"Alendronic acid": ntuziaka maka ojiji, analogs, reviews

Nke na-achọ "Alendronic acid"? Azịza nke a ọgwụ nke, ị ga-amụta site na ihe ndị a n'isiokwu a. Ke adianade do, anyị ga-agwa gị banyere otú na-na nkà mmụta ọgwụ, nke ikpe ọ bụghị na-achọsi ike iji, na ọ bụrụ na ha nwere ihe ọ bụla na-akpata. Ị ga-amụtakwa banyere ụdị ndị anyị na-atụle dị n'aka, ma o nwere ndị ogbo na ọrịa na-ekwu banyere ya.

The mejupụtara nke ọgwụ na ya ntọhapụ ụdị na nkwakọ

"Alendronic acid", ma ọ bụ na-akpọ ọgwụ "Alendronate", a na-ahịa na ụdị ọcha gburugburu mbadamba. The n'ọrụ mgwa nke ọgwụ bụ alendronate sodium trihydrate, ma ọ bụ alendronic acid.

Ma ihe ndị ọzọ na-ọcha, na-arụsi ọrụ ike iji ọgwụ mejupụtara ndị na-esonụ: monohydrate, povidone, microcrystalline cellulose, croscarmellose sodium na magnesium stearate.

Na pharmacies "Alendronic acid" nwere ike dị na blisters 4 mbadamba ọ bụla.

The pharmacological Njirimara nke ọgwụ

Gịnị bụ a "Alendronic acid"? Guide nkwadebe na-enye na ngwá ọrụ bụ ihe inhibitor nke ọkpụkpụ resorption. The usoro nke ihe nke a ọgwụ jikọtara a ọnụ ke ọrụ nke osteoclasts. Ọ nwayọọ nwayọọ na-enwekwu ndị njupụta (ịnweta) ọkpụkpụ anụ ahụ, nakwa dị ka so na ya guzobere.

The pharmacokinetics nke ọgwụ

Olee otú etinye obi gị dum "Alendronic acid"? Ntuziaka maka ojiji nke a ọgwụ nwere ozi na mgbe ndinọ na ihe efu afo (2 awa tupu nri ụtụtụ), na a onunu ogwu nke 70 mg bioavailability nke nọ n'ọrụ mmewere ke fairer mmekọahụ bụ banyere 0,65%, na ike n'ala - banyere 0,6%.

Ọ bụrụ na ị-aṅụ ọgwụ maka ọkara otu awa ma ọ bụ otu awa tupu a nri, ọ budata mbelata bioavailability (ruo 0,45% na 0.4%, karị).

Ikweta na ọgwụ n'ime 2 awa mgbe a nri adịghị emetụta bioavailability. Otú ọ dị, mgbe oriri nke kọfị na ihe ọṅụṅụ oroma belata bioavailability site 60%.

Nkịtị nke nọ n'ọrụ mgwa nke ọgwụ na ọbara na-edozi bụ mkpokọta 78%.

Mgbe anata mbụ ọgwụ na-ekesa na-adụ anụ ahụ, na mgbe ahụ na ọkpụkpụ ebe na, n'eziokwu, bụ ya fixation, na remnants nke na akụrụ ya.

Ịta nke ọgwụ na ọbara pụtara mgbe na-anata a ọgwụgwọ dose bụ n'okpuru n'ihe ịgba (erughị 5 and / ml).

The agwọ ọrịa bụ biotransformation. Ọ na-anyụpụ si ahụ na-agbanweghi agbanwe. The nkwadebe e ji a ngwa ngwa ọnụ ke ọbara ịta, na a nnọọ ngwa ngwa ntọhapụ nke ọkpụkpụ anụ ahụ.

Egosi maka ojiji nke mbadamba

Ugbu a na ị maara ihe a "Alendronic acid". Gịnị mere anyị mkpa ngwá ọrụ a? Dị ka mmasị ntuziaka, ọgwụ nwere ndị na-esonụ na-egosi:

• osteoporosis na fairer mmekọahụ postmenopausal nwanyi (dị ka a mgbochi nke ọkpụkpụ fractures, gụnyere spain na n'úkwù);
• osteoporosis na ike mmekọahụ;
• Osteoporosis, bụ nke e mere site ruo ogologo oge iji glucocorticoid mmadụ;
• Paget oria.

"Alendronic acid": contraindications na ojiji nke

Mgbe i nwere ike iji ọgwụ ọjọọ na anyị n'ihu? Ntuziaka maka ojiji nke ọgwụ na-ekwu na a ọgwụ nwere ndị na-esonụ contraindications:

• hypocalcemia;
• Mụbara ndidi agwọ ọrịa uche na bekee;
• enweghi onye ọrịa bụ na ihe ziri ezi na ọnọdụ (ọdụ elu ogologo ma ọ bụ na-eguzo) maka ọkara otu awa;
• oké ọrịa na ịnweta metabolism;
• oké gbasara akụrụ odida;
• hypoparathyroidism arọ;
• achalasia ma ọ bụ stricture nke na nkọlọ, nakwa dị ka ndị ọzọ ọnọdụ na-eduga na ihe mgbochi nke nri site na nkọlọ;
• glucose-galactose malabsorption, lactase erughi ma ọ bụ lactose ekweghị ibe nọrọ ;
• lactation;
• Calcium malabsorption;
• ime;
• ụmụ afọ.

Akọ na-ewere ọgwụ

Mgbe ụfọdụ, "Alendronic acid" e kenyere na-elezi anya? N'okpuru ike ike na-elekọta ga-abụ na udi nke ọrịa, nke bụ ihe ọ bụla ndiiche na digestive tract (eg, dị ọrịa dị ka esophagitis, dysphagia, duodenitis, mgbu, peptic ọnyá afọ ọrịa 12 duodenal ọnyá afọ na afo). Ke adianade do, ọgwụ kwesịrị ihe ókè ịkpachara anya na ọrịa na a erughi nke vitamin D.

"Alendronic acid": ntuziaka maka ojiji nke ọgwụ

Agwọ ọrịa "Alendronate" kwesịrị naanị iwere ọnụ ke ichekwa 1 mbadamba. Mgbe a ọgwụ adịghị atụ aro ka na-ata, ma ọ bụ igbari. Ya na-ahụ na-ebu ọnụ n'ihi na 2 awa tupu nri ụtụtụ (dịkarịa ala, ọkara otu awa tupu mbụ dose of nri, mmiri, ma ọ bụ ndị ọzọ ngwaọrụ ahụike).

The ọgwụ ga-aṅụ mmiri nkịtị. Nke a bụ n'ihi na eziokwu na ndị ọzọ na-aba n'anya (eg, ịnweta mmiri, tii, kọfị, na ihe ọṅụṅụ oroma) ịrịba belata absorption nke nọ n'ọrụ umi.

The na-atụ aro usoro onunu ogwu nke agwọ ọrịa bụ 1 mbadamba (ma ọ bụ 10 mg) kwa ụbọchị ugboro n'ime. Mgbe ụfọdụ, ndị dọkịta ọzọ dose ndinọ ka a ndidi, nke bụ ka ndị a: 1 mbadamba (ma ọ bụ 70 mg), 1 oge kwa izu.

Maka ọgwụgwọ nke osteoporosis na ndị ikom na ndị inyom (na postmenopausal inyom), nakwa dị ka osteoporosis, nke e mere site ruo ogologo oge iji glucocorticoid mmadụ, ọgwụ a na-e site na 10 mg kwa ụbọchị ma ọ bụ 70 mg otu izu.

Na nke a na ọrịa dị ka Paget ọrịa, atụle site anyị ọgwụ ndinọ na a onunu ogwu nke 40 mg kwa ụbọchị. Na oge nke ọgwụ bụ 6 ọnwa.

Ọ bụrụ na ị na mmadụ na mberede na-atụ uche a nkwadebe mode 1 kwa izu, mbadamba kwesịrị iwere ụtụtụ echi ya. Ọ na-aju iji ọgwụ na ego nke mbadamba nkume abụọ otu ugboro n'ụbọchị.

Ovadozu nke ọgwụ

Gịnị na-eme ma ọ bụrụ na onye ọrịa na-aghọ n'ekweghị ngụgụ na-dị otú ahụ dị ka "Alendronic acid"? Preparations nke ụdị nwere mgbaàmà nke ihe ovadozu ka hypophosphatemia, nrekasi obi, hypocalcemia, erosive na ọnyá ọnya nke eriri afọ tract, esophagitis, afọ ọsịsa.

N'ihe banyere ọrịa ọkọnọ pụta kwesịrị dum mmiri ara ehi ma ọ bụ calcium-nwere antacids. Ọ dị mkpa ka ndị na-adịgide adịgide nke ọgwụ. Na echiche nke nke ịrịa esophageal mucosa iyatesịt adịghị atụ aro ka eji vomiting. Bụrụ na nke ovadozu onye ọrịa ga-ke ziri ezi onodu.

Mmetụta na-erukwa na mgbe ochichi nke ọgwụ

Nwere ike ime ka "Alendronic acid" na-ezighị ezi onu? Nyocha nke ọrịa na dọkịta na-ekwu na ọgwụ nwere a dịtụ ukwuu nke mmetụta. Gịnị kpọmkwem, anyị na-a obere n'ihu.

• Digestive usoro: esophagitis, afọ ọsịsa, dysphagia, dyspepsia, abdominal mgbu, bloating, afọ ntachi, na nrekasi obi. Oputara adịkarịghị mgbe dosing na ọrịa na-enwe vomiting, melena, ọgbụgbọ, esophageal stricture, mgbu, esophageal ọnyá afọ, ọnyá afọ pharynx na onu oghere mucous membranes, esophageal ọnyá perforation na biakwa obibia nke ọbara ọgbụgba.
• Ụjọ usoro: isi ọwụwa.
• Nweekwa usoro: mgbu na uru, ọkpụkpụ na nkwonkwo.
• Akụkụ nke ọhụụ: scleritis na uveitis.
• Allergy: edema angioedema, ọkụ ọkụ, Stevens-Johnson syndrome na-egbu egbu epidermal necrolysis (na obere okwu).
• Ọzọ mmetụta: erythema, ọkụ ọkụ, photodermatosis, itching na symptomatic hypocalcemia. E nwekwara ikpe nke osteonecrosis nke ala na elu agha na ọrịa na cancer, bụ ndị gabigaworo anticancer ọgwụ na-agụnye iji ihe bisphosphonates. N'ihi ya, omume nke osteonecrosis ihe ize ndụ ihe na-agụnye: iji ọgwụ, cancer, ọgwụgwọ na corticosteroids, radieshon ọgwụ, ogbenye onu ọcha na ịdị ọcha, obodo ọrịa ma ọ bụ mbufụt, gụnyere osteomyelitis.
• Laboratory ule:-akwụsị akwụsị na nta ọnụ ke ịta nke calcium na phosphate.

Anyị nwere ike ikwu na-ahụkarị ihe mgbaàmà na mmalite nke usoro ọgwụ na-na-esonụ: malaise, myalgia, na ahụ ọkụ.

Mmekọrịta ndị ọzọ ọgwụ ọjọọ eme ihe

Ọnụ na ọgwụ ọ bụla ọrịa dịghị mgbe e kenyere "Alendronic acid", ya synonyms?

Dị ka ntụziaka, ọ bụghị kwesịrị ekwesị n'ihi na n'otu oge n'ikuku nke ngwá ọrụ na ọgwụ nke nwere calcium na Ọdịdị na antacids (n'ihi a ga-ekwe omume ọnụ absorption nke nọ n'ọrụ ọgwụ umi).

The nkeji n'etiti ochichi nke ọgwụ ọjọọ, "Alendronate" na ojiji nke ndị ọzọ ọgwụ kwesịrị ịbụ ihe na-erughị ọkara otu awa.

Ndị so ná ndị mmadụ, nakwa dị ka acetylsalicylic acid ike budata dịkwuo mmetụta nke ọgwụ na eriri afọ tract akụkụ.

Jikọtara n'ikuku "alendronate" (ma ọ bụghị ma) na estrogen na-adịghị esonyere site na a mgbanwe nke omume ha na mmepe nke ọ bụla mmetụta.

N'ikuku nke ndị dị otú ahụ a ọgwụ, dị ka a "prednisolone", na-adịghị esonyere ịrịba mgbanwe bioavailability acid.

Special ntuziaka maka inweta a na ngwaọrụ ụlọọgwụ

Ihe i kwesịrị ịma tupu ị malite na-anata a ngwá ọrụ ndị dị ka "Alendronic acid"? Analogs, na ya weere ọgwụ nwere ike imetụta ndị eriri afọ akụkụ. Ya mere, iji belata irritant mmetụta nke ọgwụ na-atụ aro na-ụtụtụ na ihe efu afo a iko mmiri.

Mgbe na-anata ọgwụ dị mkpa maka ọkara otu awa na ziri ezi onodu. Iji kehoraizin ọnọdụ ma ọ bụ na alakpu ụra enwekwu ihe ize ndụ nke dị otú ahụ nupụsịrị ka esophagitis.

Onye ọrịa a ga-asian nke discontinuation nke ọgwụ mgbe nrekasi obi na-adị, ọdịdị nke ihe mgbu na obi na-elo ihe, nakwa dị ka mmepe nke dysphagia.

Ọ bụrụ na hypocalcemia ga-eduzi ya mgbazi tupu mmalite nke ọgwụ. Ọ na-atụ aro iji wepụ nsogbu nke ịnweta metabolism na-eduga a ndiiche.

N'oge ojiji nke bisphosphonates onye ọrịa kwesịrị ịgba mbọ hụ na oriri nke ezigbo ichekwa vitamin D na calcium.

Na N'ezie nke ọgwụ n'ihi na uru nke acid na ọkpụkpụ ịnweta njupụta a ndidi nwere ike a nta ọnụ ke ịta nke phosphate na calcium na ọbara.

Mbemiso ọgwụgwọ na bisphosphonates na ọrịa na concomitant ihe ize ndụ ihe (na cancer na-anara ọgwụ, radieshon ọgwụ, wdg). Jide n'aka na-agafe eze nyochaa.

Price na analogues nke ọgwụ

Ugbu a na ị maara otú a ọgwụ kwesịrị iwere dị ka "Alendronic acid". Gịnị ka nke a na nkà mmụta ọgwụ kenyere site dọkịta, anyị na-achọta. Otú ọ dị, ọtụtụ ndị ọrịa bụ ndị e kenyere a na nkà mmụta ọgwụ, mgbe nile nchegbu banyere otu ajụjụ: otú ihe ọ na-eri?

Taa "Alendronic acid" nwere ike zụrụ maka 350 rubles (4 mbadamba). Nyere dosing oge (otu ugboro a izu), price bụ nnọọ elu.

Ọ bụrụ na anyị n'ihu ndị ọgwụ adịghị ona gị maka ihe ọ bụla, ọ ga-anọchi kachasị yitebe. A na-agụnye ọgwụ ndị dị otú ahụ dị ka "Tevanat", "Ostalon", "Alendronate", "Strongos", "Alendrokern", "Ostealen", "Lindron", "Alental", "Foroza", "Osterepar ',' FOSAMAX "na na.

Nyocha nke ọrịa na dọkịta banyere ọgwụ

Gịnị na-eme ndị ọrịa na ndị dibịa banyere nke a owuwu ka "Alendronic acid"? Dị ka ha na-azaghachi, ọgwụ si anagide ọrụ. Ọ dị mma na-eme ka ọkpụkpụ anụ ahụ, na-emeso osteoporosis na Paget oria.

Otú ọ dị, ọ gaghị ekwe omume ka ọ ghara iburu eziokwu na nke a ọgwụ ọjọọ nwere a dịtụ ukwuu nke mmetụta. Ya mere, ọgwụ kwesịrị iwere na na nhọpụta nke ndị ọkachamara. Nke ikpeazụ mgbe niile kwesịrị agwa onye ọrịa banyere contraindications.

The ọnụ ọgụgụ kasị ukwuu nke na-ezighị ezi reviews na adreesị "alendronic acid" si ọrịa ndị nwere nsogbu na digestive tract. Nke a bụ n'ihi na eziokwu na nke a ọgwụ ọjọọ nwere ike imetụta na afo, na nkọlọ na eriri afọ.