"Ursosan": mmetụta, ngwa, nzaghachi na analogues

Ị banye ọgwụ "Ursosan"? Mmetụta nke ọgwụ, ndị na-egosi maka anara ya na ntuziaka maka ojiji ga-ọkọnọ a n'isiokwu a. Ị ga-amụtakwa banyere ụdị nke na ọgwụ dị maka ire ere, nke bụ akụkụ nke ya, ma o nwere ihe ọ bụla analogues na contraindications.

Ụdị nke ụlọ ọgwụ na ya mejupụtara

Ọ bụrụ na ị na-kenyere ọgwụgwọ "ursosan", mgbe ahụ, i kwesịrị ịma na ihe ụdị ya nwere ike zụrụ. Ugbu a, ndị ọgwụ ọjọọ na-eresị na-echekwa naanị n'ụdị gelatin ike capsules. Ha bụ opaque na nwere a na-acha ọcha na agba.

Na-ebu anyị weere Capsule? Ha ọdịnaya - acha ọcha ma ọ fọrọ nke nta na-acha ọcha ntụ ntụ. Ọ nwere ike na-ewetara a ìhè ibu iberibe. Ọzọkwa, na ntụ ntụ na-compacted na a kọlụm. Mgbe nsogbu-chebaara mbadamba-etisasị.

Ugbu a, ị maara, ọgwụ "Ursosan" dị n'ụdị ọ bụla. Mmetụta nke a ọgwụ na-metụtara ya mejupụtara. Otu Capsule nke ngwá ọrụ nwere ursodeoxycholic acid na ego nke 250 mg. Nwa na-agụnye nkwado ọcha n'ụdị ọka starch, magnesium stearate, titanium dioxide, colloidal silica, na gelatin.

Ahịa ọgwụ agwọ ọrịa abatakwa katọn igbe, nke nwere ike ịbụ 10, 50 ma ọ bụ 100 capsules.

The pharmacological Njirimara nke a na ngwaọrụ ụlọọgwụ

Gịnị bụ a ọgwụ ọjọọ, "Ursosan" onye mmetụta ga-kọwara a obere n'ihu? Nke a hepatoprotective, na-enye cholelitolitic, choleretic, ipoholesterinemicheskoe, lipid-ẹsụhọde na immunomodulatory mmetụta.

The ọgwụ nwere nnukwu pola Njirimara. N'ọrụ mmewere (ursodeoxycholic acid) Nleta apolar (nsí) bile acid weere micelles nontoxic. Nke a na-ebelata ikike nke gastric reflyuktata apịa cell akpụkpọ ahụ na ndị dị otú ahụ pathologies ka reflux esophagitis na reflux mgbu (biliary).

Anyị apụghị ikwu na-arụsi ọrụ ike umi bụ ike nke na-akpụ a abụọ ụmụ irighiri ihe na-akụkụ nke cholangiocytes, na cell membranes nke hepatocytes, epithelial sel nke digestive tract, kwụsie ike ha na-eme ka ọ na-eguzogide ọgwụ na mmetụta nke cytotoxic micelles.

Ụkpụrụ nke ime ihe nke a agwọ ọrịa

Olee otú ahụ na nkà mmụta ọgwụ "Ursosan" (analogs)? A ọgwụ lowers a ịta nke bile na-egbu egbu na hepatocytes akpali cholepoiesis asịd na uba bicarbonate. Ọ ga-karịsịa kwuru na-arụsi ọrụ ike mmewere nke ọgwụ n'ụzọ dị irè na-enyere na ọgwụgwọ nke intrahepatic cholestasis. Ọ na-ebelata cholesterol saturation nke bile. Na nke a emee ruru ka mgbochi nke absorption nke bekee na eriri afọ, suppression nke hepatic njikọ na secretory ọnụ ke bile.

The ọgwụ enwekwu solubility nke cholesterol na bile. N'otu oge ahụ na ọ Nleta a mmiri mmiri crystal, na-ebelata lithogenic index nke bile.

The N'ihi nke ọgwụgwọ site agwọ ọrịa ugbu a bụ zuru ezu na mgbasa nke gallstones (cholesterol). Ọzọkwa, ọgwụ na-egbochi e guzobere ọhụrụ nkume.

Immunomodulating mmetụta "ursosan" mere ka mgbochi nke HLA antigen okwu 2nd klas cholangiocytes na HLA klas 1 na hepatocyte membranes. Ọzọkwa, ọgwụ apụta eke egbu lymphocyte ọrụ.

Ọkachamara gosiri na ọgwụ na-egbu oge na mmepe nke fibrosis na ọrịa na cystic fibrosis, biliary imeju (isi) na-aba steatohepatitis. N'otu oge ahụ na ọ lowers ihe ize ndụ nke esophageal varices.

N'ọrụ umi na-atụle site anyị ọgwụ slows ala usoro nke nká na ọnwụ nke mkpụrụ ndụ (hepatocytes na cholangiocytes).

Pharmacokinetics

N'ihi n'ezinụlọ mgbasa (ihe dị ka 90%) nke ursodeoxycholic acid a na-etinye obi gị dum na obere eriri afọ. The ileum absorption emee ya ruru-arụsi ọrụ ike iga. Ịta nke nọ n'ọrụ akụrụngwa mgbe ndinọ na a dose nke 50 mg ọ bụla ọkara awa, 60 nkeji na ọkara awa bụ karị: 3,8 millimoles kwa liter, 5.5 millimoles kwa liter na 3.7 mmol kwa liter. Oke ngwaahịa ịta na-ruru mgbe banyere 1-3 awa.

Plasma protein nkịtị nke ọgwụ na dịtụ elu (banyere 97-99%). N'ọrụ umi bụ ike banye site na Plasenta. Na mgbe nile were nke ọgwụ na-aghọ isi ifịk mmewere nke bile acid ke iyịp.

Agwọ ọrịa metabolized na imeju. Iji nke 55-70% nke ọgwụ na-aga ọnụ na bile. A obere ego nke acid nevsosavsheysya abatakwa nnukwu eriri afọ, ebe ọ na-dabara cleavage.

Ọgwụ "Ursosan": egosi maka ojiji

The nke anyị n'ihu na-kenyere ọgwụ ma ọ bụrụ na onye ọrịa e tiri na-esonụ pathologies:

• -adịghị mgbagwoju cholelithiasis (na biliary sludge, mgbasa nke biliary cholesterol nkume na ńsí eriri afo, ma ọ bụrụ na ọ gaghị ekwe omume iji wepụ ha endoscopically ma ọ bụ surgically, dị ka nlọghachi azụ mgbochi nke nkume guzobere mgbe cholecystectomy);
• ịba ọcha n'anya-adịghị ala ala ọrụ;
• na-egbu egbu, nke gụnyere ọgwụ, imeju mmebi;
• nonalcoholic steatohepatitis;
• mmanya na ọrịa imeju;
• ọrịa sclerosing cholangitis Primary
• nnukwu ịba ọcha n'anya;
• isi imeju (biliary);
• Cystic fibrosis (ma ọ bụ na-akpọ cystic fibrosis) nke imeju;
• dyskinesia na ọrịa ndị ọzọ nke biliary tract;
• intrahepatic biliary atresia ụzọ, gụnyere congenital atresia, biliary ducts;
• biliary dyspeptic syndrome (na dyskinesias na holetsistopatii);
• biliary reflux esophagitis na reflux mgbu;
• mgbochi nke imeju ọrịa mepụtara mgbe ojiji nke cytostatics na mmiri ọgwụ gbochie afọ.

Contraindications ojiji nke ọgwụ

Ugbu a na ị maara ihe a pụtara ọgwụ ọjọọ, "Ursosan" (egosi maka ojiji e kwuru banyere ha n'elu). Ma contraindication, na-enyo enyo na-agụnye ndị na-esonụ ihe:

• emeghasịkwa nke gallbladder;
• rentgenpolozhitelnye gallstones (elu calcium);
• afo, ńsí ma ọ bụ nsia fistula;
• nnukwu cholangitis;
• nnukwu cholecystitis;
• Hypersensitivity ka ọcha nke Nwa;
• imeju nke imeju decompensation;
• gbasara akụrụ odida;
• na-efe efe (ọtụtụ nkọ), opi mgbailu na ńsí eriri afo;
• hepatic ọdịda;
• obturation biliary tract;
• gallbladder empyema.

Imefusi ọgwụ

Mgbe m ga-eji ọgwụ ọjọọ, "Ursosan" na-elezi anya? Egosi maka ojiji nke ngwá ọrụ na-ekwu na-ewere ọgwụ n'ihi na ụmụ 2 4 afọ na-ekwe naanị n'okpuru torola eto. Nke a bụ n'ihi na eziokwu na e nwere a puru isi ike ilo capsules. Ke ofụri ofụri, n'ọrụ akụrụngwa nke ọgwụ nwere dịghị afọ mgbochi eji.

Medicine "Ursosan": ngwa

Nyocha nke a nkwadebe, anyị na-akọwa na njedebe nke isiokwu. Ugbu a anyị na-agwa banyere otú ọ ga-abụ.

The capsules nke ọgwụ ga-elo dum, asa ala na mmiri nkịtị.

Olee otú ga-ewere "Ursosan" n'okpuru ụfọdụ deviations? ntuziaka maka ojiji nke a nwere ndị na-esonụ ozi:

• Na cholelithiasis na asị ibe imeju pathologies ọgwụ kenyere a ogologo oge (nọgidere) at a dose of 2-5 capsules (dabere na aru uka). Mgbe deviations agbasa kwa ego nke ọgwụ na-ekewa 3 doses. Mgbe na-ewere a "Ursosan" Capsule: iso nri ma ọ bụ mgbe? The nkà mmụta ọgwụ a ga-eji n'oge nri oriri.
• Ọ bụrụ na cholelithiasis kwa ụbọchị dose e ugboro tupu alakpu ụra. Duration nke ọgwụ (igbari nkume) - 3 ọnwa, na mgbe a ole na ole ọzọ izu maka mgbochi nke ugboro.
• Dị otú ahụ na abnormalities ka reflux oesophagitis na biliary reflux mgbu, ọgwụ na-kenyere otu Capsule n'abalị. The ọgwụgwọ nwere ike ịbụ na 15 ụbọchị na 7 ọnwa (ma ọ bụrụ na ọ dị mkpa, 2 afọ).
• Mgbe cholecystectomy na-atụ aro usoro onunu ogwu bụ 250 mg ugboro abụọ n'ụbọchị ruo ọtụtụ ọnwa.
• Mgbe ọgwụ ọjọọ na-egbu egbu imeju mmebi, nakwa dị ka atresia na biliary tract ọrịa na-aba ọgwụ kenyere ọnụego nke 10-15 mg kwa 1 n'arọ nke ahu arọ, na-aṅụ na 3 ekewa doses. Duration ọgwụgwọ - 6-12 ọnwa ma ọ bụ ogologo.
• Na biliary imeju (isi) na-enweta agwọ ọrịa ọnụego nke 10-15 mg kwa 1 n'arọ arọ nke onye ọrịa kwa ụbọchị (ghara gafere 20 mg kwa n'arọ) na 3 ekewa doses. Na oge nke ọgwụgwọ dị malite si 6 ọnwa ka ọtụtụ afọ.
• Mgbe ọrịa sclerosing cholangitis (isi) na-aṅụ ọgwụ na a onunu ogwu nke 12-15 mg kwa 1 n'arọ nke ahu arọ kwa ụbọchị (ruo 20 mg kwa n'arọ) na 3 ekewa doses. Duration ọgwụgwọ - 6 ọnwa ka ọtụtụ afọ.
• Mgbe nonalcoholic steatohepatitis - 13-15 mg kwa 1 n'arọ nke ahu arọ kwa ụbọchị (3 doses). Duration ọgwụgwọ - 6 ọnwa ka ọtụtụ afọ.
• Na cystic fibrosis kenyere onunu ogwu ọnụego nke 20-30 mg kwa 1 n'arọ ahu arọ (3 kwa ụbọchị doses). Duration ọgwụgwọ - 6 ọnwa ka ọtụtụ afọ.
• Children si 2 afọ, ego nke iwesa agwọ ọrịa setịpụrụ n'otu n'otu (ma ọ bụghị ihe karịrị 10-20 mg kwa 1 n'arọ nke ahu arọ kwa ụbọchị ahụ).

mmetụta

Nwere ike a na-adịghị mma mmetụta na ozu ọgwụ "Ursosan"? Mmetụta a ọgwụ bụ n'ezie. Ka anyị tụlee ha na ihe zuru ezu.

1. Digestive tract: vomiting, afọ ọsịsa, calcification nke gallstones, ọgbụgbọ, afọ ntachi, mụbara imeju transaminases.
2. Ndị ọzọ: exacerbation nke psoriasis, azụ mgbu, allergies, alopecia.

Pregnancy na lactation

Ọ ga-ekwe omume n'oge gestation eji ọgwụ "Ursosan"? Ngwa (reviews nke agwọ ọrịa ga-ọkọnọ e mesịrị) ursodeoxycholic acid n'oge ime na-kwere na ọ bụrụ na a tụrụ anya na uru nne nke-eme n'ọdịnihu bụ nnọọ ukwuu karịa ihe ize ndụ ka nke nwa ebu n'afọ.

Ozi banyere ntọhapụ nke ndị nọ n'ọrụ ọgwụ umi ke mmiri ara na-adịghị.

Ntuziaka maka ojiji nke ọgwụ

Drug "Ursosan" (yiri ọgwụ ọjọọ akpan akpan) ga na-eji igbari gallstones (cholesterol), na nke nke nke adịghị gafere 15-20 mm.

Na ogologo oge omume (ogologo karịa otu ọnwa) bụla izu ise dị mkpa na-ebu a ọbara ule (Biochemical).

Olee otú oge mgbe na mgbasa nke nkume kwesịrị iwere ọgwụ "Ursosan"? Nyocha nke ọrịa na dọkịta na-ekwu na mgbe ọgwụgwọ ọ dị mkpa iji banyere ọnwa atọ.

The na-eri nke ọgwụ ọjọọ na ya analogues

Ọtụtụ ndị na-eche otú ukwuu ọgwụ ọjọọ, "Ursosan"? Analogs dị ọnụ ala karịa ga-ọkọnọ n'okpuru, dị ka ndị si n'aka, ọ bụ na o siri ike ego. Na pharmacies, 10 capsules ị ga-akwụ banyere 200 rubles. Nyere oge nke ọgwụ na a ọgwụ (a ọnwa ole na ole ma ọ bụ ọbụna ọtụtụ afọ), anyị nwere ike ikwubi na ọgwụgwọ nke ọrịa bụ ọnụ.

Gịnị nwere ike dochie nkà mmụta ọgwụ "Ursosan"? Dị ọnụ ala karịa analogues-achọta ọ bụla na-ere ọgwụ. Ma tupu ị na-azụta ya na-atụ aro ka ịkpọ onye dọkịta.

esonụ n'aka ga-achọsi ike igbunye n'etiti ọgbọ anyị n'ihu ọgwụ "Livodeksa" "Ursodeoxycholic acid", "Urdoksa" (50 ml - 600 rubles), "Ursodez" (50 ml - 500 rubles), "Ursol" (50 ml - 500 rubles ). The ike nke ihe dị oké ọnụ ogbo, "Ursofalk", "Ursol", "cursor Rompharm", "Choludexan" Ursodeks "," Ekskhol "na na.

nleba

Ihe ndị mmadụ na-ekwu banyere ọgwụ "Ursosan"? Nyocha nke ọrịa na-ekwu na n'ozuzu ọgwụ ịnagide ọrụ. Ọ dị mma dissolves nkume ma gbochie nlọghachite nke ọrịa. Na-emekarị, ọ na-eme mgbe ọnwa atọ mgbe nnabata nke ọgwụ (mgbe ụfọdụ ọ na-ewe ogologo oge na n'ikuku).

Anyị-atụle ọgwụ nwere ọjọọ nzaghachi. Ọtụtụ mgbe ha na-ejikọta ya na mmetụta (ọgbụgbọ, afọ ọsịsa) na-erukwa na mgbe na-anata agwọ ọrịa. Ke adianade do, dị nnọọ ọtụtụ ndị ọrịa na-enweghị afọ ojuju na price nke ọgwụ. N'ihi na eziokwu na-aṅụ ọgwụ dị mkpa maka a ogologo oge, ihe omume bụ oke ọnụ. Otú ọ dị, ndị ọkachamara na-arụ ụka na ọgwụ dị irè na ọgwụgwọ nke gallstone ọrịa. Ọ bụrụ na ị na-ele nsogbu ahụ si na nke a echiche, ya price a n'ụzọ zuru ezu n'onye ezi omume.