Multiple myeloma

Multiple myeloma (ọrịa Rustitskogo Clair) bụ onye ọzọ karịa ụmị ọkpụkpụ akpụ, nke na-emi esịnede plasma sel nke dị iche iche okè. Description nke ọrịa dị na XIX narị afọ. Ihu ọma, ọrịa bụ isiokwu nke okenye nke ndị bi na ndị agadi.

Ọ na-kweere na ihe ga-esi multiple myeloma nwere mmụba nke B-lymphocytes. The ọrịa bụ enweghị nchịkwa proliferation nke plasma mkpụrụ ndụ, nke na-eduga ná mbibi nke ọkpụkpụ umi na ọkpụkpụ mbibi. Dị ka a n'ihi nke Filiks, Ugboro fractures na-agbanwe ha udi. Toro na ọnụ ọgụgụ buru ibu, plasma mkpụrụ ndụ na-emepụta paraprotein, na-eme na-abawanye na protein ọdịnaya ọbara. Hyperproteinemia na-akpatakarị ọrịa akụrụ na mmepe nke phenomena nke gbasara akụrụ odida. Ibute esịk na tubules, paraprotein akpata nefrogidroz na amyloidosis.
Ná nke ọrịa na-eduga ná enweghị nchịkwa mgbanwe ọbara, mkpọchị hematopoiesis. Ke ndise i nwere ike ịhụ na ọbara anaemia, ala ọbara kpụkọta na mkpụrụ ndụ ọbara ọcha.

ọrịa ngosipụta

Multiple myeloma bụghị a ogologo oge na-eme ka ya onwe ya chere, na ọrịa na-arịa nwere ike ịdị na-eju afọ. Na mbụ oge nke ọrịa na-egosi malaise, ike ọgwụgwụ, asthenia. Na-emekarị, nke mbụ mgbaàmà na-akpali ịhụ dọkịta, bụ a mgbu na ala azụ, spain na ọkpụkpụ, na ihe mgbu yiri ka na-amụba. Ọzọkwa mgbaàmà nwere ike ejikọta ya na mkpọchị hematopoiesis (anaemia, thrombocytopenia), ịzụlite hemorrhagic syndrome, myocardial viscera, thromboses. N'etiti ọrịa mgbaàmà na-metụtara na-amụba gbasara akụrụ insufficiency na Hyperproteinemia.

nchọpụta nsogbu

Na mbụ mgbe e nwere onye na-abawanye na ọbara erythrocyte sedimentation ọnụego ka ịkpata dysproteinemia. Na progression nke usoro apụta anaemia, ebelata platelet na leukocytes. Na analysis of mmamịrị protein ọnwụ hụrụ nnukwu. Mgbe Biochemical analysis of ọbara kpebisiri ike site na-abawanye nke ngụkọta protein. Na mgbaàmà nke akụrụ odida - abawanye na creatinine na urea, electrolyte ahaghị nhata.
The nchoputa nke "multiple myeloma" atọrọ dabeere na a n'ihi nke analysis of ụmị ọkpụkpụ mkpụrụ ndụ. Nke a bụ isi na-achọpụta ọrịa eme. Inyeaka usoro bụ na-ebu X-ray ọkpụkpụ ịchọpụta ntụpọ na ọkpụkpụ deformities, osteoporosis ọnya. Ọ bụ ihe amamihe na-eduzi proteinogram.

Ọgwụgwọ nke Multiple Myeloma

Ọ bụrụ na nnyocha ahụ chọpụtara myeloma, ọgwụgwọ nke ọrịa a na ụbọchị - nsogbu ha na-edozilighị. Ọ kwesịrị maara nke oge nke ndụ nke ọrịa na nri ọgwụgwọ na a dịtụ ewepụghị N'ezie nke ọrịa bụ afọ ise. The ọgwụ ndị a na ọrịa metụtara ọgwụgwọ nke inhibit akpụ mmepe (cytostatics). Ma ọgwụ ndị a na ogologo ndụ nke ọrịa. Ná mmalite nke ọgwụgwọ ha a na-kenyere na doses nke ujo, mgbe emecha N'ezie ịmafe mmezi ọgwụ.

"Prednisolone" na-eji na Nchikota na cytotoxic ọgwụ ọjọọ. Ya iji na-egbochi mbibi nke ọkpụkpụ na otu nwere a mmetụta dị mma na onye na-abawanye na calcium. Mepere regimens na-agụnye ọtụtụ ihe n'ịgwa nke ọgwụ ọjọọ, dị iche iche doses dabere n'ogo na ụdị myeloma. The results nke ọgwụgwọ na-inyocha mgbe ọnwa atọ mgbe mmalite nke na-anara ọgwụ.

N'elu accession, gbasara akụrụ odida, nwere ike ịchọ usoro ọgwụgwọ hemodialysis.

Ikekwe ojiji nke radieshon ọgwụ. Ọ na-kenyere maka ọgwụgwọ nke mmachi akpụ ọnụ dị na ọkpụkpụ na adụ arọ.