Gịnị "Lyrics" mbadamba? The ojiji nke price

Medicine "lyrics" (mbadamba), ego nke nke si na 700 4000 rubles., - ya zuru ezu, maara nke ọma ọgwụ. Active umi - pregabalin - analọg nke gamma-aminobutyric (Geba) acid (Geba). Mgbe e mesịrị na isiokwu a ga-enye annotation ka ọgwụ. Ka anyị chọpụta ihe mkpụrụ ọgwụ "Lyrics" iji ọrịa.

usoro nke ihe

Pregabalin egosipụta ya nrụpụta na ọgwụgwọ nke ọrịa neuropathy na postherpetic neuralgia, n'ihi na nke mkpụrụ ọgwụ "lyrics" kenyere ọnụego ruo 13 izu na a kwa ụbọchị oriri ọnụego 2 ugboro na ruo 8 izu, 3 ugboro n'ụbọchị. Against ndabere nke mmepe nke n'aka gosiri otu mmetụta. Ndị ha na fibromyalgia bụ doro anya na anya Mbelata ke mgbu mgbaàmà Point mgbe na-ewere ọgwụ doses nke 300-600 mg kwa ụbọchị. Daily onunu ogwu nke 450 mg na 600 mg a pụrụ iji tụnyere maka arụmọrụ, ma nke abụọ bụ obere ọma anabata. The ọgwụ ebelata ịdị njọ nke akwụkwụ ọdịdọ, nke mbadamba "lyrics" nwere ike ikwu na a N'ezie nke 12 izu, 2 ma ọ bụ 3 ugboro kwa ụbọchị. N'oge n'ikuku emee otú ahụ nke mmetụta na irè nke ọgwụ na a dose. ọdịdọ ugboro amalite ibelata ke akpa izu nke ọgwụgwọ. Symptomatology nke generalized nchegbu aghara na-egosi a ọchịchọ ibelata ke akpa ụbọchị asaa nke ọgwụgwọ. Mgbe asatọ izu 52% nke ọgwụ ọrịa na-anata pregabalin na 38% nke ọrịa na-anata placebo, gosiri a 50 percent Mbelata ke mgbaàmà nke Hamilton ọnụ ọgụgụ (HAM-A).

Pharmacokinetics

The agwọ ọrịa "lyrics" (mbadamba) - User-egosi nke a - na-atụ aro kwa doses na n'akụkụ pharmacokinetic ji linearity, ala (<20%) interindividual mgbanwe. Ugboro ugboro ngwa nke pharmacokinetics nke ọgwụ nwere ike buru amụma na ndabere nke a unit nke onunu ogwu data. Ya mere mgbe nile nyochaa ịta nke nọ n'ọrụ mgwa adịghị mkpa. Pharmacokinetic parameters nke ọgwụ "Lyrics" na ike ọrụ afọ ofufo, ọrịa na Akwụkwụ na-adọ na-anata antiepileptic ọgwụ, nakwa dị ka na-anata ọgwụ maka n'igbochi mgbu ọrịamkpokọta ndị yiri.

Absorption na mmechi

Mgbe na-ewere na ihe efu afo pregabalin na-etinye obi gị dum ngwa ngwa. Otu awa mgbe e mesịrị, na plasma Cmax enweta dị ka mgbe n'itinye maka oge mbụ, na ugboro ugboro. Na ndabere nke pregabalin onu bioavailability bụ na ≥90% na bụ onwe ha nke dose. Ịha a na-enweta mgbe ewere ugboro ugboro na a oge nke 24-48 awa. Ọ bụrụ na ọgwụ a na-etinyere mgbe a nri, Cmax nwere ike belata 25-30% ma na-amụba ya nweta oge awa 2.5. Otú ọ dị, ọ dịghị clinically ịrịba utịp ke absorption nke ọgwụ enweghị nri. Ihu ọma ọgwụ anyụpụ site na akụrụ na-agbanweghi agbanwe. T1 / 2 nkezi nke 6.3 awa.

Pharmacokinetics pụrụ iche ikpe

Ọ bụrụ na ị mie gbasara akụrụ ọrụ, ọ dị mkpa iji gaa na akaụntụ ahụ peculiarity nke pregabalin nwechapụ, ọ bụ ihe ra nrata nye creatinine nwechapụ. Ihu ọma ọgwụ anyụpụ site akụrụ, ya mere ọ dị mkpa na ikpe nke na mebiri nke ha ọrụ iji belata dose. E wezụga akụrụ, agwọ ọrịa nwere ike n'ụzọ dị irè wepụrụ si plasma site hemodialysis (4-hour hemodialysis nnọkọ enye 50% ọnụ ke ọgwụ ịta na plasma) mgbe ọzọ na-achọsi ike oru ọgwụ dose. A pụrụ iche na-amụ pharmacokinetics nke mmadụ "Lyrics" na ọrịa na mkpọchị imeju ọrụ na e duziri.

Pregabalin metabolized fọrọ nke nta na-adịghị kpughere, na egosiri ọnụ na mmamịrị na-agbanweghi agbanwe ụdị, ọ dị isi imeju ọrụ anaghị budata emetụta ịta nke ọgwụ na plasma. Mgbe ọgwụ e nyere ndị ọrịa n'elu 65 afọ, ị ga-eburu n'uche na na afọ Pregabalin nwechapụ nēche ibelata. Ọ bụrụ na onye agadi nke na-ebelata gbasara akụrụ ọrụ, ọ dị mkpa gụnyere ọgwụ kenyere dose.

onunu ogwu

The kwa ego nke nkwadebe kọwaa 150-600 mg kwa ụbọchị. Admission a rụrụ ugboro abụọ ma ọ bụ ugboro atọ, n'agbanyeghị nke nri. The agwọ ọrịa "lyrics" (mbadamba) ntụziaka ntuziaka na-atụ aro na-ewere na neuropathic mgbu na 150 mg kwa ụbọchị. Ọ bụrụ na ndị na-enweta mmetụta na tolerability mma otu izu kwa ụbọchị dose nwere ike ụba 300 mg (ihe "lyrics 300" mbadamba). Ọ bụrụ na ọ dị mkpa, na kacha dose nke 600 mg kwa ụbọchị nwere ike ndinọ otu izu ka e mesịrị. N'otu aka ahụ gbakọọ dose na ọgwụgwọ nke Akwụkwụ na-adọ. Dị ka e kwuru n'elu, ọ na-atụ aro iji ọgwụ maka ọgwụgwọ nke fibromyalgia, nke mbadamba "lyrics" ihe nzuzo ahụ dị na a dose nke 75 mg kwa ụbọchị abụọ doses. On amụba dose 300 mg emetụta enweta mmetụta na tolerability. Ọ bụrụ na e nweghị mmetụta dị mma, na-amụba dose na 450 mg, na ọ bụrụ na ọ dị mkpa - otu izu iji 600 mg. Emeso generalized nchegbu aghara amalite a dose nke 150 mg. Ọzọkwa a izu, na-edebe ihe ndị enweta mmetụta na tolerability, kwa ụbọchị dose mụbara 450 mg, na mgbe 7 ụbọchị - ruo 600 mg (ma ọ bụrụ na ọ dị mkpa).

mwepụ nke ọgwụ

Ọ bụrụ na ọ dị mkpa, ọgwụgwọ discontinuation na-atụ aro na-eme ya na ala, n'ihi na a izu a jiri nwayọọ nwayọọ na Mbelata ke dose. Ọrịa ndị isi ọrụ nke akụrụ, rụrụ onye nhọrọ nke doses. Na omume nke oghom mmetụta na ọrịa na-anata pụtara "Lyrics" Erere-kachasị yitebe ahọrọ ndị ọkachamara. Otu n'ime ihe ndị kasị nkịtị n'aka na mmetụta yiri nwere ike kwuru ọgwụ ọjọọ "Mydocalm" "Apizartron" "Sedavit" "Ambene".

na-agba akaebe

Ọgwụ na-atụ aro maka mkpochapu neuropathic mgbu, dị ka adjunctive ọgwụ maka ele mmadụ anya n'ihu ihe ọdịdọ nke Akwụkwụ na-adọ, na-ebu ma ọ bụ na-esonyere sekọndrị generalization. N'aka gosiri maka nchegbu aghara generalized uwa, nakwa dị ka fibromyalgia.

contraindications

E nweghị ndị na data na ojiji nke ọgwụ na ụmụaka na-eto eto ruo 17 afọ yana idobe okirikiri. Na njikọ na nke a ọgwụ na-kenyere naanị ndị okenye. Contraindications gụnyere butere n'aka ọrịa dị ka galactose ekweghị ibe nọrọ, lactase erughi, nakwa dị ka malabsorption nke glucose / galactose. The ngwá ọrụ na-adịghị gosiri maka hypersensitivity. Iji nọgide na a imefusi ọgwụ na ọrịa na gbasara akụrụ na obi ọdịda.

mmetụta

Dị ka ahụmahụ nke na-adakarị ngwa nke agwọ ọrịa, nnọọ iro ụra na dizziness ka ekwesighi pụta. Ndị a phenomena agbasaghị ekem ke agafeghị oke ma ọ bụ nwayọọ ogo. Tinyere ihe ndị ọzọ mmetụta rụpụtara discontinuation ọgwụ ọgwụgwọ, ọ ga-kwuru asthenia, mgbagwoju anya, bịara ikiri ọhụụ, incoordination, ataxia, elu edema. Ọzọkwa n'etiti mmetụta ọjọọ kwuru isi ọwụwa, ọnwụ nke nsụhọ, ọdụdọ, ọzịza nke ire, afọ ọsịsa, ọgbụgbọ, keratitis. Adịkarịghị nwere itchy akpụkpọ angioneurotic mmeghachi omume. E nwere urinary njigide, akpa ume edema na gynecomastia. Tinyere ihe ndị ọzọ mmetụta na-akpọ ike ọgwụgwụ.