DNA methylation: otu nnyocha

Methylation bụ isonyere nke otu carbon na atọ hydrogen atọm ọzọ molekul. Nke a na onu na-atụle ga ikpeazụ okwu na nlekọta ahụ ike. Ọ na-esonyere mmejuputa nke fọrọ nke nta niile si arụ ọrụ.

ọrụ

Methyl otu (carbon na hydrogen atọm) na-arụ:

1. Ahụ omume na-akpata nchekasị.
2. Development na nhazi nke glutathione. Ọ na-eme dị ka a isi antioxidant ke idem.
3. Detoxification homonụ, arọ ọla na chemical ogige.
4. Ejikwa mkpali Filiks.
5. Dịghachi mkpụrụ ndụ.
6. Dịghịzi omume na ụkpụrụ megide nje virus na-na-efe efe, na-eme ka akara nke T-mkpụrụ ndụ.

. Dịkwa mkpa bụ usoro nke DNA methylation. Ka anyị tụlee ya na ihe zuru ezu.

Epigenetic akara

способствует передаче паттернов следующему поколению клеток при митозе. DNA methylation nakawa etu esi mmemmem nyefe nke ọgbọ ọzọ nke mkpụrụ ndụ na mitosis. Dịtụ nso nso, ọ na-e chọpụtara na usoro nke na isonyere iche iche nke atọm na-anaghị ala ala-ọdịiche dị owuwu nwere ụfọdụ njikọ na guzobere ebe nchekwa na synaptic plasticity. K. Miller na D. Sweet nyochaworo DNA methylation. Ịmụ ihe onu na ha dugara na ya ikwubi na ọrụ nke methyltransferase dezoksiribonukleinovokislotnoy budata ụba na ụmụ anụmanụ n'oge n'isi ọhụrụ. Nke a na-enyere aka belata ngosipụta nke mkpụrụ ndụ ihe nketa nke ebelata ebe nchekwa Filiks. Ke adianade do, ndị dere kwuru na otu ihe. The na-eme nnyocha na-akọ na ndị protein reelin site n'usoro ebighị, akwalite mgbanwe na synaptic njikọ aka na-enweghị nchịkwa na N'ezie nke isi mgbaka na-emetụta ebe nchekwa guzobere. Mgbe a na-akpata na-oyi demitalazy-enzymes enye DNA demethylation (ntọhapụ si methyl iche iche). Guzosie Ike eziokwu na-eduga ná otu ihe dị mkpa. , а также обратное ему явление, играют существенную роль при хранении информации и запоминании. DNA methylation dị ka otu n'ime epigenetic usoro, nakwa dị ka inverse onu, na-egwu dị oké mkpa ọrụ na ozi nchekwa na ebe nchekwa. Nke a echiche na-egosi na ihe ndị na ìgwè ọmụmụ E. Costa. Ọ hụrụ na demitilirovanie reelin na glutamate decarboxylase mkpụrụ ndụ ihe nketa nwere ike oyi ụmụ oke obere ụmụ irighiri ihe na-egbochi osisi DNA na ntọala. Ndị a chọpụtara gosiri bụghị nanị ekwe omume nke na-agbanwe agbanwe ẹdude echiche banyere guzobere ebe nchekwa. является динамическим. Ha na-na-ezo aka n'eziokwu ahụ bụ na mbụ chere na-adịgide adịgide DNA methylation-akpa ike. Ọzọkwa, ọ ga-eji na ọgwụ.

atụmatụ

имеют определенную связь, нельзя назвать новой. The echiche na ebe nchekwa na DNA methylation nwere ihe ụfọdụ na mmekọrịta, ike na-akpọ ọhụrụ. Ọ esesịn a guzosie ike conditionality synaptic nnyefe histone acetylation. Ha na-etolite na ọkpụkpụ na nke DNA na-emerụ. Acetylation ebelata mmekọrita nke histone ka nucleic asịd. Nke a ga-emepe ohere DNA na ndị ọzọ na-edozi metụtara, gụnyere ndị ọzọ, na ebighị nke mkpụrụ ndụ ihe nketa. N'ezie, histone ọrụ atsetilotransferaznaya CREBBP (nkịtị protein), eme ka a isi transcription akpata akwara ozi e jikọtara ya na mmetụta nke a protein na ihe n'isi. Ọzọkwa, e kpughere amplification inogide agwa ebe nchekwa n'oge ojiji nke histone deacetylase inhibitors. Ọ ada otu osooso nke histone acetylation.

hypotheses

Sweet na Miller jụrụ ajụjụ ndị na-akwanyere ndị histone-dabere suppression nke okwu nakawa etu esi. ? Ọ bụrụ na ọ nwere ike na-ekere òkè inye iwu na ebe nchekwa, ga-eduga otu mmetụta ma DNA methylation? Nke a na onu hụrụ isi ihe dị ka ụzọ nke ịnọgide na-enwe ọrụ n'oge mitosis na owuwu akpụ usoro. Otú ọ dị, na mammalian ụbụrụ matured hụrụ osisi ike methylases, n'agbanyeghị eziokwu na ọtụtụ n'ime mkpụrụ ndụ na-nondividing. N'ihi na eziokwu na-ewere onu na-eme ka suppression nke site n'usoro okwu, na-eme nnyocha na-enweghị ike na-ajụ nkwurịta okwu puru methylase na usoro iwu Filiks ke akwara ozi.

ịlele echiche

этого явления в формировании памяти, обрабатывали срезы гиппокампа ингибиторами дезоксирибонуклеинокислотных метилтрансфераз. Sweet na ibe ya site n'inyocha methylation nke DNA, nke a pụtara onu na guzobere ebe nchekwa, hippocampal Mpekere-emeso ya na inhibitors dezoksiribonukleinokislotnyh methyltransferases. Ha chọpụtara na ọ na-egbochi mmalite nke ogologo oge potentiation - ike nke synaptic njikọ omume neuronal ọrụ. Usoro a na-akpata na mmetụta nke mmụta na ebe nchekwa usoro. Ọkà mmụta sayensị na-hụrụ na inhibitors ebelata larịị nke methylation na DNA reelin. Ọ kwuru ya reversibility.

nwere

Ikpebi gaa n'ihu na ọmụmụ ha, Sweet na Miller malitere inyocha mgbanwe ndị na-methylation ụkpụrụ na ụmụ oke na a nlereanya na nke ụmụ anụmanụ na-amụta na-akpakọrịta a kpọmkwem ebe na wetara stimuli, akpan akpan, na-adịghị ike ịtụnanya. Àgwà ibuo anata inhibitors, na-ekwupụta na o na-amụta ihe isi ike. -Ahụ onwe ha a ọnọdụ ebe ha aghaghị ịdị na a egwu, ha froze budata erughị akara ụmụ anụmanụ.

Nchoputa

Olee methylation ike emetụta ebe nchekwa nke ụmụ oke? Ọkà mmụta sayensị kọwara nke a dị ka ndị a. The DNA bụ ugbu a ọtụtụ òkè nke pụrụ imetụta isonyere iche iche nke hydrogen na carbon atọm. Na nke a, na-eme nnyocha kpebiri itinye ndị na-esonụ onu. Ha na-amụ isi methylation nke mkpụrụ ndụ ihe nketa onye ọrụ e guzobere ebe nchekwa esesịn a setịpụrụ. Ọ mbụ e ebe nke protein phosphatase ebe nchekwa Filiks na-ewute ya. ebelata okwu nwere ike ime ka ndị na-abụghị mmetụta. N'ezie, otu hour nke oyi Contextual egwu methylation larịị ụba ihe karịrị otu narị ugboro. Na nke a, na mRNA etoju ke hippocampal CA1 region doro a na-adịghị ike, ma statistically ịrịba Mbelata. Nke a pụrụ isi kwuo ya na-dị na ụbụrụ nke ụmụ anụmanụ na a Nchikota obere ịtụnanya nsọtụ na onodu nke ọhụrụ. Iche iche, ndị a ịkpali adịghị inye mmetụta ọ bụla methylation. N'ihi ya, isonyere iche iche a rụrụ nanị n'ihe ndị dị ugbu ozizi.

DNA methylation na ịka nká

Nsogbu nke afọ na ọdịdị cancer bụ otu n'ime ndị kasị na-atụle isiokwu. N'ime ọtụtụ afọ nke nnyocha, ọkà mmụta sayensị na-atụ aro a dịgasị iche iche nke echiche ndị na ụdị. Otú ọ dị, ọ dịghịkwa ihe na echiche ugbu a dịghị aza ọma ka niile ajụjụ. Ka ọ dịgodị, onye kasị ukwuu mmasị na-achọ ihe ngwọta bụ ọmụmụ nke ịka nká mgbanwe site n'usoro ọrụ. Karịsịa, ya na uche na okwu kwuru Prọfesọ Anisimov. Ọ na-ekwu na ngosipụta (okwu) nke mkpụrụ ndụ ihe nketa na-adabere, ihe ndị ọzọ, site methylation, nke nwere ike imetụta ọnụego nke ịka nká. Up 5% nke agakọta residues nke deoxyribonucleic acid na-isonyere iche iche nke carbon na hydrogen atọm etolite 5mTs (5-methylcytosine). Nke a na isi-atụle ga-naanị mgbe nile na DNA nke elu ntule. N'abụ iche iche na-ewe ebe na ma strands symmetrically. Anọgide 5mTs mgbe zoo n'azụ Gwanine residues. Na nke a Ọdịdị nwere dị iche iche ọrụ. Otú ọ dị, ọ dị mkpa iburu n'obi na methylation bụ idem ke ụkpụrụ nke mkpụrụ ndụ ihe nketa ọrụ. Mgbanwe na N'ezie nke isonyere iche iche e mere site ọdịda na larịị nke transcription.

ihe

Age-demethylation mbụ kọwara na 1973. Nke a dị iche e achọpụtara ogo nkewa nke iche iche na oke arọ. Na ụbụrụ, demethylation wee ọzọ ifịk ifịk karịa na imeju. Ọ na-e ekemende kpebisiri 5mTs ojuju na afọ na akpa ume, nakwa dị ka fibroblast akpụkpọ formations. The na-eme nnyocha na-atụ aro na afọ-demethylation predispose mkpụrụ ndụ ajọ mgbanwe. Nke a na onu nwere ike kwupụtara na mfe dị ka ndị a. An-adịghị ejekwa ozi site n'usoro e tinyere na methyl otu. N'okpuru nduzi nke chemical Jeremaya mere na-aga na ya disconnection. N'ihi ya, site n'usoro na-arụ ọrụ. Group arụ ọrụ nke atọm fuuz. The nta ọnụ ọgụgụ, ihe differentiated mkpụrụ ndụ ma si otú tọrọ ha ọzọ - n'ihi ya, ọ bụ obere. A kpochapụwo atụ na ọtụtụ-eji akwụkwọ, nwere ike ịkpata na mmepe nke ụdị nke salmon. A onu nke ha nnọọ ngwa ngwa ọnwụ ozugbo-akpata. Ụnyaahụ ka eto eto ndị mmadụ nke omumu afọ anwụ n'ime a obere oge. Na ndu plan, a onu na-accelerated ịka nká, nke na-esonyere nnukwu-ọnụ ọgụgụ DNA demethylation.

Olee aka na ahụ?

E nwere ụzọ dị iche iche site na nke ka mma pụta ụwa DNA methylation. Otu n'ime ihe ndị kasị ewu ewu na a ga-akpọ:

1. Riri ọhụrụ elu. akwụkwọ na-karịsịa na-atụ aro. Ha na-eme ka a isi iyi nke folic acid dị mkpa iji hụ na kwesịrị ekwesị methylation.
2. Vitamin B12 na B6, riboflavin. Ha si enweta ya bụ akwa, azu, almọnd, walnuts, asparagus na na.
3. Ịnata a zuru ezu ego nke zinc na magnesium. Ha na-enye mmezi methylation.
4. Admission probiotics. Ha na-eme ka nkwadebe na absorption nke vitamin B ìgwè na folic to-unu.

Ọ dịkwa mkpa na-ebelata nrụgide, enye àgwà ọjọọ (mmanya oriri, ịṅụ sịga). Care kwesịrị iwere ya na ahụ ga-esi na-egbu egbu umi. A ogige buru methyl iche iche n'elu imeju.