"DioCore 160": ntuziaka maka ojiji, n'ezie na ogbo. "DioCore solo 160": ntuziaka maka ojiji, n'ezie na

Ọnụ ọgụgụ nke ndị mmadụ mgbe ụfọdụ na-ata ahụhụ site na ọbara mgbali elu. Otú ọ dị, ndị dị otú ahụ a-enweghị nchịkwa na ọnọdụ bụghị nanị na-eweta ịrịba erughị ala na-enwe ndidi, ma na-egwu ya ndụ. Ya mere, na taa na-emepụta ọgwụ ahịa e nwere ọtụtụ ngwaahịa na-eme ka ẹsụhọde ọbara mgbali.

The kasị ewu ewu n'etiti ndị nọ bụ onye na-ata ahụhụ site na ọbara mgbali elu, na-eji a ọgwụ dị ka "DioCore 160". Ntuziaka maka ojiji, analogues nke a na nkà mmụta ọgwụ, nakwa dị ka reviews banyere ya, atụmatụ na Njirimara ga-ọkọnọ a obere ka e mesịrị.

Mejupụtara, nkọwa, nkwakọ ngwaahịa na udi

Medicine "DioCore 160", okwu na-dị na a igbe mere nke katọn, arụpụtara n'ụdị mbadamba. Ha bụ film-ntekwasa na-ebu ndị dị otú ahụ nọ n'ọrụ Efrata ka valsartan na hydrochlorothiazide. Ọzọkwa akuko n'aka na-agụnye microcrystalline cellulose, sodium lauryl sulfate, nduku starch, talc, ọka starch, croscarmellose sodium, magnesium stearate, colloidal anhydrous silica na opadry II Orange.

Anyị nwere ike ikwu na ndị dị otú ahụ a ọgwụ, na pụrụ ịchọta na ire ere dị ka "DioCore solo 160". Site bu ụzọ ọ dị iche na nke ya nọ n'ọrụ mgwa eme naanị valsartan.

Ụkpụrụ nke ime ihe nke a agwọ ọrịa

Gịnị bụ ọgwụ "DioCore 160"? Ntuziaka maka ojiji na-akọ na a antihypertensive gị n'ụlọnga, nke a na-ekewet nke a thiazide mamịrị na ihe angiotensin II ihe nnabata-eti ọkpọ.

Ngwá ọrụ a nwere a dịgasị iche iche nke n'ahụ mmetụta nke na-e dị ka anọ na kpọmkwem akụkụ na ọbara mgbali iwu. Angiotensin II bụ ike vasoconstrictor gị n'ụlọnga mere site a kpọmkwem pressor mmetụta. Ọ na-egbu oge na sodium na-akpali secretion nke aldosterone.

Valsartan akpọ arụsi ọrụ ike na kpọmkwem angiotensin II ihe nnabata-eti ọkpọ. Ọ e mere maka onu nlekọta na bibiri eme na AT1 ihe nnabata subtype na-ahụ maka mmetụta nke angiotensin II. Ele Mmadụ Anya n'Ihu agonist ọrụ na ihe nnabata subtype AT1, a mmewere adịghị egosi.

Ọzọkwa valsartan bụghị inhibit Ace, nke atọghata angiotensin m ka angiotensin II, bradykinin ebibi. Chọpụtabeghị na mmetụta mere site bradykinin.

Na ndị mmadụ na ọbara mgbali elu, na ọgwụ na-akpata a ọnụ ke ọbara mgbali. Na nke a, na o nweghị mmetụta obi ọnụego.

Ọtụtụ ndị ọrịa mgbe a otu dose of isiokwu ọgwụ mbido antihypertensive ọrụ hụrụ n'ime 2 awa, na ọbara mgbali Mbelata n'elu 6 awa.

The antihypertensive mmetụta nke ọgwụ adịgide ruo ihe karịrị otu ụbọchị. Na mgbe Erere kacha ọgwụgwọ mmetụta a na-enweta n'ime izu anọ na nọgidere na-enwe n'oge nile nke ogologo oge ọgwụ.

Pharmacokinetics

Gịnị bụ pụta ụwa kinetic Njirimara nke agwọ ọrịa "DioCore 160"? Ntuziaka maka ojiji (mbadamba ga-kenyere naanị dọkịta) na-ekwu na mgbe na-ewere ọgwụ n'ime absorption nke hydrochlorothiazide na valsartan dị nnọọ ngwa ngwa. The nkezi zuru bioavailability nke a gị n'ụlọnga bụ 23%.

The kinetics nke valsartan bụ linear. Ugboro ugboro ojiji nke ọgwụ na-adịghị amị ọ bụla mgbanwe. Na otu Erere nke ha ìgwè bụ negligible.

Valsartan na-agbụ na plasma-edozi na 94-98%. Ya excretion a rụrụ na ndị na nsị na mmamịrị. Mgbe e ọnụ na AUC nke valsartan nri na-belata 48%.

Mgbe anata mbadamba n'ime hydrochlorothiazide absorption emee kama ngwa ngwa (banyere 2 awa). Ọzọkwa, ya bioavailability bụ 60-80%. Na-egosiputa ya na mmamịrị.

Na Nchikota valsartan na hydrochlorothiazide systemic bioavailability nke ikpeazụ na-belata odika 30%.

egosi mbadamba

N'okpuru ihe ọnọdụ onye ọrịa nwere ike họpụtara ọgwụ "DioCore 160"? Ntuziaka maka ojiji, ezigbo dọkịta na-akọ na ngwá ọrụ a nke ọma pụta ìhè onwe ya na ọbara mgbali elu, dị ka nke ọma dị ka enweghị irè nke a na ọrịa naanị.

Contraindications na-enweta ndị mbadamba

Ị maara na mgbe ụfọdụ, adịghị kenyere mkpụrụ ọgwụ "DioCore 160"? Manual na-ekwu na ndị dị otú na nkà mmụta ọgwụ na-contraindicated na onye ekweghị ibe nọrọ nke ya Efrata.

Ke adianade do, ọ na-aju maka ojiji na ọrịa na cholestasis, oké imeju impairment, na biliary imeju. Ọzọkwa, ọ na-adịghị kenyere ndị na-ata ahụhụ site na ihe ọ bụla ụdị oké na-agafeghị oke gbasara akụrụ dysfunction, a mgbaàmà nke anuria, belata sodium na potassium etoju ke ọbara, hypercalcemia na hyperuricemia.

Mbadamba "DioCore 160": ntuziaka maka ojiji

Dị ka a n'ozuzu na-achị, iwepụ ọbara mgbali elu n'ụlọ ndị ọrịa nwere ike ikwu na e si eji otu mbadamba "DioCore 80" otu ugboro n'ụbọchị. Amaedi "DioCore 160" nke ọgwụ, ọ na-kenyere naanị na a ọgwụ. Na nke a, ọrịa ga-n'okpuru elekọta ya mgbe nile nke a dọkịta.

Dị ka omume na-egosi, a kwesiri ngosi mmetụta na ike ọbara mgbali hụrụ 2-3 izu mgbe mmalite nke ọgwụ.

N'ihi na ndị mmadụ na-agafeghị oke ma ọ bụ ịrịba hepatic ma ọ bụ gbasara akụrụ impairment a chọrọ na-ebu mkpa mgbazi nke onunu ogwu nso (n'otu n'otu).

Na oge nke ọgwụgwọ na a na nkà mmụta ọgwụ kwesịrị ikpebisi ike naanị site ịga dọkịta.

mmetụta

Olee ụdị mmetụta onye ọrịa kwesịrị maara nke tupu ijiri a na nkà mmụta ọgwụ "DioCore solo 160"? Ntuziaka maka Iji na-ekwu na-ewere ọgwụ na-adịkarịghị na-akpata oghom ihe ndị nwere ejighị n'aka na ọrịa na-kọwaa agwa.

Odika 1% nke ọrịa mgbe na-ewere a ọgwụ pụtara na-adịghị ike isi ọwụwa, azụ mgbu, ike ọgwụgwụ, ụkwara, dizziness na nasopharyngitis.

Na-erughị 1% mere mkpesa nke abdominal mgbu, nchegbu, ahụ erughị ala na olu na obi, ike ọgwụgwụ, nkwonkwo mgbu, serous bronchitis, iro ụra, laryngitis, iku ume ọkụ ọkụ, afọ ọsịsa ọrịa, belata erection, ibelata salivation, hypotension, gastroenteritis, paresthesia, ụba sweating, ebelata uche, muscle cramps, ehighi ura, elu edema, ọgbụgbọ, ntị na-efe efe, ọ dịghị òkè mkpọchi na a nta ịrị elu ahu okpomọkụ. Mgbe ụfọdụ, ọrịa na-isi ọhụụ, ejighị n'aka tachycardia na tinnitus. Ọ ga-kwuru na a kpọmkwem mmekọrịta omume nke ndị a Jeremaya mere na ọgwụ na a ike.

Olee ihe ndị ọzọ mmetụta nwere ike ime ka ọgwụ "DioCore solo 160"? Ntuziaka na ngwa na-egosi na mgbe eji ngwá ọrụ a, e nwere ndị dịpụrụ adịpụ ikpe nke mmalite nke ọkụ ọkụ, itching na ndị ọzọ na-adịghị anabata ngosipụta, gụnyere vasculitis, na ọbara ọrịa. Ke adianade do, ọrịa mgbe ụfọdụ ịzụlite myalgias na nefralnaya dysfunction.

Nnọọ obere ụdị mmetụta mgbe na-ewere "DioCore 160" ngwaahịa bụ ihe dị mfe na-abụghị cardiogenic edema na-ejikọta ya na onye ekweghị ibe nọrọ nke hydrochlorothiazide.

Studies gosiri na ụfọdụ ndị ọrịa emeso ya na ngwá ọrụ a, na-ebelata potassium na ọbara, elu creatinine na urea, nakwa dị ka a mara nwayọọ neutropenia.

mgbaàmà nke ovadozu

Gịnị bụ ihe mgbaàmà "DioCore solo 160" na elu doses nke ọgwụ? Manual na-ekwu na otú ahụ ikpe na-amaghị n'oge a.

Isi ihe ịrịba ama nke mụbara dose ọgwụ pụrụ isi ike hypotension. Ọ bụrụ na ọgwụ e kuchiri dịtụ na-adịbeghị anya, na aja na-chọrọ iji artificially eji vomiting. Ọzọkwa ọgụ hypotension nwere ike rụrụ site igba ogwu n'akwara ochichi nke nkịtị saline.

Ọ ga-eti na ọ gaghị ekwe omume ikwubi na-ewere ọgwụ ọjọọ si ahụ site hemodialysis. Nke a bụ n'ihi na eziokwu na valsartin, gụnyere ya mejupụtara, ọ mkpatụ na plasma-edozi. Otú ọ dị, ọ ga-ahụ kwuru na hydrochlorothiazide na-tutu amama n'ụzọ dị otú a nnọọ ihe ịga nke ọma.

Drug mmekọrịta ọgwụ ndị ọzọ

Ọ ga-ekwe omume na ikpokọta na ndị ọzọ pụtara "DioCore 160"? Ntụziaka na-ekwu na Nchikota a ọgwụ na ndị ọzọ antihypertensive ọgwụ otu nwere ike na-eme ka aka na mmetụta nke ẹsụhọde ọbara mgbali.

The imekotaotuugbo ojiji nke agwọ ọrịa na potassium-nwere nwekwara, nwayọọ diuretics, solezamenitelyami na bekee na-amụba ọdịnaya nke potassium ke idem, na-achọ mgbe nile ule ịta nke potassium na ọbara ọbara.

Mgbe imekotaotuugbo nlekọta "DioCore" na Ace inhibitors e kwuru na reversible abawanye na ịta nke lithium ke iyịp.

Gịnị ọgwụ nwere ike n'enweghị iji ọgwụ "DioCore 160"? Guide na-akọ na monotherapy ọbara mgbali ngwá ọrụ a na-hụrụ ọ bụla na mmekọrịta ya na "glibenclamide", "amlodipine", "warfarin", "cimetidine", "Digoxin", "furosemide", "indomethacin" Atenolol ".

Ebe ọ bụ na ọgwụ ọjọọ na ihe ndị mejupụtara n'okpuru echiche na-agụnye thiazide mamịrị otu, ya puru omume na-esonụ mmekọrịta:

• ibelata na mamịrị mmetụta nke ọgwụ mgbe ọ na-eji ọnụ na NSAID (e.g., salicylates ma ọ bụ "Indomethacin");
• potentiation nke muscle relaxants.

Gịnị ọzọ ọgwụ interactions kwesịrị ịma tupu ewere na "DioCore 160"? Ntuziaka, reviews na-egosi na mgbe na-eji ngwá ọrụ a na kaliynesberegayuschimi diuretics, salicylates, ACTH, amphotericin karbenokslolonom na ikekwe a nkọ ọnụ ke ịta nke potassium ke iyịp.

Mgbe e ji injectable na onu antidiabetic ọgwụ ọjọọ ga-rụrụ n'otu n'otu ịgbanwe ha onunu ogwu.

Ọ na-adịghị atụ aro iji na-etinye na-ewere agwọ ọrịa ọnụ na diuretics thiazide otu, dị ka nke a nwere ike ikowa n'elu-e kwuru mmetụta nke ọgwụ ọjọọ na-eme ka hypersensitivity Jeremaya mere.

Mgbe etinyere n'out oge na methyldopa hydrochlorothiazide nwere ike ịzụlite hemolytic anaemia.

Mgbe jikọtara ọgwụ "DioCore 160" na kolestiraminom mbelata ya bioavailability na absorption.

Tupu ọgwụ na vitamin D n'ime ọbara calcium ịta nwere ike mụbara na ọrịa.

A machibidoro iwu na-"DioCore" na cyclosporine, dị ka nke a nwere ike ime ka ihe mgbaàmà na ọnọdụ podagropodobnye giperurikekii.

Specific kwe nkwa na Erere

Ihe i kwesịrị ịma tupu ị na-eji ọgwụ "DioCore solo 160"? Ntuziaka maka ojiji, reviews na-ekwu na n'oge ọgwụgwọ na a gị n'ụlọnga na-enwe ndidi ga-mgbe nile nlekota nke ọbara etoju nke electrolytes ke iyịp.

Na mmepe nke na-emetụta hypotension ga-converted n'ime a kehoraizin ọnọdụ. Ọ bụrụ na achọrọ, mepụta ihe igba ogwu n'akwara infusion nke nkịtị saline. Mgbe kwụsie ike na nsogbu ọgwụgwọ nwere ike gara n'ihu.

Ndị na-unilateral ma ọ bụ bilateral gbasara akụrụ akwara stenosis ndibọbọ valsartan nwere ike ime ka onye na-abawanye na ọbara creatinine ma ọ bụ ọbara urea.

Mgbe na-ekenye ndị agwọ ọrịa ka ọrịa na mkpọchị ọrụ nke akụrụ dose ukpụhọde na-achọrọ, ma na-achọ oge nlekota nke creatinine na uric acid, na potassium ọdịnaya nke ọbara.

E nwere ihe àmà gosiri na thiazide diuretics nwere ike exacerbate systemic lupus erythematosus. ha onwe-ha na-agbanwe glucose ndidi onye ọrịa, dịkwuo ịta nke cholesterol, na uric acid n'ime ọbara triglyceride. Na nke a, ọrịa na-arịa ọrịa shuga nwere ike ịchọ ukpụhọde nke dose nke ọnụ na hypoglycemic mmadụ ma ọ bụ insulin.

Na ọrịa na-agafeghị oke na obere imeju impairment enweghị cholestasis ndị dose ukpụhọde a chọrọ. Ma n'okpuru ọnọdụ ndị a ọgwụ kwesịrị iwere na oké ịkpachara anya.

E nwere akụkọ nke photosensitivity n'oge ọgwụgwọ na thiazide diuretics. Ọ bụrụ na ọ na ọgwụ na nke a pụtara na e nwere a mmeghachi omume nke photosensitivity, ọgwụgwọ a ga-kwụsịrị.

Ọ bụrụ na ọ dị mkpa, ugboro ugboro ochichi nke a mamịrị na-atụ aro iji chebe ngwangwa òkè nke wuru ultraviolet radieshon ma ọ bụ anyanwụ.

ọgwụ analogues

Gịnị nwere ike na-ewere iji dochie anyị n'aka? Dị ọkà yiri Njirimara bụ ọgwụ ọjọọ ndị dị ka "Air-osimiri", "Dentokind", "Intsena", "Cinnabsin", "Softovak", "Medotsef" "Vinblastine-Teva".

Nyocha nkwadebe

Ugbu a, na ị maara otú e si eji ọgwụ ọjọọ, "DioCore 160". Ntuziaka maka ojiji nke a na nkà mmụta ọgwụ e kọwara n'ụzọ zuru ezu n'elu.

Nke a na ngwá ọrụ bụ nnọọ ewu ewu n'etiti ndị ọrịa na dọkịta. Ndị ọkachamara na-na-akọ na ọ dị irè na-egosipụta onwe ya na ọnụnọ nke oké ọbara hyperplasia. Bụghịkwa n'ụzọ zuru ezu na-ekweta na nke a. Dị ka ha na-eme, na-ewere otu mbadamba akwalite mweghachi nke ọbara mgbali, nakwa dị ka ikwado ọnọdụ ha.

Ọ gaghị ekwe omume ka ọ ghara mara eziokwu ahụ bụ na ọgwụ ọjọọ nwere a adaba ụdị nke ntọhapụ na usoro onunu ogwu. Otú ọ dị, na-ewere a elu dose nke ọgwụ ga na-enwe n'ụlọ ọgwụ, n'okpuru nlekọta nke a dibịa.