"Estrozhel": ntuziaka maka ojiji, a nkọwa nke nkwadebe, analogs, mmetụta

Ọ bụ mba na nzuzo na maka climacteric syndrome ji autonomic-vaskụla, uche na metabolic na endocrine ọrịa na-ebilite si fairer mmekọahụ na a ngụkọta afọ involution nke organism, nakwa dị ka na ndabere nke gradual ikpochapu nke mmiri ọgwụ ovarian ọrụ.

Na oge a tara akpụ n'ihi na ndị inyom ha na-eche na-ekpo ọkụ flushes isi, elu ahu na ogwe aka.

Ke adianade do, ihe mgbaàmà nke menopause agụnye oké mgbakasị, ehighị ụra nke ọma, ịda mbà n'obi, adịghị ike na mmetụta nke mgbe nile egwu. Mgbe mgbe, fairer mmekọahụ na-agbanwe agụụ ichegbu migraine, vertigo, nakwa dị ka na-enwe oké sweating, edema na vasospasm.

Iji mfe nwaanyị ahụ ọnọdụ, ọgwụ na ụlọ ọrụ ndị malitere na-emepụta protivoklimaktericheskie ọgwụ ọjọọ. Ndị kasị dị irè nke a na-agụnye ndị dị otú ahụ na nkà mmụta ọgwụ dị ka "Estrozhel". Nyocha (n'oge menopause bụ ụzọ kenyere ukwuu mgbe) ọrụ ga-ọkọnọ n'okpuru. Ị ga-amụtakwa otú e si eji kwuru ọgwụ, ole ọ na-efu, na na.

Description, mejupụtara, nkwakọ ngwaahịa na ntọhapụ ụdị

ere ọgwụ "Estrozhel" Olee ụdị? Nyocha nke nwanyi haa na a ọgwụ pụrụ ịchọta n'ụdị a transdermal jel. Ọ bụ colorless, uzo, na nwere ísì ethanol.

The n'ọrụ mgwa nke a gị n'ụlọnga eme estradiol. Inyeaka Efrata agwọ ọrịa nwere carbomer, ethanol, trolamine na ọcha mmiri.

Nkwadebe "Estrozhel" (jel) eresị ke akpa nke aluminum. Ọzọkwa gụnyere bụ a pụrụ iche applicator maka ịkwadebe.

pharmacological atụmatụ

Gịnị bụ a jel "Estrozhel"? Ntuziaka na ngwa na-egosi na ọ bụ a mmiri ọgwụ gị n'ụlọnga, nke na-eme maka na enweghị estrogen na a nwanyi ahu.

Ekele ya n'ọrụ Efrata nke a na nkà mmụta ọgwụ nwere estrogenic ọrụ. Ọ na-aduak naanị maka mpụga ma ọ bụ Nde ngwa.

Na ọgwụgwọ nke a owuwu na fairer mmekọahụ budata belata mgbaàmà nke menopausal syndrome, gụnyere ịda mbà n'obi, ihe ọkụ ọkụ, na-ekpo ọkụ flushes na mmamiri nkụ.

Na ya na-adakarị arụmọrụ ke ọgwụgwọ nke postmenopausal mgbaàmà atụle ọgwụ adịghị-ekwenyere ọgwụgwọ na onu estrogen ọgwụ. Ọzọkwa, mgbe eji ngwá ọrụ a na menopausal ọrịa akara slowing nke Filiks na belata njupụta nke ọkpụkpụ anụ ahụ.

Ọzọkwa nọrọ ọgwụ na-enyere belata ngụkọta cholesterol.

Anyị apụghị ikwu na ọgwụ "Estrozhel", ego nke nke na-egosi n'okpuru, nwere procoagulant arụmọrụ. Ọ na-ebelata ego nke antithrombin III na enwekwu hepatic njikọ nke K-dabere ọbara clotting mmadụ.

pharmacokinetic Njirimara

Ma ọgwụ etinye obi gị dum "Estrozhel"? Nyocha ọkachamara na-ekwu na mgbe ngwa nke jel etịbe nnọọ ngwa ngwa evaporating na ethanol, adịru estradiol ozugbo penetrates ikpa. A akụkụ buru ibu nke ọgwụ ozugbo abatakwa systemic mgbasa, na nta - a nọgidere na subcutaneous abụba, nke a na-tọhapụrụ nwayọọ nwayọọ.

Mgbe obodo ojiji nke jel kacha ịta nke estradiol n'ime ọbara hụrụ mgbe 180-240 nkeji. The bioavailability nke ọgwụ bụ 82%.

E lee ya anya agwọ ọrịa na-adịghị doro mmetụta nke "mbụ ngafe", nke na-enye a elu plasma ịta nke estradiol tụnyere onu analogues.

Ndọrọ ego nke estradiol na ya metabolic mgbanwe tụnyere ndị maka otu eke estrogen.

Egosi maka ngwa nke mpụga nkwadebe

N'ihi nzube dị aṅaa ọgwụ "Estrozhel" ike ga-eji? Ntuziaka maka ojiji na-egosi na nke a usọbọ na-atụ aro iji belata ma ọ bụ kwụsị mgbaàmà nke climacteric syndrome, gụnyere artificially rata menopause. Ke adianade do, ọgwụ na ajụjụ a na-eji maka igbochi na ọgwụgwọ nke osteoporosis n'oge menopause.

contraindications

Ị maara mgbe ị na-ekwesịghị iji jel "Estrozhel"? Ntuziaka maka ojiji na-akọ na na zuru contraindications nke ngwá ọrụ a na-agụnye ndị na-esonụ ọnọdụ:

• Rotor syndrome;
• ischemic ma ọ bụ haemorrhagic ọrịa strok;
• nnukwu thrombophlebitis ma ọ bụ thromboembolism;
• n'oge ime;
• eriri akpa nwa ọbara ọgbụgba nke aghọtabeghị si;
• gbasara akụrụ odida;
• ara;

• ; Johnson - syndrome Dubin
• estrogen-dabere malignancies ma ọ bụ enyo nke ha n'iru ya;
• hypersensitivity;
• benign ma ọ bụ ịza aza etuto ahụ nke pituitary;
• Serious ọrịa imeju na nnukwu-adọ, imeju etuto ahụ, na jaundice.

Nlezianya ojiji nke agwọ ọrịa

Mgbe ga m etinye jel "Estrozhel" ihe ókè ịkpachara anya? Ọbịa ọkachamara na-ekwu banyere ndị na-esonụ ọnọdụ:

• leiomyoma;
• akwara akwara ọrịa;
• endometriosis;
• disturbances nke imeju ọrụ;
• pancreatitis;
• arịa ọrịa shuga;
• migraine;
• akwụkwụ na-adọ;
• ụkwara ume ọkụ;
• ezinụlọ hyperlipoproteinemia;
• hepatic porphyria;
• mkpali ọrịa nke omumu usoro na fairer mmekọahụ;
• hụrụ tupu jaundice, gụnyere ya pụta ìhè na N'ezie nke ikpeazụ dị ime;
• trombozay, thrombophlebitis ma ọ bụ thromboembolism (tụnyere estrogen ọgwụgwọ);
• ọbara mgbali oké;
• daa ọrịa gallbladder na cholelithiasis (akụkọ ihe mere eme);
• hypercalcemia metụtara na ọkpụkpụ metastases ara anụ ahụ na etuto ahụ;
• ọbara ọrịa.

Jel "Estrozhel": ntuziaka maka ojiji

E lee ya anya nkwadebe na-eji naanị topically. Ke idaha ọ na-eji nọgidere ma ọ bụ cyclically. Duration nke ọgwụgwọ na onunu ogwu nke ọgwụ na-ahọrọ n'otu n'otu.

Otu dose of jel "Estrozhel" (2,5 g) nwere 1.5 mg nke estradiol.

Na ọgwụgwọ nke menopause mgbaàmà gosiri disposable itinye ọgwụ kwa ụbọchị na ihe ego kwa dose. The jel e thinly gbasara akpụkpọ nọ n'ógbè nke lumbar region, aka, afo ma ọ bụ ubu, ma na-echere ya zuru mmiri.

The saịtị nke anụ ebe ọgwụ mee ihe, agaghi-erughị ebe nke aka ya abụọ nke onye ọrịa.

Maka ezi arụmọrụ nke ngwa na ndị kasị dị irè n'ihi e ji absorption nke ọgwụ na 3 nkeji. N'otu oge ichebe stickiness mgbe ngwa nke otu dose nke ọgwụ maka 5 nkeji na-egosi a enweghị ohere na-eji akpụkpọ.

Mee ọgwụ ga ọrịa (n'ụtụtụ ma ọ bụ mgbede). Gbasoo jel na-achọsi ike ka na mbụ kpochara mkpuchite.

mmetụta

Gịnị bụ achọghị mmetụta ime mgbe iji "Estrozhel" jel? Nyocha nke ndị inyom na-akọ mmetụta:

• akpụkpọ iyatesịt, anụ flushing, isi ọwụwa na oké isi ọwụwa;
• ọnọdụ swings, na dizziness;
• uche na-abawanye na size nke mammary glands, ha mgbu, menorrhagia, amenorrhea, itunanya agba ọbara;
• etuto ahụ na mammary glands, mụbara libido, smearing mmamiri agbapụta n'ahụ, gụnyere intermenstrual oge;
• afọ mgbu, ńsí eriri afo mgbochi, ọgbụgbọ, vomiting, ịba ọcha n'anya, epigastric mgbu, anorexia, pancreatitis;
• cholelithiasis, cholestatic jaundice, afọ ọsịsa, afo cramps, bloating;
• thromboembolism, kọntaktị oghere ekweghị ibe nọrọ, ibu mgbanwe, elu edema;
• ụba ọbara mgbali, nfụkasị Jeremaya (gụnyere urticaria na itching nke anụ), na kọntaktị dermatitis.

All nke a mmetụta na-owụt kama weakly. Ha na-emekarị-eme ná mmalite nkebi nke ọgwụ na fọrọ nke nta mgbe achọ discontinuation nke ọgwụ.

mgbaàmà nke ovadozu

Gịnị ga-eme mgbe a nnukwu ego nke ọgwụ "Estrozhel" (esi etinye ngwá ọrụ a, anyị gwara n'elu)? N'ihe banyere nke elu doses nke agwọ ọrịa na-enwe ndidi ọgbụgbọ na vomiting, nakwa dị ka ịzụlite eriri akpa nwa ọbara ọgbụgba. Na e guzobere a mgbaàmà iji jel ozugbo kwụsị.

Mmekọrịta ndị ọzọ ọgwụ ọjọọ eme ihe

Ọ ga-ekwe omume na ikpokọta na ọgwụ ọjọọ ndị ọzọ ọgwụ ọjọọ, "Estrozhel" (jel)?

• Na a yiri ngwa nke antihypertensive na hypoglycemic mmadụ, na anticoagulants nwere ike belata ha irè, nke na-achọ a nyochaa nke dosing ọchịchị.
• The Nchikota "Estrozhelya" na lipid-ẹsụhọde ọgwụ ọjọọ na-eduga onye ubara mmetụta nke ikpeazụ.
• Na n'otu oge eji ọgwụ ọjọọ nke bụ inducers nke microsomal imeju enzymes (e.g., "rifamycins", "Carbamazepine", "griseofulvin" na barbiturates), plasma estradiol nwere ike ibelata.
• The ojiji nke jel ebelata ịdị irè nke diuretics na nwoke mmekọahụ homonụ.
• The n'otu oge iji ọgwụ, opioid analgesics na ọgwụ ọjọọ na-eji maka general ná Nkụnwụ Ahụ, accelerates metabolism nke estradiol.
• The Nchikota na nje ụfọdụ (gụnyere "Rifampicin" na "ampicillin"), nakwa dị ka "phenylbutazone" ebelata plasma kasịnụ nke estradiol.
• Imekotaotuugbo ọgwụgwọ na folic acid na thyroid hormone enwekwu estradiol mmetụta n'aka.

kpọmkwem na-atụ aro

Drug "Estrozhel" oji a machibidoro kpam kpam n'oge ime. Ọ kwesịkwara kwuru na tupu ngwa nke jel inyom kwesịrị ijide n'aka inweta a zuru gynecological nyochaa. Na ogologo oge nke ọgwụ, dị usoro a ga-rụrụ dịkarịa ala otu ugboro n'afọ.

Dị ka na-atụ aro a ọkachamara ọgwụgwọ a na advantageously rụrụ na Nchikota na estradiol, progestin ọgwụ. Ndị dị otú ahụ a Nchikota ga-echebe endometrium.

Ọ ga-echebe ndị mucosa nke vulva na ikpu, nakwa dị ka akpụkpọ na ara si na ha na-ewere ọgwụ ọjọọ.

Ruo ogologo oge iji ọgwụ, gụnyere elu doses, enwekwu ihe ize ndụ nke ara na endometrial cancer.

Ọ bụrụ na ị chọrọ nhoputa usiakidem, ndị estrogen ọgwụ ga-kwụsịrị maka 4-6 izu tupu.

"Estrozhel" na-agaghị na-eji n'oge ime atụmatụ. Ọ kwesịkwara kwuru na-arụsi ọrụ ike agwọ ọrịa anaghị ogwu Njirimara na adịghị egbochi tụụrụ ime ya.

Drugs "Estrozhel" na "Utrozhestan" - a zuru okè Nchikota. N'ihi ndokwa a àgwà nke ọrịa ndụ n'oge menopause budata mma.

Na-eri na yiri preparations

Ego ole ka a jel "Estrozhel"? The price nke a gị n'ụlọnga bụ banyere 700 rubles. Ọ bụrụ na chọrọ, ọ ga-anọchi ndị ọzọ ọgwụ ọjọọ eme ihe ndị dị otú ahụ dị ka "Estrokad", "Esterlan", "Estrovagin", "Ovestin", "Sinestrol", "Kolpotrofin", "ethinylestradiol", "Elvagin", "Ovipol Clio", "Pauzogest "," Klim "na ndị ọzọ.

Nyocha inyom

The fairer mmekọahụ iji a n'aka maka enyemaka nke menopausal mgbaàmà, na-ahapụ ya naanị mma nzaghachi. Ha mara na ya elu arụmọrụ na a obere ugboro ole na ogo nke mmetụta tụnyere onu ogbo.

Ọzọ àgwà ọma nke ọgwụ na-agụnye ya adaba dosing usoro, enweghị tackiness mgbe usoro na ngwa absorption n'ime anụ.