Conjugated linoleic acid: ngwa na mmetụta. Conjugated linoleic acid: reviews

N'oge na-adịbeghị i nwere ike ịnụ a ọtụtụ ihe ọmụma banyere uru dietary Mmeju, nke na-a akụrụngwa nke a conjugated linoleic acid. Gịnị bụ linoleic, ọbụna conjugated, mmadụ ole na ole mara. Nkịtị a ọzọ ma ọ bụ na-erughị doro anya okwu na onwu na nkà mmụta ọgwụ "acid". Ịzụ ngwaahịa na ngwaahịa nwere nke a mgwa, ọtụtụ n'ime anyị na-eduzi ozi ke ntụziaka na-atụ anya kpokọtara pụta. Gbalịa ịghọta ihe nwere ike na-atụ anya si ngwaahịa a.

linoleic acid

N'ihi na a ike ndụ na kwesịrị ịrụ ọrụ nile ụmụ mmadụ na akụkụ dị oké mkpa na ha nwere aru nke dị oké mkpa ọdụdụ asịd, nke na-agụnye linoleic. Ọ bụ a linear yinye carbon atọm, nke na-agukọta maka mma biochemists. N'etiti 9 na 10th, na n'etiti nke 12 na nke 13 atọm ọ na e dere otu nkwurịta okwu substituents. Ejibeghi carbons kewara ha, na-egbochi ndị a njikọ egbochi onye ọ bụla ọzọ karịa Njirimara nke umi na-ekpebisi ike. Conjugated linoleic acid pụrụ inweta dị ka onye n'etiti na akakabarede usoro mfe linoleic acid ka stearic. All atọ ndị dị mkpa maka ahụ mmadụ metabolism. Enweghị ọdụdụ asịd, karịsịa linoleic, na ahụ imebi metabolic Filiks na-ata ahụhụ obi usoro, ọbara, atherosclerosis amalite na njọ ike niile arọ. Ọtụtụ n'ime linoleic acid bụ na structuring nke membranes nke mmadụ mkpụrụ ndụ. Ọ bụ ya mere oké mkpa iji na-eri oriri nwere ya.

Gịnị bụ conjugated linoleic acid

Na nke a, isomer-anọchite anya na-agbanwe ha ebe. Otu n'ime ha na-emi odude n'etiti 6 na 7th carbons, na ndị ọzọ n'etiti 8th na 9. Nke a nso ebe-enye ha ohere inwe mmetụta ọ bụla ọzọ, dị ka nke ọma dị ka otu free nkekọ carbon atọm, guzo n'etiti ha. Nke abụọ dị iche na abụọ metụtara asịd ebe linkages substituents ikwu na ụgbọelu nke yinye. Na mfe linoleic bụ CIS-ụdị, ya bụ, na otu akụkụ, na e nwere ike ịbụ conjugated trans-ụdị, nke dị iche. Ekele ndị a ka obere iche conjugated linoleic acid enweta ọhụrụ Njirimara. Karịsịa, ọ bụ ike nke na-arụ abụọ ọrụ - na-ebelata ọrụ ma ọbara abụba transporter na mkpụrụ ndụ, lipoprotein lipase, na n'otu oge ahụ welie disintegration ẹdude ahu abụba, mgbe nkịtị linoleic, on Kama nke ahụ, na-eme ka ìgwè abụba. Ọzọ na-akpali akpali iche bụ eziokwu ahụ bụ na linoleic acid iche na-akwalite cholesterol susceptibility na ọxịdashọn Jeremaya mere, na conjugated ya stabilizes.

Oghere nke American ndị ọkà mmụta sayensị

N'agbanyeghị ọhụrụ technology, conjugated linoleic acid (CLA) e meghere na nso nso. Na afọ 1979-1980 a ìgwè nke ndị ọkà mmụta sayensị si University of Texas mụụrụ a ọnụ ọgụgụ nke ọmụmụ na mmetụta dị iche iche oriri na ndụ nke organism. Michael Peyriz, onye bụ mgbe osote, chọpụtara na eji pụrụ iche n'ụzọ na-egbochi mmụba na DNA nke muscle mkpụrụ ndụ na ụmụ anụmanụ. Ọ hụrụ na a onwunwe ha hụrụ a umi ke anụ. Ọzọkwa nnyocha meghere na ndị ọzọ bara uru Njirimara nke ọhụrụ mmewere, akpan akpan ike inhibit uto nke kansa etuto ahụ. Nke a na-eje ozi dị ka a ike kwalite maka ọmụmụ nke Biochemical Filiks enwekwukwa ọrụ conjugated linoleic acid.

bara uru Njirimara

Mgbe a na ogbo, ọmụmụ gosiri na conjugated linoleic acid (CLA) bụ ike nke na:

• mee ngwangwa ahụ metabolism;
• inyere dịkwuo muscle uka;
• ala cholesterol;
• belata ihe ize ndụ nke ọrịa shuga site insulin na-eguzogide;
• mma ọgụ;
• a bara uru utịp ke Mbelata ikpe nke nri ahu anataghi.

CLA preparations inhibit usoro nke ìgwè abụba, karịsịa na peritoneum (visceral). Nke a na ụdị nke abụba na ike weghara imeju, obi na ọbara arịa, dị nnọọ ize ndụ na-akpatakarị nkụchi obi, ọrịa strok, thrombosis, na nsogbu ndị ọzọ. CLA enwekwu uche nke muscle mkpụrụ ndụ insulin, otú abụba nakwa dị ka glucose na-esiwanye gabiga akpụkpọ ahụ, n'egbughị oge "na idobere". N'ihi ya, pasent nke abụba bụ belatara na muscle uka na-abawanye.

Laboratory ọmụmụ na nnwale

N'agbanyeghị eziokwu na ọtụtụ ịtụnanya Njirimara ka conjugated linoleic acid, reviews nke dọkịta na-eme nnyocha bụ ambiguous banyere ya. Nke a bụ n'ihi na eziokwu na na a ogbo na ojiji nke ọgwụ ọjọọ, ọtụtụ nwere a rụrụ na ụmụ anụmanụ. Ihe atụ, na oke kwa nri na ṅara n'ọkụ anụ, budata egbochi akpụ guzobere usoro. N'eziokwu, ọ dịghị ekwe omume iji chọpụta na ihe ogbo ọ na-eme - na n'oge, na-aga n'ihu ma ọ bụ na ọnụ mgbe cancer amalite metastasize. E nwere ihe ọtụtụ ndị chere na ọgwụ na-arụ ọrụ niile atọ. Ọzọkwa, na òké, ụmụ oke, na ọkụkọ CLA budata ewusi dịghịzi usoro, dị ka na-eto eto na ụmụ anụmanụ na mgbakwunye na-akwalite nọ n'ọrụ ibu. Ọzọ ìgwè nke ụmụ anụmanụ - bekee hamsters - CLA egbochi ndị ibelata nke akwara mere site atherosclerotic mbadamba nkume ndị e. N'ihu ọha, yiri nwere e duziri, wee jide anya ubiere bụ akaghi aka.

Nlele na arọ ọnwụ

Ị nwere ike ịchọta okwu ndị na-ukwuu na-enyere aka ifelata conjugated linoleic acid. Nyocha nke ndị mmadụ ndị na-agbalị ya ihe na ya onwe ya, a na-agwakọta. Ụfọdụ na-nma n'anya, ndị ọzọ mmetụta na-adịghị hụrụ. Ke 2000, Swedish ọkà mmụta sayensị bipụtara ihe ha nwere na otu ìgwè nke ndị ọrụ afọ ofufo, hudevshih iji CLA. All nke ha 64 ụbọchị gwusia site 3.4g conjugate acid. Agaghị efu ọ bụla onye soò. N'otu afọ, ndị ọzọ nọọrọ onwe ha na-eme nnyocha bipụtara emegiderịta pụta nwere eduziri ọzọ ìgwè nke obese ndị mmadụ. Dị ka a data, ọnụ ke arọ ahụ chọpụtara nnọọ na ndị were CLA preparations. Ọzọ nnwale ekenịmde, ọkà mmụta sayensị na Norway. Ha kewara ndị na-nnwale n'ime anọ dị iche iche, ọ bụla na a kwa ụbọchị oriri nke CLA bụ 1.7 g, 3.4 g, 5.1 na 6.8. ibu ọnụ bụ naanị na abụọ ikpeazụ iche, bụ ndị iwesa elu doses nke ọgwụ.

Ahụmahụ na ubiere nke Michael Peyriza

Olee otú ndị mmadụ, ma ọ bụghị naanị na ụmụ anụmanụ conjugated linoleic acid dị ka a n'aka n'ihi na arọ ọnwụ? The ọmụmụ e duziri pụtara nnukwu. Gara site ikom na ndị inyom nke afọ niile nke dị iche iche agbụrụ. Michael Peyriz, onye chọpụtara na umi abuana ke nnwale a ìgwè nke obese ndị mmadụ (71 ọrụ afọ ofufo). All bụ n'ime 2 ọnwa nke-ewere 3.4 grams nke ọgwụ kwa ụbọchị, na-eso a na nri nke Ewezuga nri, inye onyinye ibu ibu. The akara otu efu ibu site nri naanị, na-enweghị ọgwụ. Project sonyere n'ezie efu arọ, ma na njedebe nke nri ọzọ malitere n'oru ya, were ọgwụ naanị wuru muscle uka, mgbe ke akara otu ụba uto nke ahu abụba ọzọ. Ndị a data ga-ekwe ka ndị ọkà mmụta sayensị na-eme ka a na nkwupụta na CLA bụghị naanị ebelata size nke abụba, otú ọtụtụ na-egbochi n'ihu dịkwuo ha. The nnwale gosiri na ọgwụ na-enwe ike eme ka insulin secretion na ọrịa na ụdị II-arịa ọrịa shuga ma belata quantitative egosi nke ọbara glucose. Ndị a pụta nọ na-hụrụ na ihe dị ụzọ abụọ n'ụzọ atọ nke ule ndị ọrụ afọ ofufo.

Ọgwụ na CLA

Ọtụtụ ndị nwere mmasị na ajụjụ nke conjugated linoleic acid na nke ọgwụ nwere. Lee ụfọdụ n'ime ihe ndị na-atụ aro na pharmacies na egwuregwu na-echekwa bioactive Mmeju na a mgwa:

1. "Linofit". Packaging accommodates 60 capsules, onye ọ bụla 800 mg acid. The price maka Russian ahịa site na 1500 rubles. Yana CLA na capsules nwere ayodiin na vitamin B6, nke budata enwekwu ndị bara uru Njirimara nke dietary emeju.
2. "Reduxine ìhè." Emepụta ngwugwu 30, 90, 120 na 180 capsules, onye ọ bụla nwere 500 mg nke conjugate acid na vitamin E. Price si 1000 na 2720 rubles (dabere na ọnụ ọgụgụ nke capsules).
3. "Chocolate bụ ndụ." Mbukota 10 mejupụtara a ngwugwu na CLA powder site na nke ihe ọṅụṅụ a na-kwadebere. Price site na 300 rubles.

E nwekwara mba ọzọ ogbo: Zerofat, CLA, CLAextrim na ndị ọzọ. The atụmatụ price nke 15 dollar.

eke na isi mmalite

E nwere nnọọ ọtụtụ nke ekwukwa n'akwụkwọ Mmeju si dị iche iche Nsukka, nke isi akụrụngwa bụ a conjugated linoleic acid. Ahịa erite ịdị iche iche dị ka nke ọma dị ka ihe nnyocha sayensị. E nwere ọtụtụ ndị na-chọpụtara a mmetụta dị mma. N'otu oge, ọtụtụ n'ime ndị na-a hụrụ iji belata ibu na ọ bụ nnọọ obere. Ke adianade dietary Mmeju, CLA na-hụrụ na a nnukwu udi nke eke ngwaahịa, nke mere na ha nwere ike na-eri eri na kwa ụbọchị na-enweghị mmabido ọ bụla. Gosiri na table na ọnụ ọgụgụ maka mmiri ara ehi, anụ na àkwá bụ anụmanụ-akpọlite na eke fiidi.

contraindications

Ahụbeghị na a ezi uche ojiji nke n'elu ngwaahịa ka oghom Jeremaya mere nke ahụ (ma e wezụga n'ihi na onye ọgụ na ndị mmadụ n'otu n'otu). Na iji ọgwụ ọjọọ eme nke nwere conjugated linoleic acid, mmetụta dị mwute ikwu na ime. Ihe atụ, ụfọdụ ndị ahịa ndị ji dietary Mmeju na CLA, kwuru, na-akawanye njọ tupu ẹdude hemorrhọidị, ụfọdụ n'ime ndị digestive tract, ọkụ ọkụ, ọgbụgbọ. Na naanị 47 ndị mmadụ na Sweden n'oge nnwale si 60, bụ ndị na-nnwale ndị ike ruo ụzọ dum. Ndị fọdụrụ a manyere mbà n'ihi nke ụfọdụ nsogbu ahụ ike.