"Ramipril": analogues, nzaghachi na ntụziaka. "Ramipril-C3"

Ụfọdụ n'ime ọrịa na ike budata belata na-adịru ndụ na-emetụta ya àgwà, iche iche guzo ọbara mgbali. Ọ na-amalite nwayọọ nwayọọ na-aga n'ihu n'ihu na-emetụta ọbara arịa, ụbụrụ, akụrụ, na myocardium. Na mbụ nkebi ọrịa siri ike achọpụta ọrịa, n'ihi na ọ na-egosi na ọ baghị mkpesa.

E mesịa, ha na-egosi, na onye ọrịa ahụ kwuru na ọbara mgbali nnọọ elu karịa nkịtị. Ọnọdụ a na-achọ mmalite nke pharmacological ọgwụgwọ, nke bụ omume na ojiji nke 5 na klas nke ọgwụ ọjọọ. Na "Ramipril" bụ ihe kasị zuru okè nke ha, ebute n'ihi monotherapy ma ọ bụ dị ka akụkụ nke a jikọtara multicomponent ọgwụgwọ.

System nke ngwaahịa e ji mara

"Ramipril" analogues nke ọgwụ, nakwa dị ka zuru ezu gwọọ ndị antihypertensive mmadụ. Ramipril n'onwe ya - nke nọ n'ọrụ mgwa na-dị na ọtụtụ preparations. Nke a Ace inhibitor ike igbochi enzyme na belata ọbara mgbali. Ọ-enye gị ohere budata melite prognosis nke ọrịa N'ezie na ndị agadi.

Na-adakarị ọmụmụ gosiri na ramiprilat, na-arụsi ọrụ ike metabolite nke "Ramipril" nnọọ ike na-egbochi angiotensin-n'ịtụgharị enzyme. N'ihi nke a "Ramipril" analogues na mgbagwoju ngwaahịa bụ oke nke n'aka ndị siri ike ịchịkwa ọbara mgbali.

analogs

Ebe ọ bụ na ọgwụ ọjọọ nwere ike idiọk igbochi Ace ma na-enyere aka ịchịkwa elu nsogbu na ọgwụ "Ramipril" ọtụtụ analogues. All nke ha na-ọma-eji na ọgwụgwọ nke ọbara mgbali. Ọzọkwa, mbụ ọgwụ ramipril bụ "Tritatse". All ndị fọdụrụ - ya ọnyà ọgwụ ọjọọ, onye irè ga-jiri ya tụnyere ya. Admission ire ga enen ọgwụ bioequivalence "Tritatse".

N'oge, ndepụta nke analogues nke na-esonụ: "Amprilan", "Vazolong", "Dilaprel", "Korpril", "ọgbọ", "Ramepress", "Ramigamma", "Ramikardiya", "Tritatse," "Hart". "Ramipril" na-emepụta site Russian ụlọ ọrụ "Tatkhimpharmpreparaty" "Biocom" na "North Star". Products ikpeazụ a na-akpọ "Ramipril Nsụgharị Ụwa Ọhụrụ".

Standard Dosages na mgbagwoju preparations

Antihypertensive ọgwụ "Ramipril" mfe rute na-enweta. Ọrụ na-atụ aro atọ unit Dosages nke ọgwụ. Nke a 2,5 mg, 10 mg na 5 mg. Mbadamba dị otú ahụ pụta na-e ugboro abụọ n'ụbọchị. integrated na nkà mmụta ọgwụ na-adị nwere ramipril na hydrochlorothiazide: "Amprilan nd", "Amprilan nl", "Vazolong H", "Remazid", "Triapin", "Tritatse Plus", "Hart D", "Egipress". Ebe a, ego nke ramipril àmà site 2,5 10 mg, na hydrochlorothiazide dose - si 12.5 25 mg kwa mbadamba.

The abụọ udi nke mgbagwoju ngwaahịa - a Nchikota "Ramipril" na a calcium-eti ọkpọ - "Amlodipine". Otu ihe atụ nke ọgwụ bụ "Egipress" nke dị na ọkọlọtọ abụọ Dosages: 10 mg na ramipril 5 mg nke amlodipine na na 10 \ 10 mg. Tụkwasị na nke a Nchikota, ọ dị ihe ọzọ ụdị Nwa nwere ihe Ace inhibitor "Ramipril" na calcium-eti ọkpọ "Felodipine". Nke a "Triapin", nke nwere 2,5 mg nke ramipril na felodipine 2,5 mg.

The ndokwa nke ntuziaka maka ojiji

Na mgbakwunye na-atụ aro nke dọkịta ọrịa ga-gaa na akaụntụ ntuziaka maka ojiji. O nwere ihe ọmụma banyere ihe ndị na-egosi, mmetụta, na onunu ogwu na-enweta ụdịdị, contraindications na anya. Ọzọkwa mmasị ka ọgwụ ọjọọ, "Ramipril" ntuziaka maka ojiji na-akọwa mkpa ịjụ mmanya na ọgwụgwọ nke ọbara mgbali.

na-agba akaebe

"Ramipril" analogues nke ọgwụ ọjọọ na ọnyà "Tritatse" show na:

• oké mkpa ọbara mgbali ;
• na mgbagwoju multi-klas ọgwụgwọ nke ala ala obi odida;
• ọrịa nephropathy na ndị ọzọ na-adakarị ma ọ bụ subclinical, na-adịghị metụtara gbasara akụrụ akwara stenosis ;
• na symptomatic ọbara mgbali;
• maka mgbochi nke myocardial infarction, belata enwe nke ọrịa na gbasara obi ọrịa, nakwa dị ka maka ọgwụgwọ nke ọbara mgbali elu ngụkọta obi n'ihe ize ndụ.

Isi na-egosi bụ ọbara mgbali. Nke a bụ ihe kasị Ugboro ọrịa n'etiti na nká, na-achọ mgbazi. "Ramipril" Ọzọkwa, ma ọ bụ ọgwụ ndị ọzọ Ace inhibitor ga-ndinọ ọrịa n'oge mbụ 2-9 ụbọchị nke nnukwu myocardial infarction oge. ọgwụ dose kwesịrị karịa anabata ọbụna mgbe ọrịa anaghị ata ahụhụ site na ọbara mgbali. Nke a bụ n'ihi na ndị dị ike cardioprotective mmetụta nke Ace inhibitors.

contraindications

Nkwadebe "Ramipril SoC" kwesịghị etinyere na a akụkọ ihe mere eme nke angioneurotic edema ọ bụla analogue ọgwụ ọjọọ, nakwa dị ka ọ bụla anabata, nke mepụtara na ya n'ikuku. Contraindicated oru na ọnụnọ nke hemodynamically ịrịba stenosis nke akwara na abụọ. Ọ bụrụ na ndị stenosis bụ unilateral na ndidi ọrụ ejikari tinyere akụrụ ya abụọ, nhọpụta nwere ike na-elezi anya na n'okpuru nlekọta nke GFR.

Nkwadebe "Ramipril" (5 mg, ma ọ bụ na-atụ aro na ọ bụla ọzọ onunu ogwu) na-adịghị emetụta mgbe hypotension n'okpuru 90 mmHg. Art. Ọzọkwa, ọgwụ na-agaghị na-eji na hemodynamically ịrịba stenosis nke aortic ma ọ bụ mitral valvụ, na hypertrophic okpo cardiomyopathy, bụ isi hyperaldosteronism, ala ala gbasara akụrụ odida na-egosi maka creatinine nwechapụ (GFR) nke na-erughị 20 ml / min.

Mmasị ka ọgwụ ọjọọ, "Ramipril" ntụziaka ntuziaka (a akwụkwọ dịghị analogues) nwere na-egosi nke enweghi ike iji ọgwụ ọjọọ n'oge ime na lactation. A ga-ajụkwa iji ọgwụ maka ụmụaka. Mgbe ọ dị afọ 18 afọ adakarị ahụmahụ bụ ezughi oke na-apụghị-egosi na nchekwa.

dosing regimens

Ihe bụ isi Nwa nke ọgwụ "Ramipril" - mbadamba. The Capsule ọ bụ ụkọ. Na nke a na-atụ aro amalite dose bụ 1.25 mg. The kasị nta dose nke ọgwụ - 2,5 mg, ese ike ya abụọ. Ọnụnọ nke a akara na mbadamba-ahapụ ị na-eme nke a n'ụzọ dị mfe.

Mgbe ọ bụla nke iche nke ọbara mgbali mbụ dose bụ 1.25 mg ugboro kwa ụbọchị. Mgbe ahụ dose nke nta nke nta ka okpukpu abụọ na ezi tolerability. Dose titration a rụrụ ruo mgbe dị otú ahụ n'oge dị ka ọbara mgbali nke Nọsi'ike. The criterion nke irè ọgwụgwọ nke ọbara mgbali - ọbara mgbali mgbe nile, nke na-adịkarịghị adahade naanị.

precautionary jikoro

The ọgwụ ga-a nrụgide akara, karịsịa n'oge mbụ oru. Ọ dị mkpa ka systolic ọbara mgbali ahụ belatara bụghị ala karịa 90 mm. HG. Art. Mgbe ọbara mgbali dara n'okpuru nke a n'ogo na-atụ aro recourse mkpara. Iji gbochie tụlee ke ọbara mgbali na-adịghị atụ aro iji "Ramipril" ọnụ na nitrates, klas m antiarrhythmic ọgwụ ọjọọ ( "Procainamide") na Alfa 1-blockers ( "Alfuzosin," Tamsulosin ").

The ọgwụ kwesịrị iwere anya ma na-ọkacha mma na otu hour. Nke a na-eme ka o kwe omume iji imeghari na renin-angiotensin-aldosterone usoro, nke achịkwakwa ọbara mgbali. Ọzọkwa, ọ bụghị uche na-ewere ọgwụ na pụrụ igosipụta oké hypertensive nsogbu. Nkọ ịjụ n'ikuku nwere ike ime ka ọrịa strok, ihe ize ndụ nke na-ụba na oge a.

Nyocha nke ọrịa na ọgwụ

"Tritatse" na ya generics - elu-edu ngwaahịa na-ọma na-achịkwa ọbara mgbali. Ka ụbọchị, a ọgwụ bụ ihe kasị nke nwere ike antihypertensive n'ụlọnga. Na nke a na-enwe ndidi testimonials banyere ya na dum mma. Ha na-akọwa ya dị ka a pụrụ ịdabere na-ike ọgwụ na-ọma na-achịkwa ọbara mgbali. Mkpa karịsịa bụ Ibọrọ nke ndị ọrịa ndị na-na mbụ e ọgwụ ọjọọ ndị ọzọ na otu a.

Ọrịa kwuru a obere ego nke oghom Jeremaya mere metụtara na toxicity. High mmekọrita maka Ace, nakwa dị ka a obere ọgwụ dose agbanwe a ọnụ ọgụgụ nke metabolic mmetụta, nwere ike ekwesighi ma ọ bụrụ na-eji mgbe nile. Ọ dị mkpa na ọnụ ọgụgụ nke ọdụdọ na mgbe nile iji "Ramipril" ukwuu belata. Otú ọ dị, ha zuru ezu mkpochapu gaghị ekwe omume monotherapy.

Nyocha nke dọkịta banyere ọgwụ

ọbara mgbali mwute ọnụ ọgụgụ. Ọ na-egosi na ọ dị mkpa nke ọrịa a maka oge a na nkà mmụta ọgwụ. Ọ dịkwa mkpa na daa ọrịa budata ebelata ndu ndimmadu. Ọbara mgbali amalite ruru ka overproduction nke renin, nke enwekwu ego nke angiotensin ọbara. Mgbochi nke enzyme na-eduga ná Mbelata nsogbu. Ọ dị mkpa ka mgbochi nke vaskụla sclerosis mgbidi na ntoputa nke oké nsogbu nke ọbara mgbali.

Dị ka retrospective Clinical ọmụmụ, ọtụtụ mgbe nke atrial fibrillation na ischemic ọrịa obi na ọrịa na-amalite mgbe a ndidi nwere ruo oge ụfọdụ asọpụta ọbara mgbali. N'ihi na ọ dị mkpa ya ọgwụgwọ bụ nnukwu. Na ndị ọzọ ihe, n'ihi ya, bụ ikike iji kpochapụ ọnụnọ nke ọrịa site na ọgwụ ACEI otu. N'etiti ha, "Ramipril" ka bụ ike kacha ike ma dị irè.

Dọkịta banyere ọ na-egosi ya uru. The nkwadebe bụ mfe iji, nwere ole na ole n'akụkụ Jeremaya mere na bụ irè ezuru. Otú ọ dị, n'agbanyeghị na àgwà ndị a, o nwere ike ọ gaghị ezu maka ọgwụgwọ nke oké ọbara mgbali. Ọ fọrọ nke nta 40-50% nke na-adakarị ikpe.

N'ihi na ha ọgwụ na-achọ Nchikota circuit esịnede ihe Ace inhibitor, a mamịrị, a calcium na-eti ọkpọ na beta blocker mgbe ụfọdụ. Dị ka ihe angiotensin n'ịtụgharị enzyme inhibitor "Ramipril" mma ruru eru. N'ihi na n'ebe-ya na ọgwụgwọ nke ọbara mgbali ọ ga-ewe, mgbe ọ bụla a na-anara. Ọ bụ ezie na ọtụtụ ndị ọrịa na-ahụ ya n'ihi enweghị ya dịtụ elu na-eri.