"Gordoks": egosi maka ojiji, contraindications, reviews

Gịnị bụ ọgwụ "Gordoks"? Egosi maka ojiji nke ngwá ọrụ ga-ọkọnọ n'okpuru. Anyị na-agwa gị banyere ụdị nke na ọgwụ a na-tọhapụrụ, ma ọ bụrụ na ha nwere ihe ọ bụla contraindications, otú ọ ga-ekwesị na-eji, ihe mmetụta nwere ike ime mgbe ngwa, na na.

Hapụ ụdị ọgwụ, nkwakọ ngwaahịa na mejupụtara

Na ihe ụdị ike ịzụta ọgwụ "Gordoks"? Egosi maka ojiji nke ngwá ọrụ ndị dị otú ahụ na ọ kasị dị irè naanị mgbe ndinọ intravenously. Ya mere, nke a ọgwụ naanị wepụtara na 10 ml vials na a ngwọta.

N'ọrụ akụrụngwa nke gị n'ụlọnga bụ aprotinin. Drug na-agụnye inyeaka mmiri dị ka mmiri maka ogwu ogbugba, benzyl mmanya na sodium chloride. Otu katọn igbe bụ 25 ampoules.

The pharmacological Njirimara nke ọgwụ

Gịnị mere m mkpa ọgwụ "Gordoks"? Egosi maka ojiji nke ngwá ọrụ a na-agụnye ọrịa nke digestive usoro. N'ọrụ ọgwụ akụrụngwa nwere antiproteoliticheskoe, hemostatic na antifibrinolytic mmetụta. Ọ bụ irè ọrịa nke pancreas. Ọzọkwa, a na ọgwụ bụ ike ịrịba belata fibrinolytic ọrụ nke ọbara. Ọ bụ mgbe e kenyere ka a mgbochi ọgwụ niile ụdị nke na-ekwu nke na-akpata.

Ụkpụrụ nke ọrụ ụlọ ọgwụ

Gịnị bụ ihe ngwọta "Gordoks"? Iji na ụmụaka na ndị okenye ga-eme naanị na ndenye ọgwụ. Nke a bụ n'ihi na eziokwu na-arụsi ọrụ ike iji ọgwụ bụ ihe inhibitor nke proteolytic enzymes nwere antifibrinolytic Njirimara.

Mgbe e guzobere stoichiometric okụre reversible ọgwụ nọ n'ọrụ umi-egbochi ọrụ nke anụ ahụ na plasma kallikrein, plasmin na trypsin. Dị ka a n'ihi nke ndị dị otú ahụ n'ebe a na-ebelata fibrinolytic ọrụ nke ọbara.

E wezụga, aprotinin bụ ike nke na rụọ ọrụ na kọntaktị na-adọ nke coagulation ibelata ọtụtụ ndị ogbugbo attenuate mkpali Ibọrọ, mbenata thrombin ọgbọ na fibrinolysis.

Gịnị na-eji nkà mmụta ọgwụ "Gordoks"? Egosi gụnyere ịwa ahụ aka. Site na nke a pụtara belatara ọbara ọnwụ na mkpa maka mmịnye.

Pharmacokinetics nke ọgwụ

Otú ngwa ngwa eme ọgwụ ọjọọ, "Gordoks"? The ojiji na ọgwụgwọ ọrịa anụmanụ na nkà mmụta ọgwụ na ọgwụ na-egosi na mgbe igba ogwu n'akwara ochichi nke nọ n'ọrụ mgwa ịta n'ime ọbara ngwa ngwa mbelata ruru ka ọgwụ na-ekesa na extracellular ohere. The mbụ ọkara ndụ nke ọgwụ a hụrụ na 0.4-0.8 awa ikpeazụ - mgbe 5-10 awa.

Communication plasma protein bụ 80%.

Aprotinin n'ụzọ accumulates na akụrụ, na a nta na - na cartilage anụ ahụ. The ìgwè nke ọgwụ na akụrụ rụrụ ruru ya nkịtị na epithelial sel nke gbasara akụrụ tubules. Ma ìgwè ke anụ ahụ nke cartilage, nke a bụ n'ihi na mmekọrita nke aprotinin, nke bụ, n'eziokwu, bụ ha isi.

The ìgwè nke nọ n'ọrụ mgwa nke ọgwụ na ndị ọzọ na akụkụ tụnyere ya ịta na plasma. The kasị ala pasent a hụrụ na ụbụrụ. Ọ kwesịkwara kwuru na a ole na ole nke aprotinin nwere ike iru site placental mgbochi.

Active ọgwụ akụrụngwa metabolized na akụrụ (lysosomal enzymes) na-adịghị ejekwa ozi metabolites. The obere ego nke aprotinin na mmamịrị mmepụta.

Ọgwụ "Gordoks": egosi maka ojiji

Nyocha banyere ngwá ọrụ a, anyị ga-ewetara n'okpuru. Banyere nke a na ngalaba nke isiokwu, mgbe ahụ, ọ ga-achọ ịgwa gị banyere ihe a na-ewere a na nkà mmụta ọgwụ kenyere ka ọrịa.

N'ihi ya, na-egosi maka ojiji nke a ọgwụ na-na-esonụ enweghị nchịkwa ọnọdụ:

• na-adịghị ala ala pancreatitis (ọgwụ etinyere na Ugboro nlọghachi, nakwa dị ka ndị dị oké ọrịa);
• pancreatitis na nnukwu ụdị (a na nkà mmụta ọgwụ na-eji naanị na mgbagwoju ọgwụ);
• pancreatitis, nke mepụtara ka a n'ihi nke unan ma ọ bụ usoro ịwa ahụ;
• pancreatic;
• mbụ ọbara ọgbụgba na mere megide backdrop nke hyperfibrinolysis (mgbe ịwa ahụ, a dịgasị iche iche nke unan, mgbe nnyefe na n'iru ha, mgbe polimenoree);
• dị ka a mgbochi ụfọdụ nonspecific postoperative mumps;
• angioedema;
• achọpụta ọrịa ule na pancreas, na ịwa ahụ;
• ịrịba ama nke ujo (e.g., na-egbu egbu, na-akpasasị uche ma ọ bụ hemorrhagic);
• Dị iche iche anụ ahụ mmerụ (sara mbara ma miri).

Mere ka na-eji ọgwụ "Gordoks"? Egosi maka ojiji na-agụnye, na ndị dị otú ahụ ndiiche dị ka coagulopathy, n'oge nke e nwere oké ọbara ọgbụgba na sekọndrị hyperfibrinolysis (dị ka adjuvant ọgwụ).

Anyị apụghị ikwu na ngwá ọrụ a na-arụsi ọrụ ndinọ maka prophylactic ọgwụgwọ nke na-agba ọbara mgbe ịwa ahụ na akpa ume embolism.

Contraindications ojiji nke a na nkà mmụta ọgwụ

Mgbe ụfọdụ, i nwere ike iji ọgwụ ọjọọ "Gordoks"? Ngwa nke pancreatitis emee ihe mgbe mgbe, nke a bụ isi ihe na-egosi. Banyere contraindications, mgbe ahụ, ha bụ ndị a:

• hypersensitivity onye ọrịa ma ọ bụ ike akpọ nfụkasị Jeremaya na-arụsi ọrụ ike iji ọgwụ umi (i.e. aprotinin);
• ndị mbụ na-atọ trimesters nke dị ime;
• n'oge ara.

Ọ kwesịkwara kwuru na ọgwụ na ajụjụ a ga-eji na-ekwesịghị n'oge gbasara obi njide n'ihi na n'ihe ize ndụ nke gbasara akụrụ odida, miri hypothermia, nakwa dị ka anataghi (mgbe gara aga ọgwụ aprotinin).

Drug "Gordoks": ntuziaka maka ojiji

Na pancreatitis, nakwa dị ka ndị ọzọ na-egosi ọgwụ agbara nwayọọ nwayọọ intravenously. Oke ọnụego nke ọgwụ ochichi kwesịrị banyere 5-10 ml kwa nkeji.

N'oge infusion nke ọgwụ ọrịa kwesịrị ịbụ naanị na supine ọnọdụ. The ọgwụ ekwesịghị naanị ga-ndinọ site a akwara idé. Na-eji ha na-ịme ọzọ pụtara na ọ na-nditịm ajuru aju.

Nyere na mgbe na ojiji nke agwọ ọrịa bụ a elu n'ihe ize ndụ nke anaphylactic na nfụkasị Jeremaya niile ọrịa n'ime 10 nkeji tupu ochichi nke isi dosing a chọrọ ịbanye ule olu nke bụ 1 ml (ma ọ bụ 10 puku. KIU). Ọ bụrụ na mgbe ọ na-adịghị oghom Jeremaya mere abụghị sochirinụ, mgbe ndinọ a ọgwụgwọ dose nke ọgwụ.

Ọ kwesịkwara kwuru na ekwe omume ojiji nke blockers nke histamine H1- na H2-anabata maka ¼ hour tupu infusion nke agwọ ọrịa. Na nke ọ bụla, ọ ga-abụrụ na-nyere na niile nke ọkọlọtọ mberede jikoro nke na-eduzi ndị na ọgwụgwọ nke anabata ma ọ bụ anaphylactic mmeghachi omume.

Adults nwere ike ikwu na-ewere ọgwụ ndinọ intravenously na mbụ dose nke bụ 1-2 nde. KIU. Eme ya ji nwayọọ nwayọọ na, n'elu a ụzọ n'ụzọ anọ nke otu awa mgbe mmalite nke ná Nkụnwụ na tupu sternotomy.

Mgbe mmezu nke bolus infusion nke ọgwụ na-enwe ndidi tinyere (na a ọnụego nke 250-500 puku. KIU kwa hour) na mmechi ọrụ. Ngụkọta ego nke aprotinin ndinọ n'oge dum N'ezie, agaghị elu karịa 7 nde KIU.

Ndị na-mkpọchị ọrụ nke akụrụ, nakwa dị ka agadi ọrịa onunu ogwu ukpụhọde a chọrọ.

Mmetụta nke a na nkà mmụta ọgwụ

Gịnị bụ mmetụta nke a ọgwụ ọjọọ, "Gordoks" agụ, nke na-contraindications e kọwara n'elu?

Dị ka omume na-egosi, ndị ọrịa na-anata aprotinin maka oge mbụ, adịghị egbochi mmepe nke anaphylactic ma ọ bụ nfụkasị Jeremaya. Ma re-ochichi nke ọgwụ, ugboro nke mmetụta mụbara 5%. Nke a bụ eziokwu karịsịa n'ihe ebe ndị dị otú ahụ na ojiji nke ọgwụ ọjọọ e rụrụ maka 6 ọnwa.

Mgbe reusing n'aka karịa 6 ọnwa, a kwere omume ize ndụ nke anaphylactic na nfụkasị Jeremaya bụ banyere 0,9%.

Ihe ize ndụ nke oké mmetụta na-ukwuu ụba na ihe omume ahụ nke ọkara a afọ, aprotinin e ji mee ihe karịa ugboro abụọ.

Mgbe reusing njikere nke ọ bụla ihe ịrịba ama nke nfụkasị Jeremaya na-hụrụ, ụdi ngwa nke ọgwụ ahụ pụrụ nnọọ mfe na-eduga mmepe nke ekwesighi phenomena, ọbụna na-egbu egbu.

Mgbaàmà nke anaphylactic na nfụkasị Jeremaya mgbe ojiji nke ọgwụ nwere ike na-egosipụta onwe dị ka a dịgasị iche iche nke ọrịa nke digestive tract, na obi na akụkụ okuku ume na usoro, nakwa dị ka anụ.

N'ihe banyere mmetụta, na ojiji nke ọgwụ ga-ozugbo kagburu. Ọ dịkwa mkpa iji hụ na niile ọkọlọtọ mberede jikoro (eg, infusion ọgwụ, ochichi nke epinephrine, epinephrine, corticosteroids).

Ya mere, ihe na-na-achọghị mmetụta ime mgbe ojiji nke ọgwụ ọjọọ, "Gordoks"? Ngwa ophthalmology, esịtidem na nkà mmụta ọgwụ, na ọgwụgwọ ọrịa anụmanụ na nkà mmụta ọgwụ nwere ike ime ka onye ahụ nke na-esonụ abnormalities:

• Allergy: anaphylaxis, anaphylactic na nfụkasị Jeremaya, anaphylactic ujo (ikekwe na-egbu egbu).
• Obi usoro: thrombosis, ischemia, pericardial effusion, myocardial infarction, thrombosis ma ọ bụ occlusion nke akwara akwara, akpa ume embolism na ọbara thrombosis, nke nwere ike ime na ọrịa nke dị oké mkpa akụkụ ndị dị ka akpa ume, akụrụ na ụbụrụ.
• hematopoietic usoro: coagulopathy, gụnyere DIC.
• Urinary System: nsogbu nke akụrụ ọrụ na akụrụ odida.
• Obodo oghom Jeremaya mere: thrombophlebitis, mmeghachi omume na infusion ma ọ bụ ogwu ogbugba.

Specific ntuziaka maka ojiji nke ọgwụ

Ugbu a na ị maara otú a ọgwụ owuwu ga-eji dị ka "Gordoks". Ntuziaka maka ojiji na pancreatitis na ọrịa ndị ọzọ e gosiri dị n'elu. Otú ọ dị, tupu ọgwụgwọ na a ọgwụ na-atụ aro na-eduzi akpụkpọ ule a chọrọ iji mee ka a onye na-ekpebi onye uche na-arụsi ọrụ ike mgwa elekọta mmadụ (i.e. aprotinin).

Ọ bụrụ na a akụkọ ihe mere eme nke nfụkasị Jeremaya e kpọmkwem, mgbe ahụ, tupu ọgwụgwọ ọrịa ga-corticosteroids na histamine H1 ihe nnabata blockers.

Mgbe ndị dị otú ahụ deviations ka hyperfibrinolysis na DIC, ọgwụ ga-eji nanị mgbe data phenomena ga-kpamkpam tutu amama. The otu na-emetụta na otu ebe onye ọrịa nwere a mgbochi mmetụta nke heparin.

Nnọọ nlezianya na-atụle ọgwụ na-kenyere ndị ọrịa ndị na-maka ụbọchị ole na ole tupu mmalite nke ọgwụ natara muscle relaxants.

Dị ka akụkụ nke ọgwụ ọjọọ, "Gordoks" nwere benzyl mmanya. Na nke a, ya maximal olu kwa ụbọchị ekwesịghị gafere 90 mg kwa n'arọ ahu aro.

Agwọ ọrịa "Gordoks" bụghị a dochie anya ndị dị otú ahụ ọgwụ ọjọọ eme ihe dị ka "heparin".

Ozugbo vial e meghere na ngwọta, ọ ga-eji ozugbo. N'oge re-eji nke ọgwụ inye ọgwụ site na-emeghe akpa a ka amachibidoro.

Ọ bụ nke ukwuu ekwesighi mix ọgwụ "Gordoks" na ndị ọzọ ọgwụ.

Ọ ga-ekwe omume ịme ọgwụ Pita?

Ọ na-ekwe ka tinye nkịta na nwamba ọgwụ "Gordoks"? The were na-kwere na ụmụ anụmanụ. Otú ọ dị, na onunu ogwu nke ọgwụ kwesịrị naanị kọwaa a vetiran soja nwoke, na nanị mgbe ultrasound nnyocha nke abdominal oghere nke a Pita.

Olee otú ịbanye "Gordoks"? The ojiji nke nwamba na nkịta, ọgwụ kwesịrị ịkpachapụ nnọọ anya. Nke a bụ n'ihi na eziokwu na ọgwụ a na-ewere allergenic.

The ọgwụ na-ndinọ intravenously via a pụrụ iche catheter. Ọ nwekwara ike ga-ndinọ subcutaneously, na-akpọ "olu akwa". Ọ ga-kwuru na mbụ ụbọchị abụọ nke ọgwụgwọ nke pancreatitis ga-rụrụ site na igba ogwu n'akwara infusion. Ọ bụ nanị mgbe Pita ga-enwe ike na-ahụ nri na-enweghị vomiting, ọgwụ nwere ike ndinọ na kpọnwụọ ọbụna n'ihi 5-7 ụbọchị.

Gịnị kwesịrị ịbụ na onunu ogwu maka ọgwụgwọ nke ọgwụ ọjọọ, "Gordoks"? Jiri na nkịta nkezi size na ibu ibu na udi (banyere 15 n'arọ) na-agụnye ochichi nke a ọgwụ na ego adịghị nnọọ 10 puku. KIU (ugboro atọ n'ụbọchị). Banyere nwamba (banyere 5 n'arọ), na onunu ogwu kwesịrị 5 puku. KIU (mbụ na-atụ aro na ịkpọ a vetiran soja nwoke).

Maka ochichi nke ọgwụ via IV ọdịnaya nke vial na a ntụtụ, wee wetara ụmụ anụmanụ pelt ma n'ụzọ ziri ezi na-edu agịga n'ime subcutaneous ohere. Na nke a, ọgwụ na-nwayọọ nwayọọ kewapụrụ nke ntụtụ.

ọgwụ Nyocha

Dị ka reviews nke dọkịta na anụmanụ, ọgwụ "Gordoks" ezi ihe n'ụzọ dị irè na ngwa ngwa na-emeso-adịghị ala ala na nnukwu pancreatitis. Ke adianade do, o nwere ike ịkwụsị ihe ọ bụla ọbara ọgbụgba.

The naanị drawback nke a ọgwụ eme dị ka a nnukwu ọnụ ọgụgụ nke mmetụta, nke pụrụ ọbụna iduga ọnwụ. Ya mere, nke a ọgwụ ga-eji na na na-agba akaebe, na na maka nzube nke ịga dọkịta. Ọzọkwa, n'oge na ọgwụgwọ nke na nke a pụtara na-enwe ndidi ga-abụrụ na-n'okpuru ike nlekọta nke dọkịta gị.