Epinephrine hydrochloride: ntuziaka maka ojiji, a nkọwa nke nkwadebe

A nkọ ọnụ ke ọbara mgbali dị ka a n'ihi nke allergies, ọgwụ overdoses ma ọ bụ ọzọ na-akpata nwere ike ime ka irreversible pụta na ahu na ọbụna ọnwụ. Iji ụbọchị, omume nke na nkà mmụta ọgwụ na-ewepụ ọrịa si na steeti a na-eji adrenaline hydrochloride. Ọ na, dabere complexity nke ọnọdụ, ndị ọrịa na-ndinọ subcutaneously, intramuscularly ma ọ bụ intravenously, na ihe ndị kasị oké ikpe - intracardiac.

pharmacological mmetụta

The isi mmetụta nke ọgwụ na-na metụtara mmetụta na A- na b-adrenergic anabata, na n'ọtụtụ ụzọ, o yiri akwara eriri excitation mmetụta. Mgbe ndinọ ka epinephrine hydrochloride akwalite vasoconstriction niile abdominal akụkụ na n'omume skeletal uru. N'ihi dị otú ahụ gụnyere ya ná lumen ọbara ọwa emee abawanye na ọbara mgbali.

Otú ọ dị, ọ ga-ahụ kwuru na mmetụta nke adrenalin mmetụta na ozu, n'ihi na mmetụta na b-adrenergic anabata, obere mgbe nile tụnyere noradrenaline. Uma nke mgbanwe nke obi ọrụ bụ nnọọ mgbagwoju. Mgbe mmetuta nke adrenergic anabata na-eme ka ndị ọzọ Ugboro na ụba obi ọnụego, na n'otu oge ahụ, mgbe ọbara mgbali adahade, etiti bụ obi ụtọ vagus akwara, nke na-egbochi ndị ọrụ nke obi. Ọ bụ ya mere n'oge hypoxia anamde ibọ ọgwụ nwere ike ime ka arrhythmia.

Ke adianade do, ọgwụ na-akpata akwụkwọ dilation, ntụrụndụ nke uru ahụ nke eriri afọ na bronchi. Ọ na-egosi na ọrịa na-accelerated anụ ahụ metabolism na glucose adahade na ọbara mgbe a otu dose of a ngwá ọrụ ndị dị otú ahụ dị ka epinephrine hydrochloride. Ntuziaka maka ojiji na e dere ozi banyere na ọgwụ weghachiri ọtọ ike nke skeletal muscle anụ ahụ, gụnyere na ike ọgwụgwụ.

Banyere Central ụjọ usoro, ọgwụgwọ dose nke ọgwụ, dị ka a na-achị, na-adịghị a akpọ mmetụta na ya.

Iji gosi ọgwụ?

Jiri nke epinephrine hydrochloride na a nkọ ọnụ ke ọbara mgbali (dị ike na ọnọdụ onye ọrịa a na-akpọ ida). Bilie dị otú ahụ a nsogbu nwere ike ịkpata a mmadụ ovadozu ọgwụ, ọtịta ahụhụ na nnukwu nfụkasị Jeremaya.

Ọzọ na-egosi maka ọgwụ - hypoglycemia, nke na-adị mgbe ihe ovadozu nke insulin. Na steeti a, onye ọrịa na-ngwa ngwa idobe ọbara mgbali bụghị naanị arụmọrụ, ma larịị nke ọbara sugar.

Na ophthalmology ọgwụ kenyere ka ọrịa na ụba intraocular nsogbu (glaucoma). Na ENT omume ọ na-eji dị ka a vasoconstrictor.

Tụkwasị na nke a na-egosi, epinephrine hydrochloride na-ndinọ ka ọrịa na ventricular fibrillation.

dosing usoro na usoro nke eji

Dabere na ọrịa na ya ogo ọgwụ onye ọrịa nwere ike na-egosi subcutaneously, intramuscularly na intravenously. N'ihi ya iji 0.1% ngwọta nke 0,2 / 0.3 / 0,5 ma ọ bụ 1 ml. Ọrịa na nnukwu gbasara obi njide ndinọ 1 ml nke nkwadebe, otu dose na-eji, na ventricular fibrillation. Ọ ga-kwuru na-ekesa circuit ahọrọ naanị ndị dọkịta maka nke ọ bụla.

Na ophthalmology nweta obodo vasoconstrictive mmetụta nke epinephrine hydrochloride na-etinyere na mucous membranes nke anya.

Bronchial ụkwara ume ọkụ cropped ọgwụ ochichi subcutaneously na 0.3 - 0,5 - 0,7 ml. Ma, dị ka ọgwụgwọ doses nke epinephrine ngwọta maka parenteral ojiji, mgbe ahụ, dị ka a na-achị, ha na-chepụtara maka okenye ọrịa 0.3 - 0,5 - 0,75 ml. Nwa ọhụrụ, na ọ bụrụ na ọ dị mkpa ngwa nke a agwọ ọrịa dị ka afọ na-ndinọ 0.1-0.5 ml.

The mejupụtara nke ọgwụ

Epinephrine hydrochloride dị ọcha ụdị bụ a ubé pink ma ọ bụ na-acha ọcha crystalline ntụ ntụ. N'okpuru nduzi nke oxygen na ìhè bụ ike ịgbanwe ya. Otú ọ dị, ndị dị otú ahụ ụdị, nkwadebe na-adịghị nyere n'ji. Tupu ọ ga-eji na-agwọ ọrịa na aseptic ọnọdụ ọgwụ ụlọ mmepụta ihe ọ na-jiriwo a ngwọta nke hydrochloric acid. Eji pharmacists dị ka nchekwa sodium metabisulphite na chlorobutanol.

Nanị mgbe na pharmacies, ọrịa nwere ike nweta epinephrine hydrochloride solution, n'ụzọ zuru ezu njikere maka ojiji.

Hapụ ụdị ọgwụ

Ka ụbọchị, ọgwụ dị naanị na n'ji n'ụdị 0,1% ngwọta nke dị na vials na ampoules. First Volume nke 30 ml, ma nke abụọ - naanị 1 ml. Ampoules nke 6 PC. packaged ke katọn igbe.

Anya ya yiri ihe ngwọta bụ kpam kpam uzo mmiri mmiri, ọ dịghị ịkpali na nerastvoronnyh dị iche iche ọcha.

A ọgwụ na-contraindicated?

Ọ bụrụ na anyị na-atụle na isi na-egosi maka ojiji nke ọgwụ ọjọọ eme ihe - na-abawanye na ọbara mgbali ruru ka ibelata nke ọbara arịa, ọ bụ ihe ezi uche na ya nnọọ ike ga-eji na hypertensive ọrịa. Ọzọkwa pụtara machibidoro na atherosclerosis, hyperthyroidism na-arịa ọrịa shuga, n'ihi na pharmacological mmetụta nke ọgwụ nwere ike ọ bụghị naanị na njọ n'oge n'elu kwuru banyere ọrịa, ma na-eduga nnọọ ize ndụ pụta. Ka ihe atụ, myocardial infarction, ọrịa strok na ndị ọzọ.

Ọ gbasaghị epinephrine hydrochloride na n'oge awa ahụ arụmọrụ, cyclopropane ma ọ bụ halothane ná Nkụnwụ.

Ọ kwesịkwara kwuru na ọgwụ a machibidoro kpam kpam n'oge ime na lactation. Na na njikọ na ọgwụ "Oxytocin" ọgwụ ọjọọ na-eduga ná ụba toxicity.

mmetụta

N'agbanyeghị eziokwu na na ọtụtụ ọrịa ọgwụ nwere ike ịzọpụta onye ọrịa ahụ ndụ, dị nnọọ ka o yiri, na ọ nwere ike na-ewute ma ọ bụrụ na ị na-gaa na akaụntụ onye e ji mara onye ọrịa ma ọ bụ gafere na allowable dose.

Ya mere, ọbụna mgbe na-eji nke ọma, ọgwụ a nwere ike ịdị onye dizziness, nchegbu, ịma jijiji, nchegbu na n'ozuzu ike. Ke adianade do, a ndidi mgbe ochichi nke ọgwụ pụrụ hụrụ pallor (n'ihi vasoconstriction), ọsụsọ na-agba na-akwụsị akwụsị na-abawanye na ọbara mgbali. Otú ọ dị, oghom mgbaàmà, n'ihi na nke obere oge, ọ dịghị achọ ka a ọgwụ na mgbazi ma ọ bụ zuru ezu abolition nke ọgwụ.

Ndị ahụ e gosiri adrenaline hydrochloride, ntụziaka ntuziaka adọ aka ná ntị banyere omume mmepe nke gbasara obi arrhythmias, tachycardia, a nkọ ọbara mgbali elu. Na ọrịa na akwara akwara ọrịa ndị na-eji ọgwụ na-enwekwu ihe ize ndụ nke rịaworo ọgụ.

ovadozu

Onye ọ bụla maara na nkà mmụta ọgwụ na ọgwụ na-atụ anya na-eji na kpọmkwem usoro onunu ogwu na naanị na ndenye ọgwụ. Ma ọ bụghị ya, onye ọrịa ahụ ike na ili ize ndụ. Na epinephrine hydrochloride bụghị isịneke.

Mgbe uku na ime onunu ogwu ngwọta (ọbụna mgbe ndinọ subcutaneously) a ọrịa ozugbo amalite ngwa ngwa mydriasis na ụba ọbara mgbali. Ke adianade do, budata quickens obi ọnụego, nke na ụfọdụ na-enwe ọganihu na ventricular fibrillation. Ma ọ bụrụ na onye ọrịa ike dịkwuo ndị hydrostatic mgbali na ndị kasị nta na ọbara arịa na permeability nke akpa ume capillary mgbidi, nwere ike ịzụlite akpa ume edema arọ.

Olee otú igbochi mmetụta ọjọọ nke ọgwụ?

Ịgbasi Mgba Ike na a ọnụ ọgụgụ nke oghom omume nke adrenalin antagonistically eme via α- na β-blockers. A na-agụnye "Inderal" ọgwụ "Tropafen", "Phentolamine" na ndị ọzọ. Ọtụtụ mgbe ndị dọkịta na-ewepụ mmetụta nke adrenaline na ngwa ngwa iji nitrites. Otú ọ dị, ojiji nke n'elu iche iche nke ọgwụ bụ nanị nti mgbe ìhè Nleta a usoro nke mmetụta dị otú ahụ dị ka adrenaline hydrochloride (usoro bụ: 1-1- (3,4-dihydroxyphenyl) -2-methylaminoethanol hydrochloride).

Ọ bụrụ na onye ọrịa mgbe eji a ọgwụ hụrụ njọ nsogbu ndị dị otú ahụ dị ka ventricular fibrillation ma ọ bụ ọtụtụ akpa ume edema, elu-ọsọ ngwa nke nitrite na-ezuru dị iche iche blockers. Maka nzọpụta nke ndị ọrịa na ndị a, ndị dọkịta na nakweere a mgbagwoju ọgwụ, nke nwere ike na-agụnye ọbụna eletriki defibrillation nke obi.

Ọnọdụ nke ọkọnọ nke ọgwụ

Ọ bụ naanị ezi uche na nkà mmụta ọgwụ bụ nkà mmụta ọgwụ dabeere na adrenaline machibidoro free ere ka ọgwụgwụ onye ọrụ. Mgbe onwe pụtara data pụrụ iduga-ezighị ezi pụta ibu ọbụna na ike nnabata ya na dosing usoro. Ke adianade do, ụfọdụ ọrịa na iwebata a obere ego nke ihe adrenaline hydrochloride (okwu na-agba akaebe na nke a) oké anabata nwere ike ime.

Ya mere, tupu ị na-aga ahịa ọgwụ maka ndị a ọgwụ ọjọọ eme ihe, ị kwesịrị ịkpọ onye dọkịta ndị ga-ede a ọgwụ. Ọ bụ akwụkwọ a, bụ nke nwere ozi na nọmba na onunu ogwu nke ọgwụ, na ọgwụ ga-ọkọnọ mgbe ịzụta ọgwụ.

ọgwụ interactions

Dọkịta nile maara na ojiji nke adrenaline na dị iche iche symptomatology na-nditịm ajuru aju. Mgbe niile, ndị dị otú ahụ a Nchikota nwere mmako mmetụta na-eduga ná igbu egbu.

Unu na-eji nke a ọgwụ maka ọgwụgwọ nke ọrịa ndị na-ewere ọgwụ ụra na narcotic analgesics. Ke adianade do, allergies, nke n'usoro eji Antihistamines, ọ bụla dọkịta, kwa, jụ dee a ọgwụ. Adrenaline hydrochloride na nke a abụghị naanị a ike odachi - o nwere ike ịbụ na-egbu egbu.

Ekwegh Nchikota ọgwụ na inhalation anestetiiki, dị ka nke a nwere ike na-eduga mmepe nke mgbagwoju gbasara obi ọrịa a ndidi.

analogues na nkà mmụta ọgwụ

N'ihi na eziokwu na ndị ọkà mmụta sayensị adịghị akwụsị na-enweta ihe na-anọgide na-arụ ọrụ na ihe e kere eke nke ọhụrụ ọgwụ ọjọọ eme ihe na-esi n'aka epinephrine hydrochloride maka taa ugbua nwere otu nnukwu ndepụta analogues. Otú ọ dị, na oke nke ọgwụ ọjọọ, yiri ke edinam na adrenaline, a rụrụ nanị site na ịga dibịa. Na nke a, ndị ọkachamara na-eduzi ọ bụghị nanị na ọdịdị na ogo nke ọrịa ọrịa, ma na-elebara ha n'otu n'otu e ji mara.

Dochie epinephrine hydrochloride dibịa nwere ike ọgwụ ọjọọ eme ihe ndị dị otú ahụ dị ka "Epinifrin", "Tonogen", "Glaukozan" "crank hydrochloride" "Suprarenalin" "Epinephrine hydrochloride," "Levorenin", "Eppie", "Renostiptitsin", "Suprarenin" "glauconite", "Epirenan", "Adrenamin", "Gipernefrin", "Stiptirenal", "Paranefrin", "Glaukonin" et al.

N'agbanyeghị ihe ndepụta nke ogbo, onye kwesịrị na-eche na ha nwere ike ịbụ kpamkpam na-azụta ke ahịa ọgwụ. Site ịzụta adrenaline hydrochloride, a ọgwụ na Latin a chọrọ iji gosi na ọgwụ. Otu a chọrọ ma ọ bụrụ na ị chọrọ ịzụta ọ bụla dị n'elu ọgwụ.