PTH ụba - dị ka ọ pụtara ìhè site analysis?

Parathyroid hormone (ma na-akpọ parathyroid hormone, parathyrin) - a hormone emepụta site na parathyroid anụ ahụ (parathyroid) glands, nke na-emi odude ke anterolateral n'akụkụ nke n'olu. Ha na-akpata thyroid gland, nke bụ anya n'akụkụ aka n'azụ elu ya na ala akụkụ nke ma ya òkè. Parathyroid hormone na ha chemical agwa bụ a mgbagwoju protein umi - polypeptide amino acid emepụta.

Ya isi ọrụ bụ na-ekere òkè na iwu nke calcium na site metabolism ke idem. Ọdịnaya nke calcium na ọbara na secretion nke parathyroid hormone bụ kpọmkwem dabere ọ bụla ọzọ. The hormone nwere ike dịkwuo calcium ịta site n'ime on ọkpụkpụ anụ ahụ, akụrụ na eriri afọ tract. Ọkpụkpụ parathyrin enwekwu logoff dissolving na ịnweta akụkụ site na-akpali akpali njikọ nke kpọmkwem enzymes na-ahụ maka ndị mmebi nke ọkpụkpụ ihe onwunwe. Ọkpụkpụ anụ ahụ na-doro n'okpuru nduzi nke PTH resorption na calcium ion na-emi odude ke iyịp. Ọnụ na calcium mgbanwe paratgormot enyere mezie larịị nke phosphate ke idem. Mbenata ike nke mbụ ndu usoro, ọ na-eme ka nke abụọ eruba. Ọzọkwa, hormone na-agụnye ime njikọ nke calcitriol na eriri afọ, na-enyere calcium reabsorption. Parathyroid hormone na-ewe na-apụtachaghị ìhè akụkụ na ụkpụrụ nke na-eme ihe niile calcium-dabere enzymes katalirizuemye ha mmeghachi omume. N'okpuru ya mmetụta na-na-akawanye ọbara coagulation usoro.

Ọ bụrụ na PTH na-elu, mgbe ahụ, kpụrụ oké endocrine ọrịa metụtara na ọkpụkpụ ike n'ezi mebiri - hyperparathyroidism, na osteoporosis. The N'ihi nke ndị dị otú ahụ n'ahụ nkwarụ sharply mbelata na ọbara calcium etoju, nke na-eduga ụba neuromuscular excitability. Comorbidities na nke a nwere ike ije ozi elu alkali ọdịnaya na ahu na mmepe nke gbasara akụrụ odida. Site na mbenata ọdịnaya nke calcium na oghere cataract anya na-adị.

Etoju nke hormone nke parathyroid glands na ọbara bụ isiokwu a circadian n'afọ iri na ụma. The basal larịị atọrọ na ihe 8 am, mgbe ke 14-16 awa nke ụbọchị, mgbe otu nwoke bụ na ọnụ ọgụgụ kasị elu nke ọrụ, parathyroid hormone ụba. ọbara ule na-rụrụ site na ọnụ ọgụgụ nke parathyrin immunohemilyuminestsentsii. Ọ ga-eme ka agụụ, na a ụbọchị ma ọ bụ abụọ tupu ọbara nlele kpochapụ mmanya oriri na oké mmega ruo ọtụtụ awa tupu usoro, adịghị aṅụ sịga.

On analysis of parathyroid hormone na-kenyere naanị mgbe a ndidi na-enyo enyo na ịdị adị nke ọrịa ndị dị ka hyper- na gipokaltsimiya, urolithiasis na neurofibromatosis. Ọzọkwa na-egosi maka analysis nzube pụrụ ịgụnye: osteoporosis psevdoperelomy ogologo ọkpụkpụ, ọ bụla n'ahụ agbanwe osteosclerosis ọkpụkpụ ma ọ bụ vertebral ozu na-enyo enyo na multiple endocrine neoplasia ụdị 1 na ụdị 2 (MEN 1.2). On parathormone ọnụego onye okenye a na-ewere 9,5-75 Ntuziaka Nne na Nna / ml. Nke a metụtara ma ndị ikom ma ndị inyom nke omumu afọ. Ọ bụrụ na achọpụtara na PTH na-elu, e nwere ezi ihe mere ha iche na onye ọrịa nwere isi, nke abụọ, tertiary hyperparathyroidism, pseudohypoparathyreosis ma ọ bụ Zollinger-Ellison syndrome.

N'okpuru jikọtara isi hyperparathyroidism hyperplasia nke parathyroid gland, cancer nke prostate anụ ahụ na endocrine neoplasia abụọ na ụdị. Co. sekọndrị hyperparathyroidism gụnyere ala ala gbasara akụrụ insufficiency, hypervitaminosis D, ọnyá afọ, rickets, Crohn oria. Ọ bụrụ na PTH na-elu, mgbe ahụ, analysis na-emekarị mere na njikọ na definition nke larịị nke calcium na ọbara na-eme n'ọdịnihu na ihe atụ nke abụọ na-egosi na a mata dependencies.