Ọgwụ "Baraklyud": ntuziaka maka ojiji, nkọwa, mejupụtara na reviews

"Baraklyud" na-ezo aka mgbochi retroviral ọgwụ ọjọọ, akụkụ nke ìgwè nke abụọ n'ime analogues. Kenyere maka ọgwụgwọ nke ala ala HBV-ọrịa. The n'ọrụ mgwa nke ọgwụ entecavir ngwa ngwa suppresses malitere ịrịa replication nke ịba ọcha n'anya.

Ọ ga-abụrụ-amụ annotation tupu ewere ọgwụ. Dị ka e gosiri site ntuziaka maka ojiji? "Baraklyud" (Baraclud) - a ọgwụ nke na-aduak na-amalite backflow nke fibrotic Filiks ke ọrịa na imeju imeju.

ọgwụ

The ọgwụ dị na abụọ onunu ogwu nhọrọ - 0,5 na 1 mg entecavir ifịk akụrụngwa anya dị iche iche na e ji esiji ákwà na agba (na-acha ọcha ma ọ bụ pink, karị).

The nkwadebe na-agụnye:

• polysorbate;
• magnesium stearate;
• lactose monohydrate;
• Valium;
• povidone;
• colorant Opadry.

pharmacological mmetụta

The n'ọrụ mgwa ihe bụ entecavir nke bụ ihe analogue nke abụọ n'ime guanosine, kwuworo nhọrọ ọrụ ịba ọcha n'anya B.

Entecavir na-phosphorylated na-arụsi ọrụ triphosphate na a ọkara ndụ nke banyere 15 awa, intracellular ọdịnaya nke nke na-metụtara ịta nke entecavir n'èzí mkpụrụ ndụ. Mgbe a na-adịghị hụrụ appreciable ìgwè nke nọ n'ọrụ umi ke idem. Medicine "Baraklyud" ntuziaka maka ojiji nke na-egosi na ya elu arụmọrụ, suppresses ọrụ nke malitere ịrịa polymerase, impacting n'out oge na ihe atọ:

• njikọ nke ziri Strand nke DNA HBV;
• laa azu transcription nke na-adịghị mma na eri pregenomic mRNA;
• HBV priming enzyme.

Triphosphate bụghị a ike retarders enzyme cellular DNA, ọbụna na a ọkpụrụkpụ ọdịnaya nke dịghị mmetụta mitochondrial DNA njikọ.

mmetụta nke ọgwụ

N'ọrụ ọgwụ umi bụ ike nke na a obere oge na-etinye obi gị dum na digestive usoro na esịmde karịa nke ọdịnaya na 30-90 nkeji mgbe na-ewere mbadamba.

Commensurate abawanye na Cmax na AUC indices emee ụdi ojiji nke 0.1-1 mg nke agwọ ọrịa "Baraklyud". Ntuziaka maka ojiji na-ekwu banyere ọbọ a itule na 6-10-nke ụbọchị nke a otu dose nke ọgwụ kwa ụbọchị. Jiri nke ọdụdụ oriri budata sikwuoro entecavir absorption usoro, subtracting codes Cmax na AUC site 45% na 20% karị.

The ọgwụ na-ngwa ngwa etinye obi gị dum na anụ ahụ na site na 13% ibikwa na plasma-edozi. N'ọrụ ọgwụ akụrụngwa bụghị ọdabara substrates, enzyme inhibitors ma ọ bụ inducers nke P450 usoro. Ọ bụ ike imubanye na ahu na mmepụta site gbasara akụrụ usoro site glomerular filtration na tubular agbapụta n'ahụ.

egosi

Agwọ ọrịa "Baraklyud" na-atụ aro iji na-mgbagwoju ọgwụgwọ nke ịba ọcha n'anya B:

• Na ugbu a mgbaàmà nke malitere ịrịa replication na-abawanye nke na ogo nke ọrụ nke transaminases na ọbara, na ọnụnọ nke histological ngosipụta nke na-aga n'ihu mbufụt nke imeju.
• Unrecovered imeju ọnya.

Ịrịba Ama enyemaka nke ọrịa imeju mgbaàmà ime mgbe ọgwụ nlekọta "Baraklyud". Mbadamba ntụziaka ntuziaka na-atụ aro na ọrịa na-adịghị ala ala ịba ọcha n'anya B, ọrịa imeju mgbagwoju anya site na-esonụ:

• dị decompensated;
• enweghị nchịkwa imeju ọnọdụ na a ụgwọ nzọụkwụ mgbe arụnyere malitere ịrịa replication chọpụtara ngosipụta nke imeju fibrosis na ụba AST na Alt.

contraindications

Ọgwụ "Baraklyud" nwere ndị na-esonụ contraindications:

• ụba susceptibility ka entecavir na ndị ọzọ na bekee gụnyere ọgwụ mejupụtara;
• butere n'aka lactose ekweghị ibe nọrọ, glucose-galactose malabsorption, erughi ma ọ bụ na-anọghị na ahu nke enzyme lactase ;
• afọ obere karịrị afọ 18.

Ndị na-akụrụ odida mkpa iji ọgwụ na ọgwụ na mgbe nile nlekọta nke ndị ọrụ.

N'ikuku "Baraklyuda" n'oge ime adịghị atụ aro n'oge ọgwụ mkpa iji kwụsị ya ara.

mmetụta

E nwere ike ịbụ a dịgasị iche iche nke ọrịa nke digestive usoro n'oge ọgwụ ọgwụgwọ "Baraklyud". Ntuziaka maka ojiji na-n'ụzọ doro anya kọwaa mmetụta:

• digestive ọrịa;
• afọ ọsịsa;
• ọgbụgbọ na vomiting;
• dyspepsia.

Ị nwekwara ike na-enweta isi ọwụwa, ehighị ụra nke ọma ma ọ bụ iro ụra, ọnwụ nke agụụ, na nfụkasị Jeremaya.

Ime ọgwụ ka a ọbụ ọgwụgwọ gị n'ụlọnga ma ọ bụ na Nchikota na ndị ọzọ ọgwụ nwere ike ime ka oké hepatomegaly na steatosis, nke pụrụ iduga ọrịa ahụ nwụrụ.

Na ọrịa na decompensated echiche laktatsiadoz ọnya nwere ike ime imeju, nke e ji:

• general muscle adịghị ike;
• ngwa iku ume na ọdịdị iku ume ọkụ ọkụ;
• ọgbụgbọ;
• ịrịba Mbelata arọ ahụ;
• mgbu na peritoneum, epigastric.

Ọzọkwa, ọgwụ nwere ike ime ka dị iche iche Jeremaya mere na aru:

• nhapụ hepatic transaminases;
• akpụkpọ ọkụ ọkụ;
• anaphylactoid mmeghachi omume.

The ọrịa atakwa ahụhụ decompensated ọrịa imeju, ke adianade do, ndị dị otú ahụ Jeremaya mere bụ egosiwokwa organism:

• gbasara akụrụ odida (na obere okwu);
• ụba bilirubin ọdịnaya ọbara;
• . Ẹsụhọde nke platelet gụọ na 50 puku / mm ³ ma ọ bụ obere;
• Mbelata bicarbonate na ọbara;
• abawanye nke Alt;
• karịa atọ-n'ogige atụrụ na-abawanye na ọrụ nke lipase;
• belata etoju nke albumin.

Agwọ ọrịa "Baraklyud": Ọnụọgụ ọgwụ na ochichi

The ọgwụ kwesịrị iwere na ihe efu afo, oge si nri ikpeazụ tupu dosing kwesịrị ịbụ ihe karịrị awa abụọ.

Mgbe ahụ ụgwọ atụrụ imeju mmebi na-atụ aro n'ikuku "Baraklyuda" 0,5 mg kwa ụbọchị. Na-akọwapụta iguzogide lamivudine onunu ogwu ga-okpukpu abụọ.

Ọrịa na imeju ọnya unrepaired kenyere kwa ụbọchị oriri nke 1 mg. N'ihi na ndị agadi na ndị ọrịa na gbasara akụrụ insufficiency, ndị dose kwesịrị ịgbanwe dabere n'ogo nke CK (creatinine ịta) na ọbara.

ovadozu

Ozi na ikpe nke ọgwụ ovadozu ezughị.

Volunteers, nke e clinically nwalere, natara a kwa ụbọchị onunu ogwu nke 20 mg izu abụọ e nyere ha otu elu dose - 40 mg ọgwụ "Baraklyud". Ntuziaka maka Iji na-ekwu na mmetụta ọjọọ na-ahụrụ.

Na-atụ aro posindromnoe ọgwụgwọ n'okpuru nlekọta nke na-adakarị n'obiọma.

Mmekọrịta ndị ọzọ ọgwụ ọjọọ eme ihe

N'ihi na eziokwu na-arụsi ọrụ ike akụrụngwa entecavir ọ na-anyụpụ isi site na gbasara akụrụ usoro, mgbagwoju ọgwụ na Nchikota na ndị ọzọ ọgwụ ọjọọ eme ihe na-enye kpọmkwem ma ọ bụ anọ na mmetụta na-akụrụ ọrụ na-emetụta tubular secretion, nwere ike ịkpata ihe abawanye na aru nke entecavir na-arụ ọrụ bekee nke ọgwụ ọjọọ.

Mmekọrịta "Baraklyuda" na adenovirom, tenofovir, lamivudine e dere.

precautionary jikoro

Ịnakwere ọgwụ ọrịa eguzogide lamivudine eduga ihe ize ndụ nke na-emepe emepe na-eguzogide.

Ọzọkwa, e nwere ihe àmà nke omume nke exacerbations nke ịba ọcha n'anya B mgbe discontinuation nke ọgwụ "Baraklyud". Ntuziaka maka ojiji na-akọwa enyemaka nke exacerbations enweghị ọzọ ọgwụ.

adọ aka ná ntị

N'ikuku "Baraklyuda" ke kpuchie nke monotherapy na jikọtara ọgwụgwọ na ndị ọzọ alụso nje virus ọgụ mmadụ, nwere ike ime ka lactic acidosis, hepatomegaly na steatosis. Na nke a, e nwere ihe ize ndụ nke ọnwụ.

Na n'ihe ize ndụ ọrịa na-agụnye ndị na-esonụ na ige:

• na-ata ahụhụ site na hepatomegaly;
• na-emeso na ojiji nke abụọ n'ime analogues;
• enwe ibu;
• nwanyi ọrịa.

Ntuziaka maka ojiji nke ọgwụ ọjọọ, "Baraklyud" ka akwụkwọ ekwe omume nke guzobere eguzogide malitere ịrịa pụta. Active mgwa entecavir ọgwụ na-adịghị akwadoro maka ọgwụgwọ nke ụmụ mmadụ immunodeficiency virus n'ihi na nke arụmọrụ nke a na-adịghị ma na-amụ na zuru.

Na ọgwụgwọ nke ọrịa na daa ọrịa nke gbasara akụrụ usoro, dị mkpa iji dozie dose.

The nchekwa na irè nke eji "Baraklyuda" maka ọgwụgwọ nke ọrịa mgbe imeju transplantation na-amaghị na-achọ pụrụ iche na-elekọta nnabata jikoro.

Nchekwa na ọnọdụ na-eri

Nchekwa na njem nke pellets ga-rụrụ na okpomọkụ nso 15-25 Celsius C. The nkwadebe bụ ihe kwesịrị ekwesị maka ojiji afọ abụọ si ụbọchị nke rụpụta.

The ọgwụ a gụnyere na a iche iche otu nke dị oké mkpa ọgwụ, na n'ihi na ụfọdụ na edemede nke ụmụ amaala ka free nnyefe nke ọgwụ "Baraklyud". Ntuziaka maka ojiji were eziokwu a.

Price n'aka na Moscow pharmacies amalite site 12 puku. Rubles.

Echiche nke ọrịa

Ọ na-egosi na elu nrụpụta nke ọgwụ "Baraklyud" ntụziaka ntuziaka. Price, reviews nke nke gosiri na ọ bụ onye kwuo uche ya tụnyere analogues nke ọgwụ, dịgasị n'etiti 12-17 puku kwa ngwugwu, na nke 30 pellets. Nke a na-eme ka ọgwụ a na-ewu ewu na na ina n'etiti ọrịa maka ọgwụgwọ nke ịba ọcha n'anya B.

Na-adịghị mma nzaghachi tumadi zoro proitvopokazaniya ma mmetụta nke ọgwụ, ndị dị ka ehighị ụra nke ọma, na agbọ onunu.