Ace inhibitors - irè ọgwụ ọjọọ nke oge a na Cardiology

Inhibitors ma ọ bụ Ace angiotensin n'ịtụgharị akpata na-akpọ nwere ike vasodilators eji na Cardiology maka ọgwụgwọ nke ọbara mgbali. The ihe nke otu a ọgwụ ọjọọ eme ihe na-ruo ogologo oge igbochi adrenal hormone angiotensin II - pressor isi ihe na-emetụta ndị na ọbara mgbali uru. Ace inhibitors gbochie mmebi nke bradykinin, nke na-emetụta ọnọdụ nke arịa, na ya mere na elu nke ọbara mgbali. Ọgwụ ndị a enyere dịkwuo ọbara etoju nke vasodilator prostaglandins belata mgbaàmà nke-adịghị ala ala obi ọdịda, na-emekarị hụrụ ọrịa na oké mkpa ọbara mgbali. N'otu oge ahụ, Ace inhibitors, n'adịghị ka ndị ọzọ ọgwụ ọjọọ eme ihe na ala ọbara mgbali na-enweghị mmetụta na glucose na lipid metabolism, belata urinary protein akụrụ ya.

Ace inhibitors na-eji ihe karịrị afọ 40. Nke mbụ nke otu a ọgwụ ọjọọ eme ihe na 1975 e synthesized captopril, eji taa. A afọ ole na ole mgbe e mesịrị nwetara enalapril na lisinopril. Ha na-anọchi ọzọ oge a na Ace inhibitors a ọgbọ ọhụrụ.

Na oge a Cardiology Ace inhibitors na-eji dị ka isi ọgwụ ọjọọ eme ihe maka ọgwụgwọ nke hypertensive ọrịa, ischemic ọrịa obi, ọrịa na-adịghị ala obi ọdịda.

Ace inhibitors nhazi ọkwa

E nwere ọtụtụ classifications nke Ace inhibitors, nke dabeere na ụzọ mwepụ nke ọgwụ ọjọọ si ahụ, dabere na chemical otu na molekul mmekọrịta na Ace center ọrụ nzọụkwụ. The kasị nhazi ọkwa nke pharmacological edinam.

Dị ka pharmacological edinam nke angiotensin n'ịtụgharị inhibitors niile ihe na-ekewa atọ dị iche iche.

Ìgwè nke mbụ bụ captopril ma ọ bụ enyeghachi ya okpukpu anọ, nke na-egbochi, i.e. egbochi angiotensin m n'ịtụgharị ọrụ nke hormone na a ụdi adọ - angiotensin II. Iji nọgide na-captopril ma ọ bụ kapoten nkịtị ọbara mgbali e atọ na anọ ugboro n'ụbọchị.

Iji ìgwè nke abụọ bụ nke enalapril, ramipril, trandalopril, tsilazipril, fosinopril, quinapril na ọgwụ ọjọọ ndị ọzọ na-tọghatara ke idem n'ime n'ọrụ ogige nwere a vasodilatory mmetụta. Ndị a ọgwụ ọjọọ eme ihe bụ iji were nanị otu ugboro n'ụbọchị.

N'ikpeazụ, ndị nke atọ ahụ mejupụtara lisinopril Zestril, prinivil, prestarium ma ọ bụ perindopril. Ace inhibitors bụ ndị nke atọ ahụ a na-atụ aro na-ozugbo ma ọ bụ ugboro abụọ n'ụbọchị.

Mmetụta nke Ace inhibitors

Mgbe ị na-enweta otu a ọgwụ ọjọọ eme ihe kwesịrị maara nke na o kwere omume mmepe nke oghom mmetụta. Mgbe ụfọdụ, na-ewere Ace inhibitors pụrụ iyi akọrọ ụkwara, mụbara potassium etoju ke ọbara, dizziness, anabata akpụkpọ ọkụ ọkụ, angioedema. A nsogbu na-kpamkpam tutu amama mgbe ọgwụ ndọrọ ego. Akọrọ ụkwara na-egosi na atọ ise nke ọgwụgwọ. Ọdịdị ya bụ n'ihi na ìgwè ke akpa ume nke bradykinin. Ụkwara kpamkpam kpamkpam mgbe discontinuation nke inhibitors. Ụfọdụ ọrịa nwere ike ibelata agụụ na nsogbu n'obi uto uzọ.

Otu n'ime ndị isi contraindications na ojiji nke Ace inhibitors bụ bilateral gbasara akụrụ akwara constriction. Na nke a, na ọbara mgbali na-amụba site n'ịzụ larịị nke renin na ọbara nke ndị a ọgwụ ọjọọ eme ihe na-enweghị mmetụta.

Special elekọta kwesịrị nyere Ace inhibitors na-adịghị ala ala umeji akụrụ ọrịa na mmepe nke mgbaàmà nke hepatic na gbasara akụrụ insufficiency.