụ - adịghị karịa 3 tụlee (2 mg). Ọzọkwa, kpọmkwem ọnụ ọgụgụ ike atasị na a obere mpempe akọrọ nri ma ọ bụ sugar. Ya ndidi kwesịrị ịnọgide dị ka ogologo dị ka o kwere na ihe n'ọnụ. Na ezughi oke n'ihi onunu ogwu nke ọgwụ na-ụba nwayọọ nwayọọ ruo mgbe adakarị nrụpụta. Na nke a, ya niile na-adabere na onye ahụ. Na ụdi ngosipụta nke na-amụba ọbara mgbali kwesịrị iduzi kpomkwem na set dose. Ọzọkwa, e nwere ihe ọzọ kpọmkwem criterion. Ọ dabeere n'eziokwu na ọ bụrụ na ọbara mgbali bilie 190 / 100-220 / 110 mm HG. v., mgbe ahụ, na-ewere ọgwụ tụlee nwere ike jiri nwayọọ nwayọọ na ụba na 10-15 (6,7-10 mg). Ọ ga-gaa na akaụntụ mgbanwe ndị na mgbali na a nyere ndidi. Ọ dị mkpa ịmara.

Ị nwekwara mkpa gaa na akaụntụ ọnụnọ nke ụba uche na ụfọdụ ọrịa na a ọgwụ dị ka "Farmadipin" (tụlee), nke reviews na-nti. N'ọnọdụ dị otú ahụ, na onunu ogwu họrọ n'otu n'otu. Malite na 3 tụlee, na mgbe ahụ ji nwayọọ nwayọọ zụlitere ka 2-3 (1,34-2 mg) rue oge mgbe chọrọ na-adakarị mmetụta na-enweta.

Ọ ga-eti na na ngafe nke mbụ dose nke ọgwụ nwere ike ime ka a nkọ ọnụ ke ọbara mgbali!

n'akụkụ mmetụta

Na ngwa nke a nkwadebe dị ka "Farmadipin" (dobe mgbali), e nwere ike ịbụ ihe mgbaàmà nke ọgbụgbọ, tachycardia, hypotension, "tides" ọbara na ihu. Mgbe ụfọdụ, nwere ike ime ka nfụkasị Jeremaya mere na ụdị ụkwụ edema, anụ ọkụ ọkụ. Ha nwekwara ike igosipụta mgbaàmà nke adịghị ike, dizziness, isi ọwụwa.

contraindications

N'ikuku nke ndị dị otú ahụ a ọgwụ, dị ka a "Farmadipin" (dobe) a machibidoro iwu na-ebu na ọnụnọ nke mụbara uche na ya mmiri, cardiogenic ujo, oké aortic na mitral stenosis, hypotension, tachycardia, nakwa dị ka n'oge ime na lactation.

ovadozu

Na nke a, ụfọdụ ndị na-adịghị mma mgbaàmà nwere ike ime. Ya bụ ovadozu nke ndị dị otú ahụ ọgwụ ọjọọ eme ihe dị ka "Farmadipin" (tụlee), nwere ike ike so omume nke obi ọdịda, ujo, metabolic acidosis na ụfụ, a nkọ dobe na ọbara mgbali. Mgbe mpụta ìhè nke ndị a mgbaàmà dị mkpa iji na-amalite na-ngwa ngwa na nke jikoro aka. Ha na-agụnye na gastric lavage, rụọ ọrụ carbon, calcium chloride na iwebata sympathomimetics, symptomatic ọgwụ.

eji atụmatụ

"Farmadipin" (dobe mgbali) ma ọ bụ dochie anya ya-na etinyere nanị na-akpachara anya na-adakarị nlekota nke agadi ọrịa na ndị ọrịa bụ ndị na-:

- ejighị n'aka rịaworo.

- oké obi ọdịda.

- hypertrophic cardiomyopathy.

- Nnukwu aortic stenosis.

- oké akpa ume ọbara mgbali.

- nnukwu ọrịa strok.

- Diabetes mellitus.

- gbasara akụrụ ọrụ na imeju na.

The onunu ogwu nke ọzọ ọgwụ ndị e ji nifedipine ga-ga na n'otu n'otu. Gbasara obi glycosides nwekwara ike ga-eji n'oge n'ikuku nke ndị dị otú ahụ ọgwụ dị ka "Farmadipin" (tụlee), analogs nke na-egosi n'okpuru a ederede.

Mgbe e nke imekotaotuugbo ngwa nke nifedipine na igba ogwu n'akwara magnesium sulphate ụmụ nwaanyị dị ime mkpa igosipụta ịkpachara anya nlekota nke ọbara mgbali. Nke a ga-eme n'ihi na e nwere a-ekwe omume nke ẹsụhọde ọbara mgbali nwere ike imerụ ma nne ya na nwa ebu n'afọ.

Ọrịa na mkpọchị hepatic arụmọrụ, na-achọ ịkpachara anya nlekota oru. Na oké ikpe, na dose ga-belata.

Nifedipine tsitohromichnuyu metabolized site na P450 3A4 usoro. N'ihi ya, ọgwụ ndị na inhibit ma ọ bụ ime ka ahụ kwuru kpọmkwem ebe enzyme nwere ike ịgbanwe mmetụta nke "mbụ nnyefe" ma ọ bụ nwechapụ nke umi. Ọ bụrụ na concomitant ojiji nke nifedipine na ọgwụ ọjọọ nke ụdị ga-achịkwa ọbara mgbali. Ọ bụrụ na ọ dị mkpa, ga-amalite a gụnyere ya ná onunu ogwu nke ọgwụ, dị ka "Farmadipin" (tụlee).

Iduziri iche iche nwere na vitro kpugheere a mmekọrịta dị n'etiti ojiji nke calcium na-akụ ọkpọ na nke a nifedipine na Biochemical inverse spermatozoa mgbanwe na-emetụta ndị na-arịa ọrịa ike nke ikpeazụ mejuputa njikọta.

Inweta "Farmadipin" (tụlee), ọ ga-ezere omume pụrụ ịdị ize ndụ ụdị, na-achọ ukwuu anya. Ya bụ, mgbe ọ na-adịghị mkpa iji ụgbọala ugbo ala na-arụ ọrụ na ndị ọzọ usoro, na na.

mmekọrịta

"Farmadipin" (droplet) nwere a hypotensive edinam. Nke a na atụmatụ enhances ọgwụ ọjọọ si na udi blockers. Nke ahụ bụ, "Farmadipin" (dobe) enwekwu β-adrenergic mmetụta, diuretics, nitrates, na ndị ọzọ na antihypertensive mmadụ, preparations na-aba n'anya na ndị nwere mmanya, tricyclic antidepressants. Mgbe ụfọdụ, nifedipine ebelata quinidine ịta na ọbara plasma. Ma ka a kagbuo ya ihe ọ enwekwu. N'ihi ya, na-eji Nchikota ọgwụ na-atụ aro ka nyochaa ọkwa nke quinidine ịta n'ime ọbara plasma.

"Diltiazem" ebelata nwechapụ nke ọgwụ dị ka "Farmadipin" (ụmụ irighiri mmiri). "Fentanyl" budata enhances ngosipụta nke hypotensive mmetụta. N'ihi ya, tupu ochichi nke ọgwụ (na-erughị awa 36.) Kwesịrị kwụsị n'ikuku "Farmadipina". Joint ojiji nke β-blockers na nifedipine pụrụ iduga hypotension. "Farmadipin" (tụlee) mma ịta nke theophylline, carbamazepine na digoxin ke iyịp. "Rifampicin" na-eduga ná idem emem nke ọgwụgwọ utịp nifedipine, si otú ọsọ ọsọ omume nke ya metabolism. "Cimetidine" enhances ịta "Farmadipina" n'ime ọbara plasma.

Usoro na ọnọdụ nke nchekwa

Na nke a, e nwere ndị ụfọdụ ibiere. Store "Farmadipin" (dobe) ga-abụ na ụlọ okpomọkụ na a kpọrọ nkụ. The ọgwụ ga-echebe site ìhè na-apụghị iru nke ụmụ. Nchekwa nke a ọgwụ e mere maka ruo 1 afọ na ọnwa 6. Ozugbo meghere vial - 28 ụbọchị.

ezumike

"Farmadipin" (tụlee) nwere ike ọfiọk naanị site ọgwụ.

mbukota

Na vials nke 25 ml ma ọ bụ 5 ml. Ha nyekwara ke a mkpọ.

"Farmadipin" (tụlee) analogues na Russia

E nwere ọtụtụ ndị nọ n'ọnọdụ ọgwụ. Ndị bụ isi bụ:

- "cordipin".

- "Nifedipine".

- "Adalat".

- "Kordafleks".

- "Corinfar Uno".

- "Kordafleks Rd".

- "fenigidin".

- "Osmo-Adalat".

- "cordipin ghara."

- "cordipin XL".

ọgwụgwụ

Ugbu a na ị maara ihe ndị dị otú ahụ dị ka "Farmadipin" (dobe) na nkà mmụta ọgwụ, site na nke ọ na-enyere aka na ihe Njirimara. Na nke ọ bụla, tupu ewere a ọgwụ kwesịrị ịkpọ onye dọkịta.