"Endoxane": ntuziaka maka ojiji, n'ezie na ogbo, na emeputa

Drug "endoxane" na-ezo aka a otu nke mgbochi na-akpụ mmadụ. Dabere na ụdị ntọhapụ ọ ga-ndinọ ọnụ ma ọ bụ parenterally. Olee ụdị ọgwụ inye na na ihe onunu ogwu, doziri naanị dọkịta na ndabere nke ahụ n'ezie ọnọdụ nke ọrịa na-arịa.

The mejupụtara na Njirimara nke ọgwụ

Isi nọ n'ọrụ mgwa nke ọgwụ "endoxane" ntuziaka maka ojiji na-ezo aka cyclophosphamide. Otu mbadamba nwere 50 mg nke ya. The na nkà mmụta ọgwụ na-ezo aka a ìgwè nke antitumor ọgwụ ọjọọ na bụ a biconcave mbadamba na a na-acha ọcha envelopu na isi nke otu hue. Dị ka ndị ọzọ mmiri ifịk ọgwụ ngwaahịa gụnyere calcium carbonate na hydrogen phosphate, sodium karamellozu, glycerol, gelatin, lactose, ọka starch, macrogol, magnesium stearate, polysorbate, sucrose, talc, silica na titanium.

Gịnị bụ pharmacology nke ọgwụ?

Isi nọ n'ọrụ ọgwụ umi, ya bụ cyclophosphamide, alkylating na nwere cytostatic mmetụta. Site na ya agwa, ọ bụ nso mustard gas, nitrogen ịbụ ya analogue.

The usoro nke ihe nke cyclophosphamide dabeere na guzobere crosslinks n'etiti DNA ụmụ irighiri na RNA na protein njikọ n'igbochi ozu.

The pharmacokinetics nke ọgwụ

Isi nọ n'ọrụ mgwa "endoxane" ọgwụ nwere fọrọ nke nta ezu ogo absorbability si eriri afọ tract. Ya ịta na ọbara mgbe onu na igba ogwu n'akwara ochichi bụ otu. Cyclophosphamide metabolism emee isi na imeju, ebe n'okpuru nduzi nke microsomal oxidase usoro bụ guzobe nke nọ n'ọrụ alkylating metabolites. Ụfọdụ n'ime ha na-converted n'ime-adịghị ejekwa ozi iche-iche, ọzọ ìgwè na-kwagara n'ime mkpụrụ ndụ, ebe enzymatic edinam nke phosphatases ghọọ bekee na cytotoxic Njirimara.

Ogo nkịtị nke mbụ ụdị ọgwụ na ọbara na-edozi bụ negligible na bụ 12-14%. Otú ọ dị, otu egosi metabolites ama nhata 60%.

cyclophosphamide emepụta site gbasara akụrụ excretion ukwuu n'ime n'ụdị metabolites. Odika 5-25% nke ọgwụ na-anyụpụ ke akpasarade ụdị ke mmamịrị na bile.

Oke T1 / 2 na ọgwụ ọjọọ nhata 7 awa n'ihi na ndị okenye na 4 awa maka ụmụaka.

Na ihe dose na-na nkà mmụta ọgwụ?

Drug "endoxane" na mbadamba ụdị e jikwa ọnụ tupu nri ma ọ bụ ọkara otu awa mgbe eri, mgbe 2 awa.

N'ihi na eziokwu na-emepụta ọgwụ na ngwaahịa gụnyere ke ukwuu nke chemotherapeutic regimens, nhọrọ mode nke ochichi na onunu ogwu dibịa atụle n'otu n'otu.

"Endoxan" - mbadamba - ndu na-atụ aro na onunu ogwu 1-3 mg / n'arọ ahu arọ kwa ụbọchị, nke nwere ike ịbụ site 50 ruo 200 mg cyclophosphamide ka awa 24. Na oge nke ọgwụgwọ bụ 2-3 izu.

Ọ bụrụ na ọgwụ a na-e ọnụ na ndị ọzọ ọgwụ ọjọọ nwere mgbochi-akpụ Njirimara, na onunu ogwu nke niile ọcha nke ọgwụ dabara mgbazi.

Ga na-ịṅụfe ọgwụ ike ókè?

Ọnụnọ nke a kpọmkwem ngwọta na nkwadebe "endoxane 'ntuziaka maka ojiji na-adịghị enen. Bụrụ na nke-uku chọrọ dose akwadoro maka mmezi ọgwụgwọ dị ka ọgwụgwọ kwesịrị ekwesị nke na-efe efe, ịkwụsị ịṅụ cardiotoxicity na myelosuppression mkpochapu.

Dị ka a na nkà mmụta ọgwụ na-achọkwa na ndị ọzọ ọgwụ ọjọọ eme ihe?

Ọ bụrụ na onye ọrịa na-ewe n'aka akpali iche microsomal ọxịdashọn na imeju, mgbe ahụ jikọtara ọgwụgwọ na ọgwụ "endoxan" ntụziaka egosi ubara njikọ nke metabolites na alkylating ọrụ, ebelata ọkara ndụ nke cyclophosphamide ma na-amụba ya arụmọrụ.

A ọgwụ na-egbochi cholinesterase ọrụ na metabolic ụzọ cocaine, amụba ya toxicity, na-enwekwu ndị arụmọrụ nke suxamethonium.

Ọ bụrụ na "endoxane" eji na njikọ na "Allopurinol" na e nwere mụbara mmetụta ọjọọ ya na ụmị ọkpụkpụ.

N'ihe banyere n'otu oge ọgwụgwọ na cyclophosphamide, colchicine, probenecid, sulfinpyrazone dọkịta na-emekarị na-agbazi dose mgbochi gout ọgwụ ọjọọ. Nke a na-ejikọta ya na n'ihe ize ndụ nke nephropathy na a nkwonkwo ngwa "endoxane" na uricosuric ọgwụ ọjọọ.

Cyclophosphamide ebelata njikọ ihe na imeju, na-ahụ maka ọbara clotting na platelet mmepụta, Otú ọ dị, mgbe ọgwụgwọ na anticoagulants mbelata ọrụ nke ikpeazụ.

Ọrịa na-ewere ọgwụ ọjọọ, "endoxan" ntụziaka ntuziaka na-atụ aro a nri ewepu mmiri grape, ebe ọ nwere mmiri na-emerụ ebighị arụmọrụ na isi n'ọrụ mgwa nke agwọ ọrịa.

Mgbe ngalaba-ndinọ na cyclophosphamide "Doxorubicin" ma ọ bụ "daunorubicin" na-adịkwu cardiotoxic mmetụta nke ndị a ọgwụ ọjọọ.

Nchikota na ndị ọzọ immunosuppressants, dị ka "Azathioprine" "Tacrolimus", "Chlorambucil", "SSC", "Merkapturin" na-eduga onye na-abawanye na omume nke abụọ na-efe efe na akpụ ụdị.

Na ikpe nke na nkwonkwo eji "endoxane" na "Lovastina" na ọrịa na obi transplantation nwere ike ịbụ ihe ize ndụ nke rhabdomyolysis na gbasara akụrụ odida na nnukwu ụdị.

Ọ bụrụ na ọgwụgwọ na cyclophosphamide jikọtara na mielosupressantami ma ọ bụ na radieshon ọgwụ, ọ bụ ike iji nweta ugneeniya ụmị ọkpụkpụ ọrụ.

Imekotaotuugbo n'ikuku "endoxan" na elu-dose cytarabine n'oge preparatory manipulations na ụmị ọkpụkpụ transplantation enwekwu omume nke na-egbu egbu cardiomyopathy.

Olee otú nke a ọgwụ na omumu ọrụ?

Drug "endoxane" ndidi testimonials-egosi ya, pụrụ ịkpasu Vol na ọrịa nke ma sexes, nke nwere ike ịbụ irreversible.

N'ọnọdụ ka ukwuu, nwanyi amenorrhea emee, ma ịhụ nsọ mgbe nile na-emekarị naghachi n'ime ọnwa ole na ole mgbe omume na cyclophosphamide. Ọ bụrụ na ọgwụ e rụrụ na prepubertal ụmụ agbọghọ, deviations na mmepe nke abụọ mmekọahụ ngosipụta na-hụrụ. Ịhụ nsọ bụ nkịtị, ọmụmụ furu efu.

Na ọgwụgwọ nke nwoke ọgwụ "endoxane" ntụziaka na-egosi na ụfọdụ e kọrọ azoospermia ma ọ bụ oligospermia. Nke a bụ n'ihi na ụba mmepụta nke gonadotropins na a ọnụego nke testosterone tọhapụ. libido larịị ma potency na ndị ikom na-adịghị belata. Ọ bụrụ na ọgwụgwọ na cyclophosphamide emepụta prepubertal ụmụ nwoke, na obazovanie sekọndrị mmekọahụ ngosipụta mere kwesịrị. Otú ọ dị, ikpe nke azoospermia, oligospermia na mma nke gonadotropins e kwuru. Ọ nwekwara ike ime testicular atrophy. Ọ bụ uru na-arịba ama na azoospermia bụ reversible, ọ bụ ezie na mgbake nke ọrụ nwere ike ime n'ime afọ ole na ole mgbe ọgwụgwụ nke usoro ọgwụgwọ.

Gịnị bụ mmetụta nke a ọgwụ?

Na-ewere ọgwụ "endoxane 'ntuziaka maka ojiji na-egosi, o nwere ike ime ka ụfọdụ ndị na-anaghị ekwe nke hemopoietic usoro:

• Leukopenia, neutropenia - ezi mgbe.
• Naa nkịtị bụ anaemia na thrombocytopenia.

Mgbe 1-2 izu site na mmalite nke ọgwụgwọ, onye ọrịa gosiri na kacha Mbelata leukocytes na platelet na ọbara. Ndị a kwa na-eweghachi nkịtị n'ime 7-10 ụbọchị nke njedebe nke ọgwụ.

Na ọgwụgwọ na cyclophosphamide nwere ike ime ka n'akụkụ Jeremaya mere nke eriri afọ tract:

• Ọgbụgbọ na vomiting.
• Anorekisya.
• Stomatitis.
• Mgbu na abdominal mpaghara.
• Ifịm ụfọdụ.
• Jaundice.
• Hemorrhagic afọ.

Adịkarịghị ime imeju dysfunction jikọtara ubara ọrụ nke enzymes na bilirubin etoju ebili. Ezi a nnukwu ìgwè ndị ọrịa nwere aplastic anaemia na-enweta elu-dose "endoxane" ma ọ bụ na ijikọta ya busulfan, na-ekwu endoflebit hepatic veins. Nke a na onu nwere ike ime 1-3 izu mgbe ụmị ọkpụkpụ transplantation na-egosipụta na a nkọ na-abawanye na aru uka, ascites, hepatomegaly na hyperbilirubinemia, hepatic encephalopathy.

Tupu ọgwụ nwere ike ime ka ekwesighi Jeremaya mere na akpụkpọ:

• Reversible alopecia.
• Ihe ọkụ ọkụ.
• The pigmentation nke anụ ahụ na mbọ.

Ọ nwekwara ike triggered site a mebiri nke urinary usoro na ọgwụgwọ nke ọgwụ ọjọọ, "endoxane". Ntuziaka, reviews nke dọkịta na ndị ọrịa na-egosi dị iche iche na-ekwu:

• Cystitis tinyere fibrosis eriri afo (ma ọ bụ na-enweghị ya).
• Hemorrhagic urethritis.
• Necrotic phenomena tubule ruo ọnwụ.

Na mmamịrị, onye ọrịa nwere ike ahụrụ site epithelium nke urinary eriri afo. Ọ bụrụ na ụdị nke hemorrhagic cystitis arọ, kwụsị ịṅụ ọgwụ ọjọọ. The kacha mma mgbochi nke ọnọdụ a bụ ọgwụ "Mesna". Ọ bụrụ na "endoxan" dose mụbara, pụrụ ịzụlite akụrụ dysfunction ka nephropathy na giperurekemii.

Ọ bụrụ na onye ọrịa nwere a siri ike ruo n'ókè nke immunosuppression, mgbe ahụ, ọgwụgwọ nke cyclophosphamide nwere ike oké efe efe.

Ọzọkwa nwere ike ịzụlite na-esonụ mmetụta:

• Cardiotoxicity (elu doses), oké ogo obi ọdịda.
• Akpa ume fibrosis, interstitial okike.
• Emeghasịkwa nke spermatogenesis na oogenesis, reversible na irreversible Vol.
• Mmepe nke abụọ ajọ neoplasms dị ka ọrịa cancer nke eriri afo, mieloproliferatsiya na lymphoproliferation.
• Allergy dị ka ọkụ ọkụ, itching, urticaria, mgbe ụfọdụ n'ụdị ihe anaphylactic mmeghachi omume.
• Ogbenye ọnya na-agwọ ọrịa.
• Ihu flushing, sweating, isi ọwụwa.

Ịdị adị nke oké njọ mmetụta si ewere ọgwụ na-mgbe na-ewelite ajụjụ banyere omume uru megide omume ize ndụ n'ihi na onye ndidi.

Nke ọrịa nye iwu a ọgwụ?

Mbadamba "endoxan" nwere ike ikenye ọrịa ma ọ bụrụ na o nwere ndị na-esonụ ọrịa:

• Hodgkin oria.
• Multiple myeloma.
• Ara cancer.
• Ajọ lymphoma na nnukwu ma ọ bụ ala ala ụdị.
• Non-Hodgkin si lymphoma ụdị.
• Retinoblastoma.
• Neuroblastoma.
• Mycosis gribkovidnogo agwa.

O na-egosi ga-anabata na nke ngwa na mgbagwoju anticancer ọgwụ mmasị ka ọgwụ ọjọọ, "endoxane" ntụziaka. The emeputa na-atụ aro na ọ na-agụnye na ọgwụgwọ nke cervical cancer na eriri afo cancer, ọrịa cancer akpa ume na prostate cancer, sarcomas na reticulosarcoma, ọrịa Ewing na Wilms.

The ọgwụ cyclophosphamide dabeere ike ga-eji dị ka immunosuppressant nwayọọ autoimmune ọrịa ndị dị ka, psoriatic na ọrịa ogbu ogbu na nkwonkwo, haemolytic anaemia, collagen ọrịa, nephrotic syndrome, nakwa dị ka zere aka jụrụ.

Mgbe ọgwụ ọjọọ na-contraindicated?

The agwọ ọrịa "endoxan" nwere a ibu contraindications, gụnyere:

• Pregnancy na lactation.
• Cystitis.
• Efe efe na-arụsi ọrụ ike ụdị.
• Mebiri nke ụmị ọkpụkpụ ịrụ ọrụ akpọ ụdị.
• Ọnụnọ nke hypersensitivity ka ndị bụ isi na ndị ọzọ ọgwụ bekee.
• urinary njigide.

Special elekọta dọkịta idepụta ọgwụ na ọrịa obi, akụrụ na imeju na, oké, gout, adrenalectomy, ọnụnọ nke infiltration Filiks ke ụmị ọkpụkpụ, nefrourolitiaze.

Specific nduzi na ọgwụgwọ nke

N'oge ingestion "endoxan" n'okpuru iwu akara ọbara (neutrophils na platelet ọnụ) na mmamịrị (ọnụnọ nke mkpụrụ ndụ ọbara uhie) nke a ndidi.

ọ na-atụ aro ka a kwụsị ọgwụgwọ "endoxane" pụtara na ụfọdụ. Ntuziaka na ojiji nke ọgwụ na-atụ aro na-eme otú n'okpuru ndị na-esonụ ọnọdụ:

• Ediyarade egosi cystitis.
• Ẹsụhọde ịta nke leukocytes na platelet na oké egwu ụkpụrụ.
• Omume nke ọrịa (dose mgbazi bụ omume).

Ọ bụrụ na "endoxane" na-eji na elu doses, onye ọrịa na-kenyere ọgwụ, "Meena" maka mgbochi nke hemorrhagic cystitis ụdị.

Na ọgwụgwọ na a ọgwụ kwesịrị izere-aṅụ mmanya na-eji a pụrụ ịdabere na ụzọ nke igbochi afọ.

Ọ bụrụ na onye ọrịa na-kenyere "endoxan" maka 10 ụbọchị mgbe ịwa ahụ na izugbe ná Nkụnwụ Ahụ, nke nkụnwụ na-asian banyere nke a.

Mgbe adrenalectomy rụrụ a dose ukpụhọde "endoxane" na ndị ọzọ ọgwụ ọjọọ corticosteroids.

ọgwụ analogues

Ọ bụrụ na e nwere oké njọ contraindications na ihe ize ndụ, mgbe ahụ, e nyere na-enye elu na-ewere ọgwụ na "endoxane" ntụziaka. Analogs nwere ike kenyere onye dọkịta dị ka a kwesịrị ekwesị ọzọ. N'etiti ha:

• "Ledoksin".
• "Cyclophosphamide".
• "Cytoxan."
• "Cyclophosphamide - Teva".
• "Cyclophosphamide -Lens".
• "Endoxane - Astana".

Nke a na ozi bụ a mfe version of ntuziaka ka ọgwụ "endoxane". Nzube nke a ọgwụ e mere naanị site ịga dibịa.