4 (free): na-emekarị. Mmiri ọgwụ T4 (free): ọbara ule maka thyroid homonụ

Nke dị oké mkpa na kwesịrị ịrụ ọrụ nke thyroid gland bụ hypothalamic-pituitary thyroid usoro. Ọ na-enye akara nke njikọ, mmepụta na ọrụ nke thyroid homonụ.

Isi

The hypothalamus atanyekwa abụba (tireotro-pin-atọhapụ ihe na-akpata). Ọ, n'aka, akpali ntọhapụ na njikọ nke thyroid na-akpali akpali hormone (TSH - TTG). TSH a na-Filiks jikọtara ndị ọzọ Steroid. Karịsịa, ọ na-akpali secretion, ìgwè, metabolism na njikọ nke triiodothyronine (T3) na thyroxine (T4). N'ime 99% nke abụọ ndị a Steroid n'ime ọbara-ekesa na metụtara iga-edozi ụdị. Na-erughị otu percent bụ na free ụdị. Unbound steroid etoju na ọtụtụ ndị mmadụ na-interconnected na ọtọ ala nke thyroid gland.

Njirimara thyroxine

Mmiri ọgwụ T4 (free) mmemmem ụkpụrụ nke nkịtị na mmepe, huu mmezi nke ahu okpomọkụ na otú ịnọgide na-enwe okpomọkụ buildup. The compound nwere mmetụta niile nkebi nke carbohydrate metabolism, na akụkụ - na vitamin na lipid metabolism. Mmiri ọgwụ T4 (free) bụ ihe dị mkpa akụrụngwa nke mmepe na utero na neonatal oge. Ịta na-egosi na-adakarị ọnọdụ nke thyroid ọnọdụ, dị ka mgbanwe na n'ozuzu larịị nke thyroxine nwere ike triggered site na-enwe nsogbu ndị ọrụ nke thyroid gland ma ọ bụ mgbanwe na ọnụ ọgụgụ nke iga na-edozi. N'oge ehihie, na kacha ọdịnaya nke steroid kpebisiri ike site 8 na 12 awa, na nke kacha nta - na 23 3. N'oge afọ, ndị kasị elu larịị 4 (free) esịmde si September ka February, nke kasị ala - n'oge okpomọkụ. Na prenatal oge (n'oge gestation) thyroxine ịta ụba, na-eru a kacha larịị ka nwayọọ nwayọọ atọ trimester. Kemgbe ndụ nke thyroxin ọdịnaya ndị mmadụ nọ n'agbanyeghị okike na-anọgide dịtụ mgbe nile. Belata hormone etoju hụrụ mgbe iri afọ anọ.

Gịnị nwere ike ịgwa larịị nke thyroxine?

Ọ bụrụ na T4 (free) n'ụzọ doro anya na ụba, mgbe ahụ, ọ na-atụle a nkwenye nke hyperthyroidism. Belata ịta egosi hypothyroidism. The nnwere onwe nke ndị steroid ọdịnaya nke thyroxine nkịtị globulin na-eme ka o kwe omume na-eji ya dị ka a pụrụ ịdabere na-achọpụta ọrịa ule. Nke a dị mkpa karịsịa na ọnọdụ ndị na-na-ebu mgbanwe etoju nke thyroxine-ekechikwa globulin. Ndị a gụnyere ndị na-edeghị ede gbochie afọ (onu), afọ ime, na-androgen ma ọ bụ estrogen. Mgbanwe ndị e ji mara na ndị na-a butere n'aka pụrụ ịrịa dịkwuo ma ọ bụ ibelata ịta nke globulin. Onyinye ọbara maka free T4 akwadoro maka nchoputa ụdị abụọ hypothyroidism ruru pathologies na hypothalamo-pituitary larịị. Na nke a TTG ọdịnaya adịghị agbanwe ma ọ bụ na-abawanye. A, elu etoju nke thyroxine nwere ike ịbụ n'ihi na elu-etoju nke ọbara bilirubin, ibu oké ibu, nakwa dị ka a tourniquet, mgbe ga ọbara ule. 4 (free) adịghị agbanwe n'okpuru oké ọrịa na ndị na-abụghị thyroid ọrụ. Larịị nke ngụkọta thyroxine nwere ike ibelata.

Nkwadebe maka laabu ule

A ọnwa tupu enye ọbara Ewezuga ochichi nke homonụ (ma e nwere ihe ntụziaka endocrinologist). Abụọ ma ọ bụ ụbọchị atọ, na-akwụsị na ojiji nke analysis of ayodiin-nwere ọgwụ ọjọọ. Blood ga-agabiga tupu radiological ọmụmụ iji iche mmadụ. Na eve nke na-enye ọbara kwesịrị izere ọrụ ahụ, kwụsị akpata nrụgide. Tupu ọmụmụ, ọkara otu awa, ị kwesịrị ị na wetuo obi, ime ka iku ume nkịtị. The analysis a rụrụ na ihe efu afo. Na nri ikpeazụ ga-abụ ihe na-erughị awa asatọ (ma ọkacha mma 12 awa). Ọ na-adịghị ekwe ka na-aṅụ kọfị, tii ma ọ bụ ihe ọṅụṅụ. Nwere ike na mmiri.

Belata etoju nke thyroxine

4 (free) (nkịtị inyom na ndị ikom - 9-19 pmol / l) nwere ike belata na postoperative oge, mgbe nke abụọ hypothyroidism (mbufụt nke pituitary, tireotropinome, syndrome, Sheehan). Mbenata ịta ọ na-e kwuru na ndabere nke n'ikuku anabolics, thyreostatics, anticonvulsant ọgwụ ọjọọ, lithium preparations. Thyroxine larịị mbelata mgbe eji onu gbochie afọ, octreotide, methadone, clofibrate. Ekwe Omume akpata na-agụnye a na-eri na a ole na ole nke protein, ayodiin erughi, heroin ojiji, ikpughe na-edu. 4 (free) nwere ike belata na tertiary (akwara hypothalamus TBI), enwetara, congenital hypothyroidism (gburugburu ọtụtụ resection nke akpụ na thyroid, autoimmune thyroiditis, jupụtara ejupụta goiter).

Ịba kasịnụ

Larịị nke dị hormone dị ka T4 (free) (nkịtị inyom na ndị ikom gosiri n'elu) nwere ike ụba mgbe nsí goiter, TSH-onwe ha hyperthyroidism, ibu oké ibu. Ịba ịta hụrụ na ndabere nke nephrotic syndrome, heparin ọgwụ. Ihe mere na-agụnye choriocarcinoma, n'ikuku nke a thyroxine na ndabere nke hypothyroidism, post-Natal mgbanwe ọrụ nke thyroid gland, adịghị ala ala ọrịa imeju. 4 (free) nwere ike elu na thyroid eguzogide syndrome Steroid, mkpụrụ ndụ ihe nketa dizalbunemicheskoy hyperthyroxinemia, kwuru, sị, nākpasu a ọnụ tiroksinsyazyvayuschego globulin ịta.

Thyroxine na ime

Thyroid homonụ na-abuana ke fọrọ nke nta ka ọ bụla usoro ke idem. Dị ka e kwuru n'elu, na ogige mezie metabolism, na-emetụta ọrụ nke ndị ọzọ Steroid. Thyroid daa ọrịa nwere ike-esonyere ma na-abawanye na a ọnụ ya ọrụ. Of otu dị mkpa mebiri nke ngwa na-eme nwere n'oge ịmụ nwa, nwa. The mgbanwe nke ọtọ ala nke thyroid gland na-emetụta omume nke afọ ime, ya agwa, na ihe ga-esi ọnọdụ nke nwa amụrụ ọhụrụ. Adịkarịghị vynashivanie aga mgbe owụt endocrine pathologies. Ọrịa nke a, dị ka a na-achị, iduga omumu dysfunction, infertility. Ọtụtụ mgbe a chọpụtara n'oge ime goiter (na-abawanye na thyroid asị ibe uwa) na euthyrosis ichebe, nakwa dị ka autoimmune thyroiditis, nākpasu mgbanwe mmiri ọgwụ ndabere. N'ihi prenatal oge e ji mgbanwe ọtọ ala nke gland.

na-atụ aro

N'ụzọ ziri ezi na-akọwa na ihe laabu ule n'oge ime ga-gaa na akaụntụ ụfọdụ ihe. Mkpebi Siri Ike nke ngụkọta T3 na T4 abụghị ihe ọmụma. Nke a bụ n'ihi na eziokwu na n'oge ime, ha ịta na-amụba site ọkara. Mgbe unbound thyroxine larịị ọmụmụ ya ịta kwesịrị ikpebisi ike na njikọ na ọdịnaya TTG. Thyroxine dịtụ mụbara na banyere 2% nke ime ndị inyom. Ke akpa ọkara nke a nkịtị prenatal oge akara ibelata TTG (ihe dị ka 20-30% nke ọrịa na singletons na N'ọnọdụ nile nke multiple ime). Na ọgwụgwọ nke hyperthyroidism T4 nyochaworo naanị (free). Unbound thyroxine larịị ke ukperedem nkebi nwere ike marginally belata. N'ihi ya TSH ịta ga-nọgidere na-enwe na nkịtị nso.