Dehydroepiandrosterone sulphate (DHEA-S)

Dehydroepiandrosterone sulphate (DHEA-S) - androgen bụ na pubati bụghị ejikọrọ. Synthesized na secreted site adrenal glands ya. Ọ na-akọ na dehydroepiandrosterone sulfate ketosteroids.

DHEA-S na-synthesized n'ụzọ dị ukwuu nke cholesterol Ester sulfate. Ihe bụ isi ego nke androgen catabolized na, dị ka a na-achị, na iri percent anyụpụ na mmamịrị.

Dehydroepiandrosterone sulfate na-adịghị metụtara kpọmkwem edozi ọbara plasma, ya mere, ha ịta n'ogo nke DHEA-S na-adịghị emetụta. Otú ọ dị, a steroid ejikọ na albumin na ọbara.

Ke adianade DHEA-S na mejupụtara nke na-ekesa ọbara ọ gụnyere dehydroepiandrosterone. Part nke ya guzobere na adrenal cortex emee ikpe - gonads. N'ihi na metabolic nwechapụ nke DHEA nnọọ ngwa ngwa, ya ịta tụnyere DHEA-C n'okpuru.

Ruru akwa kasịnụ nke dehydroepiandrosterone sulfate, elu kwụsie ike na ogologo ọkara ndụ, na eziokwu ahụ bụ na isi iyi nke ya, n'ihi na ọtụtụ akụkụ, bụ adrenal steroid bụ ihe magburu onwe egosi androgen secretion.

E wezụga adrenal cortex na ndị ikom na obere akụkụ (5%) na-emepụta na gonads. Na ndị inyom, ovaries na-emepụta ya na e nwere. Ịta nke a hormone androgensinteticheskuyu egosiputa ọrụ nke adrenal. Dehydroepiandrosterone sulphate nwere obere androgenic ọrụ. Otú ọ dị, n'oge ya metabolism, nke pụtara na elu anụ ahụ, na-emepụta dihydrotestosterone na testosterone.

DHEAS nwechapụ ọnụego ala. Nke a na egosi na-eji na nchoputa nke hyperandrogenic ekwu aa na nwanyi. Ndị a gụnyere alopecia, hirsutism, a aghara nke omumu ọrụ. N'ihi ya hyperandrogenism nwere ovarian ma ọ bụ adrenal malite. N'ihi ya, endocrinological ule-amalite na-ekpebi ihe ịta nke dehydroepiandrosterone sulfate na testosterone. Ụba ha na-egosi na-egosi hyperandrogenism nke adrenal malite. Ke adianade do, na ọnụego eji na-adabere na ọnọdụ nke androgens na ndabere nke na-egbu oge mmekọahụ development.

Kemgbe afọ ime, na mmepụta nke dehydroepiandrosterone sulfate pụtara na cortex nke adrenal glands nke nwa ebu n'afọ na nne. N'ihi na njikọ nke estrogens na Plasenta bụ a hormone precursor.

Na ụmụ nwaanyị dị ime, ịta nke dehydroepiandrosterone sulfate n'ime ọbara mbelata moderately. Site na oge nke mmalite oge uto na ụmụ ya larịị na-abawanye, mgbe nwayọọ nwayọọ mbelata na afọ.

Dehydroepiandrosterone sulfate elu na:

- congenital adrenal hyperplasia;

- syndrome (ọrịa) Cushing ;

- etuto ahụ nke adrenal cortex (ụkpụrụ na cancer elu karịa adenoma);

- polycystic ovary syndrome ;

- etuto ektopichesoky ngwaahịa;

- verilnom syndrome.

Belata hormone ịta hụrụ na:

- sekọndrị na isi adrenal insufficiency;

- ime;

- isi hypogonadism (castration, Klinefelter si syndrome) na ndị mmadụ;

- abụọ hypogonadism (pituitary) na ndị inyom;

- onu gbochie afọ;

- pangipopituarizme;

- osteoporosis.

Dehydroepiandrosterone sulfate, ọnụego n'ihi na ndị ikom 21 ruo 39 na afọ nke 1,0-4,2 g / ml, n'ihi na ụmụ nwaanyị si 19 ruo 39 afọ - a, 8-2,9 g / ml.

Na elu na-etoju nke testosterone nwanyi akọwapụta DHEA-S ịta nwere ike ịchọpụta ma ala nke a ọrịa metụtara na ovarian ma ọ bụ adrenal ọrịa. dehydroepiandrosterone sulfate larịị egosi naanị mgbe ụba adrenal pathologies. A na-agụnye, akpan akpan, na-agụnye etuto ahụ, hyperplasia na ọrịa ndị ọzọ.