"Pradaksa" - analogues. "Warfarin", "Ksarelto": reviews, ahịa

N'etiti antithrombotic mmadụ iji wepụ a thromboembolism na veins mgbe ịwa ahụ, ndị kasị oru oma na-egosi njikere "Pradaksa". Ya analogues nwere nabatara umu-egosi maka ojiji na na Ọdịdị nwere dị iche iche n'ọrụ Efrata. Anticoagulants dị siri ike onunu ogwu ụdị dị iche iche na Dosages.

Description "Pradaksa" ọgwụ

Emeputa antithrombotic na anticoagulant ọgwụ "Pradaksa" bụ ụlọ ọrụ "Boehringer Ingelheim Pharma GmbH & Co. KG. KG ". Dị n'aka na ike capsules, nke dị n'ime obere odo pellets. N'ọrụ umi dabigatran etexilate atụle-adịghị ejekwa ozi ụdị, ọnụ ọgụgụ nke ndị nke na-ekpebi na onunu ogwu nke ọgwụ. O nwere ike ịbụ 75 mg, 110 mg na 150 mg.

Gịnị ọgwụ "Pradaksa" a na-eji

Isi nzube nke capsules jikọọ na mgbochi nke venous thromboembolism mgbe ịwa ahụ ngalaba na nweekwa usoro.

Olee ngwá ọrụ "Pradaksa"

Ọ jikọtara ya na suppression nke thrombin ọrụ usoro nke ihe nke ọgwụ ọjọọ "Pradaksa". Analogs igosipụta ubé dị iche iche Njirimara. N'ịbụ a obere molekul, dabigatran etexilate nwere dịghị pharmacological edinam.

Naanị banyere ahụ mmadụ, umi na-kewaa mgbe hydrolysis na free dabigatran-arụsi ọrụ ike reversible kpọmkwem asọmpi inhibitor nke thrombin enzyme. The ọrụ nke thrombin na-ekechikwa ka fibrin, thrombin, mbenata cell aggregation nke platelet mere site thrombin ọrụ.

a ngwaọrụ

Nwere ọgwụ ọjọọ, "Pradaksa" ogbo. Ma na ya mejupụtara, ha adịghị nwere dabigatran etexilate, ọ na-anọchi na ndị ọzọ anticoagulant mmadụ. N'ihi ya, n'ọrụ mgwa yiri pụtara "Warfarin" bụ warfarin, na agwọ ọrịa "Ksarelto" nwere rivaroxaban. Synonyms nkwadebe "Pradaksa" bụ "Marcumar" na "Fenilin" na-agụnye phenprocoumon na phenindione karị.

Description "Warfarin" ọgwụ

Anyị na-ama depụtara, nke nwere ọgwụ "Pradaksa" ogbo. Ka anyị tụlee ugbu a na ihe nkowa otu n'ime ha.

The agwọ ọrịa "Warfarin" na-emepụta n'ụdị mbadamba na a onunu ogwu nke nọ n'ọrụ mgwa, 2,5 mg. The emeputa nke ọgwụ bụ Russian ụlọ ọrụ "Kanonfarma mmepụta."

E nwere ndị ọzọ onunu ogwu (1 mg, 2 mg, 3 mg na 5 mg) mba ọzọ dabeere ọgwụ warfarin. The udi, na agba na size nke mbadamba bụ dị iche iche na ma akụkụ nke etinyere dose na mg.

N'ihi na ihe ọgwụ na-eji

N'ikuku "Warfarin" bụ omume:

• thrombosis nke venous usoro ma ọ bụ pụrụ ịrịa;
• maka prophylactic ọgwụgwọ nke thrombosis na thromboembolism;
• na nnukwu venous thrombosis n'oge na embolism na akpa ume anụ ahụ;
• na postoperative thrombosis;
• nnukwu myocardial obi muscle;
• n'oge ịwa ahụ na thrombolytic ọgwụ nke thrombosis;
• na-akwụsị akwụsị ischemic ọgụ;
• maka ruo ogologo oge ọgwụgwọ nke ntighari venous thrombosis;
• n'oge a prosthetic valvụ n'ime obi.

Olee otú ndị gị n'ụlọnga

Specific ihe nke okwu "warfarin" belata ọbara clotting ihe inhibit mmepụta nke (X, IX, VII, II), vitamin K-dabere ọbara na-akpata coagulation. Hepatic Anticoagulant edozi C na S na-synthesized na a nta ruo n'ókè n'okpuru nduzi nke ọgwụ. All a na-ebelata guzobe egbochi mkpụkọ nke ọbara na iduga guzobe egbochi mkpụkọ nke ọbara.

Iji kpochapụ venous thrombosis dọkịta nye iwu ọgwụgwọ na anọ anticoagulants. Nke a adịghị re-ịzụlite thrombosis, nke nwere ike ime ka nsogbu.

Ngụkọta oge nke dose of warfarin n'ọtụtụ dịgasị iche iche INR

Oge akara aka "Warfarin" ọgwụ ọjọọ kwere mee mgbe ntụle zuru ezu, bụ nke na-egosipụta ihe niile contraindications. The analysis maka inwekwu omume na-ahọrọ chọrọ ego nke agwọ ọrịa "Warfarin". The dose kwa ụbọchị ekwesịghị gafere 5 mg nke isi nọ n'ọrụ umi. Na ezughi oke ọgwụgwọ mmetụta nke ọgwụgwọ rụrụ mgbazi. Ọ na-atụ aro idekọ natara dose, INR etoju na-akpata ịda maka analysis of ọgwụ.

N'okpuru INR (mba normalized ruru) gosiri ọkọlọtọ n'ihi ịchọpụta ọrụ nke clotting ọbara ọcha. ọbara clotting ihe ga-ekpebi uru nke egosi. Ọ dị mkpa inyocha na ịchọpụtakwa INR mgbe inweta "warfarin" machiri nke bụ inversely proportional ka ọbara clotting. N'ihi ya, na elu normalized ruru slows clotting na enwekwu hypocoagulation.

Mgbe dị iche iche na-ekwu, a ga-ekwu na ụfọdụ INR.

1. N'ihi na a mma organism, ya norm bụ banyere 1.0 (ma ọ bụ deviates ubé - si 0,85 ka 1,25).
2. Adịghị ala ala atrial fibrillation mgbe inweta "Warfarin" pellets ga-esonyere a normalized ruru nke 2.0 na 3.0 nkeji.
3. Mechanical valvụ prosthesis ji ihe INR nke 2.0 na 3.0, a n'ibu prosthetic mitral valvụ si 2.5 na 3.5.
4. Na ọgwụgwọ nke thromboembolism na akpa ume akwara na ụfọdụ obi ntụpọ mkpa a larịị index nke 2.0 na 3.0.
5. Iji gbochie thrombosis ke miri veins mgbe ịwa ahụ na maka ọgwụgwọ nke venous thrombosis, rube isi ụkpụrụ nke 2.0-3.0.

Ọgwụ "Warfarin" ga-rụrụ na-akpachara anya nlekota nke INR index na iwu siri ike ọgwụ na-elekọta, ga-enwe ike ịgbanwe na onunu ogwu. Stabilization normalized ruru na nhọrọ nke chọrọ ego nke agwọ ọrịa a rụrụ maka banyere otu izu, na mgbe ọ bụla 4 izu a bara uru na-enyocha.

Iji si na mmetụta nke ngwa nke "Warfarin" nke ọgwụ, otú e si lee karịa na-asa ala na ma Nchikota nri, mkpa ka ị mara. Mbadamba-aṅụ ugboro abụọ n'ụbọchị, ọ bụghị na ijikọta na oriri nke nri. Ha asa ala na mmiri na iwere n'otu oge. Ke adianade do, nnyefe nke nyochara na INR kwesịrị ke otu awa na na-adịgide adịgide laabu. Mgbe awụgharị doses dị mkpa na-ebu na-esote òkè nke n'ikuku oge.

Na udu-erughị 2.0 INR a na-ewere ọbara oké, ọgwụ bụ adighi ike, ya mere, ọ dị mkpa iji a elu onunu ogwu "warfarin".

Na usoro nke ihe karịrị 3.0 INR ọ na-atụle mmiri mmiri na ọbara, ọbara ọgbụgba nwere ike ime, ya mere ọ dị mkpa itinye dịkarịa ala elu onunu ogwu nke ọgwụ.

The price nke a na nkà mmụta ọgwụ "Warfarin"

Tụnyere ndị German ọgwụ "Pradaksa" ya Russian Ẹkot "Warfarin", ego nke nke si na 80 rubles kwa mkpọ, ọ bụ ọtụtụ ihe dị ọnụ ala karịa na ndị ọzọ inweta.

Description "Ksarelto" ọgwụ

Na agwọ ọrịa "Pradaksa" analogs nwere ike na anticoagulant Njirimara, nwere kpọmkwem mmetụta. ọgwụ ọjọọ, "Ksarelto" na-ezo aka ha. Ọ na-emepụta ya na ụdị gburugburu film ntekwasa mbadamba nkume ndị ahụ German ụlọ ọrụ "Flo Rida feat".

The mejupụtara nwere rivaroxaban na micronized ụdị. Mbadamba "Ksarelto" bụ ndị na-esonụ Dosages: 2,5 mg, 10 mg, 15 mg na 20 mg.

usoro nke ihe

Rivaroxaban kwuru na dị ka ukwuu nhọrọ kpọmkwem ihe na-akpata Xa inhibitors nwere elu bioavailability hụrụ mgbe onu ochichi.

The coagulation cascade a kpụrụ site ebighị nke na-akpata X, nke, n'ihi na esịtidem na mpụga coagulation ụzọ converted n'ime ihe na-akpata Xa. Nke a akụrụngwa na-agụnye guzobe nke prothrombinase compound si edinam nke prothrombin na-ghọrọ ka thrombin. Ndị a Filiks na-etolite a fibrin clot, na activates platelet. E nwere a "ịkụ" nke ruru ka a na-akpata Xa molekul na-synthesized ka otu puku mmadụ na nke ndị a na mkpụrụ ndụ ọbara.

Iji nhọrọ inhibitors na belata ọrụ activator emee kwụsị "thrombin mgbawa". Action rivaroxaban eduzi ịgbanwe ihe ndị a kpọmkwem ma ọ bụ ofụri ofụri nnyocha site estimating a ala nke coagulation usoro. Lekọtara Xa ọrụ dịgasị dabere inhibitor dose, nke na-eje ozi dị ka ọgwụ "Ksarelto" (15 mg nke mbadamba ma ọ bụ ndị ọzọ onunu ogwu ya).

Na-emeso ya na a ọgwụ

The ntuziaka na-akọwa na ojiji nke a agwọ ọrịa maka mgbochi nke ọnwụ mgbe ọrịa obi jikọtara myocardial obi muscle na nnukwu akwara syndrome. Medicine "Ksarelto" mma agwa ratings nwetara maka irè Nchikota ọgwụ na njikọ na aspirin ma ọ bụ aspirin na thienopyridine.

Olee na-dị iche iche doses nke ọgwụ

The ọgwụ na-zubere maka esịtidem were. Mbadamba niile doses iwere na nri.

Iji kpochapụ nnukwu akwara syndrome na-gwara otu mbadamba nkume nke 2,5 mg ugboro abụọ n'ụbọchị. Ọnụ na nkwadebe "Ksarelto" (ratings egosi ịdị irè nke iji ndị dị otú ahụ a Nchikota ya) nwere ike ndinọ acetylsalicylic acid na a kwa ụbọchị dose nke si 75 na 100 mg, na Nchikota aspirin na clopidogrel ke ichekwa 75 mg kwa ụbọchị. Nke a ọgwụ na-achọ mgbe nile na-nlekọta nke ndị ọrụ maka ememe nke itule, nke a na-dechapụ n'otu akụkụ nwere ike ime ka ischemic ma ọ bụ ọbara na-agba nsogbu. Na-ewere ọgwụ ọjọọ na ogologo na-ewe banyere otu afọ, na ụfọdụ ndị ọrịa ruo afọ abụọ.

The mbadamba na onunu ogwu nke 10 mg rivaroxaban ewe otu oge a ụbọchị. The mbụ ọṅụṅụ mgbe 6-9 awa nke ubi ịwa ahụ na irè hemostasis. Na oge nke ọgwụgwọ na-ekpebisi ike dị otú ahụ a buru ibu nke ọgwụ ọ bụla ndidi n'otu n'otu, na-adabere n'ihe ize ndụ nke venous thromboembolism, mgbagwoju na ụdị ahụ ahụ.

Mgbe okwu ọgwụ nlekọta "Ksarelto" hip nnọchi (10 mg mbadamba) dịruru ruo 5 izu, n'oge ikpere arthroplasty na e were ya 14 ụbọchị.

Ọ bụrụ na onye ọrịa echezọwo-aṅụ otu dose of rivaroxaban, ọ ga-ozugbo iwesa, na-esote ụbọchị na-anọgide na ọgwụgwọ, 1 mbadamba.

Higher Dosages nke 15 mg ma ọ bụ 20 mg-adịghị na-na ihe efu afo.

Iji gbochie nke ala nke a ọrịa strok na systemic embolism agwa ndị na-abụghị valvular atrial fibrillation eke atrial obi na iji otu mbadamba dose of 20 mg otu ugboro n'ụbọchị.

Na gbasara akụrụ odida, mgbe ọnụego creatinine mkpochapu ọkara ndụ-nke na-erughị 30 ml maka 1 nkeji, eji a dose of 15 mg 1 oge kwa ụbọchị.

Na oge nke ọgwụgwọ na-adabere na ọnụnọ nke iyi egwu nke MKpọnwụ na thromboembolism ala Ịhazi.

The kacha gānagide kwa onunu ogwu ekwesịghị ịbụ ihe karịrị 20 mg rivaroxaban.

Thrombosis, miri akwara na-emetụta, n'ihi na mgbochi nke nlọghachite nke ọrịa na thromboembolic emetụta akpa ume akwara, na-eji ihe mbụ dose nke 15 mg ugboro abụọ n'ụbọchị n'oge mbụ izu atọ. Ekemende-akpụ akpụ na mbadamba nkume nke 20 mg rivaroxaban otu ugboro n'ụbọchị maka a ogologo oge ọgwụgwọ na mgbochi nke re-thrombosis na ntighari akpa ume embolism.

Ọ bụghị mgbe niile kwere omume ọrịa ilo dum mbadamba, karịsịa a nnukwu size, mgbe ahụ, ọ na-ekwe ka-egweri na agwakọta dị ọcha mmiri ma ọ bụ a mmiri mmiri na nri tupu oriri. Ozugbo na-ewere ọgwụ na-enwe ndidi ga-eri.

Ọ dịkwa ike ịme na-echi ọnụ n'ala ọgwụ site gavage, ọnọdụ nke nke na digestive usoro a na-achikota n'ọdịnihu na dọkịta gị. Okwu na-eme echi ọnụ n'ala mbadamba otú a mejupụtara na agwakọta ọgwụ na a obere ego nke mmiri na ụdi ka ochichi. Mgbe nke jupụtara a obere ọmụmụ wepụ ọgwụ residues si nyocha. Ịgbaso ọgwụ dị mkpa ka mepụta enteral nri oriri.

The price nke ọgwụ "Ksarelto"

Ngwá ọrụ a na-emetụta dị ọgwụ ọjọọ na elu na-eri. Ka ihe atụ, ọgwụ ọjọọ, "Ksarelto" price nke kasị nta dose ga-56 pellets nke banyere 950 rubles. Ọ bụ ihe ndị ọzọ dị oké ọnụ karịa ya Russian analogue - ọgwụ "Warfarin". Na nkà mmụta ọgwụ "Ksarelto" price na-abawanye na-adabere na-abawanye na usoro onunu ogwu. N'ihi ya, uru 14 mbadamba 15 mg rivaroxaban ga-abụ ihe 850 rubles, mgbe mbukota (28 iberibe mbadamba) na kasị elu dose (20 mg isi n'ọrụ mgwa) ga-akwụ 1450 rubles.