Ọgwụ "Ursodez" - ntuziaka maka ojiji. Mbadamba "Ursodez": analogs na reviews

Drug "Ursodez" - hepatoprotective ọgwụ. Ọ nwere choleretic agwọ ọrịa, hypolipidemic, holeliticheskoe edinam, nwere hypocholesterolemic na immunomodulating mmetụta negligible. Active umi - ursodeoxycholic acid. The ọgwụ nwere dịghị onunu ogwu ụdị "mkpụrụ ọgwụ". "Ursodez" na-emepụta n'ụdị capsules.

ọrụ usoro

N'ọrụ ọgwụ umi nwere ike na-webata akpụkpọ ahụ nke hepatocytes, kwụsie ike ya Ọdịdị. Dị ka a N'ihi ya, mkpụrụ ndụ na-echebe site na-enye nsogbu n'obi ihe, ọrụ nke bile acid salts. The ọgwụgwọ mmetụta nke ọgwụ Egosipụta otú ẹsụhọde a cytotoxic mmetụta. Against ndabere nke cholestasis activates Ca2 + dabere protease Alfa-kpaliri exocytosis. Pụtara "Ursodez" (User ngwa na-egosi na ọ) ukwuu ebelata nsí bile asịd (deoxycholic, lithocholic, chenodeoxycholic na ndị ọzọ) na elu kasịnụ ke ọrịa na hepatic pathologies na-adịghị ala ala N'ezie.

Mgbe anata ọgwụ akara ọnụ ke cholesterol njikọ na secretion, mgbochi nke ya absorption na eriri afọ. N'ihi na nke a, ọ mbelata saturation nke bile na a compound. The nkwadebe nwere ikike competitively ibelata absorbability nke lipophilic asịd na eriri afọ, na-amụba ha fractional ntụgharị ala enterohepatic mgbasa. Ọgwụ akpali excretion of asịd, mụbara Itie.

The usoro nke edinam nke ọgwụ na-dabeere na screening nonpolar bile asịd. N'ihi nke a na-egbu egbu mbuaha micelles. Pụtara Njọ na biliary usoro, solubility nke cholesterol, akawanye mmepụta na secretion nke bile. The ọgwụ na-ebelata ya lithogenicity, enwekwu ịta nke asịd, si otú akpali iche na-abawanye na ọrụ nke pancreatic na gastric secretion.

Mgbe anata capsules nwere zuru ezu ma ọ bụ ele mmadụ anya n'ihu na mgbasa nke nkume. Site mbenata bile cholesterol saturation enwekwukwa nchikota ndi mmadu di nke nkume. Immunomodulatory ọrụ na-gosipụtawo n'ihi na mmetụta na iche mmeghachi omume site imeju. The ọgwụ na-ebelata ihe ngosipụta nke a ọnụ ọgụgụ nke histocompatibility abụkwara. The agwọ ọrịa nwere mmetụta na larịị nke T-lymphocytes, ọnụ ọgụgụ nke eosinophils.

Pharmacokinetics n'aka

Absorption nke ọgwụ "Ursodez" (ntụziaka ntuziaka na-egosi nke a) na obere eriri afọ rụrụ site a usoro nke n'ezinụlọ mgbasa. Amịpụtara na banyere 90% nke nọ n'ọrụ akụrụngwa. Na ileum umi na-etinye obi gị dum site na-arụsi ọrụ ike iga. The kasị elu ọdịnaya nke nọ n'ọrụ akụrụngwa esịmde dị ka otu awa. The compound nwere nnukwu pasent nke nkịtị protein - 99%. Ursodeoxycholic acid bụ ike banye n'ime Plasenta.

The ọgwụgwọ nrụpụta ọrụ nke ọgwụ na-adabere na ịta nke nọ n'ọrụ mgwa na bile. Na mgbe Ịhazi ndibọbọ a bile acid na-aghọ ihe bụ isi ọbara. ursodeoxycholic acid ịta bụ banyere 48%.

The compound na-metabolized, ọ na-agabiga imeju mkpụrụ ndụ. N'ihi ya, kpụrụ glycine na taurine conjugates. The ire ere ngwaahịa na-secreted n'ime bile. About 50-70% natara ọgwụ ọ na-anyụpụ na na nsị. A obere ego nke ọgwụ na-ebu n'ime colon. E nwere ya na-kewaa site n'oru nke bacteria (7-dehydroxylation).

Lithocholic acid, nke na-kpụrụ site na usoro a, na-doro a ele mmadụ anya n'ihu absorption eriri afọ nke nnukwu, ma na-aga sulfation na imeju na-na-anyụpụ ka sulfolitoholiltaurinovogo ma ọ bụ sulfolitoholilglitsinovogo conjugate.

na-agba akaebe

Medicine "Ursodez" na-atụ aro ka a symptomatic ọgwụ ndị bụ isi biliary imeju enweghị ihe ịrịba ama decompensation. Igosipụta a n'aka igbari ọkara na obere cholesterol nkume, na-arụsi ọrụ ike gallbladder. Prescribers na biliary reflux mgbu.

contraindications

Pụtara "Ursodez" ntụziaka na ngwa adịghị ekwe ka na-aga ma ọ bụrụ na onye ọrịa rentgenpolozhitelnyh (elu ịta nke Ca2 +) gallstones ekweghị ibe nọrọ agwọ ọrịa mmiri. Contraindications gụnyere imeju ke nzọụkwụ decompensation owụt ọrịa nke pancreas, akụrụ. Na-atụ aro iji ọgwụ maka ndị mmadụ na-abụghị na-arụ ọrụ ńsí eriri afo, nnukwu mkpali pathologies nke ya agwa, dị ka nke ọma dị ka bowel ọrịa na bile duct. Ekwela idepụta ọgwụ ime na nwa ara na. Pụtara contraindicated n'ihi na ndị okenye na ụmụaka erikpu erughị 34 n'arọ.

mmetụta

Mgbe ụfọdụ, ịzụlite achọghị mmetụta mgbe na-ewere ọgwụ, "Ursodez". Ntuziaka maka ojiji na aka nke-ekwe omume nke ọgbụgbọ, afọ ọsịsa, vomiting. Na ala omume nwere ike na-etolite calcified gallstones. Amplification imeju transaminase ọrụ, abdominal mgbu, nfụkasị Jeremaya (gụnyere urticaria) nwekwara ekwesighi pụta ingestion "Ursodez".

Nleba egosi ezi tolerability. Isiokwu na dọkịta prescriptions mmetụta na-eleghi anya. Mgbe ụfọdụ, n'oge ọgwụgwọ nke biliary imeju hụrụ na-akwụsị akwụsị decompensation. Dị ka a na-achị, a onu naanị nọgidekwara mgbe discontinuation nke ọgwụ.

Drug "Ursodez". Price. ntụziaka

Pụtara na-ewere mgbede. The kwa onunu ogwu maka dissolving nkume - nkezi nke 10 mg / n'arọ. N'ihi ndị na-erikpu ruo 60 n'arọ ya kwekọrọ 2nd capsules kwa ụbọchị 81 kg- 3-m, 100 kg - 4 ọzọ 100 - 5. Duration - si ọnwa isii ọnwa 12. Mgbe dissolving nkume iji gbochie guzobe ọhụrụ atụ aro oriri ọzọ ọtụtụ ọnwa.

Ọgwụgwọ biliary imeju rụrụ na a dose nke 250 mg / ụbọchị. Duration nke N'ezie - 10-14 ụbọchị. ruo ọnwa isii. Mgbe ụfọdụ, oge nke ọgwụ na-ụba na-afọ abụọ. Dị ka a symptomatic ọgwụgwọ agwọ ọrịa ndinọ 10-15 mg / ụbọchị. Mgbe uka na 34 n'arọ aro n'aka kwụsịtụrụ ụdị. The na-eri nke ọgwụ na Capsule ụdị - si otu narị rubles.

Ọ na-eme ọ pụtara "Ursodez" ogbo?

Ọgwụ ndị na-ebu otu ihe ahụ nọ n'ọrụ umi, mepụtara nnọọ ọtụtụ. Otu n'ime ha ọ bụ uru banyere dị otú ahụ dị ka "Ursodoksa", "Ursol". Otu n'ime ndị kasị ewu ewu bụ ọgwụ "Ursosan". Egosi maka ojiji nke ọgwụ bụ dịtụ nabatara umu. Karịsịa, ọ na-ndinọ na cystic fibrosis imeju skleroziluyuschem cholangitis-adịghị ala ala ụdị.

Ọtụtụ ndị ọrịa bụ ndị nwere mmasị na ihe mma nkwadebe "Ursodez" ma ọ bụ "Ursosan". Ọ ga-kwuru na dọkịta họrọ otu ma ọ bụ ndị ọzọ na-esi dị na ọdịdị, N'ezie nke daa ọrịa na-enwe ndidi na-anabata ọgwụ ahụ. Na ọrịa na nke imeju, na gallbladder na-adịghị ukwuu tụrụ aro onwe. Tupu ewere ọgwụ ọ bụla ị chọrọ nnyocha na oge na a ọkachamara.

Nlekota irè nke ọgwụgwọ a ga-rụrụ ọ bụla 6 ọnwa. A na njikọ ya na-kenyere a mgbe nile ultrasound na X-ray ule n'afọ mbụ nke ọgwụgwọ. Ọ bụrụ na ọnwa isii mbụ nke mgbasa nke nkume emeghị, ọ bụ eleghị anya n'ihu nke N'ezie impractical ruru inefficiency.

na ozi ndị ọzọ

Iji hụ na ihe ịga nke ọma na mgbasa nke nkume ọ dị mkpa na nkume ndị na cholesterol, ma ha size adịghị gafere 15 ma ọ bụ 20 millimeters. N'otu oge ahụ jupụta na ńsí eriri afo ga-adị ọzọ karịa ọkara, na biliary tract ga-ejigide ya ọrụ kpam kpam.

Na ikpe nke na-aga ruo ogologo oge ọgwụgwọ, ihe karịrị otu ọnwa, ọ dị mkpa na-ebu a Biochemical nnwale maka atụle ọrụ nke transaminases na imeju. Ọzọkwa, ọ ga-achịkwa ịta nke bilirubin na ndị ọzọ na ogige. kwụsị ịṅụ "Ursodez" pụtara ma na-elu arụmọrụ. Nyocha nke ọtụtụ ndị ọkachamara na Otú ọ dị, nke oma ihe banyere ịdị irè nke ọgwụ.

ọgwụgwụ

Ọ bụrụ na ọ dịghị N'ihi nwere ike kenyere ọzọ agwọ ọrịa ma ọ bụ ọgwụgwọ atụmatụ deghar. N'ihu iji ngwaahịa kwesịrị emehe ye annotation.