Hyperandrogenism nwanyi: akpata, ihe mgbaàmà, na ọgwụgwọ. The ize ndụ hyperandrogenism nwanyi

Na nkà mmụta ọgwụ, a nsogbu maara dị ka hyperandrogenism na nwanyi. Akpata, mgbaàmà, ọgwụgwọ dị otú ahụ na a nchoputa na-achọ nwale na òkè nke ruru eru dọkịta. Ọ bụ ezie na a na ọrịa bụ nnọọ ike imeri kpamkpam, na-atụgharị dọkịta mma n'egbughị oge.

Ihe kachasi mkpa nke ọrịa

Mgbe ọ na-abịa ọrịa a dị ka hyperandrogenism na ndị inyom, na-akpata ihe mgbaàmà, ọgwụgwọ na mgbochi na-mgbe na-ejikọta ya na ndị dị otú ahụ a nsogbu, dị ka mmetụta na ozu adrogenov. Usoro a na-eduga ná mpụta nke nwanyi n'ile oke àgwà, na ndị ọzọ adịghị otú obi ụtọ mgbanwe. Na ọzọ zuru ezu, anyị na-ekwu okwu banyere ndị dị otú ahụ bụ ngosipụta dị ka ọdịdị ihu ntutu na ajị ahụ, miri olu, na-agbanwe ụfọdụ nke ndị ọcha ọgụgụ.

Ọ bụ uru na-arịba ama eziokwu na nne endocrine usoro daa ọrịa bụ ọsọ, na ike ọ bụghị naanị ime ka wetara mpụga mgbanwe, kamakwa ime ka infertility. Ya mere, mgbe ndị mbụ mgbaàmà nke hyperandrogenism, kwesịrị ozugbo ịtọọ oge a nleta na nke dọkịta.

Mere ịzụlite a daa ọrịa

The isiokwu nke "hyperandrogenism nwanyi: akpata mgbaàmà, ọgwụgwọ» Ọ dị ezigbo mkpa ka fairer mmekọahụ, n'ihi na nsogbu a na-egosi na ihe dị ka 20% nke ọrịa. N'ihi ya, ọ na-eme ka uche na-na ntị ka ihe na Filiks na-eduga mmepe nke ọrịa a.

Isi ihe mere nwere ike kpebisie AGS - adrenogenital syndrome. The ala akara bụ na adrenal glands nwere ike na-amị ọtụtụ ndị ọzọ homonụ, na mgbakwunye na adrogenov, dị ka glucocorticoids. Nke ikpeazụ na-egosi n'okpuru nduzi nke a ụfọdụ enzyme. The ndabere maka ha omume na-akwakọba androgens. Mgbe ụfọdụ, ndị inyom na-na-ama ugbu na nwa ntụpọ nke enzyme, dapụtara na a nwoke homonụ na-abụghị converted na-anakọtara na a mgbe niile, na-aghọ a na-akpata nke wetara mgbanwe nwanyi ahu.

E nwere ihe ọzọ usoro, nke na-amalite n'ihi hyperandrogenism nke adrenal malite. Anyị na-ekwu okwu banyere etuto ahụ nke adrenal glands. Ha na-guzobere na-na ndabere nke na-amụba kasịnụ nke androgens.

The ize ndụ nke ọrịa kwuru n'elu na-egosi na ọ bụrụ na e nwere a na mmepụta nke nwoke homonụ na a nwaanyị ovaries. Ọzọkwa, mkpụrụ ndụ ndị na-amị Adrogué nwere ike ime ka akpụ guzobere na ovaries.

hyperandrogenism syndrome bụ mgbe ụfọdụ n'ihi nke ikpughe na endocrine pathologies nke ndị ọzọ na akụkụ, ndị dị ka pituitary gland.

Ịrịba ama nke androgen ngafe

Ọ bụrụ na anyị na-ekwu banyere adakarị mgbaàmà nke elu kasịnụ nke nwoke hormone, ha nwere ike kọwara dị ka ndị a:

• otutu;
• ke ọkpọiso ntutu ọnwụ na nkwọcha tụrụ (alopecia adrogennaya);

• sebaceous glands ebido mepụtaba oké ichekwa secretion, n'ihi mmanu mmanu akpụkpọ abawanye;
• barifoniya ahụ pụtara anyịnwa ịhụkwu nke olu;
• na ya afo na obi ntutu egosi.

Ọ bụ uru na-arịba ama eziokwu na hirsutism - oké ibu nke ọnụ ntutu na nwaanyị ahụ, a chọpụta na 80% nke ọrịa na nsogbu a dị ka hyperandrogenism syndrome.

Dị otú ahụ na a ọrịa ụfọdụ nke fairer mmekọahụ omume emeghasịkwa nke ịhụ nsọ okirikiri, zuru ezu enweghị ịhụ nsọ, nakwa dị ka myocardial hypertrophy, ibu oké ibu, infertility, na ọbara mgbali.

Ịta nke nwoke homonụ nwere ike ime ka amplification nke nwanyi ahu susceptibility na-efe efe nke dị iche iche ụdị. Ọ dịkwa ike ike ọgwụgwụ na a ọchịchọ ịda mbà n'obi.

Otutu sebaceous glands

Iji ịghọta n'ụzọ doro anya ihe na-eme dị otú ahụ a nsogbu dị ka hyperandrogenism na ndị inyom, na-eme, ihe mgbaàmà, ọgwụgwọ, na nchoputa kwesịrị ịtụle juputara. Dị ka ihe na-eme ka mmepe nke ọrịa, ndị a kọwara n'elu, ọ na-eme uche na-amụ e ji mara nke ihe mgbaàmà.

Mgbe ị na-emetụ na nsogbu a dị ka ihe otutu, ọ bụ uru na-arịba ama na ha na-bụ n'ihi keratinization nke follicle mgbidi na ụba sebum mmepụta, nke na-akpali androgen kasịnụ, gụnyere plasma. Mgbe ndị dị otú ahụ ihe mgbaàmà ndị na-emekarị ọgwụ COCs ma ọ bụ antiandrogens, nke na-enye ohere budata melite ọrịa na-arịa.

Ọzọkwa n'okpuru nduzi nke nwoke homonụ na androgenozavisimyh zones apụta pigmented, oké, Ntụ ntutu kama vellus. Nke a-emekarị-eto eto. Na nke a, na mmetụta nke androgen na iku anya, nku anya, temporal na occipital akụkụ bụ ntakiri.

adrenal hyperandrogenism

Ọ bụ uru na-echeta na adrenal gland - abụọ endocrine glands na-emi odude dị n'elu akụrụ onwe ha.

Ha bụ isi iyi nke 95% na-emepụta site androgen (DHEA-sulfate). The mgbagwoju anya nke hyperandrogenism metụtara ndị a glands, Juda ala eziokwu na daa ọrịa bụ congenital na ọdịdị na na-eme ka ya onwe ya chere na ndabere androgenitalnogo syndrome. Ọ na-eduga ná a ọnụ ke oké egwu larịị ke nwaanyị ahụ enzymes mkpa iji na-emepụta homonụ dị ka glucocorticoids.

Hyperandrogenism nke adrenal si oubslovlena ọ bụ ihe a erughi, nke na-eduga onye na-abawanye na kasịnụ nke ndị ọzọ homonụ -. pregnenolone, progesterone, wdg dị otú ahụ mgbanwe na-dechara ubara mmepụta nke androgen na nwanyi ahu.

Mgbe ụfọdụ, a chọpụtara daa ọrịa, nke e mere site etuto ahụ nke adrenal glands na-emepụta nwoke hormone. Dị ka ọnụ ọgụgụ, a n'ụdị nke ọrịa dị ka adrenal hyperandrogenism bụ ofu na 30-50% nke ndị inyom na androgen nsogbu.

Mmetụta na ovaries

The akwa ịta nke nwoke homonụ pụrụ imetụta ịrụ ọrụ nke ovaries. N'ọnọdụ ka ukwuu, nsogbu a na-eme ka ya onwe ya chere site abụọ iche: gipertekoz na polycystic. Ọ dị mkpa ka ntị ka eziokwu ahụ bụ na ihe ize ndụ nke na-emepe emepe a na ọrịa na ndị inyom enwekwu na mgbe omume ike egwuregwu.

Ovarian hyperandrogenism bụ a N'ihi ya nke selata uto nke follicles n'okpuru nduzi nke androgens. N'ihi na ndị a na-iso ovaries, n'ihi nke ndị dị otú ahụ Filiks na-aghọ imperforate gara aga. The ọgwụ aha maka nsogbu a - follicular atresia.

Ma ọ bụghị ihe niile na ihe isi ike na-eso ovarian hyperandrogenism Jenesis. The ala akara bụ na nwoke hormone-eme dị ka a na-akpata megide nke amalite ndiiche guzobere fibrous connective anụ ahụ, nke na-eduga ná polycystic. Ke idaha emi, ozi ọma ahụ bụ eziokwu ahụ bụ na a yiri nsogbu chere ihu naanị 5% nke ndị inyom.

Ọzọkwa uru arịba ama bụ na a na ụdị hyperandrogenism, na fairer mmekọahụ bụ ihe na-akpata ọdịda nke etiti ụkpụrụ nke androgen etoju. Usoro a na-ewe ke larịị nke hypothalamus na pituitary. Dị ka a n'ihi nke mgbanwe mmiri ọgwụ budata.

Ịrịba ama na i kwesịrị ige ntị

E nwere ọnụ ọgụgụ nke mgbaàmà na-egosi na omume nke nsogbu kọwara n'elu. The eziokwu na anyị ga-enwe dị ka daa ọrịa nke ovarian hyperandrogenism si malite, nwere ike ịchọta na ndị na-esonụ bụ ngosipụta:

• osteoporosis;
• seborrhea;
• na ihu, na mgbakwunye na ihe otutu, e nwere ekpepụsị na mbufụt, nke siri ike neutralize ejikarịkwa ụzọ nke cosmetology;
• muscle atrophy;
• ibu oké ibu;
• na-agbanwe agbanwe na otosịrị iru nke nwanyi ahu - masculinization;
• anyịnwa ịhụkwu nke olu (barifoniya);
• uto nke ntutu isi nile ahụ, ọbụna n'agbanyeghị na;
• guzobe nkwọcha patches na isi.

Ke adianade do, e nwere ọtụtụ abụọ mgbaàmà, dị ka ụba ọbara glucose na-etoju, ọbara mgbali elu, belata ọgụ, na ndị ọzọ.

ngafe ibu

Ibu na inyom a nwere ike ime ka ovarian hyperandrogenism kọwara n'elu. Na ụdị ọrịa a na-ofu azụ estradiol.

Medical E duziri ọmụmụ, dị ka nke na-akwado ndị na-esonụ ozi: otú elu etoju nke nwoke hormone, na n'okpuru ya mmetụta nke estrogens nwere a kpọmkwem mmetụta na mmepe nke ibu oké ibu, kwekọrọ ekwekọ nwoke ụdị.

Ndị a Filiks bụ ihe kpatara nke insulin-dabere amplification na ụdi ịta nke ibu hormone ke idem nke nwoke inyom na-ata ahụhụ si na ọrịa a kọwara n'elu. Mgbe ụfọdụ, androgens emetụta bụghị underweight inyom site Central ụjọ usoro.

mbuaha ụdị

Dọkịta na mgbe etiti oge ga-emeso iche iche nke ngosipụta nke hyperandrogenism. Ọnọdụ a na-kọwara site n'eziokwu ahụ bụ na n'otu oge ahụ, e nwere ihe ịda iwu nke adrenal na ovarian ọrụ.

Ekwe omume nke ndị dị otú ahụ nsogbu dị mkpa ịtụle n'ọmụmụ ihe dị ize ndụ hyperandrogenism na nwanyi. N'ezie, a na-eme: adrenal androgens, na-etinye na adrenal glands, si otú welie larịị nke nwoke homonụ na ovaries. Usoro a pụtara na ọbara, nke na-eduga ụba mmepụta nke luteinizing hormone. Nke ikpeazụ, n'aka nke ya, na-akpalite ọdịdị hyperandrogenism syndrome.

Omume weere forms of daa ọrịa nwere ike ekewet oké trauma, mmenaanya ụbụrụ ma ọ bụ pituitary akpụ.

nchọpụta nsogbu

Ná mmalite, ndị dọkịta ga-iche ọzọ hyperandrogenic ọrịa megide nke ọ na-amalite (acromegaly, Cushing si syndrome, imeju ọrịa na ndị ọzọ.). Nzọụkwụ na-esonụ bụ iji chọpụta hormone etoju. Nke a na usoro a ga-rụrụ na ihe efu afo nke ụtụtụ. Dị otú ahụ analysis ga-arụrụ ugboro atọ dị ka homonụ na elu androgen ịta na-agbanwe mgbe nile.

A dọọrọ uche ka larịị nke dehydroepiandrosterone, elu ọdịnaya nke nke ga-egosi na nke adrenal hyperandrogenism. Ọ dịkwa mkpa na larịị nke ketosteroids na mmamịrị. Ọ bụrụ na ọdịnaya dị na mpụga na-ahụkarị, ọ na-eme uche na-eche na mmepe nke daa ọrịa.

therapies

Hyperandrogenism - nke a bụ nke dị oké njọ ihe nke na-eleghara ihe enyemaka nke ruru eru dọkịta. Ma ọ bụrụ na anyị nyochaa ụzọ dum nke ọgwụgwọ, ọ nwere ike kwubiri na ọ bụ iji na ọbọ anọ isi ebumnobi:

• removals akpụkpọ ngosipụta;
• normalisation nke ịhụ nsọ okirikiri;
• ọgwụgwọ nke infertility, nke e mere site anovulation;
• mkpochapu na mgbochi nke metabolic ọrịa metụtara isi nchoputa.

Nri maka hyperandrogenism nwanyi họpụtara na ikpe nke ịrịba ibu abawanye. Na nke a, ọ dị mkpa ka kpọmkwem na-eso niile na-atụ aro nke dọkịta, nanị n'okpuru ọnọdụ a, ị nwere ike nweta nri N'ihi.

Ndị ọrịa a na-aga ka a nwa, ọtụtụ mgbe, nye iwu hormone ọgwụ pụrụ inye a full ovulation.

Women na-adịghị na-eme atụmatụ a ime, ịbịa ọgwụgwọ, gụnyere onu gbochie afọ, na mgbe ụfọdụ, ovarian nkpirikpi resection.

Preparations maka ọgwụgwọ nke hyperandrogenism inyom a na-arụsi ọrụ ike na-eji, ma ọ bụrụ na ahụ bụ enweghị ike neutralize elu-etoju nke androgen naanị. Anyị na-ekwu okwu banyere ngwaọrụ ndị dị otú ahụ dị ka "metipred" "Dexamethasone", na ndị ọzọ. Surgery nwere ike a ga-amanye ke edinam na triggered ngwọta daa ọrịa.

pụta

The akwa ịta nke nwoke homonụ na nwanyi ahu - ọ bụ ihe karịrị a oké nsogbu na-amalite na ndabere nke na-adịghị ala ize ndụ nke ọrịa. Ya mere, mgbe mbụ mgbaàmà na ịgwọ ga-rụrụ na-enweghị-ada.