"Probenecid": ntụziaka maka iji, analogues, reviews

Kedu ọgwụ ọjọọ Probenecid? Ntuziaka maka ojiji, nkwenye, ihe analogues na akara maka iji ọgwụ a ga-egosi n'okpuru ebe a.

Ụdị, mejupụtara

Kedu ihe bụ probenecid? Ntuziaka maka iji kwuo na ọ bụ ihe na-arụsi ọrụ ike bụ nke so n'ọtụtụ ọgwụ. Ị nwere ike ịzụta ọgwụ ndị a na ụlọ ọgwụ ọ bụla na ezigbo ego. Enwere ike ịmepụta ha n'ụdị mbadamba, capsules na ọbụna ntụ ntụ maka nkwadebe nkwusioru.

Ihe banyere ọgwụ na ọgwụ ọjọọ

Kedu ka ọgwụ Probenecid si eme? Ntuziaka iji mee ihe, nyocha na-ekwu na onye na-agwọ ọrịa a, nke nwere ike igbochi reabsorption nke uric acid, nke dị na mkpịsị ụkwụ, ma mee ka ọ nwekwuo excretion.

Dika ndị ọkachamara si kwuo, mmụba dị ịrịba ama na excretion nke urinary acid n'okpuru nduzi nke ihe dị na ajụjụ nwere ike iduga n'ọganihu nke ịhapụ ya na ọbara, nke na-eme ka ọ bụrụ ọgụ nke nnukwu gout.

Ọzọkwa, ọgwụ "Probenecid", ntụziaka nke a na-akọwa n'okpuru ebe a, na-enyerekarị aka mee ka excretion nke ọgwụ ndị ọzọ jiri akụrụ, tinyekwuo uche ha na plasma. Nke a na - eme ka o kwe omume iji onye ọrụ ahụ na - ajụ ajụjụ dị ka ọgwụ ọzọ na - agwọ ọrịa ọgwụ.

Njirimara mkpụrụ ndụ

Ndi ọgwụ "Probenecid" ana etinye uche? Mgbe nchịkwa ọnụ, a na-etinye ya kpam kpam site na tract digestive. N'okwu a, a na-ebute ịta elu nke probenecid n'ime ọbara mgbe awa atọ gasịrị, ya na ndị na-edozi ya dị 85-96%.

Ebee ka e kewapụrụ ọgwụ ahụ na ajụjụ? Dịka ntụziaka ndị ahụ si dị, ọ na-etinye aka na imeju. N'okwu a, a na-akpụ isi acylglucuronide na ndị metabolite ndị ọzọ.

A na-egbochi akụrụgwụ site na akụrụ site na nlezianya na-arụsi ọrụ ike nke ikpo ọkụ na nsochi. N'ime urine ahụ, ihe dịka 75-86% nke ndị metabolites dị, ndị ọzọ adịghị agbanwe agbanwe (dabere na mmamịrị nke oge a na acidity).

Ntu

Olee ọrịa ndị na-agwọ ọgwụ ọjọọ Probenecid? Ntuziaka iji mee ihe na-ekwu na ọgwụ dị otú ahụ gosipụtara n'ụzọ dị irè na ọgwụ hyperuricemia na njedebe na-adịghị ala ala, yana hyperuricemia na iji diuretics.

Onye na-enweghị ike ịsị na dịka ọgwụgwọ ọzọ, a na-enye ọgwụ a maka ọgwụgwọ ọgwụ nje na penicillins na cephalosporins.

Contraindications

N'ọnọdụ ndị dị aṅaa ka amachibidoro itinye Probenecid n'ọrụ? Ntuziaka maka iji gosi ụdị contraindications dị ka:

• Akara;
• A gout nke nnukwu gout;
• Oge ime ime;
• Urolithiasis (gụnyere ọnụnọ nkume urate);
• Afọ ụmụaka ruo afọ abụọ;
• Mmezi na nyocha nke ọbara ọbara;
• Mmetụta dị na probenecid;
• Hyperuricemia nke abụọ, bụ nke sitere na iji ọgwụ chemotherapeutic ma ọ bụ usoro ọgwụ ọjọọ.

Ọgwụ "Probenecid": ntụziaka maka ojiji

Analogs nke ngwá ọrụ a ga-edepụtara n'okpuru ebe a.

Na ọgwụ na-adịghị ala ala, a ghaghị ịṅụ ọgwụ ahụ na 250 mg ugboro abụọ n'ụbọchị maka otu ọnwa. Otu izu mgbe mmalite nke ọgwụgwọ, ego a nwere ike ịbawanye okpukpu abụọ.

Site n'inwe ọgwụgwọ zuru ezu, a pụrụ ịgbatị usoro onunu ogugu kwa ọnwa site na 500 mg. Ekwesiri icheta na ọgwụ kachasị na ọgwụ a bụ 2 g kwa ụbọchị.

Ọ bụrụ na n'ime ọnwa isii, onye ọrịa ahụ enweghi nnukwu mwakpo nke gout, ugwo urate n'ime ọbara ahụ agaghịkwa gafere ọkwa a kwadoro, mgbe ahụ, a ga-eji nwayọọ nwayọọ belata ọnụ ọgụgụ ọgwụ ahụ ka ọ bụrụ nke kachasị dị irè (dịka ọmụmaatụ, 500 mg kwa ọnwa isii).

A pụrụ ịba ụba nke usoro probenecid na ndị na-enweta diuretics ma ọ bụ pyrazinamide.

Mgbe ị na-arụ ọgwụ nje na cephalosporins na ọgwụ ndị penicillin na ndị okenye, a na-ede ọgwụ ahụ a gwara ya na 500 mg anọ ugboro n'ụbọchị.

N'aka ụmụaka dị afọ abụọ, ọgwụ mbụ nke ọgwụ ahụ kwesịrị ịdị 25 mg kwa kilogram nke arọ ahụ, wee nwee mmụba ruo 40 mg kwa kilogram. Oge nkeji n'etiti ọgwụ a bụ awa 6.

Na ọgwụgwọ nke gonorrhea, a na-enye ọgwụ Probenecid ka eji ya mee ihe na 1 g maka ọkara otu awa tupu usoro nlekọta nne na nna nke ọgwụ.

Ihe ojoo

Kedu ihe mmeghachi omume nke ọdịdị ọjọọ nwere ike iji ọgwụ ọjọọ "Probenecid" mee? Ntuziaka na-eso ọgwụ ahụ na-egosi mmetụta ndị na-esonụ:

• itching, anorexia, nephrotic syndrome, akpịrị goms;
• Isi ọwụwa, ọkụ, dizziness;
• Urticaria, ọgbụgbọ, urination ugboro ugboro, vomiting;
• Leukopenia, ọrịa Stevens-Johnson, ọrịa necrosis, alopecia;
• Nsogbu anaphylactic, dermatitis, anaemia, afụ ọkụ;
• Anemia nke hemolytic, exacerbation nke gout, aplastic anemia.

Mmekọrịta ọgwụ ọjọọ

Dịka ntuziaka ahụ si dị, ihe dị ike dị ka probenecid nwere ike ịkwụsị excretion ma mee ka ọbara ndị ọgwụ dị ka Captopril, Acyclovir, sulfonamide conjugates, Paracetamol, sulfonylureas, Naproxen, aminosalicylates, Methotrexate, Lorazepam, Meclofenamate, Rifampicin, Indomethacin, Zidovudine, na Ketoprofen.

Ekwesiri iburu n'uche na ogwu a na-ebelata ntinye nke urine nke di na penicillamine na nitrofurantoin, nke na-eme ka ibelata aka na mmuta ha na cystinuria na oria mmiri urinary.

Nje ọgwụ "Probenecid" na-eme ka mmụba nke excretion nke aminoghippuric acid, phenylsulfonalein, 5-hydroxyindolylacetic acid na sulfobromphthalein, nakwa ọnụ ọgụgụ na-eme ka excretion nke metabolites nke hormones steroid tinyere urine.

Ozi puru iche

Kedu ihe m ga-ama tupu iji ọgwụ ọjọọ eme ihe na probenecid? Dịka ntuziaka ndị a si dị, anaghị akwado ọgwụ ndị ahụ maka hyperuricemia nke abụọ, nke usoro ọgwụgwọ na-eme ma ọ bụ iji ndị chemotherapeutic mee ihe, ebe ọ bụ na ihe a adịghị eme ka njikọ nke uric acid dị, kama ọ na-eme ka excretion ya dịkwuo n'ahụ site na redio. Ịzụlite nke a hyperuricosuria nwere ike ime ka ọrịa nịmpropathy ghara idi.

Na nlekọta pụrụ iche, a ghaghị inye ọgwụ ndị a nye ndị nwere ọrịa ọnyá peptic na ọdịda na-adịghị ala ala. N'ọnọdụ ikpe a, probenecid nwere ike ghara ịdị irè.

Mgbe ị na-eji ọgwụ a eme ihe banyere ọgwụ na-adịghị ala ala, nnukwu mwakpo ya nwere ike ịzụlite, na mmụba nke mkpịsị ụkwụ azụ nwere ike ịbawanye.

Ndị nwere ụkọ G6PD nwere ike ịnweta hememytic anemia.

Ịgbabiga anya na probenecid na-akpata mmetụ CNS, na-akwalite mmepe nke ijigide, ma pụkwara ịkpata ọnwụ n'ihi okpu ume.

O di nkpa iji zere ochichi nke probenecid na Ketorolac na salicylates.

Ndị mmadụ na-eji ọgwụ ọjọọ a eme ihe dị ala nke "Tiopental", bụ nke a chọrọ maka ịbanye n'ime nsị.

Site n'iji usoro nke usoro na probenecid mee ihe n'otu oge, a ghaghị belata dose nke onye mbụ iji belata mmetụta ya.

N'iburu na ị na-aṅụ ọgwụ a, a ga-enwe ike ịmalite ịnwale ule urine maka glucose.

Analogs, okwu ya

Gịnị nwere ike dochie ọgwụ Probenecid? A pụrụ ịzụta analogues nke ngwá ọrụ a na ụlọ ọgwụ ọ bụla. Ndị a na-agụnye ndị a: "Phytolysin", "Citrotase", "Uronefron", "Urocholum", "Baitach", "Tsiston", "Cital", "Phytolite", "Urochol" na ndị ọzọ.

N'ihe banyere nkwenye, ha na-agụnye ọgwụ dị ka "Santuril".

Nyocha gbasara onye na-ahụ maka ọgwụ ọjọọ

O di nwute, nyocha ndi ozo banyere ọgwụ "Probenecid" adighi adi. Otú ọ dị, e nwere ọtụtụ akụkọ banyere ọrụ Santurul. Ndị ọrịa na-ekwu na ọgwụ a na-egosipụta nke ọma na ọgwụgwọ hyperuricemia na gout na-adịghị ala ala, yana hyperuricemia na iji diuretics. Ọzọkwa ọ bụ ezi ọgwụgwọ gị n'ụlọnga maka nnukwu nje cystitis, nonspecific urethritis, postoperative urinary tract ọrịa na ndị ọzọ na urological nsogbu.

Otu enweghị ike ịsị na ọgwụ ahụ a na-ajụ na-enwekwa akụkụ ọjọọ. Ndị na-eji ha eme ihe gụnyere ọtụtụ mmetụta ndị na-akpata na ime mkpesa.