"Indapamide" - ntuziaka maka ojiji

Indapamide "- a ọgwụ nke na ìgwè nke thiazide diuretics nwere antihypertensive mmetụta. Medicine "Indapamide" gosiri maka ojiji na ọnụnọ nke ọbara mgbali.

Pharmacological edinam "Indapamide" ọgwụ

Guide na-ekwu na pharmacological Njirimara nke a ọgwụ ọjọọ na-metụtara thiazide diuretics. N'ebe ọgwụ ike nke bibiri igbochi "nwayọọ" calcium ọwa-eme ka ekwedo nke ọbara mgbidi, adịru e a gụnyere ya ná ngụkọta elu vaskụla eguzogide.

"Indapamide" anaghị agbanwe carbohydrate metabolism, nke bụ ihe dị mma maka ọrịa na-arịa ọrịa shuga, na adịghị emetụta ịta nke lipids na plasma. Mbadamba "Indapamide" aka belata hypertrophy nke ekpe ventricle, gharazie inwe vaskụla mgbidi nọrepinefrini na angiotensin II, akpali njikọ nke prostaglandin E2, ebelata mmepụta nke oxygen radicals. Na-emekarị a 5-7 ụbọchị ọgwụgwọ na antihypertensive mmetụta na-egosipụta, na aka iso na otu dose n'ụbọchị.

Pharmacokinetics "Indapamide" ọgwụ

Guide na-akọ na a ọgwụ e ji elu bioavailability (93%) na absorption na eriri afọ tract. Na ọnụego nke absorption emetụta nri oriri. The kasị elu ịta nke ọgwụ na ọbara na-kere n'ime otu ma ọ bụ awa abụọ mgbe na-ewere ọgwụ na ego nke 2.5 mg. The ọgwụ na-metabolized site imeju. 60% -80% nke ihe onwunwe bụ mmepụta via akụrụ n'ụdị metabolites, odika 20% - site na eriri afọ. The ọgwụ nwere dịghị ike cumulating.

Egosi "Indapamide"

Ntụziaka edepụta a ọgwụ maka ẹsụhọde ọbara mgbali. Ọzọkwa, ọgwụ na-atụ aro maka ndị na-adịghị ala ala aka na-eri eri obi ọdịda.

contraindications

"Indapamide" na-contraindicated na:

- ụba uche na ya, na ndị ọzọ na nkwekọrịta nke sulfonamide otu,

- anuria,

- hypokalemia,

- oké hepatic ma ọ bụ gbasara akụrụ insufficiency,

- oge nke lactation,

- nnukwu daa ọrịa nke ụbụrụ mgbasa,

- ime,

- afọ 18 (n'ihi na ọchịchịrị)

- n'otu oge ochichi nke pharmaceuticals amụba oge QT.

Anya ndinọ ọgwụ na ọnụnọ nke gout na-arịa ọrịa shuga decompensation.

Dosing na dosing ọgwụ ọjọọ "Indapamide"

Guide tụrụ aro na-ewere ọgwụ n'ime, bụghị mmiri mmiri. 2.5 mg (kwa ụbọchị dose) na-kacha mma na-eji ụtụtụ ma ọ bụ n'ehihie. Mgbe 1-2 ọnwa nke ọgwụ ọgwụgwọ emebeghị chọrọ ọgwụgwọ mmetụta, ndị dose adịghị atụ aro ntọt n'ihi na n'ihe ize ndụ nke mmetụta. Na nke a, na-aṅụ ọgwụ nke ọbara mgbali atụmatụ mkpa ka ịgbakwunye ọzọ antihypertensive gị n'ụlọnga na-adịghị a mamịrị. Mgbe n'imeso abụọ antihypertensive ọgwụ dose "Indapamide" na-anọgide n'otu.

ovadozu

Ovadozu mgbaàmà na-egosipụta site adịghị ike, imebi eriri afọ ọrụ, ọgbụgbọ, vomiting, ọmụmụ na electrolyte disturbances. N'ọnọdụ ụfọdụ, ọ pụrụ ime ovadozu nke akụkụ okuku ume na ịda mbà n'obi na ịṅụbiga ẹsụhọde nke ọbara mgbali. Na ọrịa na imeju nke imeju nwere ike ime hepatic amaghị onwe ya.

Bụrụ na nke ovadozu ga-rụrụ mgbazi normalize mmiri-electrolyte itule: a gastric lavage na symptomatic ọgwụ.

mmekọrịta

Enhances mmetụta nke ọgwụ ọjọọ ndị ọzọ maka ọbara mgbali elu. Ekwela ikpokọta ọgwụ nwere lithium, vincamine, kaliyvyvodyaschie diuretics.

Mmetụta nke ọgwụ "Indapamide"

N'otu aka ahụ, dị ka ọ na ikpe nke ovadozu. Ikekwe obi n'afọ iri na ụma na-enwe nsogbu n'ihi na ọnwụ nke potassium. Ọzọkwa, mmetụta nwere ike ime adịghị ike, a nkọ ọnụ ke mgbali mgbe guzo, ọgbụgbọ, abdominal mgbu, afọ ọsịsa, ụfụ, nfụkasị Jeremaya. Na obere okwu, nwere ike gout, cramps.