"Octagam": ntuziaka maka ojiji, na-egosi, mmetụta

Ọ na-ezo aka a ọgwụ na enhances dịghịzi usoro, "Octagam". Regulations ga-eti na nke a bụ a dị oké njọ ọgwụ, ọ na-ẹkenam naanị na a ọgwụ, nditịm na ndenye ọgwụ. Eji dị nnọchi na immunomodulatory ọgwụgwọ.

Ụdị hapụ ọgwụ ọjọọ na ya mejupụtara

Ọ na-emepụta naanị n'ụdị ihe ngwọta maka infusion nkwadebe "Octagam". Ntuziaka mmasị na ya na bụ isiokwu amanyere bụ iwu na-amụ tupu n'itinye. Ihe ngwọta bụ uzo, na a acha tinge. The ọgwụ na-emepụta na iko vials 20, 50, 100, 200 ml, nke na-emechi na a roba stopa na aluminum burnishing juru n'ọnụ ke a kaadiboodu igbe, ebe na mgbakwunye ntuziaka maka ojiji bụ a plastic-ntupu njide.

The agwọ ọrịa nwere na 1 ml nke dịkarịa ala 95% immunoglobulin G. The egosi bụ Ẹkot ego nke protein ndị dị na plasma ọbara mmadụ. Ọzọ bekee na ihe ndị mejupụtara nke ọgwụ na-:

• maltose;
• octoxynol;
• tributyl phosphate;
• mmiri maka injections.

The ọgwụ na-ekwesịghị ifriizi ma ọ bụ na-ekpughe na ìhè anyanwụ. Ọ na-echekwara na okpomọkụ nke 2-8 Celsius C, na-apụghị iru nke ụmụ.

Pharmacology na pharmacokinetics

Drug "Octagam" (ntuziaka adọ aka ná ntị banyere contraindications na o kwere omume na-esi nke iji ọgwụ ọjọọ eme) na-emetụta ndị mmadụ ji alụso ọrịa ọgụ usoro na-ezo aka immunoglobulins.

Ọgwụ bụ a akụkụ nke immunoglobulin klas G, nke na-emepụta-alụso ọrịa ọgụ dị iche iche na-efe efe Filiks ke idem. The ọgwụ nwere subclasses nke immunoglobulin G, yiri ka ụmụ mmadụ na plasma, ikwugharị niile ya Njirimara na e ji mara. The mmeghe nke ọgwụ n'ime ahu weghachiri belatara etoju nke IgG, na-eduga ná ya ka a kwesịrị ikwu. IgG ụmụ irighiri ruru enzymatic na chemical ikpughe agbanweghị. The ọrụ nke-alụso ọrịa ọgụ bụ ike kpamkpam ịzọpụta.

Na nkwadebe "Octagam" bụ karịa 3% polima, ndị fọdụrụnụ na-gua site monomers na dimers bụ banyere 90%.

Mgbe ị mepụtara na ngwá ọrụ na-eji ọbara nke 3500 nnọọ ahụ donors. -Alụso ọrịa ọgụ na ha nọ ugbu a na plasma ndị a ndị mmadụ nọrọ na nke a nkwadebe na-agbanweghi agbanwe ma nọgide na-n'ụzọ zuru ezu n'ọrụ.

Mgbe ọgwụ ọjọọ ochichi n'ime a akwara immunoglobulin G ozugbo abatakwa systemic mgbasa, nke a na-ekesa n'etiti vaskụla ohere na plasma. Na n'itinye "Oktagama" ọrịa na-arịa mma n'ime 3-5 ụbọchị. Ewepụtara na nkà mmụta ọgwụ na 24-36 nke ụbọchị. The ọkara ndụ bụ dị iche iche onye ọ bụla na-adabere na ọrịa afọ, ogo immunodeficiency. Immunoglobulin G ma ọ bụ ndị ọzọ dịghịzi okụre nwere ifịk akụrụngwa, ebibi site reticuloendothelial usoro.

Mgbe na-eji "Octagam"?

Etinyere "Octagam" dochie anya ọgwụ, mgbe e nwere bụ isi immunodeficiency ọrịamkpokọta, nke mbụ niile, a congenital hypogammaglobulinemia, agammaglobulinemia na Wiskott-Aldrich syndrome. Nke a na-agụnye agbanwe unclassifiable immunodeficiency ụdị na jikọtara immunodeficiencies.

The ngosi maka ọgwụ na-aduak multiple myeloma, lymphocytic-adịghị ala ala ụdị. Kenyere ọgwụ maka ọrịa na ntighari na-efe efe, na nchoputa nke HIV na ụmụ.

The nkà mmụta ọgwụ hụrụ na ya iji na ọgwụgwọ. Nke ahụ bụ, ọ na-eji na mgbawa thrombocytopenic purpura (ITP), Bilie ihe ize ndụ nke ọbara ọgbụgba. Ọzọkwa, ọgwụ na-eji tupu a waa ka normalize platelet ọnụ. Kenyere ọgwụ na Guillain-Barré syndrome. Ọ na-eje ozi dị ka ihe na-egosi Kawasaki ọrịa na ụmụaka na ndị okenye.

Jiri "Octagam" (User ngwa nkọwa zuru ezu na usoro nke ochichi na onunu ogwu nke ọgwụ) na allogeneic ụmị ọkpụkpụ transplantation.

Contraindications maka infusions

Ọ dọrọ aka ná ntị na ọ dị mkpa iji gaa na akaụntụ contraindications tupu eji "Octagam" nkwadebe ntuziaka. Ị na-eji nkà mmụta ọgwụ na ọnụnọ nke hypersensitivity ya constituent bekee ma ọ bụ ka homologous immunoglobulins.

Na ike na-elekọta inye ọrịa ọgwụ buru oké ibu. Ha nwere a pụrụ ịrịa ịzụlite thrombosis. Pụtara na-contraindicated ma ọ bụrụ na e nwere a "nchoputa nke ọbara mgbali elu," ọrịa shuga, ọrịa nke obi usoro, akp stay enweghị okporo ụzọ, na-amụba na viscosity nke ọbara.

Mgbe elu viscosity nke plasma immunoglobulin, tinye n'ọbara, na-akpali iche ihe ize ndụ nke myocardial infarction, akpa ume embolism, ọrịa strok, venous thrombosis.

Anya ga-eji nke a ọgwụ, ọrịa na gbasara akụrụ odida na ọrịa na hypovolemia na emume ha Ọrịa nephrotoxic mmadụ. Ọ bụrụ na e nwere onye na nnukwu ochichi nke immunoglobulin-ogbo gbasara akụrụ ọrịa, "Oktagamom" ọgwụ na-kwụsịrị.

Ọrịa na nnukwu gbasara akụrụ odida na udi dị ka nke ọma dị ka ndị mmadụ na thromboembolic nsogbu nke igba ogwu n'akwara ntapu ma ọ bụ ọgwụ, ọgwụ na-ndinọ nwayọọ nwayọọ na na ntakiri ichekwa.

Mmetụta nke ọgwụ ọjọọ na ime, lactating inyom e mụọ, otú ahụ oge gosiri na ọgwụ a ga-eji na oké ịkpachara anya. N'agbanyeghị nke a, na omume na-egosi na ojiji nke immunoglobulins adịghị ime ọ bụla mmetụta ọjọọ n'oge ime. The ọgwụ nwere dịghị utịp ke nwa ebu n'afọ na-adịghị emetụta nwa site na mmiri ara nne. Immunoglobulins, na-echefu n'ime mmiri ara, na-eme ka ọ bụla nsogbu na nwa ọhụrụ, na-alụso ọrịa ọgụ ẹdude n'ime, naanị-eme ka e guzobere ike ọgụ.

Ọnụọgụ ọgwụ

"Octagam" ọgwụ na-ndinọ naanị intravenously. Tupu ịmalite na-ụtọ na ụlọ okpomọkụ, ihe ngwọta na usoro. The mmiri mmiri ga-kpamkpam uzo na enweghị ịkpali na turbidity.

Onye ọ bụla ọgwụ ochichi na-dere na akụkọ ihe mere eme nke ọrịa. E nwekwara ka ọgwụ ogbe nọmba na aha. Nke a na-eme ka mma nlekota nke ọrịa na-arịa. The ọgwụ fọdụrụ mgbe ndị infusion, ike ịchekwa na a ga-ebibi.

The mbụ ọnụego nke iwebata sostvlyaet 0.01 ka 0,02 ml / n'arọ ahu arọ na otu nkeji, na na maka ọkara otu awa. Ezi tolerability agwọ ọrịa ọnụego nwayọọ nwayọọ nwere ike mụbara ka 0,12 ml / n'arọ ahu arọ kwa nkeji.

The ego nke ọgwụ ọjọọ na oge nke ọgwụ kpebisiri ike n'otu n'otu n'ihi na onye ọ bụla ndidi. Ihe niile na-adabere na-adakarị omume na a akpan akpan ndidi, na ọnọdụ ya na nchoputa nke ọrịa.

Nnọchi immunomodulating ọgwụ na isi immunodeficiency agụnye amụba ichekwa immunoglobulin G ka 4.0-6.0 g / l, ọ e tụrụ tupu ọ bụla infusion. Iji nweta ndị dị otú ahụ a na ọnụ ọgụgụ ga-achọ 3-6 ọnwa nke ọgwụgwọ. Mbụ dose ochichi bụ 0.4-0.8 g / n'arọ. Ekemende ọgwụ na-ndinọ ọrịa ọ bụla izu atọ na 0,2 g / n'arọ. Iji nweta ihe lekwasịrị immunoglobulin 6.0 g / L, onye ọrịa ga-enịm na kwa ọnwa 0.2-0.8 g / n'arọ nke ọgwụ. Ozugbo ndidi o kwesịrị ikwu, ọgwụ ka na-ndinọ ọ bụla 2-4 izu, mgbe atụ ịta nke immunoglobulin G na ọbara. Nke a ga-enyere gị aka ịhọrọ ezigbo usoro onunu ogwu.

Nnọchi ọgwụ ọgwụ na-ekenịmde ke ala ala lymphocytic leukemia, nke na-aga na nke abụọ hypogammaglobulinemia oké ụdị, na otutu myeloma, nakwa dị ka na nchoputa nke "nje HIV" na ụmụaka na ntighari na nje Filiks. Ọnụọgụ ọgwụ otú na-agbanwe agbanwe gburugburu 0.2-0.4 g / n'arọ. Multiplicity nke iwebata - ọ bụla 3-4 izu.

N'oge ọgwụgwọ nke nnukwu ji nke mgbawa thrombocytopenic purpura (ITP) na-eji na a onunu ogwu nke ọgwụ 0.8-1.0 g / n'arọ mgbe ndinọ ke akpa usen. Ọ bụrụ na ọ dị mkpa, na iwerekwa nke agwọ ọrịa na-emepụta na 2-5 ụbọchị ke ichekwa 0.4 g / n'arọ. Ọ bụrụ na ikpe nke exacerbation nke ọrịa lọghachiri, ọgwụ na-ndinọ ọzọ.

Guillain-Barre syndrome ọgwụgwọ na-agụnye na 0.4 g / n'arọ nke ọgwụ kwa ụbọchị maka 3-7 ụbọchị. Na nke a, iwere nke ọgwụ maka ụmụaka na-amachaghị.

Kawasaki ọrịa ụmụaka na ndị okenye-emeso ya na a onunu ogwu nke 1.6-2.0 g / n'arọ. The ọgwụ na-ndinọ n'otu dose n'elu 2-5 ụbọchị. Hapụrụ otu ọgwụ Nwa ke ichekwa 2.0 g / n'arọ. N'oge na-aga n'ihu ọgwụgwọ nke ọrịa n'out oge na iwebata "Oktagama" mkpa na-eji ọgwụ mgbu.

Immunoglobulin a na-eji mgbe allogeneic ụmị ọkpụkpụ transplantation preparatory ọgwụgwọ. Administration nke a ọgwụ na-egbochi omume nke ọrịa na mmepe nke syndrome nke "aka vesos usu". The onunu ogwu maka nke ọ bụla ndidi a họọrọ n'otu n'otu. Ọ na-atụ aro ka na-amalite site a dose of 0,5 g / n'arọ kwa izu. injection usoro a ga-amalite a izu tupu ndị na-abịa ngwa transplantation. Agwọ ruo ọnwa atọ mgbe ịwa ahụ. Ọ bụrụ na e a mgbe nile na-enweghị immunoglobulins, na nkà mmụta ọgwụ-eji na-0,5 g / n'arọ kwa ọnwa ogologo oge ka ha ọdịnaya adịghị abịa azụ nkịtị etoju.

mmetụta

Isiokwu na amanyere bụ iwu nke ọmụmụ tupu n'itinye ọgwụ "Octagam" ntụziaka ntuziaka. Mmepe nke mmetụta mgbe eji ọgwụ na-adabere na dose na ọnụego nke ochichi.

Igba ogwu n'akwara ọgwụ na ọgwụ nwere ike ime ka leukopenia, hemolysis na reversible hemolytic anaemia. Na ọgwụgwọ nke na o kwere omume na-adịghị mma mmeghachi omume nke dịghịzi usoro, nke na-owụt ke mpụta ìhè nke hypersensitivity. Na obere okwu ibili anaphylactoid na anaphylactic Jeremaya mere, puffiness nke ihu, angioedema.

HIV ọgwụ na ụmụ na ọgwụgwọ nke ọrịa ndị ọzọ na-akpatakarị isi ọwụwa. Ọ bụ obere nsogbu n'ụbụrụ ọbara ekesa, oké obi ụtọ, aseptic meningitis. The ọgwụ nwere ike ime ka isi ọwụwa, paresthesia na vertigo.

N'oge ọgwụgwọ, na e nwere a puru nke omume nke myocardial infarction. E nwere ike ịbụ ihe mụbara obi otiti na tahikradiya. Mgbe ụfọdụ, ụjọ cyanosis, hypotension na thrombosis. Ọ bụ nnọọ obere ọbara insufficiency, miri akwara thrombosis, ọbara mgbali.

The ọgwụ nwere ike ime ka ihe oghom mmeghachi omume na akụkụ nke akụkụ okuku ume na usoro. Nke a akụkụ okuku ume na ọdịda, akpa ume edema, iku ume ọkụ ọkụ. The-ezighị ezi pụta na-owụt ke a kwesịrị ekwesị nke, ụkwara, bronchospasm, akpa ume embolism.

The omume nwere ike ime ka ọgbụgbọ, vomiting mpiaji, abdominal mgbu, afọ ọsịsa. Na obere okwu, e nwere eczema, urticaria na itching. Na ụfọdụ ndị ọrịa, mgbe iji ọgwụ bilie dermatitis, alopecia, na pruritus.

Ọ na-adịkarịghị hụrụ Jeremaya mere dị ka ihe mgbu na azụ ebe, myalgia na arthralgia. More na ọgwụgwọ nwere ike ịzụlite gbasara akụrụ insufficiency, mụbara ọbara creatinine, ichegbu fever, oké ike ọgwụgwụ, ahụ erughị ala mmeghachi omume ime na ọgwụ na saịtị. N'etiti ugboro ugboro oghom ihe hụrụ akpata oyi, ihe mgbu na obi, flushing, malaise, ọkụ ọkụ na pyrexia. Na obere ọnọdụ, ọrịa nwere ala ọbara mgbali, anaphylactic ujo.

Ọdịdị nke kwere omume mmetụta na ọrịa, ochichi nke ọgwụ na-anabata na mbụ ọma. "Octagam" na-akpata na-abawanye na imeju enzymes na glucose kasịnụ ke laabu ọbara ọmụmụ.

Mgbe kwesịrị ekwesị họrọ dose nwere ike ime overdosing mgbaàmà. Ọ na-adịkarị ọmụmụ njigide ke idem, mụbaa ọbara viscosity, nke a hụrụ na ndị mmadụ n'otu n'otu na akụrụ ọrịa, na ndị agadi na-arịa ọrịa.

Na niile n'elu mgbe, symptomatic omume na-atụ aro.

adọ aka ná ntị

The ọgwụ na-enwe ike iji belata mmetụta nke ndụ attenuated virus ọgwụ mgbochi maka oge nke izu isii iji ọnwa atọ. Iji zere nke a, ị kwesịrị ị na-eche mgbe ngwa nke "Octagam" ọnwa atọ nke nkwadebe. Ọgwụ na-ebelata ịdị irè nke Measles ogwu n'afọ, ya mere, tupu na ikpo nke a ịgba ọgwụ mgbochi ọrịa ga-enyocha titer Measles-alụso ọrịa ọgụ.

Ọgwụgwọ na a ọgwụ nwere ike ime ka a ọnụ ọgụgụ nke mmetụta, ya mere ọ dị mkpa na-enupughi isi na iwu ntuziaka maka onunu ogwu na ochichi ọnụego. Na N'ezie nke ọgwụ dị mkpa mgbe niile nyochaa ahụ ike nke ọrịa.

Ọrịa ndị na-ndinọ igba ogwu n'akwara immunoglobulin, kwesịrị ịnata ezigbo hydration tupu usoro, na-eduzi nlekota nke mmamịrị mmepụta na ọbara creatinine. Ọ dị mkpa ka kpamkpam wepu ngwa nke "loop" diuretics.

Ọ bụrụ na e nwere iwe dị mkpa iji belata ọnụego nke ọgwụ ochichi ma ọ bụ kpam kpam kwụsị iji ya. The ọgwụ na-adabere kpam na ogo na ọdịdị nke oghom ihe. Ọ bụrụ na e a ujo, ọ dị mkpa iji na-amalite mgbochi ujo ọgwụ, nke a ga-jikọtara na ọgwụgwọ.

Ọtụtụ mgbe na-akpata oghom Jeremaya mere ngwa ngwa ọnụego nke ochichi, karịsịa hypo- na agammaglobulinemia na itinye isi immunoglobulin. Mmetụta nwere ike ime mgbe na-ebufe a ndidi immunoglobulin otu emeputa ọzọ ọgwụ, na ọ bụrụ na a otutu oge agafeela kemgbe ikpeazụ infusion.

Control n'ime ndị ọrịa (na a na-agụnye ọrịa na nje HIV status) ga-rụrụ nọgidere ofụri oge nke mbụ infusion nke edinam, karịsịa n'oge mbụ awa mgbe usoro. Ọrịa ndị na-enweghị mmetụta, ọ kwesịrị n'okpuru a dọkịta na-elekọta mgbe infusion "Oktagamom" akpa 20 nkeji.

N'oge ọgwụ ga-ọkọlọtọ anya iji gbochie na-efe efe na-ekwe omume mgbe eji ọgwụ mere si ọbara mmadụ ma ọ bụ plasma. A na-agụnye nhọrọ nke kwesịrị ekwesị donors, nlekota nke onye servings na plasma ọdọ mmiri maka kpọmkwem nrịbama nke ibute ọrịa. Usoro a ga-agụnye ihe maka inactivation / mkpochapu nje.

N'agbanyeghị niile anya na ọgwụgwọ nke ndị dị otú ahụ ọgwụ ọjọọ eme ihe, anyị nwere ike ewepu-ekwe omume nke nyefe nke a ọnụ ọgụgụ nke ndị ozi nke na-efe efe, nje virus na ndị ọzọ pathogens. All nke n'elu jikoro na-arụ ọrụ na mkpebi siri ike nke kpuchiri nje HIV, ịba ọcha n'anya nke B na C. The dịghị ihe ọzọ ha chọpụta ndị na-ebu parvovirus B19 na gipatita A. Clinical ahụmahụ nke ọgwụgwọ mmadụ nwere mmadụ immunoglobulin na-egosi na parvovirus B19 na ịba ọcha n'anya A na ọgwụgwọ nke ọgwụ ọjọọ eme ihe na-ebute site ná data. Nke dị oké mkpa na antiviral nchekwa bụ ọnụnọ ke ọgwụ ngwaahịa kwekọrọ ekwekọ-alụso ọrịa ọgụ.

N'oge Itie nke ọgwụgwọ N'ezie nanị bufee-alụso ọrịa ọgụ na ọrịa ọbara nwere ike inye ụgha pụta mgbe arụ serologic ule. Maltose ẹdude ke nkwadebe bụ ike nke na-ugha ịgwagbu ọbara glucose larịị.

Enwekwukwa arụmọrụ ke ọbara glucose ịta hụrụ n'oge mwepụ nke ọgwụ si organism ma ọ bụ iri na ise awa mgbe ya mmechi. Na nke a, na e nwere a-ekwe omume nke etịbe nzube insulin dose na pụrụ ịkpasu hypoglycemia. Ya mere, naanị glyukozospetsificheskie ụzọ kpebie larịị nke glucose dị n'ọbara na-eji na ọgwụgwọ nke "0ktagamom". Test ngwa iwu maka nlekota ọbara sugar ga-enwe ike ịmata a oke na ọrịa na-ewere ọgwụ na maltose.

Ọ bụrụ na bụghị emebiela, mgbe ahụ, na-ekwe ka na-echekwa ọgwụ ọjọọ "Octagam" (50 ml na 100 ml) na okpomọkụ ruo + 25 ° C ọnwa atọ enweghị nke abụọ ịtụkwasị ya na friji. Ejibeghi maka a kwuru kpọmkwem oge, ọgwụ ga-ebibi.

Ọgwụ adịghị emetụta ikike iji ụgbọala ma na-eme omume nke na-achọ nlebara anya pụrụ iche e jikọrọ abụọ abụọ na ngwa ngwa psychomotor Jeremaya mere.

Drug "Octagam": ogbo

Nke a na nkà mmụta ọgwụ nwere ọtụtụ analogues na ike dochie ya na ikpe nke na mkpa, ya bụ:

• "Biaven VI."
• "Veegum-liquidity."
• "Venoglobulin".
• "Gabriglobin".
• "Gabriglobin-IgG».
• "Veegum-C."
• "Gamunex."
• "Gamma Globulin Hooman".
• "IG Vienna N.I.V. ".
• "Imbioglobulin".
• "Immunoglobulin".
• "Imbiogam".
• "Immunovenin".
• "Intratekt".
• "Sandoglobulin".
• "Endobulin".
• "Flebogamma 5%."
• "Humaglobin".

Russian nọ n'ọnọdụ dị nnọọ ọnụ ala karịa ala ọzọ ha ogbo. Na nke ọ bụla, a niile ọgwụ ndị siri ike iji bulie ma na-ga-anọchi naanị site a dọkịta, dabeere na ọrịa na-arịa.

"Octagam" Medicine: price

The na-eri nke ọgwụ bụ nnọọ elu. Ọ nwere ike zụrụ maka 9,5-12 puku rubles na 50 ml nke ọgwụ "Octagam". 100 ml Price bụ na gburugburu 20-24 puku rubles.

The echiche nke ọrịa na ndị dibịa

Drug "Octagam" nwere reviews ukwuu n'ime mma. Karịsịa ekele ya àgwà ndị, bụ ndị o nyere aka-agbake na immunodeficiency na Guillain-Barré syndrome. Ọ bụ mgbe eji maka ndị mmadụ na AIDS ịnọgide na-enwe ahụ ike ha. O gosiri na ya irè adịghị ala ala lymphocytic leukemia, myasthenia gravis. Women-eji nke a ọgwụ ọjọọ na-atụrụ ime, mụọ nwa.

Ọtụtụ n'ime ndị ọrịa ghara inwe afọ ojuju na-eri nke ọgwụ, ha mara na ọ bụ ike ịzụta ke pharmacies. Ụfọdụ na-akpọ ya a adịghị ike, isi ọwụwa, na izugbe malaise.

Dọkịta na-ekwu na ọ bụ dị ọcha nkwadebe, ọ na-ọma etinye obi gị dum site na aru ahu, na n'adịghị anụ ụlọ immunoglobulins obere yiri ka ime ka allergies.