"Heparin" (injections): ngwa, onye ọrụ, reviews, dose. The ojiji nke injections "Heparin" n'oge ime

Drug "Heparin" bụ ike iji nwayọọ na-na ọbara nwere ikike clot. Atọhapụ medicated gị n'ụlọnga na iko ampules na vials nke 5 ml. Ha na-injectable ngwọta, nke nọ n'ọrụ umi bụ 5,000 IU.

pharmacological Njirimara

Drug "Heparin" (injections) bụ anticoagulant. Ọ bụ ike iji nwayọọ na-na usoro nke fibrin guzobere, belata ọsọ ihe ọbara coagulation, na na nnukwu kasịnụ - iji belata ọrụ nke thrombin. Ọbụna obere doses nke ọgwụ bụ iji dịkwuo fibrinolytic ọrụ nke ọbara.

eji "Heparin" injections iji belata viscosity nke isi ahu nke ndu ọmụmụ. Jiri nke (a dose maka ọgwụ ahọrọ ndị dibịa n'otu n'otu) dabere na eziokwu na nke a pụtara na a na-akwakọba na endothelium nke mkpụrụ ndụ ọbara na enwekwu ha na-ezighị ezi ụgwọ. N'ihi na nke a onwunwe mbelata adhesion na aggregation nke platelet, leukocytes na erythrocytes.

Ke adianade do, "Heparin" na-egbochi mmepe nke atherosclerosis, nwere mgbochi anabata na nke dị nwayọọ vasodilator mmetụta. Nke a bụ n'ihi na eziokwu na ọ na njikọ a ọnụ ọgụgụ nke ihe nke zuo ezu usoro ma na-ebelata ya ọrụ. Ọzọkwa, ọgwụ na-egbochi guzobe immunoglobulins, lymphocyte co ejikọ histamine na serotonin.

egosi

Dị ka a n'ozuzu na-achị, ọ bụrụ na ị nwere nsogbu na ọbara clotting idepụta ọgwụ "Heparin" ọgwụ ọjọọ. Ọgwụ ma ọ bụ igba ogwu n'akwara infusion na-atụ aro na ndị a:

1) miri akwara thrombosis, akwara akwara ọrịa, akpa ume embolism;

2) myocardial infarction;

3) ejighị n'aka rịaworo;

4) Akụkụ nke mbụ nke DIC;

5) atrial fibrillation, nke na-esonyere thromboembolism.

Ọzọkwa na ụlọ ọgwụ maka arụmọrụ extracorporeal mgbasa usoro nwere ike ekenye pụtara "Heparin". Ọgwụ intravenously ma ọ bụ subcutaneously, ma ọ dị mkpa anam mmịnye ọbara, hemodialysis iji gbochie coagulation nke ndu ọmụmụ.

The n'aka eji maka ọgwụgwọ na mgbochi nke na-anaghị ekwe nke microcirculation na microthrombogenesis ihe atụ, thrombosis nke gbasara akụrụ veins, lupus nephritis, glomerulonephritis, nje endocarditis, mitral ọrịa obi, ọrịa gemolitikouremicheskom syndrome.

mmetụta nke ọgwụ

Ọ bụrụ na ị na-kenyere injections "heparin" na afo, ị maara: ha ga-eme nnọọ mgbe. Mmetụta nke ọgwụ na-adị ngwa ngwa, ma ọ bụ dị mkpụmkpụ. N'ihi ya, mgbe ndinọ intravenously pụtara clotting slows ala fọrọ nke nta ozugbo, mmetụta dịruru banyere 4-5 awa. Mgbe ndinọ intramuscularly, mmetụta ya nke ọma mgbe 15-30 nkeji na-ekwupụtakwa maka 6 awa, na mgbe agbara n'okpuru anụahụ a hụrụ mgbe 40-60 nkeji na-ekwupụtakwa 8 awa. Therapeutic edinam iji na-egbochi guzobe egbochi mkpụkọ nke ọbara, dịruru ogologo.

Nkwadebe "Heparin" enwekwu gbasara akụrụ ọbara, enwekwu vaskụla eguzogide na ụbụrụ, nwere hypolipidemic mmetụta. Tụkwasị pụtara ebelata ọrụ nke akpa ume surfactant egbochi oké njikọ nke aldosterone na adrenal cortex, amplifies ifịk mmetụta PTH ejikọ adrenaline.

eji atụmatụ

Ọtụtụ mgbe ndị mmadụ na-ata ahụhụ si na ọrịa obi, nye iwu ka "Heparin" (gbaa). The price nke a ọgwụ yiri elu ụfọdụ. Packaging of 5 ampoules of 5 ml na ihe na-eme nke 5000 IU kwa 1 ml eri 500-600 rubles. Ma na-ajụ ya ngwa agaghị ekwe omume. Mgbe niile, na ọrịa na ischemia pụtara "Heparin" ebelata ihe ize ndụ nke myocardial infarction, akwara akwara thrombosis na ọnwụ mberede. Ọzọkwa, na ojiji nke ọgwụ ọjọọ nwere ike ibelata puru nke ntighari obi ọgụ na budata belata pasent nke ọnwụ na ndị ọrịa a.

Mgbe venous thrombosis na akpa ume embolism nye iwu elu dose "Heparin" nkwadebe. Ọgwụ (ntụziaka na-enye ohere obibi otú kwesịrị ekwesị na-etinye ha) na-mere na a ụfọdụ oge. Ma, ọ bụ eziokwu, mgbe ụfọdụ, iji nweta ha ozugbo mmetụta chọrọ inye igba ogwu n'akwara n'aka.

Ọzọkwa nye iwu a n'aka "Heparin" maka mgbochi nke thromboembolic ihe, dị ka mgbe ịwa ahụ. Na nke a, ọ na-kenyere na obere doses.

Ụzọ nke eji

Họrọ chọrọ onunu ogwu na usoro nke iji ọgwụ ga naanị dọkịta, dabere na ọrịa na-arịa na ihe ndị mere na ọ chọrọ a ọgwụ. Ukwu ike ga-ndinọ intravenously dị ka a na-aga n'ihu infusion ma ọ bụ mgbe injections. Ọzọkwa, mgbe ụfọdụ, subcutaneous, ma ọ bụ nwere ike họpụtara site intramuscular ogwu ogbugba.

Iji gbochie thrombosis ọgwụ ike ga-ndinọ subcutaneously na 1 ml (5000 IU) ugboro abụọ n'ụbọchị. On mkpa nke nkọwa a bụ mmasị na ọgwụ ọjọọ, "Heparin" ntụziaka ntuziaka. Ọgwụ na-emekarị ka ke afo, na ya anterolateral mgbidi. Iji mee nke a, na-ezi agịga na igba ya miri n'ime anụ anọghị n'ogige atụrụ. Ọ na-kpụrụ mgbe enwe n'etiti mkpịsị aka na forefinger nke afo ebe ke otubo ebe. The ọgwụ ga-alternated. Na ahụkebe mgbe, injections nwere ike mere na elu nke apata ma ọ bụ elu na ogwe aka.

onunu ogwu nhọrọ

Maka ọgwụgwọ nzube na okwu nke inpatient ọgwụgwọ na ọgwụ na-emekarị kenyere igba ogwu n'akwara infusion. N'ihi na okenye ọrịa, na onunu ogwu nke 1,000 IU / hour. Ma tupu wụnye ntapu nke kacha mmetụta na ọ nwere ike tinye bolus n'ime a akwara na ego nke 5,000 IU. Nhọrọ nke kpọmkwem dose na-ndinọ na a dọkịta dabere na ọnọdụ na ọrịa na-arọ.

Ọ bụrụ na ọ gaghị ekwe omume na-eduzi ihe igba ogwu n'akwara infusion, ndị mmadụ nwere ike ga-ndinọ subcutaneously: 2 ml nke ọgwụ (nke kwekọrọ na 10000 IU) 4 ugboro kwa ụbọchị. The kacha onunu ogwu na-eji nkwadebe na 10 ụbọchị.

The chọrọ ego nke ọgwụ na-ahọrọ mgbe nwale ule results. Akpan akpan anya na-akwụ ụgwọ ndị APTT (ọrụ ele mmadụ anya n'ihu thromboplastin oge).

Mgbe na-enye onyinye ọbara, na-adịkarị ndinọ 7.5-10 puku. IU pụtara "Heparin".

Agwọ na pụrụ iche ikpe

Na nnukwu myocardial infarction ozugbo ndinọ 10-15 puku. IU intravenously, mgbe ahụ, ya wee na ojiji nke ndị dị otú ahụ a ngụkọta oge, onye ọrịa natara banyere 40 000 IU na ụbọchị mbụ, ma kpọmkwem onunu ogwu họrọ dabere na ọrịa arọ. Nke a dị mkpa iji hụ na ọbara na-akpụkọ na 2.5-3 ugboro iji nwayọọ. Site na nke abụọ ụbọchị ndị dose na-ebelata. Ọ dị mkpa na clotting oge bụ 1.5-2 ugboro elu karịa na-emekarị. Ọgwụgwọ na a ọgwụ na-8 ụbọchị. Iji kagbuo a kwa ụbọchị dose belata 5-10 puku. IU, ma etiti oge n'etiti injections adịghị mụbaa. Mgbe ekpochapụ ngafe ka anticoagulants nke anọ ihe. O nwere ike ịbụ dị otú ahụ dị ka "Fenilin", "neodikumarina" na ndị ọzọ.

Nnukwu ọbara ma ọ bụ venous mgbochi chọkwara a pụrụ iche na obibia. Maka ọgwụgwọ kenyere igba ogwu n'akwara heparin maka 3-5 ụbọchị na a dose nke 400-450 IU kwa n'arọ nke ime arọ. Nke ahụ bụ, a ọrịa nke na-ajụ Mee na ịdị elu ga-enweta a ụbọchị banyere 30-40 puku. IU "Heparin" ọgwụ ọjọọ. Mgbe ahụ, ịga na na fractional ya mmeghe, ma onunu ogwu na-amụbawo ruo ihe dị 600 IU / n'arọ, na otu na ọgwụ n'ime ahu ga-enweta 100 IU / n'arọ. Ọgwụgwọ nwere ike ịdịru ruo ụbọchị 16. Na nnọọ a ụbọchị ole na ole tupu ya ọgwụ ndọrọ ego ego na-nwayọọ nwayọọ belata. Ọgwụgwọ na-nọgidere na-eji anọ anticoagulants.

adọ aka ná ntị

N'agbanyeghị eziokwu na ụfọdụ na-ekwu banyere ekwe omume nke intramuscular ogwu ogbugba nke ọgwụ, nke a na-adịghị na-atụ aro n'ihi na eziokwu na na na-agbanye saịtị hematoma mgbe kpụrụ. Iji ọgwụ dilutions 0,9% NaCl ngwọta.

Ọ dịkwa mkpa ịmata na n'oge ọgwụgwọ "Heparin" pụtara na ọ dịghị mkpa ka ọ bụla ọ na intramuscular injection na biopsy akụkụ. Mgbe na-eji ya, mkpa ka i nyochaa steeti coagulation. Ke akpa izu nke ọgwụ, ọbara enyocha ọ bụla ụbọchị abụọ, malite na nke abụọ n'izu ọ ga-mere ọ bụla 3 ụbọchị.

Ọ bụ ezie na n'aka na ọ dịghị banye n'ime mmiri ara, lactation na oge nke ọgwụgwọ, ọ na-achọsi ike kwụsị. Ọ hụrụ na ọgwụ na-eduga na ụfọdụ imebi ọkpụkpụ azụ na osteoporosis. The nsogbu amalite mgbe 2-4 izu nke ọgwụgwọ.

Iche iche, ọ bụ uru na-arịba ama na ọgwụ ngwọta ya pụrụ atụgharị odo, ma o nweghị mmetụta na ya pharmacological Njirimara ma ọ bụ ndidi pụtara "Heparin". Ọgwụ, na price nke nwere ike budata emetụta ego n'ịhọpụta ya na elu doses, nwere ike mere ọbụna na ha onwe ha n'ụlọ.

contraindications

Dị ka ọ bụla ọzọ, i nwere ike iji ọgwụ ọjọọ "Heparin" ma ọ bụrụ na ị na-hypersensitive. Ọ na-adịghị kenyere ọ bụla ọbara ọgbụgba. Wezụga na hemorrhages na-erukwa na mgbe myocardial akpa ume (owụt ke ụdị hemoptysis) ma ọ bụ akụrụ (so hematuria).

Contraindications na-agụnye:

- hemorrhagic diathesis na ọrịa ndị ọzọ na nke mkpọchị ọbara clotting;

- ụba vaskụla permeability, dị ka Verlgofa ọrịa;

- nje endocarditis ;

- agba ọbara na akụkọ ihe mere eme;

- hypoplastic na aplastic anaemia, ala ala na nnukwu leukemias;

- oké umeji akụrụ ọrụ;

- venous ure anụ;

- mmepe nke nnukwu obi aneurysm.

precautionary jikoro

Ke adianade kpọmkwem contraindications, e nwere a ndepụta ọnọdụ ebe ọ dị mkpa ịtụle ihe niile kwere omume ize ndụ mgbe na-ewere "Heparin" ọgwụ ọjọọ. Ọgwụ na igba ogwu n'akwara eme naanị na ahụkebe ikpe na n'okpuru nlekọta nke ndị ọkachamara na etuto ahụ na ọnyá ọnya nke eriri afọ tract, ọbara mgbali elu, ọbara na postoperative oge, ma e wezụga n'ihi angioplasty.

A okwu ole na ole banyere ọgwụgwọ nke ga-eme n'ọdịnihu na nne. N'agbanyeghị eziokwu na ọgwụgwọ nke ndị inyom na ndị ezinụlọ ụzọ n'ihu anyị pụtara ekwesighi (na ọ pụrụ iduga mmepe nke nsogbu), injections "heparin" na afo na-kenyere ụfọdụ, n'oge ime. The puru nke omume nke oghom mmetụta sitere na site 10 ruo 21%. Mgbe maka a nkịtị ime ihe ize ndụ nke nsogbu bụ ihe na-erughị 3.6%.

Ọ ga-kwuru na ndị na-esi nke a kwe omume thromboembolism na abụ nne bụ ihe ize ndụ ndụ karịa ịnara pụtara "Heparin". Ọgwụ n'oge ime eme nanị n'okpuru nlekọta nke ndị ọrụ na naanị ma ọ bụrụ na e nwere zuru àmà. Ma ọgwụ nwere ike ime ka ọbara na-agba, thrombocytopenia na osteoporosis. Ọ pụtara Plasenta ọ dịghị banye.

Ekwe Omume analogs na ndidi testimonials

Ọtụtụ mgbe ndị na-ahọpụta ọgwụ "Heparin" (injections na afo), na price yiri kwa elu. Ma mgbe ọ na-eji dị ka a mgbochi ụfọdụ, 1 ngwugwu nwere ike ịpụta maka ụbọchị ole na ole. Ya mere, mkpo nke karama 5, nwere ike-ezuru a di na nwunye nke izu. A elu-dose nkwadebe na-eji na-emekarị ọ dịghị ihe karịrị 10-14 ụbọchị.

O sina dị, ọtụtụ ndị chọrọ ịmụta site na ndị ọzọ ọrịa, ọ bụ uru ịzụ ọgwụ, ha na-achọ "Heparin" nkwadebe nke reviews. Analogues nke ọgwụ ha na-nwere mmasị. Ya mere, ọ bụrụ na e nwere nsogbu na ọbara clotting, na ngwá ọrụ dị irè na-enye gị ohere iji nweta ihe ndị ha chọrọ ọgwụgwọ mmetụta nnọọ ngwa ngwa. Nke a na-egosi na ma ndị dọkịta na ndị ọrịa.

Ma, kama ọ pụkwara inye anticoagulants "Troparin", "Heparin Sandoz", "Heparin sodium Brown", "Heparin-Verein" na ndị ọzọ analogs. The onunu ogwu nke ọgwụ ndị a ga-naanị họrọ a dọkịta dabeere na ihe chọpụtara onye ọrịa, na steeti ya ike na-egosi n'ihi na nke ọgwụ na-kenyere.

Mgbe ụfọdụ, ndị dọkịta nwere ike ikwu na ala molekụla ibu heparins, ndị dị ka "Fraksiparin", "Fragmin", "Tsibor", "Eniksum", "Fraksiparin forte." Mmetụta ha, dị ka ọ pụtara ìhè site Ibọrọ nke ọrịa, fọrọ nke nta ka otu ihe ahụ nke ọgwụ n'ihu anyị.