Ntuziaka maka ojiji, nzaghachi na analọg "Ketanova"

Mere inye analọg "Ketanova" ma sị ọgwụ ahụ n'onwe ya? A, ị ga-amụta na ihe nke isiokwu. Anyị na-ịme ka ị ntuziaka maka ojiji nke ịṅụ ọgwụ, inye ihe ọmụma banyere ntọhapụ ụdị, oghom Jeremaya mere, mejupụtara, contraindications, na-eri na na.

Mejupụtara, nkwakọ, ntọhapụ ụdị

Analogue "Ketanova" na-anọchi anya ya na ngwá ọrụ ya nwere kpamkpam dị iche iche ụdị nke tọhapụ. The ọrụ na-adabere na ọdịdị nke ihe mgbu, ebe nke ha na ọnọdụ na ọnọdụ nke onye ọrịa.

Ugbu a, ọgwụ ọjọọ, "Ketanov" dị na abụọ dị iche iche iche-iche. Anyị na-atụle nke ọ bụla n'ime ndị a na ihe zuru ezu.

• Film-ntekwasa mbadamba. N'ọrụ akụrụngwa nke ọgwụ bụ ketorolac tromethamine. Dị ka ndị inyeaka mmiri, mgbe ahụ, ha na-agụnye ọka starch, magnesium stearate, microcrystalline cellulose na colloidal sịlịkọn dioxide. The mejupụtara nke film mkpuchi mejupụtara hydroxypropylmethylcellulose mbadamba, ọcha mmiri, polyethylene glycol, titanium dioxide na talc ọcha. Ọ ga-kwuru na ndị dị otú analọg "Ketanova" dị ka "Ketorolac", nwere otu ifịk umi. E lee ya anya nkwadebe ahịa ke aluminum blisters, nke na-enịm ke a ikpo nke kaadiboodu. Otu ngwugwu nwere ike si na iri na iri na otu narị mbadamba.

• Ọgwụ "Ketanov". Ọgwụ, analogues nke na-egosi n'okpuru, ịnwekwa a n'ọrụ mgwa ka ketorolac tromethamine. Ke adianade do, ngwọta na-agụnye ya mejupụtara na inyeaka mmiri n'ụdị sodium chloride, mmiri ogwu ogbugba, disodium edetate, ethanol na sodium hydroxide. Ọgwụ a na-eresị na vials nke otu milliliter. The katọn nwere ise ma ọ bụ iri vials.

The pharmacodynamic Njirimara nke ihe analgesic

Gịnị pharmacodynamic Njirimara na-atụle a ọgwụ ọjọọ na ya Ẹkot? "Ketanov" (mbadamba na injections) nwere a akpọ analgesic mmetụta. The ọgwụ nwere agafeghị oke antipyretic na mgbochi mkpali Njirimara.

Dị ka ndị ọkachamara, ụkpụrụ nke edinam nke ọgwụ jikọtara mgbochi (na-abụghị nhọrọ) ọrụ nke enzyme Cox-2 na Cox-1. Usoro a pụtara na elu arọ. Ndị dị otú ahụ n'ebe na-akpata mgbochi nke Ntuziaka Nne na Nna biosynthesis, ie modulators thermoregulation, ihe mgbu uche na mbufụt.

Ngwa mbadamba "Ketanov" ma ọ bụ intramuscular ochichi nke ngwọta na-akwalite guzobe nke a racemic ngwakọta [-] S- na [+] R-enantiomers. Na mberede, ndị analgesic mmetụta nke ọgwụ bụ n'ihi naanị [-] S-udi.

Ọ ga-abụ karịsịa kwuru na-arụsi ọrụ ike agwọ ọrịa anaghị akụda respiration, enweghị mmetụta na opioid anabata, ọ na-adịghị enweta anxiolytic na ogwuura mmetụta na-adịghị eme ka ndabere.

Ihe i kwesịrị ịma tupu ewere nke a ngwaahịa ma ọ bụ ihe yiri ya? "Ketanov" (ọgwụ na ọgwụ) na ike nke ya analgesic mmetụta bụ nke yiri naanị nke morphine. Dị ka ndị ọkachamara, nke a pụtara budata elu karịa ihe niile ọzọ na-abụghị steroidal ọgwụ ọjọọ.

Mgbe onu ma ọ bụ intramuscular ochichi analgesic mmetụta a hụrụ na otu awa na ọkara, karị. The kacha mmetụta nke ọgwụ a na-enweta site na 60-120 nkeji.

pharmacokinetic Njirimara

The mbụ ọgwụ, nakwa dị ka ọ bụla analogue "Ketanova" mgbe ingestion kama ọma etinye obi gị dum na eriri afọ tract. The kasị elu ịta nke ọgwụ na ọbara ruru mgbe banyere iri anọ nkeji mgbe ingestion-ebu ọnụ mbadamba (10 mg). Ọ ga-kwuru na oriri nke mmanu mmanu na nri ratụ ratụ nwere ike budata belata karịa ịta nke ọgwụ na ọbara na na-na ya nweta na iri isii nkeji.

About pasent 99 nke ego a na-agbụ na plasma-edozi. Mgbe ọnụ ọgụgụ nke free hypoalbuminemia bekee n'ime ọbara na-abawanye. Banyere bioavailability nke ọgwụ, ọ bụ banyere 80-100%.

Ọ bụrụ na intramuscular ochichi na ngwa ngwa etinye obi gị dum n'ime n'ọbara ọgwụ "Ketanov". Analogs (Ukraine e amị nanị "Ketorolac") nakwa etinye obi gị dum.

Mgbe intramuscular ogwu ogbugba nke 30 mg nke ọgwụ bụ ya kasị elu ịta 1,75-3,2 micrograms / ml na iji 60 mg - 3,25-5,75 g / ml. The kacha ịta nke ọgwụ na ọbara na-hụrụ 15-20 na 35-65 nkeji, karị.

Ma ọgwụ ọjọọ penetrates n'ime mmiri ara? Na oké ọnụ, ma dị ọnụ ala analogue "Ketanova", na ya weere ọgwụ nwere ike mfe banye n'ime mmiri ara. Na nke a emee ozugbo mgbe mbụ dose nke agwọ ọrịa ke ichekwa 10 milligrams. The kasị elu ịta nke ọgwụ na mmiri ara ehi na a onunu ogwu na-ruru mgbe 120 nkeji na bụ 7.3 and / l.

About 50% nke ndinọ dose nke ọgwụ na-metabolized na imeju. N'ihi ya, na-adịghị ejekwa metabolites ii. Chief n'etiti ha bụ ndị district gidroksiketorolak na glucuronides. Ha na-ejikarị na akụrụ (ihe dị ka 91%) na site eriri afọ (banyere 6%).

The ọkara ndụ nke ọgwụ na ọrịa na nkịtị gbasara akụrụ ọrụ bụ banyere 5.4 awa. Nke a bara uru na-amụbawo ndị agadi na-eto eto na-ebelata.

imeju nwere dịghị utịp ke ọkara ndụ nke ọgwụ. Ọ kwesịkwara kwuru na ọgwụ adịghị egosi na usoro nke dialysis.

egosi

Ihe e bu n'uche iji ọgwụ "Ketanov"? Analogues nke ọgwụ ọjọọ na ọ bụ nnọọ dị mkpa maka obere oge enyemaka nke ihe mgbu dị iche iche si malite.

N'ihi ya, na-ewere agwọ ọrịa kenyere:

• postoperative mgbu (gụnyere mgbe orthopedic, gynecological na abdominal ịwa ahụ);
• eze mgbu (gụnyere mgbe ịwa ahụ na dentistry);
• mgbu ọrịamkpokọta mgbe na-anata mgbaji ọkpụkpụ, na eze, na adụ anụ ahụ mmerụ;
• ọbara mgbu;
• mgbu ọrịamkpokọta aa na osteoarthritis;
• mgbu ọrịamkpokọta na-eme ka cancer;
• sciatica.

Mmadụ ole na ole maara na, ma were nke mbadamba "Ketanov" na injectable ngwọta bụghị gosiri na-adịghị ala ala mgbu ọrịamkpokọta. Ndị dị otú ahụ ọgwụ ọjọọ eme ihe bụ nanị dị mkpa maka mkpochapu na-adịghị adịte erughị ala. Na-ewere ọgwụ ọjọọ ruo ogologo oge nke oge a ka amachibidoro.

contraindications

Dị ka ndị ọzọ na-abụghị steroidal ọgwụ nkwadebe "Ketanov" eji na mgbu nwere ọtụtụ dị iche iche contraindications. Ọ bụ ya mere tupu ị na-eji ya na ị na kwesịrị ịkpọ gị dọkịta na-agụ ntụziaka. Ọ na-akọwa ndị na-esonụ contraindications:

• erosive na ọnyá ọnya nke eriri afọ tract, karịsịa na nnukwu ogbo, hypocoagulation (gụnyere hemophilia) na peptic ọnyá afọ;
• Mụbara uche na-enwe ndidi ketorolac na ndị ọzọ na NSAIDs, bronchospasm, akpịrị ịkpọ nkụ, angioedema, aspirin ụkwara ume ọkụ, hypovolemia (n'agbanyeghị ihe na-akpata ya na omume);
• imeju ma ọ bụ ọrịa akụrụ (na odida), karịsịa plasma creatinine na 50 mg / l;
• hemorrhagic ọrịa strok (-enyo enyo ma ọ bụ nkwenye), hemorrhagic diathesis, n'ihe ize ndụ nke nlọghachite ma ọ bụ ọbara na-agba (gụnyere mgbe ịwa ahụ), concomitant ojiji nke ọzọ NSAIDs, mkpọchị hematopoiesis;
• afọ n'okpuru 16 afọ;
• N'oge ime, ọmụmụ usoro na n'oge lactation;
• Ọgwụgwọ nke-adịghị ala ala mgbu ọrịamkpokọta agwa;
• Nkụnwụ tupu ịwa ahụ na n'oge ha (n'ihi na nke ibute ọbara ọgbụgba).

Anyị apụghị ikwu na ọgwụ kenyere na ịkpachara anya na ọrịa na cholecystitis, ụkwara ume ọkụ, ala ala obi ọdịda, isi ọrụ nke akụrụ (mgbe plasma creatinine erughị 50 mg / l), ọbara mgbali elu, ifịk ifịk ịba ọcha n'anya, cholestasis, sepsis, systemic lupus lupus, nakwa dị ka ndị agadi (karịrị afọ 65) na ndị na-polyps na lining nke nasopharynx na imi.

Drug "Ketanov": ntuziaka maka ojiji

Analogs nwere yiri n'aka ụzọ nke na ngwa ma onunu ogwu. Ma iji zere overdoses tupu ha were na-atụ aro ka ha hụ dọkịta.

Olee otú m ga-aṅụ mbadamba "Ketanov"? Nke a na ụdị ọgwụ dị mkpa na-a otu onu (10 mg). Ọ bụrụ na ọ dị mkpa (e.g., na a ike mgbu syndrome) agwọ ọrịa dose nwere ike okpukpu abụọ. Otú ọ dị, ọ ga-ahụ kwuru na kwa onunu ogwu nke ọgwụ ekwesịghị gafere 40 mg.

Mgbe ingestion nke ọgwụ N'ezie oge bụ ụbọchị ise (bụghị ọzọ).

Ọ bụrụ na n'ihi otu ihe ma ọ bụ ọzọ ndidi ike na-edeghị ede ụdị ọgwụ (e.g., na ọnụnọ nke erosive ma ọ bụ ọnyá ọnyá nke afo, bowel), mgbe ahụ, ọ na-kenyere a ngwọta maka ogwu ogbugba. Ndị dị otú ahụ ụdị na-ndinọ intramuscularly.

Ná mmalite nke usoro ọgwụ na-eji na kacha nta irè Dosages na họpụtara dị na osisi ike nke mgbu ọrịamkpokọta na omume nke onye ọrịa. Ọ bụrụ na ọ dị mkpa, na-enwe ndidi na-kenyere na ndị ọzọ opioid analgesics.

A otu onunu ogwu Nwa maka otu intramuscular injection:

• ndị mmadụ n'okpuru afọ 65 - banyere 10-30 mg (dabere na osisi ike nke mgbu);
• ndị mmadụ karịrị afọ 65, nakwa ọrịa na mkpọchị ọrụ nke akụrụ - 10-15 mg.

Ọnụọgụ ọgwụ mgbe ugboro ugboro intramuscular ochichi:

• ndị mmadụ 65 - banyere 10-30 mg, wee otu ego ọ bụla anọ ka awa asaa;
• ndị mmadụ tọrọ afọ 65 na ọrịa na mkpọchị ọrụ nke akụrụ - 10-15 mg ọ bụla 4-7 awa.

The kwa onunu ogwu nke ọgwụ mgbe ndinọ intramuscularly okenye ekwesịghị gafere 90 mg. Agadi ọrịa na ndị na mkpọchị ọrụ nke akụrụ, ọ dị mkpa iji belata ego nke ruo 60 mg. Na oge nke ọgwụgwọ ekwesịghị ịbụ ihe karịrị ụbọchị ise.

N'oge Transition si intramuscular ochichi nke ọgwụ na ọgwụ n'ime ngụkọta kwa onunu ogwu nke ma forms ekwesịghị gafere 90 mg n'ihi na ndị okenye na 60 mg agadi ọrịa ma ọ bụ ọrịa na mkpọchị akụrụ ọrụ.

mgbaàmà nke ovadozu

Na elu doses nke si agwọ ọrịa na-enwe ndidi pụrụ hụrụ vomiting, abdominal mgbu, gbasara akụrụ ọrụ, metabolic acidosis, ọgbụgbọ, erosive mgbu na peptic ọnyá afọ.

Dị ka ọgwụgwọ nke ọnọdụ ndị dị otú iji gastric lavage na iwebata iche iche adsorbents. Ọzọkwa symptomatic ọgwụ (ie na-akwado ndị dị mkpa ọrụ nke ahu).

ọgwụ interactions

Mgbe nkwonkwo ngwa nke ọgwụ n'okpuru echiche na ndị ọzọ NSAIDs, onye ọrịa nwere ike ịzụlite mmetụta nke adianade do, na anticoagulants (gụnyere "heparin" na obere doses na "Pentoxifylline") - ọbara ọgbụgba.

Ọ bụrụ na concomitant ojiji nke ọgwụ na-edu na Ace inhibitors, e nwere ike ịbụ ụfọdụ n'ime akụrụ.

Ọ kwesịkwara kwuru na ojiji nke ọgwụ n'okpuru nyochaa, na "Probenecid" enwekwu ọkara ndụ nke ketorolac na ya ịta na plasma.

Ọ bụrụ na i mee nke a ọgwụ na lithium, ọ bụ omume na-ibelata gbasara akụrụ nwechapụ nke lithium ma na-amụba ya ịta na plasma, ma na "Furosemide" - ẹsụhọde ya mamịrị mmetụta.

N'oge ngwa nke "Ketorolac" ọ dịghị mkpa maka ewere opioid analgesics.

The kacha mma analogue

"Ketanov" - nke a bụ a dị nnọọ ike ma dị irè analgesic ọgwụ, nke a na-eresị na fọrọ nke nta niile drugstores. Ekwu okwu nke ya analogs, ọ bụ ike na-akpọ aha ndị kasị dị irè na nkà mmụta ọgwụ. Ya mere, maka ngwa ngwa enyemaka nke ihe mgbu ọrịa mgbe dọkịta nye iwu ka ha na-agwọ bụ ọgwụ. Ma ọ bụrụ na n'ihi ihe ụfọdụ ọgwụ na-contraindicated na gị, anyị nwere ike ikwu na ị na-eji dochie ya na "Ketorolac". Dabere na mba-emeputa price nke ngwá ọrụ a nwere ike dị iche iche. The na-eri nke mbukota Russian mbadamba na-amalite mgbe ruble 20, Ukrainian - 35, na Indian - 45.

Olee ihe ọzọ a na-ewere a ọgwụ nwere ike dochie anya ya? Ọ na-enwe ihe ọ bụla ọzọ analogue? "Ketanov" na-enweghị a ọgwụ, ị nwere ike mgbe niile ịzụta na ahịa ọgwụ. Kpọmkwem n'otu ụzọ ị pụrụ ịzụta dị otú ahụ yiri media dị ka "Adolor", "Torolak", "Akyular ọgwụ", "Toradol", "Dolak", "Ketofril", "Dolomin", "Ketorolac tromethamine-Farmaplant", "Ketadrop "" Ketorolac tromethamine, "" Ketalgin "," Ketorolac-Eskom "," Ketokam "," Ketorolac-Verte "," Ketolak "," Ketorolac-OBL "," Ketorolac Rompharm "," Ketorol "na ndị ọzọ.

The na-eri nke ọgwụ ndị a nwere ike ịbụ elu mbụ na n'okpuru. Cheta na ọgwụ "Ketanov" (10 mbadamba) nwere ike zụrụ maka 50-70 rubles. Ọ kwesịkwara kwuru na ọ na-adịghị na-atụ aro iji ya na ha onwe ha ezi uche.

Nke ngwá ọrụ na-eji maka obodo mgbu efe? Ọ bụ n'ebe a kwekọrọ ekwekọ ụdị nke "Ketanov" ọgwụ ọjọọ? Ude (analogs nke si elekọta mmadụ na mbadamba e ọkọnọ n'elu) na otu nọ n'ọrụ umi bụ siri ike ịhụ. Otú ọ dị, e nwere ka a ọgwụ na ike ga-eji topically. Nke a bụ 2% nke ọgwụ na-akpọ "Ketorol" (mere na India). Ndị dị otú ahụ a-esi dị na 30-gram akpa na ngwa ngwa ewepu ihe mgbu ọrịamkpokọta (mgbe etinyere topically).

Nyocha nke ahụ mgbu

Ugbu a, ị mara na bụ ọgwụ "Ketanov", n'ihi na nke ọ na-bu n'obi. Ọ ga-kwuru na ọ fọrọ nke nta niile ọrịa Nyocha nke agwọ ọrịa na-nti. Ndị mmadụ na-oge iji mbadamba ma ọ bụ ihe ngwọta maka ọgwụ "Ketanov" obodo na ndị dị otú a ọgwụ nnọọ ngwa ngwa eliminates mgbu ọrịamkpokọta.

Dị ka ọgwụ na ahụ ike omume, mmetụta nke anestetiiki dịruru maka 12-15 awa (mgbe ụfọdụ aba). Mgbe oge a, na mkpụrụ ọgwụ ga-ugboro ugboro (ma ọ bụrụ na ihe mgbu na-adịghị gafere).

Otú ọ dị, ọ gaghị ekwe omume ghara ikwu eziokwu na nke a ọgwụ ọjọọ, dị ka ndị ọzọ NSAIDs, e nwere ọtụtụ mmetụta. Dị ka Ibọrọ nke ọrịa, mgbe ụfọdụ, a na ọgwụ na-akpata ọgbụgbọ na abdominal mgbu. Na nke a, ndị ọkachamara na-akwado na iji dochie ọnụ na ụdị ọgwụ ogwu ogbugba. Mgbe niile, onye ọ bụla na-a na nzuzo na NSAIDs nwere ike ime ka nsogbu ndị siri na afo (eg, na-eme ka ọdịdị nke onya ma ọ bụ erosions).

Ọ kwesịkwara kwuru na ọtụtụ ndị ọrịa na-karịsịa mma price akuko ngwaọrụ. Ịtụle na ọ dị mkpa na-a otu oge, na a mkpirikpi oge, a ọnya na mkpụrụ ọgwụ ike-ezuru nnọọ ogologo oge. The otu na-emetụta ndị injectable ụdị ọgwụ.