Akpụ necrosis lekọtara: preparations

Akpụ necrosis akpata (TNF) - a ìgwè nke cytokines kpọmkwem protein - hormone-dị ka bekee emepụta site dịghịzi usoro. Ọ na-akpata a otutu mmasị na nkà mmụta ọgwụ ruru ya Njirimara - ike ime ka cell ọnwụ (necrosis) intratumoral anụ ahụ. Nke a bụ ezigbo ihe itunanya na nkà mmụta ọgwụ, ekwe ka ị na-eme na ngwaahịa na TNF maka ọgwụgwọ nke cancer.

History of chọpụtara

Site na nmalite nke XX narị afọ na ọgwụ na ahụ ike na-eme ọ na-e-ahụrụ nlereanya: na ụfọdụ ndị ọrịa e a ọnụ na / ma ọ bụ ofufe nke akpụ guzobere mgbe nyefe nke ọ bụla ọrịa. Mgbe American ọkà mmụta William Coley malitere ụma ndinọ na cancer ọgwụ ọjọọ nwere nje n'ụlọ (bacteria na ha nsị). The usoro e ahụghị ịdị irè, ka nwere ike na-egbu egbu utịp ke ndidi. Ma, ọ bụ mmalite nke a ọnụ ọgụgụ nke nnyocha na-eduga na nchọpụta nke a protein, na-akpọ akpụ necrosis akpata. Hụrụ umi-eme ngwa ngwa ọnwụ nke cancer mkpụrụ ndụ tinyere n'okpuru anụ nke ibuo ụmụ oke. A obere ka e mesịrị, ọ e kewapụrụ ọcha TNF, nke ohere iji ya maka ebumnuche nyocha.

Nke a chọpụtara mee ka a itunanya ke cancer ọgwụ. Na mbụ, na-eji na-edozi cytokines ike ọma na-emeso cancer bụ nnọọ ole na ole nke Education - melanoma akpụkpọ cancer, akụrụ ọrịa kansa. Otú ọ dị, ịrịba ọganihu a na ubi kwere ka ndị na-amụ nke Njirimara nwere akpụ necrosis akpata. Preparations dabere na ya na-gụnyere ke ọgwụ na usoro.

usoro nke ihe

akpụ necrosis akpata eme na a kpọmkwem cell - lekwasịrị. E nwere ọtụtụ usoro nke edinam:

• Site pụrụ iche TNF anabata malite na multi-ogbo usoro - na odi (apoptosis). A edinam a na-akpọ a cytotoxic. N'otu oge ahụ na-edebe ihe a zuru ezu ofufe nke etuto ahụ, ma ọ bụ belata ya size.
• Site iro ma ọ bụ nchupu nke cell okirikiri. Cancer cell-enwekwaghị ike kee na akpụ uto a kwụsịrị. A edinam a na-akpọ a cytostatic. A ozizi ebe ma akwụsị na-amụba, ma ọ bụ iwetulata na size.
• Site igbochi guzobe usoro nke neovascularization nke akpụ anụ ahụ na emebi tupu-ẹdude capillaries. The akpụ na-efunahụ nke nri, necrotic, ebelata na kpamkpam.

E nwere ọnọdụ ebe ndị cancer mkpụrụ ndụ adịghị emetụ agbara ọgwụ n'ihi mmụba. Mgbe ahụ n'elu usoro adịghị bilie.

The ojiji na nkà mmụta ọgwụ

Akpụ necrosis akpata na-eji na-akpọ Cytokine ọgwụ - ọgwụgwọ kpọmkwem edozi na-eme site na mkpụrụ ndụ ọbara maka ọgụ. Usoro bụ omume ọ bụla na ogbo nke na-akpụ usoro na adighi contraindicated n'ihi na ndị mmadụ na comorbidities - obi, gbasara akụrụ, hepatic. Iji belata toxicity etinyere otụk recombination akpụ necrosis akpata.

Ọgwụgwọ na cytokines - ọhụrụ na-aga n'ihu n'ihu na-emepe emepe ubi nke oncology. The ojiji nke TNF a na-ewere ndị kasị dị irè. Ebe ọ bụ na a na umi bụ ukwuu na-egbu egbu, na ọ na-eji na-akpọ mpaghara perfusion. The usoro mejupụtara ke eziokwu na nje akpụ ngwa ma ọ bụ ahu so na-enyemaka nke pụrụ iche ngwá napụtara general mgbasa. Mgbe ahụ artificially ịkpalite ọbara na agbara TNF.

ize ndụ pụta

Na-adakarị omume, akpụ necrosis akpata eji na-ekwesịghị. A ọnụ ọgụgụ nke ọmụmụ gosi na TNF - a isi akụrụngwa na mmepe nke sepsis, na-egbu egbu na-akpata. Ọnụnọ nke a protein mụbara pathogenicity nke nje na malitere ịrịa ọrịa, nke bụ karịsịa dị ize ndụ na ọnụnọ nke HIV na a ndidi. Ọ bụ na TNF bụ idem ke eme autoimmune ọrịa na (e.g., ọrịa ogbu na nkwonkwo) na nke dịghịzi usoro na-ezighị na-enweta ihe anụ ahụ na mkpụrụ ndụ nke organism nke mba ozu na-emebi ha.

Ka iwetuo elu na-egbu egbu mmetụta na-edebe ndị na-esonụ jikoro:

• na-eji nanị mpaghara na saịtị nke akpụ guzobere;
• ikpokọta na ọgwụ ọjọọ ndị ọzọ;
• Ha na-arụ ọrụ na obere na-egbu egbu mmụba TNF na-edozi;
• ndinọ iche-alụso ọrịa ọgụ.

Ọnọdụ ndị a na-amanye mmachi ojiji nke akpụ necrosis akpata. Ọgwụgwọ ha ga-ọma-haziri.

achọpụta ọrịa egosi

A ọbara ule anaghị ịchọpụta TNF na a ike ahu. Ma, ya larịị enwekwu n'ụzọ dị egwu na-efe efe ebe ọbara abịa pathogen nsị. Mgbe ahụ, ọ nwere ike ugbu a na mmamịrị. Akpụ necrosis ihe na synovial ọmụmụ nke ọrịa ogbu ogbu na nkwonkwo na-ekwu.

Ọzọkwa dịkwuo nke a na-egosi na-ekwu okwu nke nfụkasị Jeremaya, cancer ọrịa na bụ ihe ịrịba ama nke jụrụ dọgharịala enye onyinye akụkụ. E nwere ihe àmà gosiri na-abawanye na a na-egosi ike na-egosi na ndị na-abụghị communicable ọrịa ndị dị otú ahụ dị ka obi ọdịda, bronchial ụkwara ume ọkụ.

Dị iche iche immunodeficiency (gụnyere AIDS) na oké malitere ịrịa ọrịa na-ewere ọnọdụ dị ka nke ọma dị ka unan na Burns, ọnọdụ na-kere nke belata akpụ necrosis akpata. A ọgwụ nke nwere ihe immunosuppressive mmetụta, enye a mmetụta yiri.

preparations

dabeere na TNF ọgwụ ọjọọ na-akpọ ezubere iche - ikike nke ime ihe mgbaru ọsọ, kpọmkwem ụmụ irighiri nke cancer mkpụrụ ndụ, na-eme ọnwụ nke ikpeazụ. The mmetụta ndị ọzọ na akụkụ bụ ntakiri, nke na-ebelata toxicity, nke nwere a akpụ necrosis akpata. dabeere ọgwụ ọjọọ na-eji dị ka a TNF naanị (monotherapy) na ijikọta na ndị ọrụ ọzọ.

Taa, e nwere ọtụtụ ngwaahịa na ndabere nke TNF, ya bụ:

• NGR-TNF - mba ọzọ ngwaahịa, n'ọrụ mgwa ihe bụ a emepụta nke TNF. Ọ bụ ike imebi ọbara arịa nke akpụ, anapụ ya nke ike ya.
• "Alnorin" - Russian development. Ọ bụ nke ukwuu irè na Nchikota na interferons.

"Refnot" - Russia ọhụrụ ọgwụ nwere akpụ necrosis-akpata na-thymosin Alfa 1. Ya toxicity dị ala, ma arụmọrụ bụ hà eke TNF, na ọbụna karịa ya site immunostimulatory edinam. Ọgwụ e kere na 1990. Ọ na-ọma na-agafe niile dị mkpa na-adakarị ọnwụnwa na naanị na 2009 na e dekọrọ, nke nyere ukara ikike na-emeso ha ọrịa cancer.

Self-ochichi nke ọgwụ nile na ndabere nke akpụ necrosis akpata nnọọ amachibidoro. Cancer ọgwụgwọ - ukwuu haziri ahazi usoro na-ewe ebe nanị n'okpuru nlekọta nke a ọkachamara.