"Melofleks": ntuziaka maka ojiji. Mejupụtara, reviews, contraindications, analogs

Mgbe ụfọdụ, ndị dọkịta ji nye iwu ka ha na-agwọ ọgwụ "Melofleks"? Ntuziaka maka ojiji nke si ego, ya na-egosi, mejupụtara, analogs na ntọhapụ forms ga-ọkọnọ a n'isiokwu a. Ke adianade do, site na ya, ị ga-amụta ma ma ọ bụ a ọgwụ mmetụta na contraindications, a maara banyere ikpe nke ovadozu, kwuo okwu nke ya dị ka onye ọrịa na ọkachamara, ole ọ na-akwụ ụgwọ, na na.

The mejupụtara nke ọgwụ na ụdị ya tọhapụ

Na ihe ụdị ahịa ọgwụ ọjọọ, "Melofleks"? Ọgwụ - ọ bụ naanị ya ụdị tọhapụ. The ngwọta maka intramuscular injection Nwere a nti mmewere dị ka meloxicam. Ke adianade do, Nwa-agụnye ọzọ mmiri. Ndị a gụnyere ndị na-esonụ: meglumine, sodium chloride, glikofurfurol, glycine, poloxamer, sodium hydroxide ngwọta na mmiri.

The ahịa ọgwụ injections "Melofleks" ntụziaka nke ga-ọkọnọ dịrị gaba n'ime ebe, nwere ike zụrụ katọn Ukwu nke 5 ma ọ bụ 3 ampoules n'ime (1.5 ml).

The pharmacological e ji mara ọgwụ n'aka

Gịnị bụ ọgwụ "Melofleks" (gbaa)? Ntuziaka maka ojiji nke ọgwụ na-ekwu na ọ na-akọ na mgbochi mkpali ọgwụ ọjọọ (na-abụghị steroidal). Nke a agwọ ọrịa bụ enolovoy acid emepụta, adịru oge ọ bụ ike na-akpa ịnụ ọgwụ na antipyretic edinam.

Akpọ mgbochi mkpali mmetụta nke si ọgwụ arụnyere na niile ụdị (ọkọlọtọ) mbufụt. Ụkpụrụ nke ime ihe nke a agwọ ọrịa bụ na ọ bụ ike nke na inhibiting njikọ nke prostaglandins, nke na-na, n'eziokwu, na-mara ndị ogbugbo nke mbufụt.

Ọ ga-kwuru na ọgwụ "Melofleks", ego nke nke bụ nnọọ elu, na-egbochi njikọ nke prostaglandins na mbufụt saịtị ukwuu karịa na akụrụ ma ọ bụ ndị mucosa nke afo. Ndịrịta iche ndị a nwere a kpọmkwem njikọ na a nhọrọ mgbochi nke cyclooxygenase-2 n'elu cyclooxygenase-1. Ọkachamara na-ekwu na n'ihi na mgbochi nke Cox-2 na-enye a ọgwụgwọ mmetụta nke echiche nyere. Otú ọ dị, n'ihi na-adịgide adịgide inhibiting Cox-1 isoenzyme ọ na-ukwuu mgbe eme ka mmetụta na akụrụ na afo.

The pharmacokinetics nke ọgwụ

Mgbe ojiji nke nkwadebe "Melofleks 'Fim nke na-agwakọta, ya-arụsi ọrụ akụrụngwa na-agbụ na plasma edozi ego nke 99%. Nke a agwọ ọrịa na-aga site na ọbara-anụ ihe mgbochi na-abatakwa synovial ọmụmụ. Ịta nime ya ka 50% nke ịta na plasma.

The metabolism nke agwọ ọrịa na imeju (metabolized na-adịghị ejekwa ozi metabolites). Agbala nkwadebe site eriri afọ na site na akụrụ (ke hà akụkụ). N'otu oge ahụ na ndọrọ ego nke ego na-agbanweghi agbanwe na 5% nke kwa ụbọchị dose.

Egosi maka ojiji nke NSAIDs

Ọ bụrụ na ọ bụla deviations na-egosi site n'aka "Melofleks" (gbaa)? Ntuziaka maka ojiji e dere ozi nke nọchiri anya ọgwụ na-kenyere naanị na ndị na-esonụ mgbe:

• ọrịa ogbu ogbu na nkwonkwo;
• na osteoarthritis;
• na ankylosing spondylitis (ie ankylosing spondylitis).

Anyị nwere ike ikwu na nke a na ụdị ọgwụ a na-kenyere maka symptomatic ọgwụgwọ, belata ihe mgbu na mbufụt, nke dị na oge nke ọgwụ. Ọ kwesịkwara kwuru na progression nke ọrịa na o nweghị mmetụta. Ya mere, ọ pụrụ ịbụ na-enweghị ihe ọ bụla egwu nyere ndị ọrịa na n'elu diagnoses.

Contraindications ojiji nke NSAIDs

Mgbe ụfọdụ, injections kwesịghị iji "Melofleks"? Ntuziaka maka ojiji nke ngwọta nwere a pụtara nnukwu ndepụta contraindications. Maara na ọ na ị ga-enwe ike ugbu a.

• Mụbara ndidi uche ndị ọzọ mgbochi mkpali ọgwụ ọjọọ (na-abụghị steroidal).
• Nchikota polyposis ntighari paranasal sinuses na ọ dịghị òkè na bronchial ụkwara ume ọkụ, ekweghị ibe nọrọ na acetylsalicylic acid na preparations pyrazolone usoro.
• Ọnyá ọnyá akpụkpọ ahụ nke afo na duodenum 12, karịsịa na oge nke exacerbation.
• Hypersensitivity ka ọcha nke na-agbanye ngwọta.
• Active ọbara ọgbụgba si eriri afọ tract.
• Ọnọdụ onye ọrịa wasịrị (akwara akwara).
• Ụmụaka na-eto eto (apụghị-eji ruo 18 afọ).
• Gbasara akụrụ odida (adịghị ala ala) ọrịa na-adịghị ata dialysis (creatinine nwechapụ erughị 30 ml / min.).
• Mkpali bowel ọrịa.
• akụrụ ọrịa (-aga n'ihu).
• Hyperkalemia enen.
• Hepatic bara ma ọ bụ oké ifịk ọrịa imeju.

Ngwa pụtara akọ

Mgbe ụfọdụ ihe ókè ịkpachara anya kenyere ọgwụ "Melofleks"? Ntuziaka maka ojiji nke ọgwụ ngwọta e dere ozi na a ga-nnọọ nlezianya na-ekenye ndị agadi na ọrịa na akwara akwara, ọrịa shuga, cerebrovascular ọrịa, obi ọdịda (adịghị ala ala), dyslipidemia / hyperlipidemia, elu ọrịa akwara, gbasara akụrụ insufficiency ( na CC 30-60 ml / min), ọnyá ọnya nke eriri afọ tract na akụkọ ihe mere eme, ọnụnọ Helikobekter pylori ọrịa na oké somatic ọrịa.

Ọzọkwa ihe ókè ịkpachara anya ọgwụ ga-eji maka ndị na-ese siga ma na-ata ahụhụ site aṅụrụma. Ọzọkwa, na-aṅụ sịga ruo ogologo oge iwere si NSAIDS, nakwa dị ka ya n'otu oge iwere na onu corticosteroids, gụnyere pụtara "Prednisolone", anticoagulants, gụnyere iji ọgwụ "Warfarin", antiplatelet mmadụ, gụnyere iji ọgwụ 'Clopidogrel', nhọrọ reuptake inhibitors serotonin, gụnyere ọgwụ "citalopram", "Fluoxetine", "Paroxetine" na "Sertraline".

Agwọ ọrịa "Melofleks": ntuziaka maka ojiji

Dị ka e gosiri na ọgwụ na-eji na na ihe doses? Ọ dị mkpa iji tinye miri na naanị intramuscularly. N'ihi ya igba ogwu n'akwara oji a machibidoro ngwọta.

Intramuscular ochichi nke ọgwụ na-egosi na nke mbụ ụbọchị ole na ole nke ọgwụ. Ekemende ọrịa na-emekarị nyere onu NSAID.

Ya mere, na ihe doses iji ọgwụ maka otu ọrịa? Anyị na-aza ajụjụ a ugbu a.

• Mgbochi mkpali ọgwụ ọjọọ maka osteoarthritis exacerbation ndinọ ke ichekwa 7.5 mg kwa ụbọchị. Ọ bụrụ na ọrịa na-arịa adịghị agbanwe ka mma, akwụkwọ a nwere ike mụbara ruo 15 mg kwa ụbọchị.
• Na ankylosing spondylitis na ọrịa ogbu ogbu na nkwonkwo ọkọnọ agwọ ọrịa na-ndinọ ke ichekwa 15 mg kwa ụbọchị. Dabere na mmetụta nke ngwọta olu nwere ike na-ebelata ka 7.5 mg kwa ụbọchị. Ọ na-atụ aro ghara gafere kwa ụbọchị dose nke si n'aka (15 mg).

Dị ka ndị agadi na-ebu ọgwụgwọ nke ọrịa ndị dị ka osteoarthritis (ọgwụgwọ)? mgbochi mkpali ọgwụ ọjọọ ga-eji na oké ịkpachara anya. Ruo ogologo oge ọgwụgwọ nke ankylosing spondylitis na ọrịa ogbu ogbu na nkwonkwo, na onunu ogwu bụ 7.5 mg kwa ụbọchị. Ndị na-enweghị ka n'akụkụ mmetụta, ọgwụgwọ a ga-malitere na otu usoro onunu ogwu.

Ndị ọrịa dialysis na-enwe oké ihe gbasara akụrụ insufficiency, ọgwụ nso Kenye elu kwa ụbọchị dose (7.5 mg kwa ụbọchị ahụ). Na ndị mmadụ na-agafeghị oke ma ọ bụ oké gbasara akụrụ ubé ọrụ (QC karịa 25 ml / min.) Na-adịghị mkpa iji belata onunu ogwu.

mmetụta

Gịnị ma ọ bụrụ na kwuru ọgwụ adịghị inyere onye ọrịa aka ma ọ bụ na-emetụta ya na-ezighị ezi? Isiokwu analogue ọgwụ ọjọọ kwesịrị mgbe niile. N'ihi ya, onye ọrịa nwere ike inwe a yiri ngwá ọrụ na-bụ ihe kwesịrị ekwesị n'ihi na ahụ ya.

Do injections mgbochi mkpali "Melofleks" mmetụta? Dị ka ntụziaka, ọgwụ nwere ike ime ka a ọnụ ọgụgụ nke na-ezighị ezi pụta. Gịnị? Tụlee ha ugbu a.

• Ozu ọbara: anaemia, tromotsitopeniya, mgbanwe ọbara na-adabere, tinyere leukopenia.
• Digestive usoro: dyspepsia, hyperbilirubinemia, ọgbụgbọ, onya gastroduodenal, vomiting, belching, ihe mgbu, abdominal, esophagitis, afọ ntachi, ọbara ọgbụgba si eriri afọ tract, gụnyere ndị zoro ezo, flatulence, stomatitis, afọ ọsịsa, na-akwụsị akwụsị na-abawanye na imeju transaminases, ịba ọcha n'anya, perforation nke digestive tract, mgbu na afọ.
• Akụkụ okuku ume na usoro: bronchial ụkwara ume ọkụ ọgụ na ndị mmadụ anabata NSAIDs na acetylsalicylic acid.
• Skin: ọkụ ọkụ, itching, photosensitivity, ọkụ ọkụ, bullous ọkụ ọkụ, Stevens-Johnson syndrome, erythema multiforme.
• CNS: tinnitus, vertigo, mgbagwoju anya, isi ọwụwa, mgbagwoju anya, vertigo, obi lability , na somnolence.
• Urinary usoro: nnukwu gbasara akụrụ odida, albuminuria, hypercreatininemia, hematuria, interstitial nephritis.
• Arịa na obi palpitations, elu edema, rosh ọbara na ihu na ụba ọbara mgbali.
• Allergy: anaphylactoid ma ọ bụ anaphylactic Jeremaya mere, angioedema.
• Uche ziri ezi: bịara ikiri ọhụụ, conjunctivitis, bịara ikiri ọhụụ.

ikpe nke ovadozu

Gịnị pụta ibili si ndị karịrị dose "Melofleks" ọgwụ (gbaa)? Nleba na-ekwu na dị otú ahụ ikpe ha siworo ka njọ dose metụtara mmetụta. Nke a na-enye ịrị elu na-esonụ ọrịa ekwu, sị: epigastric mgbu, nnukwu gbasara akụrụ odida, mkpọchị nsụhọ, akụkụ okuku ume na njide, ọgbụgbọ, na-agba ọbara si digestive tract, vomiting, asystole, na acute hepatic ọdịda.

Bụrụ na nke ovadozu symptomatic ọgwụgwọ a chọrọ. Na nke a alkalization mmamịrị, diuresis na hemodialysis adịghị nnọọ oru oma ruru akwa nkịtị nke ọgwụ na plasma-edozi.

Specific nduzi na ngwa nke ego

Gịnị iwu ga-agbasoriri na ojiji nke ọgwụ "Melofleks" (gbaa)? Ọbịa ọkachamara na-ekwu na ihe ngwọta ga-eji ihe ókè ịkpachara anya, karịsịa na ọgwụgwọ nke ndị mmadụ na ọrịa na nke eriri afọ tract na akụkọ ihe mere eme. Ndị dị otú ahụ ọrịa a ga-ekwu mgbe nile na a dọkịta. Ọ bụrụ na ị nwere ihe ọ bụla ọbara ọgbụgba ma ọ bụ ọnyá kwesịrị ozugbo kwụsị iji ego.

Special uche ọkachamara kwesịrị iji na ndị na-na-akuko mmepe nke achọghị mmetụta si mucous membranes na akpụkpọ. N'ọnọdụ dị otú ahụ, ọ dị mma iji tụlee ịkwụsị iji ọgwụ ọjọọ.

Na ọrịa na-ebelata-ekesa ọbara olu na-ebelata glomerular filtration nwere ike ime ka ala ala gbasara akụrụ odida. Dị ka a na-achị, nke a n'akụkụ mmetụta bụ kpam kpam reversible. Ma n'ihi nzube a ọ na-atụ aro iji kagbuo ojiji nke ihe injectable ngwọta.

Mgbe ọkpụrụkpụ mma, nakwa dị ka persistent transaminase ụkpụrụ na-agbanwe agbanwe ọzọ kwa nke imeju ọgwụ ngwa kwesịkwara kwụsịrị. Ọzọkwa, ebe ọ bụ na ọ dị mkpa iji ozugbo ebu akara ule.

Ka ụbọchị, enweghị ihe ọmụma banyere mmetụta ọjọọ nke ọgwụ na ikike iji ụgbọala ugbo ala ma ọ bụ ndị ọzọ usoro bụghị. Ọ bụrụ na onye ọrịa nwere CNS mmetụta (ike ọgwụgwụ, bịara ikiri ọhụụ, dizziness, na na.), Ndị ahụ na -eme ya bụ contraindicated.

Mmekọrịta ndị ọzọ ọgwụ ọjọọ eme ihe

Ndi ọgwụ na ọgwụ ọjọọ ndị ọzọ "Melofleks", ego nke nke dịgasị na nso nke 200-300 Russian rubles?

Imekotaotuugbo ojiji nke multiple NSAIDs enwekwu ihe ize ndụ nke erosive na ọnyá ọnya nke eriri afọ tract. Ọ bụ ya mere ọ na-adịghị na-atụ aro maka kwuru ngwaahịa na ndị ọzọ mgbochi mkpali ọgwụ ọjọọ.

N'oge na ojiji nke ọgwụ ọjọọ na mamịrị ndidi ị kwesịrị ị na-aṅụ ọtụtụ mmiri. N'ihi ya, ọ na-achọ mgbe nile ọgwụ akara nke akụrụ ọrụ.

Ndị ọkachamara na-adịghị ike ikwu na ijikọta NSAIDs na anọ anticoagulants, dị ka nke a nwere ike na-amụba ihe ize ndụ nke na-agba ọbara n'ihi mmebi nke mucous akpụkpọ ahụ nke eriri afọ ma ọ bụ na afo, nakwa dị ka suppression nke platelet ọrụ. Otu mmetụta nwere ike ime na imekotaotuugbo ojiji nke kwuru nkwadebe na thrombolytic na antithrombotic mmadụ.

Ọ kwesịkwara kwuru na agwọ ọrịa "Melofleks" nwere ike dịkwuo ịta nke lithium na ọbara ka na-egbu egbu na-etoju. Ọzọkwa, mgbe ọ na-eji n'out oge na ngwaahịa "Methotrexate" ụba na-ezighị ezi pụrụ isi kwuo na ọbara.

colestyramine accelerates ọgwụ umi mkpụrụ, na-amụba nwechapụ nke nọ n'ọrụ umi nke 50%. Anyị nwere ike ikwu na NSAIDs belata irè nke intrauterine ogwu ngwaọrụ.

Ọgwụ "Melofleks": analogs

Ugbu a, ndị ahịa ọgwụ ígwè pụrụ ịchọta ọtụtụ analogues nke si ọgwụ. Ọ ga-kwuru na price nwere ike ịbụ elu dị ka ihe mbụ ọgwụ, na n'okpuru.

N'ihi ya, ọ bụrụ na n'ihi ihe ọ bụla ị na-apụghị ịzụta a ngwọta maka injections "Melofleks", mgbe ahụ, ị ga-abụ a kemfe table analogues ọgwụ. Nke a ga-ekwe ka ị na-edebe zuo ihe kwesịrị ekwesị ọgwụ, nke ọ dịghị ụzọ usụhọde na mbụ. Otú ọ dị, ọ ga-ahụ kwuru na ndị dị otú ahụ ọgwụ ọjọọ nwere ike a kpamkpam dị iche iche mmetụta, ọgwụ interactions na contraindications. Ọ bụ ya mere tupu ha were na-atụ aro ka ịkpọ onye dọkịta. Ọ bụrụ na ndị dị otú ahụ ohere na unu adịghị, ị kwesịrị ị na-agụ nke ọma ntuziaka maka ojiji.

Ya mere, ihe analogues egosila ọgwụ? N'etiti ha, m na-achọ karịsịa mata ndị na-esonụ na ngwaahịa: "Melofleks Rompharm", "Amelotex", "bi-Xico", "Artrozan", "Lem", "free", "Matar", "Medsikam", "Melbek", "Meloxicam" "Mesipol", "Eksen-Sanovel", "Oksikamoks" na na.

Na-ewere ọgwụ n'oge lactation na n'oge ime

Suppression nke prostaglandin njikọ ezighị-emetụta nwa ebu n'afọ na mmepe. Ọ bụ ya mere ọgwụ na-ekwesịghị-eji n'oge ime. Ọ bụrụ na ọ dị mkpa, ọ ga-anọchi ọzọ, ọzọ ala n'aka. Ma n'ihi na a nwaanyị dị ime mgbe niile kwesịrị ịkpọ gị dọkịta.

Ọ kwesịkwara kwuru na ọgwụ a tọhapụrụ, tinyere mmiri ara, mere ọ dị mkpa na oge nke ya ngwa kwụsị ara-udia a nwa.

Oge na ebe nchekwa nke ọgwụ

Injectable Solution "Melofleks" kwesịrị enịm n'ebe gbara ọchịchịrị, ebe ọ bụghị gụrụ kpọmkwem ìhè anyanwụ. Ọzọkwa, ọ ga-abụ maka obere ụmụ. Echekwa agwọ ọrịa desirably na okpomọkụ karịa 25 degrees n'ihi na 4 afọ. Ná ngwụsị nke adị ndụ nke ndị ọgwụ ọjọọ na-nditịm ajuru aju.