Ọgwụ "Ofloxacin": ndidi testimonials. Ntuziaka maka ojiji nke ọgwụ nje "Ofloxacin"

Nkwadebe "Ofloxacin" Fim ọrịa nke ukwuu n'ime mma, na-anọchi anya antimicrobial gị n'ụlọnga si ìgwè nke fluoroquinolones iche iche sara mbara nke ọrụ. The ọgwụ na-emetụta ndị DNA gyrase - nje ibe akwụkwọ, na-enye supercoiling na Ya mere nkwụsi ike nke bacteria DNA (dị ka a n'ihi nke destabilization nke DNA Strand anwụ).

pharmacodynamics

Pụtara "Ofloxacin" - ọgwụ nje dị irè na-akwanyere microorganisms na-emepụta beta-lactamase, nakwa dị ka-eto ngwa ngwa gbara gharịị mycobacteria. Iji ọgwụ na-enwe mmetụta ọsọ ọsọ, ọtụtụ gram-adịghị mma bacteria, gụnyere microorganisms na na-eguzogide ọgwụ methicillin na ndị ọzọ ọgwụ nje. Streptococci, enterococci, na Mycobacterium ụkwara nta na-ji ejighị n'aka susceptibility ọgwụ "Ofloxacin". Nyocha nke dọkịta na-egosi na na ọgwụgwọ nke anaerobic efe efe mere site peptostreptokokki, peptokokki na ndị ọzọ na anaerobes, ọgwụ bụ mgbe adighi ike.

Pharmacokinetics

Mgbe e na agwọ ọrịa n'ime absorption zuru ezu (95 percent) na ngwa ngwa. Bioavailability - karịrị 96 percent. Mmekọrịta plasma-edozi - 25 percent. Mgbe otu awa abụọ mgbe onu ochichi nke kasị elu ịta imezu. Ọ bụ dose-dabere: otu eji nke abụọ na narị anọ ma ọ bụ narị isii milligrams nke ọgwụ ịta e karị 2,5, 5 ma ọ bụ 6.9 ug / ml.

Food oriri pụrụ imetụta absorption nke n'akụkụ a slowdown, ma ọ dịghị ịrịba mmetụta bioavailability. Nkwadebe "Ofloxacin" - ọgwụ nje na-enwe a bukwanu olu nke nkesa (otu narị lita), nke mere na ndinọ nkwadebe bụ fọrọ nke nta ego ole penetrates kpamkpam n'ime mkpụrụ ndụ. The kasị elu kasịnụ bụ na anụ ahụ, mmiri ahụ na akụkụ: na sel (alveolar macrophages, leukocytes), adụ anụ ahụ, anụ ahụ, ọkpụkpụ, akụkụ okuku ume na usoro, pelvic na abdominal uji eze, asu, prostatic secretions, mmamịrị, bile. The agwọ ọrịa ọma penetrates na placental na ọbara-ụbụrụ mgbochi, na-secreted si mmiri ara, na cerebrospinal ọmụmụ abatakwa na ndị na-abụghị nanị ire ọkụ na ire ọkụ ka ụbụrụ membranes (14 na 60 percent).

Banyere 5 percent nke ọgwụ na-metabolized na imeju na-etolite dimetilofloksatsina na N-oxide nke ofloxacin. N'agbanyeghị nke dose ọkara ndụ bụ n'etiti anọ na ọkara ka awa asaa. Mmepụta agbanweghi agbanwe ọgwụ ke ichekwa 75-90 percent nke akụrụ, ke ichekwa 4 percent - na bile. Erughị pasent 20 nke extrarenal nwechapụ. Mgbe a otu dose of abụọ na narị abụọ milligrams nke gị n'ụlọnga bụ detectable na mmamịrị maka 20-24 awa. N'ihe banyere hepatic ma ọ bụ gbasara akụrụ excretion nwere ike slowed. Mgbe dialysis wepụrụ site 10 ruo pasent 30 nke ndị ọgwụ.

egosi maka

Na-efe efe na mkpali oria mere site dị iche iche microorganisms, gosiri etinyere agwọ ọrịa "Ofloxacin". Nyocha kọrọ na ọ bụ ihe dị mma maka akụkụ okuku ume na tract-efe efe (oyi baa, bronchitis), elu akụkụ okuku ume na tract (otitis media, Sinusitis, laryngitis, pharyngitis). Kenye ọgwụ na adụ anụ ahụ ọnya, nkwonkwo, ọkpụkpụ, akpụkpọ, biliary tract, urinary tract (urethritis, cystitis), akụrụ (pyelonephritis), abdominal uji eze, genitalia (orchitis, colpitis, epididymitis), pelvic akụkụ (salpingitis, prostatitis, cervicitis, endometritis, oophoritis, kwa).

Ọzọkwa irè ọgwụ maka ureaplasmosis, chlamydia, gonorrhea. Jiri ya maka mgbochi nke na-efe efe na ọrịa na-anaghị ekwe nke dịghịzi ọnọdụ (gụnyere neutropenia).

The onunu ogwu ụdị. Ọdịdị

Ntọhapụ nke agwọ ọrịa bụ n'ụdị ntekwasa acha ọcha ma ọ fọrọ nke nta na-acha ọcha film-ntekwasa mbadamba biconvex gburugburu udi. The cross sectional kwesiri ngosi abụọ n'ígwé, otu onye nke nwere a acha tint. Active akụrụngwa-eme dị ka ofloxacin. Otu mbadamba ẹdude ke uka nke 200 ma ọ bụ 400 mg. Minor Efrata bụ primelloza (croscarmellose sodium), microcrystalline cellulose, Aerosil (colloidal sịlịkọn dioxide), silica Titania, povidone, hydroxypropyl methylcellulose (hypromellose), talc, magnesium stearate, polyethylene glycol 4000 (macrogol). A uru dị ukwuu nke ọgwụ "Ofloxacin" - price. Mbadamba nwere 200 mg nke nọ n'ọrụ umi bụ nkezi nke 16-20 rubles kwa 10 mbak, na ndị na-ebu 400 milligrams ofloxacin, ga-eri ihe 50-55 rubles kwa 10 mbak.

"Ofloxacin" na nkà mmụta ọgwụ. Ntuziaka maka ojiji

Mbadamba ga-aṅụ tupu ma ọ bụ mgbe a nri. Ha ga-elo dum, na-enweghị ịta, na-aṅụ mmiri obere obere. The onunu ogwu ga-họọrọ n'otu n'otu dabere na ogo nke ọrịa, orunótu nke ọrịa, onye ọrịa ahụ n'ozuzu ọnọdụ, akụrụ ọrụ, imeju, na bacteria uche.

Dị ka a na-achị, na ọgwụgwọ nke na "ofloxacin" ka n'ihi asaa ụbọchị iri. Adult kwa ụbọchị kenyere oriri nke abụọ na narị abụọ, narị isii milligrams ugboro abụọ n'ụbọchị. The dose nwere ike ụba asatọ milligrams na ikpe nke a dị oké njọ ọrịa, ma ọ bụ ma ọ bụrụ na onye ọrịa bụ ibu. A dose nke anọ milligrams nwere ike iwere otu mgbe, ọkacha mma nke ụtụtụ.

Ọrịa na mkpọchị gbasara akụrụ ọrụ ozugbo ike-ewe ihe karịrị narị mmadụ abụọ milligrams nke ọgwụ, na kacha dose kwa ụbọchị na hepatic impairment - na narị anọ milligrams. Mgbe ofufe nke mgbaàmà na normalisation nke okpomọkụ, ọbụna n'ihi na abụọ ma ọ bụ atọ ụbọchị kwesịrị ịnọgide na-ọgwụ.

Mmetụta. nleba

Ọ bụghị ihe niile ndị ọrịa ọgwụ "Ofloxacin" ọma anabata. Nyocha nke ụfọdụ ndị nwere ozi ndị na ọgwụ na-akpata isi ọwụwa, ọgbụgbọ, vomiting, afọ ọsịsa, mara jijiji, nkụnwụ nke nsọtụ. Na akụkụ nke digestive usoro nwere ike ịzụlite ka abdominal mgbu, gastralgia, bloating, cholestatic jaundice, anorexia, hyperbilirubinemia, pseudomembranous enterocolitis, na ụjọ usoro - enweghị ije, cramps, ufiop nrọ, psychotic Jeremaya mere, n'ahụhụ, nchegbu, mgbagwoju anya, atụ, ịmụ anya arọ nrọ, ịda mbà n'obi.

Ke adianade do, e nwere ihe ize ndụ nke imebi nke moto usoro (arthralgia, tendonitis, myalgias), nwee uche ziri ezi (uto ọrịa, agba ọhụụ, ntị, itule, isi), vaskụla usoro na obi (Mbelata ke ọbara mgbali, tachycardia), ikpa (dermatitis, ebe hemorrhage, papular ọkụ ọkụ), nke hematopoiesis (thrombocytopenia, anaemia, leukopenia). Mgbe anata "Ofloxacin" ọgwụ (reviews gosi na nke a), mgbe ụfọdụ ọ na-egosi itchy anụ ahụ, bronchospasm, urticaria.

contraindications

Ịnata agwọ ọrịa nso ekweghị ibe nọrọ ofloxacin na ndị ọzọ na fluoroquinolone nkwekọrịta, na ikpe nke na ụkọ glucose-6-phosphate dehydrogenase, àkwụkwụ, ọnya nke akwara, na-ebelata ọdịdọ mbata. Ke adianade do, ị nwere ike ghara iri ọgwụ "Ofloxacin" ime na lactating ụmụ nwanyị, ụmụaka na-erubeghị afọ iri na asatọ. Na nlezianya kwadebe na-kenyere ọbara ọrịa na ụbụrụ, ọrịa ụbụrụ vaskụla atherosclerosis, gbasara akụrụ odida na-adịghị ala ala CNS ọnya organic okike.

Agwọ ọrịa "Ofloxacin" na a ureaplasma. Nyocha

Ndị isi ihe bụ na ndị mmadụ na-ekwu, na-eji a ngwaahịa - na ọ bụ ya ngwa ngwa mmetụta. Ọrịa na-akọ na n'ihi bụ kwesiri ngosi ugbua na nke atọ ma ọ bụ anọ n'ụbọchị. Ma, ọ dị mkpa iji dọọ aka ná ntị na nke a apụtaghị na mmalite nke na-agwọ. Ndị ọrịa na-anaghị aṅụ mbadamba, na-enweghị na-aga site zuru N'ezie, mgbe ahụ, ọzọ nwetara ureaplasmosis mgbaàmà, n'ihi na bacteria na e kpamkpam tutu amama.

adọ aka ná ntị

Mgbe oyi baa iwe na pneumococcus, ọgwụ adighi ike. Ọzọkwa, ọ na-adịghị gosiri maka ọgwụgwọ nke nnukwu tonsillitis. Ọ dị mkpa ka a kwụsị iji ọgwụ ma ọ bụrụ na na ndabere nke ya mbanye na-enwe adịghị anabata, ndị CNS aghara, pseudomembranous afọ. Women n'itinye pụtara "Ofloxacin", ọ na-adịghị atụ aro iji tampons, n'ihi na nke a, e nwere ihe ize ndụ dị elu nke na-emepe emepe thrush.