Ọgwụ "Lovastatin": ntuziaka maka ojiji, analogs, nkọwa, mejupụtara na reviews

The nsogbu na-elu cholesterol nsogbu ọtụtụ ndị na ọbara. Nke a bụ n'ihi na eziokwu na nke a ọnọdụ pụrụ ime ka a malfunction obi na vaskụla usoro dị ka a dum. Iwepụ hyperlipoproteinemia dị mkpa ọ bụghị nanị na-eri eri, ma na-aṅụ ọgwụ ụfọdụ.

Ndị kasị dị irè iji belata cholesterol n'ime ọbara na-atụle ga a ọgwụ ọjọọ, "Lovastatin". Ntuziaka maka ojiji, price, reviews, analogs na contraindications nke ọgwụ na-ọkọnọ n'okpuru. Ị ga-amụtakwa na ọkachamara na-ekwu banyere ya na ihe ndị reviews ekpe site na-eji ọkụ.

Ụdị, mejupụtara, nkwakọ ngwaahịa na nkọwa nke ọgwụ

The agwọ ọrịa "Lovastatin" ntụziaka ntuziaka nke na-juru n'ọnụ na a kaadiboodu igbe, a na-eresị ke ụdị ọcha, gburugburu mbadamba. The n'ọrụ mgwa nke ọgwụ lovastatin eme ihe. Banyere inyeaka constituent, mgbe ahụ, ha na-agụnye lactose monohydrate, starch, cellulose, ascorbic acid, butylated hydroxyanisole, citric acid na magnesium stearate.

Dị agwọ ọrịa nke cellular blisters na Ukwu nke katọn karị.

The usoro nke edinam nke ọgwụ

Gịnị bụ ụkpụrụ nke ihe na ọgwụ ọjọọ, "Lovastatin"? Ntuziaka maka ojiji, nkịtị kọrọ na imeju-pl anabata mezie ọbara lipoproteins. Ha na-mmepụta-ya nime ya site na mmekọrịta ya na kwuru anabata. N'ihi ya, na imeju na mkpụrụ ndụ synthesized cholesterol.

The ọrụ ụkpụrụ nke ọgwụ n'okpuru echiche n'ihi na suppression nke 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Nke a enzyme, na enyem-aka nke njikọ nke cholesterol.

Mbenata guzobere cholesterol na-agụnye a compensatory mmụba nke ọnụ ọgụgụ nke LP-anabata hepatocytes. Dị ka a n'ihi nke ndị dị otú ahụ n'ebe accelerates usoro nke wepụ n'ebe ọbara ala njupụta lipoprotein, nakwa dị ka belata ngụkọta cholesterol, pl na cholesterol belata n'etiti njupụta.

Atụmatụ nke ọgwụ

Olee ihe ndị ọzọ Njirimara bụ "Lovastatin" mbadamba? Ntuziaka maka ojiji (price reviews na-n'ihu na njedebe nke isiokwu) na-egosi na gị n'ụlọnga bụ ike nke na-ebelata ihe ndị ọdịnaya nke apolipoprotein B, na triglycerides, nakwa dị ka budata dịkwuo larịị nke elu njupụta lipoproteins.

The ọgwụgwọ mmetụta mgbe ochichi nke ọgwụ na-egosipụta na izu abụọ, na kacha - na ihe a ọnwa na ọkara. Otú ọ dị, ọ nọgidere na maka izu isii mgbe discontinuation nke ọgwụ.

Nrụpụta na ogologo oge na-adịghị belata. Ọ ga na-ahụ kwuru na ọ na-emepụta si biocultures Aspergillus terreus na Monascus ruber.

kinetic Njirimara

ọgwụ ọjọọ, "Lovastatin" Olee otú ogologo na-etinye obi gị dum? Ntuziaka maka ojiji (na price nke ọgwụ adịghị nnọọ elu) rụrụ ụka na absorption nke ọgwụ si eriri afọ tract bụ ngwa ngwa. Ọzọkwa, ọ na-ebelata mkpụrụ ọgwụ na ihe efu afo.

The bioavailability nke gị n'ụlọnga dị ala (banyere 30% nke dose). Mgbe ihe awa anọ ya a na-enweta ndị kasị elu ịta ke iyịp. Mgbe a n'ihu ụbọchị, ọ na-ebelata ihe 10% nke kacha.

Weere a ọgwụ bụ 95% ibikwa na plasma-edozi. Nwechapụ nke ọgwụ na otu dose hụrụ maka 3 awa.

Gịnị bụ ọgwụ "Lovastatin"? Ntuziaka maka ojiji na-akọ na a prodrug. Mgbe mbụ Itie site imeju, ọ na-aghọ n'ọrụ n'ụdị.

Drug metabolized site isoenzymes. Ya ọkara ndụ bụ 180 nkeji. Ọgwụ eme mmewere na ya metabolites na-anyụpụ site akụrụ na eriri afọ.

Egosi maka lozenges

Na ọnụnọ nke ọ bụla ọnọdụ onye ọrịa nye iwu "Lovastatin" mbadamba? Ntuziaka maka ojiji (nkọwa nke ọgwụ na-adade ná mmalite nke isiokwu) na-akọ na ngwá ọrụ a dị irè na-isi hypercholesterolemia (hypolipoproteinaemias IIb na IIa ụdị) na elu ọdịnaya nke LDL (ma ọ bụrụ na dietary ọgwụ na ndị mmadụ na ihe ize ndụ nke ịrịa atherosclerosis bụ adighi ike) na mgbe jikọtara hypertriglyceridemia na hypercholesterolemia.

Anyị ga na-ekwukwa na na-ewere ọgwụ na-kenyere na atherosclerosis.

Contraindications na-enweta ndị prodrug

Mgbe ụfọdụ, ọrịa na-adịghị ike ikwu iji "Lovastatin" mbadamba? Ntuziaka maka ojiji (ọgwụgwọ na a ọgwụ ga-ndinọ site a dọkịta) na-akọ na gị n'ụlọnga na-contraindicated na-arụsi ọrụ ike imeju ọrịa na afọ ime ma ọ bụ puru, amụba transaminase ọrụ nke na-amaghị si, nakwa dị ka n'oge ara, na oké ọrịa na-arịa (general), na elu uche na lovastatinu.

Ọzọkwa anya ọgwụ na-adịghị kenyere a obere, ma ọ bụrụ na myopathy na cholestasis.

Na-ewere ọgwụ na-aju na Nchikota na-aba n'anya. Special nlekọta na-kenyere ka ọrịa mgbe akwara akwara wasịrị.

Drug "Lovastatin": ntuziaka maka ojiji

Price, analogues nke ngwá ọrụ a ga-atụle a obere n'ihu.

Dị ka ntụziaka, mbadamba nkume "Lovastatin" kwesịrị iwere n'ime n'oge nri abalị otu ugboro n'ụbọchị.

Na nke a na-enweghị nchịkwa na ọnọdụ bụ hyperlipidemia, a ọgwụ na-ndinọ ke ichekwa 10-80 mg ugboro (na dose adabere ruo n'ókè nke ọrịa ogo).

Ọgwụgwọ-ewere ọgwụ mmalite na obere doses. Mgbe ahụ nke nta nke nta ụba. The kasị elu kwa ụbọchị onunu ogwu nke ọgwụ nke 80 mg, nwere ike ndinọ otu ma ọ bụ ugboro abụọ n'ụbọchị (ụtụtụ na alakpu ụra). Nhọrọ nke ọgwụgwọ doses a rụrụ na otu nkeji nke otu ọnwa.

Dị ka ke akwara atherosclerosis prescribers "Lovastatin"? Ntuziaka maka ojiji na-akọ na ndị dị otú ahụ ọrịa agwọ ọrịa na-ndinọ na a dose nke 20-40 mg. Ọ bụrụ na ndị kpọmkwem ego nke agwọ ọrịa gosiri na ya adighi ike, mgbe ahụ, ọ na ụba na 60-80 mg.

Mgbe jikọtara a fibrate ma ọ bụ ọgwụ niacin ya onunu ogwu ekwesịghị ịbụ elu karịa 20 mg kwa ụbọchị.

oghom ihe

Ò mmetụta nke ọgwụ, "Lovastatin"? Ntuziaka maka ojiji na-ekwu, ndị na-esonụ oghom ihe:

• cataracts, isi ọwụwa;
• optic atrophy, dizziness;
• ehighi ura, nsogbu ihi ụra, nchegbu, adịghị ike, paresthesias;
• muscle cramps, myalgia, myositis
• na ndị na-ewere niacin, "Tacrolimus" ma ọ bụ "Gemfibrozil" n'ihe ize ndụ nke rhabdomyolysis;
• thrombocytopenia, hemolytic anaemia;
• nrekasi obi, biliary cholestasis, ọgbụgbọ, ịba ọcha n'anya, flatulence, uto ezighị, afọ ntachi, cholestatic jaundice, afọ ọsịsa;
• ụba ọrụ nke CPK na imeju na transaminase;
• ntọt ke bilirubin na alkaline phosphatase ;
• Angioedema, ọkụ ọkụ, pruritus, arthralgia, urticaria;
• alopecia ma belata potency.

Ovadozu nke ọgwụ

onye ọrịa adịghị ime na random elu doses nke ọgwụ kpọmkwem ihe mgbaàmà.

Na chọpụtara nke enweghị nchịkwa ọnọdụ saa otụk afo na kenyere n'ikuku sorbents. Ọzọkwa, ọrịa wara nlekota nke dị mkpa ọrụ nke na imeju na-ọrụ nke creatine kinez.

ọgwụ interactions

The imekotaotuugbo ojiji nke nnukwu quantities nke mmiri grape, nakwa dị ka "gemfibrozil" na "fenofibrate" na-eme ka nke ịrịa myopathy.

Ịnata ọgwụ na nicotinic acid "clarithromycin", "erythromycins", "Cyclosporins", antifungal ọgwụ ọjọọ ( "Itraconazole" "ketoconazole"), "nefazodone" na "Ritonavir" na-eduga onye na-abawanye na ọgwụ ịta na ọbara, nakwa dị ka mbibi nke muscle anụ ahụ na ihe ize ndụ nke myopathy.

Co-nlekọta "Lovastatine" na "warfarin" enwekwu ihe ize ndụ nke ọbara ọgbụgba.

Drug "Cholestyramine" ebelata bioavailability nke n'ụlọnga. Ya mere, nkeji oge n'etiti ha oriri kwesịrị dịkarịa ala 2-4 awa.

kpọmkwem na-atụ aro

Ihe ókè ịkpachara anya ọgwụ "Lovastatin" kenyere ndị na a akụkọ ihe mere eme nke ọrịa imeju. The otu na-emetụta ala ala aṅụrụma.

Ọ kwesịkwara kwuru na akpagbu pụtara na ikpe nke a persistent abawanye na imeju transaminases ọdịnaya ma ọ bụ CPK.

The na-eri nke ọgwụ ọjọọ na ya analogues

Ugbu a, ndị zuo echiche na nkà mmụta ọgwụ na drugstores nke Moscow na ndị ọzọ na Russian obodo bụ ekwe omume. Ọ bụrụ na ọ dị mkpa, o nwere ike iwu site na World Wide Web. Ahịa na online pharmacies ịdị iche iche nke ukwuu. A ọgwụ dị na nso nke 300-600 rubles.

Ọ bụrụ na ọ dị mkpa, tụlee pụtara na ị nwere ike dochie ndị dị otú ahụ ọgwụ ọjọọ eme ihe dị ka "Apekstatin", "Fluvastatin," "Cardiostatin", "Iinvastin", "Vero Lovastatin," "Pravastatin", "Holetar", "Lovasterol", "Mevacor" "Mevinakor", "Lovakor".

ọgwụ Nyocha

Ugbu a na ị maara ihe bụ ndị na ọgwụ, dị ka "Lovastatin". Ntuziaka, mejupụtara, ojiji, ọgwụ analogs na e kọwara n'isiokwu a.

Dị ka ọkachamara, lipid-ẹsụhọde ọgwụ ọjọọ eme ihe na ọgwụgwọ, nakwa dị ka ihe mgbochi nke atherosclerosis na ya nsogbu.

The na-arụ ọrụ ụkpụrụ nke a ọgwụ bụ ibelata nke atherogenic lipoproteins n'ime ọbara

Dị ka akụkọ nke dọkịta, ugbu a, m na-akwakọba nnọọ ọtụtụ nke ahụmahụ nke na-adakarị iji "Lovastatine". Ọ bụ otu n'ime ndị kasị dịrị nchebe ọgwụ. A ọgwụ nwere dịtụ mma-anabata ogologo oge ọgwụ.

Na a nyochaa nke ọrịa nnọọ obere mkpesa nke mmetụta. Mgbe ụfọdụ, a na nkà mmụta ọgwụ nwere ike ime ka flatulence, afọ ọsịsa, abdominal mgbu, afọ ntachi, ehighị ụra nke ọma na ike ahu mgbu. A, ndị dị otú ahụ Jeremaya mere akwụsị na izu abụọ mgbe mmalite nke ọgwụ ma ọ bụ n'ihi nke mbenata dose.