Benzathine benzylpenicillin: nkọwa, Njirimara na ngwa, analogs

Benzathine Benzylpenicillin bụ ọgwụ nje na bụ penicillin otu. Iji na-emeso nile di iche iche nke na-efe efe ọrịa ndị bacteria susceptible ka ya edinam. Ke ibuotikọ emi anyị ga-esi na zuru ezu ntuziaka maka ojiji, na-egosi na contraindications ọgwụ, nakwa dị ka ndepụta a ole na ole ndị ọgbọ.

Benzathine benzylpenicillin: nkọwa nke ọgwụ

A ọgwụ bụ otu n'ime ìgwè nke mbụ nke penicillin ọgwụ nje. N'agbanyeghị nnọọ ogologo okwu ngwa, ọ bụghị tụfuru ya mkpa n'ihi na dịgasị iche iche nke omume na ike igbu a dịgasị iche iche nke pathogenic bacteria. The ọgwụ, n'ihi na ihe atụ, nwere ike ịnagide anthrax, meningococci, syphilis na a plurality nke streptococci na staphylococci. E agbara ka na digestive tract na-adịghị etinye obi gị dum benzathine benzylpenicillin.

Ntụziaka na Latin na-kenyere dọkịta, na mgbe ahụ onye ọrịa siri ike ịghọta ihe e nyere ya. Iji zere nke a mgbagwoju anya, ị dị nnọọ mkpa ịmara na aha nke ọgwụ na asụsụ a - Benzathine benzylpenicillinum.

A, ọgwụ na-ndinọ intravenously ma ọ bụ intramuscularly. Ma ọ bụ omume na ọgwụ nnyefe n'ime ahu site spinal kanaal, subcutaneously ma ọ bụ site na otụk ebe.

Benzylpenicillin - ọgwụ nje ekewet si na otu nọ n'ọrụ umi. Ma, ọ na-abanyekwa ọgwụ n'ụdị salts. Ya mere, ndị umi nwere ike ịchekwa ruo ogologo oge na-enweghị na-ada ada. Na mgbe iwebata penicillin G a tọhapụrụ site na aru nke salts na-amalite ya antibacterial edinam.

Dabere na iji nke na nnu bụ ifịk umi, nwere ọtụtụ ụdị nke ọgwụ. N'agbanyeghị nke a, ha niile nwere Olee ihe enyemaka otu mmetụta, na dị iche iche ụdịdị nke ochichi na oge nke mmetụta.

na-agba akaebe

Benzathine benzylpenicillin na-kenyere ndị na-esonụ ọrịa:

• Na-efe efe nke akụkụ okuku ume na akụkụ (pleurisy, oyi baa, bronchitis, empyema , na otú pụta.).
• Ọrịa nke genitourinary usoro (syphilis, gonorrhea, urethritis, cystitis, adnexitis, salpingitis).
• Na-efe efe nke elu akụkụ okuku ume na tract (uhie uhie ahụ ọkụ, tonsillitis, Sinusitis, otitis media, Sinusitis, laryngitis, wdg).
• Purulent na-efe efe nke visual akụkụ, ọkpụkpụ na anụ ahụ, mucous membranes (ophthalmia, dacryocystitis, blepharitis, osteomyelitis, mediastinitis, erysipelas, cellulitis, emerụ ọrịa, na otú pụta.).
• Brain etuto.
• Purulent meningitis.
• Septicemia, sepsis.
• Ogbu na nkwonkwo.
• Peritonitis.
• Ọrịa ndị spirochetes (yaws, anthrax, wdg).
• Ahụ ọkụ kpatara oke aru.
• Na-efe efe mere site Listeria, Clostridium, Pasteurella.

Ọzọkwa, ọgwụ na-ndinọ na prophylactically postoperative nsogbu ahụ na nsogbu na streptococcal ọrịa (endocarditis, rheumatic fever, glomerulonephritis na na.).

Pharmacokinetics

Benzathine benzylpenicillin (Latin Benzathine benzylpenicillinum) ozugbo ochichi amalite tisaa, na-atọhapụ ndị nọ n'ọrụ umi. N'otu oge ahụ ọgwụ na-anọgide na ọbara na-esote 3 izu mgbe ogwu ogbugba. The mmiri mmiri umi penetrates nnọọ mma karịa na anụ ahụ. Ọ ga-iburu n'uche na benzyl penicillin bụ nwee ike imeri placental mgbochi a na-egosi na mmiri ara nke nwa ara na nne. Anyụpụ site na akụrụ na-agbanweghi agbanwe ụdị. N'oge mbụ 8 ụbọchị tọhapụrụ banyere 33% nke ndinọ dose.

Pregnancy na ara

Dị ka e kwuru n'elu, na ọgwụ bụ ike banye n'ime Plasenta na-abanye n'ime mmiri ara. Ya mere, ara ga-kwụsịrị mgbe anamde ibọ ọgwụ.

N'oge ime, nhọpụta nke ọgwụ-ekwe omume nanị ma ọ bụrụ na uru n'ihi na ndị inyom bụ ukwuu karịa ihe ize ndụ n'ihi na nwa. The mkpebi ga-mere site a dibịa, ịdọ aka ná ntị ga-eme n'ọdịnihu na nne banyere niile kwere omume na ya pụta.

contraindications

Benzathine benzylpenicillin (Ntụziaka nwere ike nye iwu ka a dọkịta) nwere ọtụtụ contraindications. Ọ na-ekwesịghị kenyere ndị na-esonụ ọrịa:

• Ekweghị ibe nọrọ na penicillin ma ọ bụ cephalosporin, adịghị anabata ha.
• The elu nke potassium n'ime ọbara (hyperkalaemia).
• Arrhythmia.
• Hay fever.
• Bronchial ụkwara ume ọkụ.
• Gbasara akụrụ insufficiency.
• Pseudomembranous afọ.

Anya agwọ ọrịa ndinọ ka ụmụaka ruo ọnwa isii na nká.

mmetụta

Benzathine benzylpenicillin nwere ike ime ka ụfọdụ ekwesighi mmetụta, dee ha n'okpuru ebe a.

Dị iche iche nfụkasị Jeremaya:

• fever;
• aṅụ;
• ọkụ ọkụ na mucous membranes na akpụkpọ;
• nkwonkwo mgbu;
• eosinophilia;
• erythema multiforme;
• Angioedema;
• exfoliative dermatitis;
• anaphylactic ujo.

Oghom Jeremaya mere nke obi usoro:

• thrombocytopenia;
• anaemia;
• coagulation ọrịa;
• leukopenia.

Na mgbakwunye:

• stomatitis;
• isi ọwụwa;
• glossitis;
• mgbu na ebe nke ochichi;
• ahụ etuto;
• infiltrates;
• jed elu;
• fistulas.

Na ruo ogologo oge iji na-emerụ dịkwa ka usoro ha na Micro-ntule pụrụ ịzụlite eguzogide, mgbe ọgwụ ga-atụfu ya irè.

Benzathine benzylpenicillin: ntuziaka maka ojiji

Ọrịa tọrọ afọ 12, ọgwụ ka a mgbochi ụfọdụ na ọgwụgwọ nke na-efe efe na-ndinọ otu ugboro n'izu na a onunu ogwu nke 300 600 puku. Units ma ọ bụ ugboro abụọ a ọnwa na 1.2 nde nkeji.

Dị ka mgbochi maka rheumatism prick usọbọ maka 6 izu, otu ugboro n'izu ka 600 puku nkeji. N'otu oge ahụ nye iwu aspirin ma ọ bụ ndị ọzọ NSAIDs.

Ọrịa tọrọ afọ 12, ọgwụ na-ndinọ otu ugboro n'izu na ọnụego nke 5-10 puku. Units kwa 1 n'arọ.

N'agbata injections ga-ebe ọ dịkarịa ala 8 ụbọchị. The nkezi onunu ogwu nke 2.3 nde nkeji.

Tupu were, ọgwụ e etisasịwo ke saline, mmiri ọgwụ ad hoc ma ọ bụ novocaine (2.5% ma ọ bụ 5%).

Ẹkenam ọgwụ nwere ike ịbụ na ndị na-esonụ ụzọ:

• intramuscular;
• igba ogwu n'akwara;
• subcutaneous;
• Lumbar (via na spinal kanaal);
• pleural (site na akpa ume pleura);
• subconjunctival (via na ocular anụ ahụ);
• atasị site na nti;
• atasị site imi;
• ozugbo na otụk ngwa anụ ahụ.

Nchikota na ndị ọzọ ọgwụ ọjọọ eme ihe

Benzathine benzylpenicillin (ntụziaka kpọmkwem dị ka gosiri) nwere ike emekọ ọgwụ ọjọọ ndị ọzọ. N'ihi ya, ọ benzylpenicillin nwere ndị na-esonụ: a synergistic, emegide na bacteriostatic.

Ke adianade do, ọgwụ enwekwu irè nke ọgwụ ọjọọ, nke anọ anticoagulants. Ma na-ebelata ịdị irè nke ethinyl estradiol dị iche iche onu gbochie afọ.

Jiri ọnụ na NSAIDs, allopurinol, diuretics arụpụta belatara tubular secretion na ụba kasịnụ nke nọ n'ọrụ mgwa. Ke adianade do, allopurinol ukwuu enwekwu ihe ize ndụ nke nfụkasị Jeremaya.

precautionary jikoro

Bụchaghị n'ihu mbụ ọgwụ dị mkpa aspirate. Ọ bụrụ na ọgwụ mmadụ na mberede odụk ọbara arịa, ya nwere ike ime ka ischemia ma ọ bụ embolism. Ke adianade do, e nwere ike ịbụ a mmetụta nke nchegbu, ịda mbà n'obi, na-akwụsị akwụsị bịara ikiri ọhụụ.

Na otu ebe ị chọrọ ime na abụọ injections na a oge, ọgwụ na-ndinọ na dị iche iche na ogwe aka ma ọ bụ ike.

Mgbe mbụ ngosipụta nke anabata ọgwụ ga-akwụsịtụ ozugbo. Dị ka ọnọdụ dọkịta nwere ike nye iwu ka Allergy ọgwụ.

Mgbe mgbe na benzylpenicillin inye "Levorinum" ma ọ bụ "Nystatin", dị ka e nwere ihe ize ndụ nke fungal-efe efe. Ọ bụ ya mere ogologo oge ọgwụ ọgwụ nwere ike ime mgbochi nke nsia microflora nke site na vitamin B. Na nke a, nwere ike ndinọ na intramuscular ochichi nke ndị a vitamin.

adọ aka ná ntị

Benzathine benzylpenicillin kenyere na ịkpachara anya na ọrịa ndị na-edebewo a dịgasị iche iche nke ọrụ nke akụrụ, e nwere a pụrụ ịrịa anabata ngosipụta, na elu uche na-arụsi ọrụ ike mgwa. Mkpebi ikpeazụ mgbe niile dabeere na dibịa, nke kwesịrị ịma ihe ndị mere ya ndidi.

Ọ bụghị na-atụ aro iji ọgwụ maka ọgwụgwọ nke neurosyphilis, ebe ọrịa a na-apụghị-enweta chọrọ ịta nke nọ n'ọrụ umi ke ọrịa ọbara.

analogs

E nwere ndị ọzọ ọgwụ ọjọọ eme ihe na-enwe otu mmetụta ahụ ka benzathine benzylpenicillin. Analogs, n'ezie, na-aghọ nke onye penicillin otu. Anyị depụta ihe ndị kasị ama na irè:

• "Gramoks-D" - na-emepụta na ụdị a powder zubere maka ozuzu na onu ochichi.
• "Amosin" - na-emepụta na capsules, mbadamba na powder maka onu ochichi.
• "Kịtịkpa" - e mere n'ụdị sirop.
• "Hikontsil" - dị n'ụdị nke ntụ ntụ na capsules maka onu ochichi.
• Azlocillin sodium nnu - powdered umi nke ka a ngwọta maka igba ogwu n'akwara ogwu ogbugba.
• "Ampicillin" - dị na mbadamba, capsules, nsogbu dị iche iche, ndị ọhụrụ ka a slurry, na-e jikwa ọnụ.
• "Ekobol" - emepụta mbadamba.
• "Ospamoks" - e mere n'ụdị mbadamba, capsules na powder maka onu ochichi.
• "Phenoxymethylpenicillin" - dị na mbadamba, dragees, nsogbu dị iche iche na ntụ.
• "Star-Pen" - e mere n'ụdị nsogbu dị iche iche, nke na-diluted na iwere ọnụ.
• "Oxacillin" - e mere n'ụdị mbadamba, capsules, a ntụ ntụ, nke, a ngwọta maka ogwu ogbugba.
• "Standatsillin" - dị na capsules.
• Carbenicillin disodium nnu - na-emepụta na ntụ ntụ ụdị maka imewe nke injection ngwọta.

N'ihi ya, n'agbanyeghị na dịtụ ogologo oge nke ọgwụ na nkà mmụta ọgwụ, ọ ka na-anọgide na otu n'ime ndị kasị dị irè mmadụ megide a dịgasị iche iche nke na-efe efe.