Lipid peroxidation (LPO) bụ a njikọ dị oké mkpa na metabolic mgbanwe. Ihe bụ isi ọrụ nke ya bụ imelite lipids nke cell membranes.
Na onye ahụ gbasiri ike lipid peroxidation achịkwa na-akpọ antioxidant usoro nke achịkwakwa ọsọ na phosphorylation ọrụ site nkịtị nkpasu-iwe ihe ma ọ bụ neutralize zuru ezu quantities nke peroxides iji gbochie ihe overabundance nke ọgwụgwụ ngwaahịa nke metabolism. Amplification ọxịdashọn usoro nwere ike ịbụ na-amalite mgbe na pathophysiological Filiks ịrịba ichekwa ọrịa. Usoro a na-agụnye a nzọụkwụ nke enzymatic na-abụghị enzymatic autoxidation.
ụdị
Iji nyegharịa ihe phospholipid bilayer nke cell akpụkpọ ahụ gbatịrị enzymatic ọxịdashọn. Ke adianade do, ọ na-abuana ke guzobere biologically-arụ ọrụ bekee, detoxification, metabolic Jeremaya mere. Non-enzymatic ọxịdashọn ka egosipụta onwe ya dị ka a na-ebibi ihe na ndụ nke cell. N'ihi guzobere buru ibu nke free radicals na peroxides ìgwè antioxidant usoro ọrụ ebelata na dị ka a na ya pụta, e nwere mbibi nke organism mkpụrụ ndụ.
PAUL okirikiri
Iji malite lipid peroxidation mkpa ọnụnọ nke oxygen free radicals, na-enwe ume larịị na oké otu unpaired elektrọn. Mgbe mgbake nke oxygen ụmụ irighiri emepụta superoxide nke mkpatụ na hydrogen atọm, mbịne n'ime hydrogen peroxide. N'ihi na ịchịkwa ego nke superoxide n'ime mkpụrụ ndụ adị superoxide dismutase, akpụ hydrogen peroxide na catalase, peroxidase neutralize ya mmiri. Ọ bụrụ na a bi organism e kpughere na ionizing radieshon, ọnụ ọgụgụ nke ndị free hydroxyl radicals ga-amụba n'ike n'ike. Ọzọkwa hydroxide oxygen na ya ọzọ nọ n'ọrụ forms nwere ike amalite mmalite usoro nke lipid peroxidation.
Ngwaahịa nke lipid peroxidation ma ọ bụ organism ewekarị nke, ma ọ bụ na-eji maka njikọ nke prostaglandins (bekee abuana ke mbufụt Jeremaya), thromboxanes (gụnyere thrombogenic cascade nke Jeremaya mere), adrenal homonụ.
akara usoro
Dabere na cell akpụkpọ ahụ Ọdịdị isi na-agba, na ego nke ọrụ nke dapụtara ọxịdashọn ngwaahịa nwere ike ịdị iche iche. Dị ka ihe atụ, ọrụ nke lipids peroxidation n'elu ebe a akụkụ nke cell mgbidi na-adịkwaghị unsaturated ọdụdụ asịd, na iji nwayọọ, ma ọ bụrụ na ndabere nke Cop bụ cholesterol. Ọzọkwa, ihe na-akpata-achịkwa ego na ọnụego nke guzobere free oxygen radicals, nakwa dị ka itinye n'ọrụ nke peroxides, bụ metabolic enzymes. Ọbụna na mmeghachi omume nke lipids peroxidation ekere òkè bekee na-emetụta ndị cell akpụkpọ ahụ lipid mejupụtara na aka ike mgbanwe dị mkpa nke ndị na organism. A na-agụnye vitamin E na K, thyroxine (thyroid hormone), hydrocortisone, cortisone na aldosterone (nke nzaghachi). Itisasị obodo cell mgbidi metal ion, vitamin C na D.
mebiri nke usoro
Metabolic ngwaahịa nke lipid peroxidation nwere ike akpọkọtara na nsụkọrọ na mmiri ahụ ma antioxidant usoro anaghị pụrụ nke ha na ndị dị mkpa ike ọsọ. N'ihi ya akwusila iga nke ion gafee cell akpụkpọ ahụ, nke n'ụzọ nwere ike imetụta ndị ionic mejupụtara nke mmiri mmiri òkè nke ọbara, na ọnụego nke polarization na depolarization nke muscle cell akpụkpọ ahụ (agbaji conduction nke akwara esi gboo, ha contractility, prolonging refractory oge), ikwado ntinye nke ọmụmụ n'ime extracellular ohere (edema, ọbara-egbochi mkpụkọ, electrolyte ahaghị nhata). Ke adianade do, isi ngwaahịa nke lipid peroxidation, mgbe a na usoro nke Biochemical Jeremaya mere, na-ghọrọ ka aldehydes, ketones, asịd na otú pụta. Ndị bekee nwere a na-egbu egbu utịp ke idem, nke na-egosipụta onwe ya na Mbelata ọnụego nke DNA njikọ, dịkwuo capillary permeability, dịkwuo oncotic nsogbu, dị ka mmọdo, sludge-syndrome.
Ngosipụta na ọgwụ
Ebe ọ bụ na-abawanye nke na oxygen free radicals nwere emebiri mmetụta na cell mgbidi, na metabolic ngwaahịa akpaghasị metabolism na njikọ nke nucleic asịd na nsi ahụ, ha na-pathophysiologic ihe na mmepe nke a ọnụ ọgụgụ nke na-adakarị ọnọdụ. The ọrụ nke lipid peroxidation na imeju bụ ihe dị mkpa ọrịa nke nkwonkwo, parasitic na-efe efe, hemodynamic ọrịa, oncological ọrịa, mkpasasị uche na Burns. POL bụ otu n'ime ihe maka atherosclerosis. Free radicals oxidize cholesterol na ya ala molekụla ibu nta na-etolite na ngwaahịa na imebi vaskụla mgbidi. Nke a na-amalite a cascade nke enweghị nchịkwa Jeremaya mere typical lebara mmebi. Nke a na-akpalite egbochi mkpụkọ nke ọbara, ìgwè egbochi mkpụkọ nke ọbara na lumen nke obere arịa ma ọ bụ nkekọ ha mgbidi. Dị ka a n'ihi nke ije nke ọbara na mpaghara ebe a slows ala, dị ka ama ibu a arịa lumen. Nke a na-eme ka n'ihu ìgwè egbochi mkpụkọ nke ọbara. The kasị susceptible ka mgbanwe ndị dị otú na akwara akwara, na aorta, gosi na ụlọọgwụ mgbaàmà nke akwara ọrịa nke obi.
mgbochi
Practitioners ga-echeta na omume nke na-achọpụta ọrịa na ọgwụgwọ usoro nwere ike rụọ ọrụ usoro nke lipid peroxidation. Nke a ga-adọ aka ná ntị na-enwe ndidi. Site akpali iche ihe na-agụnye radieshon ọgwụ (n'ihi na cancer), ultraviolet ìhè (na rickets, mkpali oria nke sinuses, antibacterial ọgwụgwọ ụlọ), magnetik n'ubi (MRI, CT, ọgwụgwọ anụ ahụ) sessions na a hyperbaric ulo (na bịara yie ka à, elu ọrịa).
Mgbochi na Agwọ
Personnel arụ ọrụ na rentgenkabinetom, orderlies na ndị nọọsụ, ndị ọkachamara na physiotherapy, mountaineers, ndị mmadụ na ngafe ibu mkpa ka ị na-eri oriri na-ebu eke antioxidants: azu, sunflower ma ọ bụ mmanụ oliv, herbs, àkwá, green tii. Ke adianade na-agbanwe agbanwe na ihe oriri, ọgwụ ọjọọ nwere ike ji mee na jikọtara na ụfọdụ iche iche ma ọ bụ free radicals ikpokọta na ọla nke agbanwe valency. N'ihi ya, ha na-eguzo free nke nọ n'ọrụ oxygen ụmụ irighiri ihe, na-egbochi ha si nkịtị ka lipid peroxidation amplifiers.
nchọpụta nsogbu
Na nke ugbu a na ogbo nke mmepe nke laabu research anyị na-enwe ike ịchọpụta peroxide na mejupụtara nke ndu oke mmiri nke ahụ mmadụ. Iji mee nke a, ebu fluorescence Microscopy. Nanị tinye, ịmata ihe na-lipid peroxidation. The uru nke a na-achọpụta ọrịa ule achoghidi nkọwa. N'ezie, na a ịrịba ego dabeere na ọrịa bụ oké ọrụ nke lipid peroxidation. Nchọpụta nke steeti a na-ekpebi ọgwụgwọ.
Si n'ọnọdụ nke ndị nkịtị physiology nke lipid peroxidation dị mkpa nke e guzobere steroid homonụ, mkpali ogbugbo, cytokines na thromboxanes. Ma mgbe ọnụ ọgụgụ nke chemical Jeremaya mere data mgbanwe ngwaahịa karịa ndị allowable uru na peroxide mmebi cell organelles, DNA na-akpaghasị njikọ nke na-edozi, na mmetụta na-abanyekwa antioxidant usoro na-ebelata ego nke n'ikuku oxygen na-ion nke ọla na agbanwe valency. Ke adianade do, ọ enwekwu njikọ nke catalase na peroxidase maka mkpofu ngafe peroxides na ngwaahịa nke ha n'ihu metabolism.